Experimental and Computational Modeling of Cardiac Electromechanical Coupling

  • Andrew D. McCulloch
  • Derrick Sung
  • Mary Ellen Thomas
  • Anushka Michailova
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2230)


Perturbations in ventricular mechanical loading can be arrhythmogenic and have been associated with sudden cardiac death in patients suffering from congestive heart failure, dilated cardiomyopathy, or ventricular volume overload (1–3). Stretch-induced changes in action potential propagation or repolarization could provide a mechanism for mechanically induced arrhythmias. However, there is a paucity of information regarding the effects of altered load on conduction velocity. The few existing reports present an unclear picture; some of the discrepancies may be due to the varying techniques used.


Conduction Velocity Action Potential Duration Action Potential Propagation Action Potential Amplitude Isolate Rabbit Heart 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Andrew D. McCulloch
    • 1
  • Derrick Sung
    • 1
  • Mary Ellen Thomas
    • 1
  • Anushka Michailova
    • 1
  1. 1.Department of Bioengineering, The Whitaker Institute for Biomedical EngineeringUniversity of California San DiegoLa Jolla

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