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Enantioselective Carbolithiations

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Organolithiums in Enantioselective Synthesis

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 5))

Abstract

The addition of RLi to unactivated C=C bonds is much more restricted than the addition to activated, electron-poor C=C bonds. The known examples are briefly surveyed, and the enantioselective version is detailed: in an intermolecular way (cinnamyl and non-phenylated substrates), and in an intramolecular way (cyclizations from an enantiomerically enriched organolithium derivative, or from a racemic one, under the influence of a chiral ligand).

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Authors and Affiliations

  1. Laboratoire de Chimie des Organoéléments, Université P & M Curie, 4 Place Jussieu, 75252, Paris, Cedex 05, France

    Jean F. Normant

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  1. Jean F. Normant
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  1. Dyson Perrins Laboratory Department of Chemistry, University of Oxford, South Parks Road, Oxford, 0X1 3QY, UK

    David M. Hodgson

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Normant, J.F. (2003). Enantioselective Carbolithiations. In: Hodgson, D.M. (eds) Organolithiums in Enantioselective Synthesis. Topics in Organometallic Chemistry, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36117-0_9

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  • DOI: https://doi.org/10.1007/3-540-36117-0_9

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