Nomenclature
EC number
2.1.1.4
Systematic name
S-adenosyl-l-methionine:N-acetylserotonin O-methyltransferase
Recommended name
acetylserotonin O-methyltransferase
Synonyms
ASMT
HIOMT
N-acetylserotonin O-methyltransferase
acetylserotonin methyltransferase
hydroxyindole O-methyltransferase
hydroxyindole methyltransferase
hydroxyindole-O-methyl transferase
methyltransferase, acetylserotonin
CAS registry number
9029-77-0
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Axelrod, J.; Weissbach, H.: Purification and properties of hydroxyindole-O-methyl transferase. J. Biol. Chem., 236, 211–213 (1961)
Suzuki, O.; Yagi, K.: A nonisotopic assay for acetylserotonin methyltransferase. Anal. Biochem., 88, 580–586 (1978)
Kuwano, R.; Takahashi, Y.: Binding of S-adenosylhomocysteine to hydroxyindole O-methyltransferase. Biochim. Biophys. Acta, 787, 1–7 (1984)
Sugden, D.; Klein, D.C.: Inactivation of rat pineal hydroxyindole-O-methyl-transferase by disulfide-containing compounds. J. Biol. Chem., 262, 6489–6493 (1987)
Sugden, D.; Cena, V.; Klein, D.C.: Hydroxyindole O-methyltransferase. Methods Enzymol., 142, 590–596 (1987)
Morton, D.J.; Kock, N.: Some properties of pineal gland hydroxyindole-O-methyltransferase from black rhinoceros (Diceros bicornis). J. Pineal Res., 8, 35–40 (1990)
Morton, D.J.: Mechanism of inhibition of bovine pineal gland hydroxyindole-O-methyltransferase (EC 2.1.1.4) by divalent cations. J. Pineal Res., 4, 295–303 (1987)
Sugden, D.; Voisin, P.; Klein, D.C.: Purification of rat pineal hydroxyindole-O-methyltransferase using S-adenosyl-L-homocysteine agarose chromatography. J. Pineal Res., 3, 389–395 (1986)
Nakane, M.; Yokoyama, E.; Deguchi, T.: Species heterogeneity of pineal hydroxyindole-O-methyltransferase. J. Neurochem., 40, 790–796 (1983)
Birks, E.K.; Ewing, R.D.: Characterization of hydroxyindole-O-methyltransferase (HIOMT) from the pineal gland of chinook salmon (Oncorhynchus tshawytscha). Gen. Comp. Endocrinol., 43, 269–276 (1981)
Kuwano, R.; Yoshida, Y.; Takahshim, Y.: Purification of bovine pineal hydroxyindole O-methyltransferase by immunoadsorption chromatography. J. Neurochem., 31, 815–824 (1978)
Nir, I.; Hirschmann, N.; Sulman, F.G.: Inhibition of pineal hydroxyindole-O-methyl transferase by pyridoxal-5-phosphate. Biochem. Pharmacol., 25, 581–583 (1976)
Karahasanoglu, A.M.; Ozand, P.T.: The purification and properties of bovine pineal S-adenosylmethionine: N-acetylserotonin O-methyl transferase. J. Neurochem., 19, 411–430 (1972)
Tedesco, S.C.; Moron, D.J.; Reiter, R.J.: Hydroxyindole-O-methyltransferase activity in the pineal gland of the muskox (Ovibos moschatus). J. Pineal Res., 16, 121–126 (1994)
Benyassi, A.; Schwartz, C.; Ducouret, B.; Falcon, J.: Glucocorticoid receptors and serotonin N-acetyltransferase activity in the fish pineal organ. NeuroReport, 12, 889–892 (2001)
Ribelayga, C.; Gauer, F.; Calgari, C.; Pevet, P.; Simonneaux, V.: Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity. Endocrinology, 140, 1375–1384 (1999)
Bernard, M.; Donohue, S.J.; Klein, D.C.: Human hydroxyindole-O-methyl-transferase in pineal gland, retina and Y79 retinoblastoma cells. Brain Res., 696, 37–48 (1995)
Itoh, M.T.; Ishizuka, B.; Kudo, Y.; Fusama, S.; Amemiya, A.; Sumi, Y.: Detection of melatonin and serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase activities in rat ovary. Mol. Cell. Endocrinol., 136, 7–13 (1997)
Bernard, M.; Klein, D.C.: Retinoic acid increases hydroxyindole-O-methyl-transferase activity and mRNA in human Y-79 retinoblastoma cells. J. Neu-rochem., 67, 1032–1038 (1996)
Ishio, S.; Yamada, H.; Craft, C.M.; Moriyama, Y.: Hydroxyindole-O-methyltransferase is another target for L-glutamate-evoked inhibition of melatonin synthesis in rat pinealocytes. Brain Res., 850, 73–78 (1999)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2006). Acetylserotonin O-methyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases I. Springer Handbook of Enzymes, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37715-8_4
Download citation
DOI: https://doi.org/10.1007/3-540-37715-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-31917-7
Online ISBN: 978-3-540-37715-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)