Cell differentiation and neurogenesis in evolutionary large scale chaos

  • Hiroaki Kitano
3. Adaptive and Cognitive Systems
Part of the Lecture Notes in Computer Science book series (LNCS, volume 929)


This paper reports dynamic phenomena analogous to cell differentiation. The model used in this paper is based on evolutionary large scale chaos, a large numbers of coupled chaotic elements whose logistic map is evolutionary acquired. The logistic map function itself may change dynamically according to chemical concentration in each cell by regulating its gene. Each individual starts from a single cell which can cause cell division. successfully evolved individual can form a cell cluster of the substantial size. It can form a neural network by growing axons from cells differentiated to neurite. We have observed that even such a simple dynamical system, phenomena similar to cell differentiation takes place, and creates characteristic patterns which may be observed in actual biological systems. Some of temporal patterns of axon growth observed were similar to actual growth patterns.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [Fleischer and Barr, 1994]
    Fleischer, K. and Barr, A., “A Simulation Testbed for the Study of Multicellular Development: The Multiple Mechanism of Morphogenesis,” Artificial Life III, Addison Wesley, 1994.Google Scholar
  2. [Kaneko and Yomo, 1994]
    Kaneko, K. and Yomo, T., “Cell Division, Differentiation and Dynamic Clustering,” Physica D, 1994. (to appear)Google Scholar
  3. [Kaneko, 1992]
    Kaneko, K., “Overview of coupled map lattices,” Chaos, 2 (3), 1992.Google Scholar
  4. [Kitano, 1994]
    Kitano, H., “Evolution of Metabolism for Morphogenesis,” Proc. of Alife-IV, 1994.Google Scholar
  5. [Kitano, 1995]
    Kitano, H., “A Simple Model of Neurogenesis and Cell Differentiation based on Evolutionary Large Scale Chaos,” Artificial Life, Vol. 2, No. 1, 1995.Google Scholar
  6. [Lindenmayer, 1968]
    Lindenmayer, A., “Mathematical Models for Cellular Interactions in Development,” J. theor. Biol., 18, 280–299, 1968.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Hiroaki Kitano
    • 1
  1. 1.Sony Computer Science LaboratoryTokyoJapan

Personalised recommendations