Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients

  • Hans Geinitz
Part of the Medical Radiology book series (MEDRAD)


Rectal Cancer Clin Oncol Radiat Oncol Biol Phys Eastern Cooperative Oncology Group Performance Status Radiation Pneumonitis 
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  1. Airoldi M, Cortesina G, Giordano C et al (2004) Postoperative adjuvant chemoradiotherapy in older patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 130:161–166PubMedCrossRefGoogle Scholar
  2. Allal AS, Obradovic M, Laurencet F et al (1999) Treatment of anal carcinoma in the elderly: feasibility and outcome of radical radiotherapy with or without concomitant chemotherapy. Cancer 85:26–31PubMedCrossRefGoogle Scholar
  3. Ampil FL, Mills GM, Stucker FJ et al (2001) Radical combined treatment of locally extensive head and neck cancer in the elderly. Am J Otolaryngol 22:65–69PubMedCrossRefGoogle Scholar
  4. Atagi S, Kawahara M, Ogawara M et al (2000) Phase II trial of daily low-dose carboplatin and thoracic radiotherapy in elderly patients with locally advanced non-small cell lung cancer. Jpn J Clin Oncol 30:59–64PubMedCrossRefGoogle Scholar
  5. Atagi S, Kawahara M, Tamura T et al (2005) Standard thoracic radiotherapy with or without concurrent daily lowdose carboplatin in elderly patients with locally advanced non-small cell lung cancer: a phase III trial of the Japan Clinical Oncology Group (JCOG9812). Jpn J Clin Oncol 35:195–201PubMedCrossRefGoogle Scholar
  6. Baumann M (1998) Is curative radiation therapy in elderly patients limited by increased normal tissue toxicity? Radiother Oncol 46:225–227PubMedCrossRefGoogle Scholar
  7. Berkman B, Rohan B, Sampson S (1994) Myths and biases related to cancer in the elderly. Cancer 74:2004–2008PubMedCrossRefGoogle Scholar
  8. Boehler FK, Rhomberg W, Doringer W (1992) Hypertension as risk factor for radiation induced side-effects in breast cancer. Strahlenther Onkol 168:344–349Google Scholar
  9. Brandes AA, Vastola F, Basso U et al (2003) A prospective study on glioblastoma in the elderly. Cancer 97:657–662PubMedCrossRefGoogle Scholar
  10. Charlson ME, Pompei P, Ales KL et al. (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383PubMedCrossRefGoogle Scholar
  11. Charnley N, Choudhury A, Chesser P et al (2005) Effective treatment of anal cancer in the elderly with low-dose chemotherapy. Br J Cancer 92:1221–1225PubMedCrossRefGoogle Scholar
  12. Clark AJ, Stockton D, Elder A et al (2004) Assessment of outcomes after colorectal cancer resection in the elderly as a rationale for screening and early detection. Br J Surg 91:1345–1351PubMedCrossRefGoogle Scholar
  13. Cunningham MJ, Goyer RP, Gibbons SK et al (1997) Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva. Gynecol Oncol 66:258–261PubMedCrossRefGoogle Scholar
  14. DeAngelis LM (2000) Radiotherapy of the brain in elderly patients. Arbiter. Eur J Cancer 36:451–452PubMedCrossRefGoogle Scholar
  15. Edwards B, Howe HL, Ries L et al (2002) Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden. Cancer 94:2766–2792PubMedCrossRefGoogle Scholar
  16. Geinitz H, Zimmermann FB, Molls M (1999) Strahlentherapie des alten Patienten. Verträglichkeit und Ergebnisse der Strahlentherapie älterer Personen. Strahlenther Onkol 175(3):119–127PubMedCrossRefGoogle Scholar
  17. Geinitz H, Zimmermann F, Thamm R et al (2005) 3-D conformal radiation therapy for prostate cancer in elderly patients. Radiother Oncol 76:27–34PubMedCrossRefGoogle Scholar
  18. Goffin JR, Rajan R, Souhami L (2004) Tolerance of radiotherapy and chemotherapy in elderly patients with bladder cancer. Am J Clin Oncol 27:172–177PubMedCrossRefGoogle Scholar
  19. Herold DM, Hanlon AL, Hanks GE (1999) Diabetes mellitus: a predictor for late radiation morbidity. Int J Radiat Oncol Biol Phys 43(3):475–479PubMedCrossRefGoogle Scholar
  20. Hutchins LF, Unger JM, Crowley JJ et al (1999) Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061–2067PubMedCrossRefGoogle Scholar
  21. Jeremic B, Shibamoto Y, Milicic B et al (1999a) A phase II study of concurrent accelerated hyperfractionated radiotherapy and carboplatin/oral etoposide for elderly patients with stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 44:343–348PubMedCrossRefGoogle Scholar
  22. Jeremic B, Shibamoto Y, Milicic B et al (1999b) Short-term chemotherapy and palliative radiotherapy for elderly patients with stage IV non-small cell lung cancer: a phase II study. Lung Cancer 24:1–9PubMedCrossRefGoogle Scholar
  23. Kodaira T, Fuwa N, Furutani K et al (2005) Phase I trial of weekly docetaxel and concurrent radiotherapy for head and neck cancer in elderly patients or patients with complications. Jpn J Clin Oncol 35:173–176PubMedCrossRefGoogle Scholar
  24. Mehta V (2005) Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction and prevention. Int J Radiat Oncol Biol Phys 63:5–24PubMedCrossRefGoogle Scholar
  25. Merchant TE, McCormick B, Yahalom J et al (1996) The influence of older age on breast cancer treatment decisions and outcome. Int J Radiat Oncol Biol Phys 34:565–570PubMedCrossRefGoogle Scholar
  26. Nallapareddy S, Wilding GE, Yang G et al (2005) Chemoradiation is a tolerable therapy for older adults with esophageal cancer. Anticancer Res 25:3055–3060PubMedGoogle Scholar
  27. Neugut AI, Fleischauer AT, Sundararajan V et al (2002) Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: a population-based study. J Clin Oncol 20:2643–2650PubMedCrossRefGoogle Scholar
  28. Ogle KS, Swanson GM, Woods N et al (2000) Cancer and comorbidity: redefining chronic diseases. Cancer 88:653–663PubMedCrossRefGoogle Scholar
  29. Patel B, Forman J, Fontana J et al (2005) A single institution experience with concurrent capecitabine and radiation therapy in weak and/or elderly patients with urothelial cancer. Int J Radiat Oncol Biol Phys 62:1332–1338PubMedCrossRefGoogle Scholar
  30. Pignon T, Horiot JC, Van den BW et al (1996) No age limit for radical radiotherapy in head and neck tumours. Eur J Cancer 32A:2075–2081PubMedCrossRefGoogle Scholar
  31. Pignon T, Horiot JC, Bolla M et al (1997) Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol 42:107–120PubMedCrossRefGoogle Scholar
  32. Pignon T, Gregor A, Schaake KC et al (1998) Age has no impact on acute and late toxicity of curative thoracic radiotherapy. Radiother Oncol 46:239–248PubMedCrossRefGoogle Scholar
  33. Rice DC, Correa AM, Vaporciyan AA et al (2005) Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity. Ann Thorac Surg 79:391–397PubMedCrossRefGoogle Scholar
  34. Samet J, Hunt WC, Key C et al (1986) Choice of cancer therapy varies with age of patient. J Am Med Assoc 255:3385–3390CrossRefGoogle Scholar
  35. Schild SE, Stella PS, Geyer SM et al (2003) The outcome of combined-modality therapy for stage III non-small-cell lung cancer in the elderly. J Clin Oncol 21:3201–3206PubMedCrossRefGoogle Scholar
  36. Schrag D, Gelfand SE, Bach PB et al (2001) Who gets adjuvant treatment for stage II and III rectal cancer? Insight from surveillance, epidemiology, and end results-Medicare. J Clin Oncol 19:3712–3718PubMedGoogle Scholar
  37. Uno T, Isobe K, Kawakami H et al (2004) Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer. Anticancer Res 24:2483–2486PubMedGoogle Scholar
  38. Valentini V, Morganti AG, Luzi S et al (1997) Is chemoradiation feasible in elderly patients? A study of 17 patients with anorectal carcinoma. Cancer 80:1387–1392PubMedCrossRefGoogle Scholar
  39. Wylie JP, Cowan RA, Deakin DP (1998) The role of radiotherapy in the treatment of localised intermediate and high grade non-Hodgkin’s lymphoma in elderly patients. Radiother Oncol 49:9–14PubMedCrossRefGoogle Scholar
  40. Yancik R, Ries L (1994) Cancer in older persons. Magnitude of the problem: How do we apply what we know? Cancer 74:1995–2003PubMedCrossRefGoogle Scholar
  41. Yuen AR, Zou G, Turrisi AT et al (2000) Similar outcome of elderly patients in Intergroup Trial 0096. Cisplatin, etoposide, and thoracic radiotherapy administered once or twice daily in limited small cell lung carcinoma. Cancer 89:1953–1960PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Hans Geinitz
    • 1
  1. 1.Department of Radiation OncologyKlinikum rechts der Isar der Technischen Universität MünchenMunichGermany

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