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Lysosomal Cysteine Proteases and Antigen Presentation

  • Conference paper
Book cover Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 56))

Abstract

Lysosomal proteinases are involved in two critical stages of MHC class II-mediated antigen presentation, i.e., degradation of invariant chain, a chaperone molecule critical for MHC class II assembly and transport, and generation of class II-binding peptides in the endocytic compartment. We found that two lysosomal cysteine proteinases, cathepsins S and L, were found to be differentially expressed in different types of “professional” and “nonprofessional” antigen presenting cells, including B cells, macrophages, specialized thymic epithelium, intestinal epithelium, and dendritic cells. In this chapter, our recent studies on the role of cathepsin S and L in MHC class II-mediated antigen processing and presentation in these cells types are highlighted.

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Health Sciences, Bldg. Rm I-6041 1959 NE Pacific Street, Seattle, WA, 98195, USA

    A. Rudensky

  2. Department of Immunology, University of Washington School of Medicine, Box 357370, Health Sciences, Bldg. Rm I-6041 1959 NE Pacific Street, Seattle, WA, 98195, USA

    C. Beers

Authors
  1. A. Rudensky
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  2. C. Beers
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Editor information

Editors and Affiliations

  1. Berlex Biosciences, 2600 Hilltop Drive, PO Box 4099, Richmond, CA, 94804-0099, USA

    R. Numerof

  2. University of Colorado Health Sciences Center, 4200 East Ninth Ave., B168, Denver, CO, 80262, USA

    C. A. Dinarello

  3. Corporate Research Business Area Dermatology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    K. Asadullah

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© 2005 Springer-Verlag Berlin Heidelberg

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Rudensky, A., Beers, C. (2005). Lysosomal Cysteine Proteases and Antigen Presentation. In: Numerof, R., Dinarello, C.A., Asadullah, K. (eds) Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases. Ernst Schering Research Foundation Workshop, vol 56. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37673-9_5

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  • DOI: https://doi.org/10.1007/3-540-37673-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25427-0

  • Online ISBN: 978-3-540-37673-6

  • eBook Packages: MedicineMedicine (R0)

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