Abstract
Tissue engineering is the application of the principles and methods of engineering and the life sciences towards the development of biological substitutes to restore, maintain or improve functions. It is an area which is emerging in importance worldwide. This article is to show the developments in tissue engineering research by the example of the bioartificial liver. As an alternative to liver transplantation, numerous researchers have been working towards the goal of development of a fully functional artificial liver. Liver support systems based on detoxification alone have proven ineffective because they cannot correct biochemical disorders. An effective artificial liver support system should be capable of carrying out the liver’s essential processes, such as synthetic and metabolic functions, detoxification, and excretion. It should be capable of sustaining patients with fulminant hepatic failure and preparing patients for liver transplantation when a donor liver is not readily available. Although several hepatocyte-based liver support systems have been proposed, there is no current consensus on its eventual design configuration.
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References
Langer R, Vacanti JP (1993) Science 260:920
Dixit V, Gitnick G (1998) Eur J Surg Suppl 582:71
Nyberg SL, Hibbs JR, Hardin JA, Germer JJ, Persing DH (1999) Transplantation 67:1251
Bader A, Knop E, Kern A, Boker K, Frühauf N, Crome O, Esselmann H, Pape C, Kempka G, Sewing KF (1996) Exp Cell Res 226:223
McLaughlin B, Tosone CM, Custer LM, Mullon C (1999) Ann N Y Acad Sci 875:310
Busse B, Gerlach JC (1999) Ann N Y Acad Sci 875:326
Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey C, Onions D, The XEN 111 Study Group, Otto E (1999) Science 285:1236
Kobayashi N, Fujiwara T, Westerman KA, Inoue Y, Sakaguchi M, Noguchi H, Miyazaki M, Cai J, Tanaka N, Fox IJ, Leboulch P (2000) Science 287:1258
Riordan S, Williams R (1997) Br Med Bull 53:730
Sussman NL, Chong MG, Koussayer T, He DE, Shang TA, Whisennand HH, Kelly JH ( 1992) Hepatology 16:60
Neuzil DF, Rozga J, Moscioni AD, Ro MS, Hakim R, Arnaout WS, Demetriou AA (1993) Surgery 113:340
Gerlach JC, Brombacher J, Kloppel K, Schnoy N, Neuhaus P (1994) Transplantation 57:1318
Nagamori S, Hasumura S, Matsuura T, Aizaki H, Kawada M (2000) J Gastroenterol 35:493
Werner A, Duvar S, Müthing J, Büntemeyer H, Lünsdorf H, Strauss M, Lehmann J (2000) Biotechnol Bioeng 68:59
Berry MN, Friend DS (1969) J Cell Biol 43:506
Seglen PO, Jervell KF (1969) Hoppe Seylers Z Physiol Chem 350:308
Seglen PO (1976) Methods Cell Biol 13:29.
Hoogenboom LA, Pastoor FJ, Clous WE, Hesse SE, Kuiper HA (1989) Xenobiotica 19:1207
Sakai Y, Furkawa K, Suzuki M (1992) Biotechnol Tech 6:527
Sakai Y, Naruse K, Nagashima I, Muto T, Suzuki M (1999) Cell Transpl 8:531
Kong LB, Chen S, Demetriou AA, Rozga J (1996) Int J Artif Organs 19:72
Naruse K, Sakai Y, Nagashima I, Jiang GX, Suzuki M, Muto T (1995) Int J Art Organs 19:347
Naruse K, Nagashima I, Sakai Y, Harihara Y, Jiang GX, Suzuki M, Muto T, Makuuchi M (1998) Artif Organs 22:1031
Kino Y, Sawa M, Kasai S, Mito M (1998) J Surg Res 79:71
Arnaout WS, Moscioni AD, Barbour RL, Demetriou AA (1990) J Surg Res 48:379
Dore E, Legallais C (1999) Ther Apher 3:264
Legallais C, Dore E, Paullier P (2000) Artif Organs 24:519
Hwang YJ, Kim YI, Lee JG, Lee JW, Kim JW, Chung JM (2000) Tranplant Proc 32:2349
Dixit V, Gitnick G (1996) Scand J Gastroenterol Suppl 220:101
Nyberg SL, Platt JL, Shirabe K, Payne WD, Hu WS, Cerra FB (1992) Asaio J 38: M463
Nyberg SL, Shirabe K, Peshwa MS, Sielaff TD, Crotty PL, Mann HJ (1993) Cell Transplantation 2:241
Custer L, Mullon CJ (1998) Adv Exp Med Biol 454:261
Gerlach J C, Encke J, Hole O, Muller C, Courtney JM, Neuhaus P (1994) Int J Artif Organs 17:301
Jasmund I, Schmidt-Richter I., Simmoteit R., Bader A. (2000) Int J Artif Organs 23:535
Bader A, De Bartolo L, Haverich A (2000) J Biotech 81:95
De Bartolo L, Jarosch-von Schweder G, Haverich A, Bader A (2000) Biotechnol Prog 16:102
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Dedicated to Prof. Dr. Wolf-Dieter Deckwer on the occasion of his 60th birthday
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Jasmund, I., Bader, A. (2002). Bioreactor Developments for Tissue Engineering Applications by the Example of the Bioartificial Liver. In: Schügerl, K., et al. Tools and Applications of Biochemical Engineering Science. Advances in Biochemical Engineering/Biotechnology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45736-4_5
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DOI: https://doi.org/10.1007/3-540-45736-4_5
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