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Hyphenated Methods

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Mass Spectrometry

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Abstract

The analysis of complex mixtures particularly requires the combination of both separation techniques and mass spectrometry. [1–3] The first step in this direction was made by gas chromatography-mass spectrometry coupling (GC-MS), [4] and soon, GC-MS became a routine method. [5–7] The desire to realize a liquid chromatography-mass spectrometry coupling (LC-MS) [8, 9] was the driving force for the development of API methods (Chap. 11). [10–13] Coupling of other liquid phase separation techniques to mass spectrometry followed: capillary zone electrophoresis-mass spectrometry (CZE-MS), [14–18] and supercritical fluid chromatography-mass spectrometry (SFC-MS). [19–23] Whatever the separation technique, it adds an additional dimension to the analytical measurement. The hyphen used to indicate the coupling of a separation technique to mass spectrometry led to the term hyphenated methods.

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    Dr. Jürgen H. Gross

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Gross, J.H. (2004). Hyphenated Methods. In: Mass Spectrometry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36756-X_12

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