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The Use of MassARRAY Technology for High Throughput Genotyping

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Chip Technology

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 77))

Abstract

This chapter will explore the role of mass spectrometry (MS) as a detection method for genotyping applications and will illustrate how MS evolved from an expert-user-technology to a routine laboratory method in biological sciences. The main focus will be time-of-flight (TOF) based devices and their use for analyzing single-nucleotide-polymorphisms (SNPs, pronounced snips). The first section will describe the evolution of the use of MS in the field of bio-analytical sciences and the protocols used during the early days of bioanalytical MALDI TOF mass spectrometry. The second section will provide an overview on intraspecies sequence diversity and the nature and importance of SNPs for the genomic sciences. This is followed by an exploration of the special and advantageous features of mass spectrometry as the key technology in modern bioanalytical sciences in the third chapter. Finally, the fourth section will describe the MassARRAY technology as an advanced system for automated high-throughput analysis of SNPs.

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Author information

Authors and Affiliations

  1. SEQUENOM, Inc., 3595 John Hopkins Court, San Diego, CA, 92121, USA

    Christian Jurinke, Dirk van den Boom, Charles R. Cantor & Hubert Köster

Authors
  1. Christian Jurinke
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  2. Dirk van den Boom
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  3. Charles R. Cantor
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  4. Hubert Köster
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Editor information

Editors and Affiliations

  1. Functional Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 506, 69120, Heidelberg, Germany

    Jörg Hoheisel

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© 2002 Springer-Verlag Berlin Heidelberg

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Jurinke, C., van den Boom, D., Cantor, C.R., Köster, H. (2002). The Use of MassARRAY Technology for High Throughput Genotyping. In: Hoheisel, J., et al. Chip Technology. Advances in Biochemical Engineering/Biotechnology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45713-5_4

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  • DOI: https://doi.org/10.1007/3-540-45713-5_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43215-9

  • Online ISBN: 978-3-540-45713-8

  • eBook Packages: Springer Book Archive

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