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Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors

  • Jann N. Sarkaria
Part of the Medical Radiology book series (MEDRAD)

9.7 Conclusion

Rapamycin and its analogs are versatile drugs with proven efficacy in cardiovascular and transplant medicine and with promising results in early cancer clinical trials. In specific tumor types, a select minority of patients likely will benefit from monotherapy. The challenge for the future will be to dissect further the molecular signaling pathways modulated by rapamycin in order to appreciate fully the molecular mechanisms underpinning sensitivity or resistance to mTOR inhibition. This understanding will provide insight into rational combinations of mTOR inhibitors with classic cytotoxic agents, radiation, and other molecularly targeted therapies.

Keywords

Vascular Endothelial Growth Factor Mantle Cell Lymphoma mTOR Inhibitor Mammalian Target mTOR Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Jann N. Sarkaria
    • 1
  1. 1.Department of OncologyRochesterUSA

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