Abstract
DNA-based nanotechnology is currently being developed for use in biomolecular computation, fabrication of 2D tile lattices, and engineering of 3D periodic matter. Here we present recent results on the construction and characterization of DNA nanotubes – a new self-assembling superstructure composed of DNA tiles. Triple-crossover (TAO) tiles modified with thiol-containing dsDNA stems projected out of the tile plane were utilized as the basic building block. TAO nanotubes display a constant diameter of approximately 25 nm and have been observed with lengths up to 20 microns. We present high resolution images of the constructs from transmission electron microscopy (TEM) and atomic force microscopy (AFM) as well as preliminary data on successful metallization of the nanotubes. DNA nanotubes represent a potentialb reakthrough in the self-assembly of nanometer scale circuits for electronics layout since they can be targeted to connect at specific locations on largerscale structures and can subsequently be metallized to form nanometer scale wires. The dimensions of these nanotubes are also perfectly suited for applications involving interconnection of molecular scale devices with macroscale components fabricated by conventional photolithographic methods.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adleman, L.M. (1994) Molecular computation of solutions to combinatorial problems. Science 266, 1021–1024.
Seeman, N.C. (1982) Nucleic Acid Junctions and Lattices. J. Theor. Biol. 99, 237–247.
Seeman, N.C. (1999) “DNA engineering and its application to nanotechnology”, Trends in Biotechnology 17, 437–443.
Reif, J.H., LaBean, T.H., and Seeman, N.C., (2001) Challenges and Applications for Self-Assembled DNA Nanostructures, Proc. Sixth International Workshop on DNA-Based Computers, Leiden, The Netherlands, June, 2000. DIMACS Series in Discrete Mathematics and TheoreticalC omputer Science, Edited by A. Condon and G. Rozenberg. Lecture Notes in Computer Science, Springer-Verlag, Berlin Heidelberg,vol. 2054, pp. 173–198.
LaBean, T.H. (in press, 2002) Introduction to Self-Assembling DNA Nanostructures for Computation and Nanofabrication. in CBGI 2001, Proceedings from Computational Biology and Genome Informatics, held 3/2001 Durham, NC, World Scientific Publishing.
Reif, J.H. (to appear, 2002) DNA Lattices: A Programmable Method for Molecular Scale Patterning and Computation, to appear in the special issue on Bio-Computation, Computer and Scientific Engineering Journalo f the Computer Society. 2002.
Seeman, N.C.; Chen, J.-H.; Kallenbach, N.R., 1989 Electrophoresis 10 345–354.
Holliday, R. (1964) Genet. Res. 5, 282–304.
Fu, T.-J. and Seeman, N.C. (1993) Biochemistry 32, 3211–3220.
Winfree, E., Liu, F., Wenzler, L.A., and Seeman, N.C. (1998) “Design and Self-Assembly of Two-Dimensional DNA Crystals”, Nature 394, 539–544.
LaBean, T. H., Yan, H., Kopatsch, J., Liu, F., Winfree, E., Reif, J.H. & Seeman, N.C. (2000) “The construction, analysis, ligation and self-assembly of DNA triple crossover complexes”, J. Am. Chem. Soc. 122, 1848–1860.
Liu, F. R., Sha, R. J. and Seeman, N. C. (1999) Modifying the surface features of two-dimensionalDNA crystals, J. Am. Chem. Soc. 121, 917–922.
LaBean, T.H., Winfree, E., and Reif, J.H. (2000) “Experimental progress in computation by self-assembly of DNA tilings”, 5th DIMACS Workshop on DNA Based Computers, MIT, June, 1999. DNA Based Computers, V, DIMACS Series in Discrete Mathematics and Theoretical Computer Science, (ed. E. Winfree), American Mathematical Society, 2000.
Winfree, E., Yang, X., Seeman, NC, “Universal Computation via Self-assembly of DNA: Some Theory and Experiments.” In DNA Based Computers II: DIMACS Workshop, June 10–12, 1996 (Volume 44 in DIMACS). Laura F. Landweber and Eric B. Baum, editors. American Mathematical Society, 1998, 191–213.
Mao, C., LaBean, T.H., Reif, J.H., and Seeman, N.C. (2000) “Logicalcom putation using algorithmic self-assembly of DNA triple-crossover molecules”, Nature, 407 493–496.
Alivisatos, A.P., K.P. Johnsson, X. Peng, T.E. Wilson, C.J. Loweth, M.P. Bruchez Jr., and P.G. Schultz (1996) Organization of ‘nanocrystal molecules’ using DNA. Nature, 382, 609–611
Mirkin, C.A., Letsinger, R.L., Mucic, R.C., and Storho., J.J. (1996) “A DNABased Method For Rationally Assembling Nanoparticles Into Macroscopic Materials”, Nature 382, 607–609.
Mucic, R. C.; Storho., J. J.; Mirkin, C. A.; Letsinger, R. L., (1998) “DNA-directed synthesis of binary nanoparticle network materials”, J. Am. Chem. Soc. 120, 12674–12675.
Mbindyo, J.K.N., Reiss, B.D., Martin, B.R., Keating, C.D., Natan, M.J., and Mallouk, T.E. (2001) Advanced Materials 13, 249–254.
Braun, E., Eichen, Y., Sivan, U., and Ben-Yoseph, (1998), G. DNA-templated assembly and electrode attachment of a conducting silver wire, Nature 391, 775–778.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Liu, D., Reif, J.H., La Bean, T.H. (2003). DNA Nanotubes: Construction and Characterization of Filaments Composed of TX-tile Lattice. In: Hagiya, M., Ohuchi, A. (eds) DNA Computing. DNA 2002. Lecture Notes in Computer Science, vol 2568. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36440-4_2
Download citation
DOI: https://doi.org/10.1007/3-540-36440-4_2
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00531-5
Online ISBN: 978-3-540-36440-5
eBook Packages: Springer Book Archive