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Influence of Stress on Adherent Cells

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Influence of Stress on Cell Growth and Product Formation

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 67))

Abstract

Stress is a broad term often used with animal cells. Frequently mechanical forces are meant using this term but chemical stress is also important cultivating animal cells. The chemical environment of the cell in a reactor have to be considered very carefully. The complexity of the medium requirements and the metabolic pathway cause very often growth limitations. Studying these limitations in order to find the reasons showed to be difficulty because of the complexity of the system. Nevertheless, glucose, glutamine, lactate and ammonia are found to be critical parameter as well as the osmotic pressure.

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Authors and Affiliations

  1. Institut für Technische Chemie der Universität Hannover, Callinstraße 3, D-30167, Hannover, Germany

    Gerlinde Kretzmer

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  1. Gerlinde Kretzmer
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Editors and Affiliations

  1. Institute of Technical Chemistry, University of Hannover, Callinstr. 3, D-30167, Hannover, FRG

    K. Schügerl  & G. Kretzmer  & 

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© 2000 Springer-Verlag Berlin Heidelberg

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Kretzmer, G. (2000). Influence of Stress on Adherent Cells. In: Schügerl, K., et al. Influence of Stress on Cell Growth and Product Formation. Advances in Biochemical Engineering/Biotechnology, vol 67. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-47865-5_4

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  • DOI: https://doi.org/10.1007/3-540-47865-5_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66687-5

  • Online ISBN: 978-3-540-47865-2

  • eBook Packages: Springer Book Archive

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