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Radiotherapy and Tumor-Targeted Drug Delivery

  • Zhaozhong Han
  • Ghazal Hariri
  • Dennis E. Hallahan
Part of the Medical Radiology book series (MEDRAD)

Keywords

Drug Delivery Radiat Oncol Biol Phys Phage Display Antibody Fragment Target Drug Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Advani SJ et al (1998) Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. Gene Ther 5:160–165PubMedCrossRefGoogle Scholar
  2. Agnihotri SA et al (2004) Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release 100:5–28PubMedCrossRefGoogle Scholar
  3. Arap W et al (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279:377–380PubMedCrossRefGoogle Scholar
  4. Arap W et al (2002) Steps toward mapping the human vasculature by phage display. Nat Med 8:121–127PubMedCrossRefGoogle Scholar
  5. Augustin HG (2003) Translating angiogenesis research into the clinic: the challenges ahead. Br J Radiol 76 (Spec No 1):S3–S10PubMedCrossRefGoogle Scholar
  6. Avgoustakis K (2004) Pegylated poly (lactide) and poly (lactideco-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery. Curr Drug Deliv 1:321–333PubMedCrossRefGoogle Scholar
  7. Bibikova M et al (2004) Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. Am J Pathol 165:1799–1807PubMedGoogle Scholar
  8. Bisacchi D et al (2003) Anti-angiogenesis and angioprevention: mechanisms, problems and perspectives. Cancer Detect Prev 27:229–238PubMedCrossRefGoogle Scholar
  9. Biston MC et al (2004) Cure of Fisher rats bearing radioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays. Cancer Res 64:2317–2323PubMedCrossRefGoogle Scholar
  10. Boder ET, Wittrup KD (1997) Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol 15:553–557PubMedCrossRefGoogle Scholar
  11. Borjesson J et al (1993) In vivo X-ray fluorescence analysis with applications to platinum, gold and mercury in man: experiments, improvements, and patient measurements. Basic Life Sci 60:275–280PubMedGoogle Scholar
  12. Boulter JM, Jakobsen BK (2005) Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens. Clin Exp Immunol 142:454–460PubMedGoogle Scholar
  13. Carlos TM, Harlan JM (1994) Leukocyte-endothelial adhesion molecules. Blood 84:2068–2101PubMedGoogle Scholar
  14. Carson-Walter EB et al (2001) Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res 61:6649–6655PubMedGoogle Scholar
  15. Cesareni G et al (1999) Phage displayed peptide libraries. Comb Chem High Throughput Screen 2:1–17PubMedGoogle Scholar
  16. Chen X et al (2004) Novel endothelial cell markers in hepatocellular carcinoma. Mod Pathol 17:1198–1210PubMedCrossRefGoogle Scholar
  17. Christian S et al (2003) Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J Cell Biol 163:871–878PubMedCrossRefGoogle Scholar
  18. Cox G et al (2004) Angiogenesis and non-small cell lung cancer. Lung Cancer 27:81–100CrossRefGoogle Scholar
  19. Dani M (2001) Peptide display libraries: design and construction. J Recept Signal Transduct Res 21:469–488PubMedCrossRefGoogle Scholar
  20. Davies G et al (2004) Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer. Clin Exp Metastasis 21:31–37PubMedCrossRefGoogle Scholar
  21. Davy A, Soriano P (2005) Ephrin signaling in vivo: look both ways. Dev Dyn 232:1–10PubMedCrossRefGoogle Scholar
  22. Demetriou MC et al (2004) Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer. Exp Cell Res 294:550–558PubMedCrossRefGoogle Scholar
  23. Ebnet K, Vestweber D (1999) Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines. Histochem Cell Biol 112:1–23PubMedCrossRefGoogle Scholar
  24. Feng SS et al (2004) Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. Curr Med Chem 11:413–424PubMedCrossRefGoogle Scholar
  25. Fernando NH, Hurwitz HI (2003) Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer. Semin Oncol 30:39–50PubMedGoogle Scholar
  26. Ferrari M (2005) Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5:161–171PubMedCrossRefGoogle Scholar
  27. Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182–1186PubMedCrossRefGoogle Scholar
  28. Fonsatti E et al (2003) Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies. Curr Cancer Drug Targets 3:427–432PubMedCrossRefGoogle Scholar
  29. Frankel A et al (2003) Unnatural RNA display libraries. Curr Opin Struct Biol 13:506–512PubMedCrossRefGoogle Scholar
  30. Friedman DB et al (2004) Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics 4:793–811PubMedCrossRefGoogle Scholar
  31. Fu C et al (2001) Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis. Clin Cancer Res 7:4182–4194PubMedGoogle Scholar
  32. Geng L et al (2004) Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay. J Control Release 99:369–381PubMedCrossRefGoogle Scholar
  33. Georgiou G et al (1997) Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nat Biotechnol 15:29–34PubMedCrossRefGoogle Scholar
  34. Hainfeld JF et al (2004) The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 49:N309–N315PubMedCrossRefGoogle Scholar
  35. Hallahan DE et al (1995) Spatial and temporal control of gene therapy using ionizing radiation. Nat Med 1:786–791PubMedCrossRefGoogle Scholar
  36. Hallahan DE et al (2001) Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. J Control Release 74:183–191PubMedCrossRefGoogle Scholar
  37. Hallahan D et al (2003) Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 3:63–74PubMedCrossRefGoogle Scholar
  38. Hallborn J, Carlsson R (2002) Automated screening procedure for high-throughput generation of antibody fragments. Biotech Suppl:30–37Google Scholar
  39. Hanes J et al (1998) Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries. Proc Natl Acad Sci USA 95:14130–14135PubMedCrossRefGoogle Scholar
  40. Hardwick JS et al (2005) Identification of biomarkers for tumor endothelial cell proliferation through gene expression profiling. Mol Cancer Ther 4:413–425PubMedGoogle Scholar
  41. Hofheinz RD et al (2005) Liposomal encapsulated anti-cancer drugs. Anticancer Drugs 16:691–707PubMedCrossRefGoogle Scholar
  42. Holt LJ et al (2003) Domain antibodies: proteins for therapy. Trends Biotechnol 21:484–490PubMedCrossRefGoogle Scholar
  43. Isayeva T et al (2004) Anti-angiogenic gene therapy for cancer (review). Int J Oncol 25:335–343PubMedGoogle Scholar
  44. Joiner MC et al (2001) Low-dose hypersensitivity: current status and possible mechanisms. Int J Radiat Oncol Biol Phys 49:379–389PubMedCrossRefGoogle Scholar
  45. Joyce JA et al (2003) Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4:393–403PubMedCrossRefGoogle Scholar
  46. Kerbel RS (2000) Tumor angiogenesis: past, present and the near future. Carcinogenesis 21: 505–515PubMedCrossRefGoogle Scholar
  47. Khodarev NN et al (2003) Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci 116:1013–1022PubMedCrossRefGoogle Scholar
  48. Kim JM et al (2005) Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells. Clin Cancer Res 11:473–482PubMedGoogle Scholar
  49. Kimura H et al (1995) Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. Int J Radiat Oncol Biol Phys 33:627–633PubMedCrossRefGoogle Scholar
  50. Klagsbrun M, Eichmann A (2005) A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis. Cytokine Growth Factor Rev 16:535–548PubMedCrossRefGoogle Scholar
  51. Kortt AA et al (2001) Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting. Biomol Eng 18:95–108PubMedCrossRefGoogle Scholar
  52. Kovar M et al (2002) Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect. Bioconjug Chem 13:206–215PubMedCrossRefGoogle Scholar
  53. Kukowska-Latallo JF et al (2005) Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res 65:5317–5324PubMedCrossRefGoogle Scholar
  54. Laakkonen P et al (2004) Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci USA 101:9381–9386PubMedCrossRefGoogle Scholar
  55. Lee CC et al (2005) Designing dendrimers for biological applications. Nat Biotechnol 23:1517–1526PubMedCrossRefGoogle Scholar
  56. Lee WS et al (1998) Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines. Circ Res 82:845–851PubMedGoogle Scholar
  57. Markland W et al (1991) Design, construction and function of a multicopy display vector using fusions to the major coat protein of bacteriophage M13. Gene 109:13–19PubMedCrossRefGoogle Scholar
  58. Marty C et al (2005) Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy. Cancer Lett epubGoogle Scholar
  59. McDonald WH, Yates JR (2002) Shotgun proteomics and biomarker discovery. Dis Markers 18:99–105PubMedGoogle Scholar
  60. McNeil SE (2005) Nanotechnology for the biologist. J Leukoc Biol 78:585–594PubMedCrossRefGoogle Scholar
  61. Miettinen M et al (2005) Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 29:52–68PubMedCrossRefGoogle Scholar
  62. Mikawa YG (1996) Surface display of proteins on bacteriophage lambda heads. J Mol Biol 262:21–30PubMedCrossRefGoogle Scholar
  63. Mitra S et al (2001) Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Control Release 74:317–323PubMedCrossRefGoogle Scholar
  64. Moghimi SM et al (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–318PubMedGoogle Scholar
  65. Molla M et al (1999) Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat. Int J Radiat Oncol Biol Phys 45:1011–1018PubMedCrossRefGoogle Scholar
  66. Mousa SA, Mousa AS (2004) Angiogenesis inhibitors: current and future directions. Curr Pharm Des 10:1–9PubMedCrossRefGoogle Scholar
  67. Muller OJ et al (2003) Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nat Biotechnol 21:1040–1046PubMedCrossRefGoogle Scholar
  68. Nakshatri H et al (1996) Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells. Gene 174:79–84PubMedCrossRefGoogle Scholar
  69. Nanda A, St. Croix B (2004) Tumor endothelial markers: new targets for cancer therapy. Curr Opin Oncol 16:44–49PubMedCrossRefGoogle Scholar
  70. Neufeld G et al (2002) The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc Med 12:13–19PubMedCrossRefGoogle Scholar
  71. Neufeld G et al (2005) Semaphorins in cancer. Front Biosci 10:751–760PubMedGoogle Scholar
  72. Osaki F et al (2004) A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. J Am Chem Soc 126:6520–6521PubMedCrossRefGoogle Scholar
  73. Pang H et al (2004) Epidermal growth factor suppresses induction by progestin of the adhesion protein desmoplakin in T47D breast cancer cells. Breast Cancer Res 6:R239–R245PubMedCrossRefGoogle Scholar
  74. Pasqualini R, Ruoslahti E (1996) Organ targeting in vivo using phage display peptide libraries. Nature 380:364–366PubMedCrossRefGoogle Scholar
  75. Patri AK et al (2005) Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv Drug Deliv Rev 57:2203–2214PubMedCrossRefGoogle Scholar
  76. Peirce MJ et al (2004) Expression profiling of lymphocyte plasma membrane proteins. Mol Cell Proteomics 3:56–65PubMedCrossRefGoogle Scholar
  77. Pini A et al (2004) Strategies for the construction and use of peptide and antibody libraries displayed on phages. Curr Protein Pept Sci 5:487–496PubMedCrossRefGoogle Scholar
  78. Rmali KA et al (2005) TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains. Biochem Biophys Res Commun 334:231–238PubMedCrossRefGoogle Scholar
  79. Roberts RW, Szostak JW (1997) RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci USA 94:12297–12302PubMedCrossRefGoogle Scholar
  80. Rode HJ et al (1996) Cell surface display of a single-chain antibody for attaching polypeptides. Biotechniques 21(650):655–658Google Scholar
  81. Roodink I et al (2003) Plexin D1 expression is induced on tumor vasculature and tumor cells: A novel target for diagnosis and therapy? Cancer Res 65:8317–8323CrossRefGoogle Scholar
  82. Ruoslahti E (2000) Targeting tumor vasculature with homing peptides from phage display. Semin Cancer Biol 10:435–442PubMedCrossRefGoogle Scholar
  83. Ruoslahti E (2004) Vascular zip codes in angiogenesis and metastasis. Biochem Soc Trans 32:397–402PubMedCrossRefGoogle Scholar
  84. Rybak JN et al (2005) In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature. Nat Methods 2:291–298PubMedCrossRefGoogle Scholar
  85. Schlehuber S, Skerra A (2005) Anticalins as an alternative to antibody technology. Expert Opin Biol Ther 5:1453–1462PubMedCrossRefGoogle Scholar
  86. Scott JK, Smith GP (1990) Searching for peptide ligands with an epitope library. Science 249:386–390PubMedGoogle Scholar
  87. Sengupta S et al (2005) Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 436:568–572PubMedCrossRefGoogle Scholar
  88. Shin BK et al (2003) Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem 278:7607–7616PubMedCrossRefGoogle Scholar
  89. Sidhu SS (2000) Phage display in pharmaceutical biotechnology. Curr Opin Biotechnol 11:610–616PubMedCrossRefGoogle Scholar
  90. Smith GP (1985) Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315–1317PubMedGoogle Scholar
  91. Sridhar SS, Shepherd FA (2003) Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer. Lung Cancer 42(Suppl 1):S81–S91PubMedCrossRefGoogle Scholar
  92. St. Croix B et al (2000) Genes expressed in human tumor endothelium. Science 289:1197–1202PubMedCrossRefGoogle Scholar
  93. Terashima M et al (2005) Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis. Br J Cancer 92:1130–1136PubMedCrossRefGoogle Scholar
  94. Thorpe PE (2004) Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10:415–427PubMedCrossRefGoogle Scholar
  95. Van Valckenborgh E et al (2005) Targeting an MMP-9-activated prodrug to multiple myeloma-diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia 19:1628–1633PubMedCrossRefGoogle Scholar
  96. Vinogradov SV et al (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjug Chem 15:50–60PubMedCrossRefGoogle Scholar
  97. Wang B et al (2005) Conserved molecular players for axon guidance and angiogenesis. Curr Protein Pept Sci 6:473–478PubMedCrossRefGoogle Scholar
  98. Weichselbaum RR et al (1994) Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res 54:4266–4269PubMedGoogle Scholar
  99. Wickham TJ et al (1995) Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs. Gene Ther 2:750–756PubMedGoogle Scholar
  100. Winkler F et al (2004) Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6:553–563PubMedGoogle Scholar
  101. Wu NZ et al (1994) Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation. Br J Cancer 69:883–889PubMedGoogle Scholar
  102. Wulfkuhle JD et al (2003) Proteomic applications for the early detection of cancer. Nat Rev Cancer 3:267–275PubMedCrossRefGoogle Scholar
  103. Yamamoto M (1999) Phage display cDNA cloning of protein with carbohydrate affinity. Biochem Biophys Res Commun 255:194–199PubMedCrossRefGoogle Scholar
  104. Yoo HS et al (2000) In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J Control Release 68:419–431PubMedCrossRefGoogle Scholar
  105. Yuan H et al (2003) Radiation-induced permeability and leukocyte adhesion in the rat blood-brain barrier: modulation with anti-ICAM-1 antibodies. Brain Res 969:59–69PubMedCrossRefGoogle Scholar
  106. Zhang L et al (2005) Molecular profiling of heart endothelial cells. Circulation 112:1601–1611PubMedCrossRefGoogle Scholar
  107. Zhang X et al (2004) Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res 64:8139–8142PubMedCrossRefGoogle Scholar
  108. Zurita AJ et al (2003) Mapping tumor vascular diversity by screening phage display libraries. J Control Release 91:183–186PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Zhaozhong Han
    • 1
  • Ghazal Hariri
    • 1
  • Dennis E. Hallahan
    • 2
  1. 1.Department of Radiation Oncology, School of MedicineVanderbilt UniversityNashvilleUSA
  2. 2.B-902 Vanderbilt ClinicVanderbilt UniversityNashvilleUSA

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