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Detecting and measuring higher order synchronization among neurons: A Bayesian approach

  • Laura Martignon
  • Kathryn Laskey
  • Arne Schwarz
  • Eilon Vaadia
Oral Presentations: Neurobiology Neurobiology I: Information Coding
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1112)

Abstract

A Bayesian approach to modeling and inferring patterns of synchronous activation in a group of neurons. A major objective of the research is to provide statistical tools for detecting changes in synchronization patterns. Our framework is not restricted to the case of correlated pairs, but generalizes the Boltzmann machine model to allow for higher order interactions. A Markov Chain Monte Carlo Model Composition (MC3) algorithm is applied in order to search over connectivity structures and uses Laplace's method to approximate their posterior probabilities.Performance of the method was first tested on synthetic data. The method was then applied to data obtained on multi-unit recordings of six neurons in the visual cortex of a rhesus monkey in two different attentional states. The obtained results indicate that the interaction structure predicted by the data is richer than just a set of synchronous pairs. They also confirmed the experimenter's conjecture that different attentional states were associated with different interaction structures.

Keywords

Nonhierarchical loglinear models Markov Chain Monte Carlo Model Composition Laplace's Method Neural Networks 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Laura Martignon
    • 1
  • Kathryn Laskey
    • 2
  • Arne Schwarz
    • 3
  • Eilon Vaadia
    • 4
  1. 1.Max Planck Institute for Psych.Research Center for Adaptive Behavior and CognitionMunichGermany
  2. 2.Department of Systems EngineeringGeorge Mason UniversityFairfax
  3. 3.Max Planck Institute for Psych.Research Center for Adaptive Behavior and CognitionMunichGermany
  4. 4.Dept. of Physiology, Hadassah Med. SchoolThe Hebrew University of JerusalemJerusalemIsrael

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