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Modern Solvents in Organic Synthesis pp 153–207Cite as

Solvent-free Reactions

Part of the Topics in Current Chemistry book series (TOPCURRCHEM,volume 206)

Abstract

For reasons of economy and pollution, solvent-free methods are of great interest in order to modernize classical procedures making them more clean, safe and easy to perform. Reactions on solid mineral supports, reactions without any solvent/support or catalyst, and solid-liquid phase transfer catalysis can be thus employed with noticeable increases in reactivity and selectivity. A comprehensive review of these techniques is presented here. These methodologies can moreover be improved to take advantage of microwave activation as a beneficial alternative to conventional heating under safe and efficient conditions with large enhancements in yields and savings in time.

Keywords

  • Mineral solid supports
  • Phase transfer catalysis
  • Solid state reactions
  • Reactivity
  • Selectivity
  • Microwave activation

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  1. Laboratoire des Réactions Sélectives sur Supports - CNRS UMR 8615, Paris-South University, Building 410, 91405, Orsay-Cédex, France

    André Loupy

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  1. Institut für Organische Chemie, Ludwig Maximilians-Universität München, Butenanderstr. 5 - 13, D-81377, München, Germany

    Paul Knochel

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Loupy, A. (1999). Solvent-free Reactions. In: Knochel, P. (eds) Modern Solvents in Organic Synthesis. Topics in Current Chemistry, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48664-X_7

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