Skip to main content

Phosphatidylethanolamine N-methyltransferase

  • Chapter
  • 70 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 28))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ridgway, N.D.; Vance, D.E.: Phosphatidylethanolamine N-methyltransferase from rat liver. Methods Enzymol., 209, 366–374 (1992)

    Article  PubMed  CAS  Google Scholar 

  2. Vance, D.E.; Schneider, W.J.: Conversion of phosphatidylethanolamine to phosphatidylcholine. Methods Enzymol., 71, 581–588 (1981)

    PubMed  CAS  Google Scholar 

  3. Gaynor, P.M.; Carman, G.M.: Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties. Biochim. Biophys. Acta, 1045, 156–163 (1990)

    PubMed  CAS  Google Scholar 

  4. Pajares, M.A.; Villalba, M.; Mato, J.M.: Purification of phospholipid methyltransferase from rat liver microsomal fraction. Biochem. J., 237, 699–705 (1986)

    PubMed  CAS  Google Scholar 

  5. McBride, K.; Furness, L.M.; Gibbons, W.A.: Lipid methyltransferase: purification and structure. Biochem. Soc. Trans., 15, 924–925 (1987)

    CAS  Google Scholar 

  6. Fonteh, A.N.; Gibbons, W.A.: Solubilization and purification of lipid methyltransferase. Biochem. Soc. Trans., 18, 266–267 (1990)

    PubMed  CAS  Google Scholar 

  7. Varela, I.; Merida, I.; Pajares, M.; Villalba, M.; Mato, J.M.: Activation of partially purified rat liver lipid methyltransferase by phosphorylation. Biochem. Biophys. Res. Commun., 122, 1065–1070 (1984)

    Article  PubMed  CAS  Google Scholar 

  8. Ridgway, N.D.; Vance, D.E.: Kinetic mechanism of phosphatidylethanolamine N-methyltransferase. J. Biol. Chem., 263, 16864–16871 (1988)

    PubMed  CAS  Google Scholar 

  9. Prasad, C.; Edwards, R.M.: Synthesis of phosphatidylcholine from phosphatidylethanolamine by at least two methyltransferases in rat pituitary extracts. J. Biol. Chem., 256, 13000–13003 (1981)

    CAS  Google Scholar 

  10. Dudeja, P.K.; Foster, E.S.; Brasitus, T.A.: Synthesis of phosphatidylcholine by two distinct methyltransferases in rat colonic brush-border membranes: evidence for extrinsic and intrinsic membrane activities. Biochim. Biophys. Acta, 875, 493–500 (1986)

    PubMed  CAS  Google Scholar 

  11. Ridgway, N.D.; Vance, D.E.: Purification of phosphatidylethanolamine N-methyltransferase from rat liver. J. Biol. Chem., 262, 17231–17239 (1987)

    PubMed  CAS  Google Scholar 

  12. Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.: Purification and characterization of phosphatidylethanolamine N-methyltransferase from Zymo-monas mobilis. Agric. Biol. Chem., 51, 1425–1430 (1987)

    CAS  Google Scholar 

  13. Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.: Phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis: purification and characterization. Agric. Biol. Chem., 50, 257–259 (1986)

    CAS  Google Scholar 

  14. Makishima, F.; Toyoshima, S.; Osawa, T.: Partial purification and characterization of phospholipid N-methyltransferases from murine thymocyte microsomes. Arch. Biochem. Biophys., 238, 315–324 (1985)

    Article  PubMed  CAS  Google Scholar 

  15. Morgan, T.E.: Isolation and characterization of lipid N-methyltransferase from dog lung. Biochim. Biophys. Acta, 178, 21–34 (1969)

    PubMed  CAS  Google Scholar 

  16. Vance, D.E.; Walkey, C.J.; Cui, Z.: Phosphatidylethanolamine N-methyltransferase from liver. Biochim. Biophys. Acta, 1348, 142–150 (1997)

    PubMed  CAS  Google Scholar 

  17. Cui, Z.; Shen, Y.J.; Vance, D.E.: Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth rate of perinatal rat livers. Biochim. Biophys. Acta, 1346, 10–16 (1997)

    PubMed  CAS  Google Scholar 

  18. Nishimaki-Mogami, T.; Suzuki, K.; Takahashi, A.: The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins. Biochim. Biophys. Acta, 1304, 21–31 (1996)

    PubMed  Google Scholar 

  19. Shields, D.J.; Lehner, R.; Agellon, L.B.; Vance, D.E.: Membrane topography of human phosphatidylethanolamine N-methyltransferase. J. Biol. Chem., 278, 2956–2962 (2003)

    Article  PubMed  CAS  Google Scholar 

  20. Tessitore, L.; Dianzani, I.; Cui, Z.; Vance, D.E.: Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcino-genesis. Biochem. J., 337, 23–27 (1999)

    Article  PubMed  CAS  Google Scholar 

  21. Tessitore, L.; Cui, Z.; Vance, D.E.: Transient inactivation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate:phosphocholine cytidylyltransferase during non-neoplastic liver growth. Biochem. J., 322, 151–154 (1997)

    PubMed  CAS  Google Scholar 

  22. Waite, K.A.; Vance, D.E.: Why expression of phosphatidylethanolamine N-methyltransferase does not rescue Chinese hamster ovary cells that have an impaired CDP-choline pathway. J. Biol. Chem., 275, 21197–21202 (2000)

    Article  PubMed  CAS  Google Scholar 

  23. Cui, Z.; Vance, D.E.: Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats. J. Biol. Chem., 271, 2839–2843 (1996)

    Article  PubMed  CAS  Google Scholar 

  24. Lee, M.W.; Bakovic, M.; Vance, D.E.: Overexpression of phosphatidylethanolamine N-methyltransferase 2 in CHO-K1 cells does not attenuate the activity of the CDP-choline pathway for phosphatidylcholine biosynthesis. Biochem. J., 320, 905–910 (1996)

    PubMed  CAS  Google Scholar 

  25. Lee, E.S.Y.; Charlton, C.G.: l-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation. Pharmacol. Biochem. Behav., 70, 105–114 (2001)

    Article  PubMed  CAS  Google Scholar 

  26. Tessitore, L.; Sesca, E.; Bosco, M.; Vance, D.E.: Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats. Carcinogenesis, 20, 561–567 (1999)

    Article  PubMed  CAS  Google Scholar 

  27. Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.: Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer’s disease. Neurochem. Int., 34, 41–47 (1999)

    Article  PubMed  CAS  Google Scholar 

  28. Kim, Y.J.; Park, H.S.; Choi, M.U.: Detection of cytosolic phosphatidylethanolamine N-methyltransferase in rat brain. J. Biochem. Mol. Biol., 31, 170–176 (1998)

    CAS  Google Scholar 

  29. Vance, D.E.: Phosphatidylethanolamine N-methyltransferase: Unexpected findings from curiosity-driven research. Eur. J. Med. Res., 1, 182–188 (1996)

    PubMed  CAS  Google Scholar 

  30. Roque, M.E.; Giusto, N.M.: Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina. Exp. Eye Res., 60, 631–643 (1995)

    Article  PubMed  CAS  Google Scholar 

  31. Roque, M.E.; Salvador, G.A.; Giusto, N.M.: Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin. Exp. Eye Res., 69, 555–562 (1999)

    Article  PubMed  CAS  Google Scholar 

  32. Tessitore, L.; Sesca, E.; Vance, D.E.: Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells. Int. J. Cancer, 86, 362–367 (2000)

    Article  PubMed  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2006). Phosphatidylethanolamine N-methyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases I. Springer Handbook of Enzymes, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37715-8_17

Download citation

Publish with us

Policies and ethics