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Contrast Agents II pp 151–171Cite as

Iodinated Contrast Media: from Non-Specific to Blood-Pool Agents

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 222))

Abstract

In 1998, the commercial introduction of multislice computed tomography made X-ray functional imaging possible. Specific contrast agents that could remain within the intravascular compartment for a substantially longer time than conventional nonspecific agents may allow the quantification of local blood volume, tissue perfusion and permeability and thus the characterization of several types of lesions.

We describe a new series of monodisperse, macromolecular iodinated contrast agents. The synthesis, analysis and pharmacokinetics of these molecules are presented.

Their pharmacokinetic profiles are consistent with those of blood-pool agents, of either the rapid- or slow-clearance categories. Their diffusion through the endothelium was found to be low in vitro, thus confirming early confinement of these macromolecules, unlike nonspecific contrast agents. Preclinical safety data (including renal and immunological tolerability) are promising and should allow further evaluation of these compounds to be carried out.

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Authors and Affiliations

  1. Research Division, Guerbet, BP 50400 95943, Roissy Charles de Gaulle cedex, France

    Jean-Marc Idée, Isabelle Nachman, Marc Port, Myriam Petta, Gael Le Lem, Soizic Le Greneur, Anne Dencausse, Dominique Meyer & Claire Corot

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  1. Jean-Marc Idée
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  2. Isabelle Nachman
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  3. Marc Port
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  4. Myriam Petta
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  5. Gael Le Lem
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  6. Soizic Le Greneur
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  7. Anne Dencausse
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  8. Dominique Meyer
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  9. Claire Corot
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Editors and Affiliations

  1. International Project Management Therapeutics, Schering AG, 13342, Berlin, Germany

    Werner Krause

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© 2002 Springer-Verlag Berlin Heidelberg

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Idée, JM. et al. (2002). Iodinated Contrast Media: from Non-Specific to Blood-Pool Agents. In: Krause, W. (eds) Contrast Agents II. Topics in Current Chemistry, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46009-8_5

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  • DOI: https://doi.org/10.1007/3-540-46009-8_5

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  • Print ISBN: 978-3-540-43451-1

  • Online ISBN: 978-3-540-46009-1

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