Abstract
This paper reports on a logical model of the rational use of theory in a particular discovery problem in neuropharmacology, based on a case study of a practice of drug research for Parkinson’s disease. This analysis describes how qualitative assumptions about the relation between properties of the nervous system are used to search for drug leads, i.e. properties for possible drug interventions. The logical structure of this drug lead discovery problem is briefly described together with the structure of some assumptions from the case study. It is briefly discussed how computational tools where used to explore these assumptions, and how they could possibly aid discovery in this domain.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
van den Bosch, A.P.M.: Rationality in Discovery-A Study of Logic, Cognition, Computation and Neuropharmacology, Institute for Language Logic and Computation, Amsterdam (2001)
Vos, R.: Drugs looking for diseases. Innovative drug research and the development of the beta blockers and the calcium antagonists. Kluwer Academic Press, Dordrecht (1991)
van den Bosch, A.P.M.: Qualitative Drug Lead Discovery. In working notes of the International Congress on Discovery and Creativity, Ghent, (1998) 163–165
Kuipers, T.A.F., Vos, R. & Sie, H.: Design Research Programs and the Logic of their Development. Erkenntnis (37), (1992) 37–63
van den Bosch, A.P.M.: Inference to the Best Manipulation-a case study of qualitative reasoning in neuropharmacy. In Foundations of Science 4(4). Special issue on Scientific Discovery and Creativity: Case studies and computational approaches. Guest editors: J. Meheus & T. Nickles (1999) 483–495
Kuipers, B.: Qualitative Reasoning, Modeling and simulation with incomplete knowledge. Cambridge, MA: MIT Press (1994)
Bredeweg, B.: Expertise in Qualitative Prediction of Behaviour. Ph.D. thesis, University of Amsterdam, Amsterdam, The Netherlands, (1992)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
van den Bosch, A.P. (2001). Logic of Drug Discovery: A Descriptive Model of a Practice in Neuropharmacology. In: Jantke, K.P., Shinohara, A. (eds) Discovery Science. DS 2001. Lecture Notes in Computer Science(), vol 2226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45650-3_44
Download citation
DOI: https://doi.org/10.1007/3-540-45650-3_44
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-42956-2
Online ISBN: 978-3-540-45650-6
eBook Packages: Springer Book Archive