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Chemical Ionization

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Mass Spectrometry

Abstract

Mass spectrometrists have ever been searching for ionization methods softer than EI, because molecular weight determination is of key importance for structure elucidation. Chemical ionization (CI) is the first of the soft ionization methods we are going to discuss. Historically, field ionization (FI, Chap. 8) has been applied some years earlier, and thus CI can be regarded as the second soft ionization method introduced to analytical mass spectrometry. Several aspects of CI possess rather close similarity to EI making its discussion next to EI more convenient. CI goes back to experiments of Talrose in the early 1950s [1] and was developed to an analytically useful technique by Munson and Field in the mid-1960s. [2–5] Since then, the basic concept of CI has been extended and applied in numerous different ways, meanwhile providing experimental conditions for a wide diversity of analytical tasks. [5, 6] The monograph by Harrison is especially recommended for further reading. [7]

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  1. Institute of Organic Chemistry, University of Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany

    Dr. Jürgen H. Gross

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Gross, J.H. (2004). Chemical Ionization. In: Mass Spectrometry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36756-X_7

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