Abstract
Yeasts have a longstanding history as domesticated and cultivated organisms. The brewing of beer and wine and the leavening of bread dough are well known ‘artisanal’ applications of yeast. These early examples of yeast biotechnology have clearly contributed to the acceptance of yeasts, both as biotechnological workhorses and as model systems for detailed understanding of eukaryotic molecular cell biology and genetics.
In recent years, new yeast species have proven their value and novel biotechnlogical applications have emerged. In this book, the multi-faceted genetic repertoire of several yeasts relevant to modern biotechnology is compiled, and their utilization in research and application is described in light of their genetic make up and physiological characteristics.
As a first of its kind, this book describes examples and details on research into and application of (molecular) genetics of yeasts as diverse as Saccaromyces, Kluyveromyces, Hansenula, Pichia, and Yarrowia. Scientific knowledge and innovel applications of e.g. biocontrol yeasts, and covers the whole range from classical genetics to modern functional genomics technology. As such, the book is aiming to serve a wide audience, ranging from the interested graduate student, via the experienced academic researcher to the industrial biotechnologist.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Almeida MJ, Pais CS (1996) Characterization of the yeast population from traditional corn and rye bread doughs. Lett Apl Microbiol 23:154–158
Aristidou A, Pentillä M (2000) Metabolic engineering applications to renewable resource utilization. Curr Opin Biotechnol 11:187–198
Attfield PV (1997) Stress tolerance: the key to effective strains of industrial baker’s yeast. Nat Biotechnol 15:1351–1357
Bailey JE (1991) Toward a science of metabolic engineering. Science 252:1668–1675
Bolotin-Fukuhara M, Toffano-Nioche C, Artiguenave F, Duchateau-Nguyen G, Lemaire M, Marmeisse R, Montrocher R, Robert C, Termier M, Wincker P, Wésolowski-Louvel M (2000) Genomic exploration of the hernias corny cetous yeasts: 11. Kluyveromyces lactis. FEBS Lett 487:66–70
Bonekamp FJ, Oosterom J (1994) On the safety of Kluyveromyces lactis: a review. Appl Microbiol Biotechnol 41:1–3
Chen SL, Chiger M (1985) Production of baker’s yeats. In: Moo-young M (ed) Comprehensive Biotechnology Vol. 3. Pergamon Press, Oxford, UK, pp 429–455
Corran HS (1975) A history or brewing. Davis and Charles, Newton Abbott, UK
De Deken RH (1966) The Crabtree effect: a regulatory system in yeast. J Gen Microbiol 44:149–156
Decottignies A, Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15:137–145
Demain AL, Solomon NA (1981) Industrial microbiology. sci American 245, 42–51.
Dyer JM, Chapital DC, Kuan JW, Mullen RT, Pepperman AB (2002) Metabolic engineering of Saccharomyces cerevisiae for production of novel hpid compounds. Appl Microbiol Biotechnol 59:224–230
Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195:1–10
Fronza G, Inga A, Monti P, Scott G, Campomenosi P, Menichini P, Ottaggio L, Viaggi S, Burns PA, Gold B, Abbondandolo A (2000) The yeast p53 functional assay: a new tool for molecular epidemiology. Hopes and facts. Mutation Res 462:293–301
Garfinkel DJ, Bailis AM (2002) Nucleotide excision repair, genome stability and human disease: new insight from model systems. J Biomed Biotechnol 2:55–60
Goffeau A et al. (1997) The Yeast Genome Directory. Nature 387 (suppl):1–105
Hartwell L (2002) Nobel Lecture. Yeast and cancer. Biosci Rep 22:373–394
Hollenberg CP, Gellissen G (1997) Production of recombinant proteins by methyl otrophic yeasts. Curr Opin Biotechnol 8:554–560
Huang P, Stroffekova K, Cuppoletti J, Mahanty SK, Scarborough GA (1996) Functional chim Biophys Acta 1281:80–90
Kiser GL, Gentzsch M, Kloser AK, Balzi E, Wolf DH, Goffeau A, Riordan JR (2001) Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae. ArchBiochem Biophys 390:195–205
Kurtzman CP, Fell JW (1998) The Yeasts, a taxonomic study, 3rd Edition. Elsevier Science Publishers, Amsterdam
Leathers T (2003) Bio conversions of maize residues to value-added coproducts using yeast-like fungi. FEMS Yeast Res 3:133–140
Madzak M, Gaillardin C, Beckerich JM (2003) Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica. J Biotechnol, in the press
Martin AC, Drubin DG (2003) Impact of genome-wide functional analyses on cell biology research. Curr Opin Cell Biol 15, 6–13
Nielsen J (2001) Metabolic engineering. Appl Microbiol Biotechnol 55:263–283
Nurse P (2002) Cyclin dependent kinases and cell cycle control (nobel lecture). Chembiochem 3:596–603
Powell CD, Quain DE, Smart KA (2003) The impact of brewing yeast cell age on fermentation performance, attenuation and flocculation. FEMS Yeast Res 3:149–157
Pretorius IS (2000) Tailoring wine yeast for the new millennium: novel approaches to the ancient art of wine making. Yeast 16:675–729
Que QQ, Winzeler EA (2002) Large-scale mutagenesis and functional genomics in yeast. Func Integr Genomics 2:193–198
Robinson J (1994) The Oxford Companion to Wine. Oxford Uiversity Press, Oxford, UK
Schuller D, Corte-Real M, Leao C (2001) A differential medium for the enumeration of the spoilage yeast Zygosaccharomyces bailii in wine. J Food Protect 63:1570–1575
Smardova J, Pavlova S, Koulakova H (2002) Determination of optimal conditions for analysis of p53 status inleukemic cells using functional analysis of separated alleles in yeast. Path Oncol Res 8:245–251
Swinkels BW, van Ooyen AJ, Bonekamp FJ (1993) The yeast Kluyveromyces lactis as an efficient host for heterologous gene expression. Antonie van Leeuwenhoek 64:187–201
Szczebara FM, Chandelier C, Villeret C, Masurel A, Bourot S, Duport C, Blanchard S, Groisillier A, Testet E, Costaglioli P, Cauet G, Degryse E, Balbuena D, Winter J, Achstetter T, Spagnoli R, Pompon D, Dumas B (2003) Total biosynthesis of hydrocortisone from a simple carbon source in yeast. Nat Biotechnol 21:143–149
Trivedi NB, Jacobson GK, Tesch W (1986) Baker’s yeast. CRC Crit Rev Biotechnol 4:75–109
Van den Berg JA, Van der Laken KJ, van Ooyen AJ, Renniers TC, Rietveld K, Schaap A, Brake AJ, Bishop RJ, Schultz K, Moyer D (1990) Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin. Biotechnology (NY) 8:135–139
Van Dijken H (2001) Conference Report: The 21st International Specialized symposium on Yeasts (ISSY2001) on ‘Biochemistry, Genetics, Biotechnology and Ecology of Nonconventional Yeasts’. FEMS Yeast Res 2:429–432
Vaughan-Martini A, Martini A (1995) Facts, myths and legends on the prime industrial microorganism. J Ind Microbiol 14:514–522
Walker GM (1998) Yeast physiology and biotechnology. John Wiley and Sons, Chichester,UK
Winderickx J, Holsbeeks I, Lagatie, O, Giots F, Thevelein J, de Winde JH (2002) From feast to famine; adaptation to nutrient availability in yeast. In: Topics in Current Genetics, Vol. 1 (Hohmann S, Mager WH, eds.), ‘Yeast stress responses’. Springer netics, Vol. 1 (Hohmann S, Mager WH, eds.), ‘Yeast stress responses’. Springer Verlag, Berlin. pp 305–386
Wood V et al. (2002) The genome sequence of Schvzosaccharomyces pombe. Nature 415:871–880
Zolezzi F, Fuss J, Uzawa S, Linn S (2002) Characterization of a Schizosaccharomyces pombe strain deleted for a sequence homologue of the human damaged DNA binding 1 (DDB1) gene. J Biol Chem 277:41183–41191
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
de Winde, H. (2003). Functional genetics of industrial yeasts; of ancient skills and modern applications. In: de Winde, J.H. (eds) Functional Genetics of Industrial Yeasts. Topics in Current Genetics, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37003-X_1
Download citation
DOI: https://doi.org/10.1007/3-540-37003-X_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-02489-7
Online ISBN: 978-3-540-37003-1
eBook Packages: Springer Book Archive