Overview of the Development of the Human Brain and Spinal Cord

  • Hans J. ten Donkelaar
  • Ton van der Vliet


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  1. Acampora D, Gulisano M, Broccoli V, Simeone A (2001) Otx genes in brain morphogenesis. Prog Neurobiol 64:69–95PubMedCrossRefGoogle Scholar
  2. Aicardi J (1992) Diseases of the Nervous System in Childhood. Clinics in Developmental Medicine. Nr 115/118. Mac Keith, LondonGoogle Scholar
  3. Aida N, Nishimura G, Hachiya Y, Matsui K, Takeuchi M, Itani Y (1998) MR imaging of perinatal brain damage: Comparison of clinical outcome with initial and follow-up MR findings. AJNR Am J Neuroradiol 19:1909–1921PubMedGoogle Scholar
  4. Allsop G, Gamble HJ (1979) Light and electron microscopic observations on the development of the blood vascular system of the human brain. J Anat (Lond) 128:461–477Google Scholar
  5. Altman J, Bayer SA (1997) Development of the Cerebellar System: In relation to its evolution, structure and functions. CRC, Boca Raton, FLGoogle Scholar
  6. Anderson SA, Mione M, Yun K, Rubinstein JLR (1999) Differential origins of neocortical projection and local circuit neurons: Role of Dlx genes in neocortical interneuronogenesis. Cereb Cortex 9:646–654PubMedCrossRefGoogle Scholar
  7. Anderson SA, MarÍn O, Horn C, Jennings K, Rubinstein JLR (2001) Distinct cortical migrations from the medial and lateral ganglionic eminences. Development 128:353–363PubMedGoogle Scholar
  8. Ariëns Kappers JA (1958) Structural and functional changes in the telencephalic choroid plexus during brain ontogenesis. In: Wolstenholme GEW, O’Connor CM (eds) The Cerebrospinal Fluid. Little, Brown, Boston, MA, pp 3–25Google Scholar
  9. Arnold SE, Trojanowski JQ (1996) Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features. J Comp Neurol 367:274–292PubMedCrossRefGoogle Scholar
  10. Banker BQ, Larroche JC (1962) Periventricular leukomalacia of infancy. Arch Neurol 7:386–410PubMedGoogle Scholar
  11. Barkovich AJ (2000) Pediatric Neuroimaging, 3rd ed. Lippincott Philadelphia, PAGoogle Scholar
  12. Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB (2001) Classification system for malformations of cortical development. Update 2001. Neurology 57:2168–2178Google Scholar
  13. Bartelmez GW (1923) The subdivisions of the neural folds in man. J Comp Neurol 35:231–295CrossRefGoogle Scholar
  14. Bartelmez GW, Dekaban AS (1962) The early development of the human brain. Contrib Embryol Carnegie Instn 37:13–32Google Scholar
  15. Barth PG (1993) Pontocerebellar hypoplasias. An overview of a group of inherited neurodegenerative disorders with fetal onset. Brain Dev 15:411–422PubMedCrossRefGoogle Scholar
  16. Bayer SA, Altman J (1991) Neocortical Development. Raven, New YorkGoogle Scholar
  17. Bayer SA, Altman J (2002) The Spinal Cord from Gestational Week 4 to the 4th Postnatal Month. CRC, Boca Raton, FLGoogle Scholar
  18. Bayer SA, Altman J, Russo RJ, Zhang X (1995) Embryology. In: Duckett S (ed) Pediatric Neuropathology. Williams & Wilkins, Baltimore, MD, pp 54–107Google Scholar
  19. Ben-Arie N, Bellen HJ, Armstrong DL, McCall AE, Gordadze PR, Guo Q, Matzuk MM, Zoghbi HY (1997) Math1 is essential for genesis of cerebellar granule neurons. Nature 390:169–172PubMedCrossRefGoogle Scholar
  20. Bergquist H (1952) The formation of neuromeres in Homo. Acta Soc Med Ups 57:23–32PubMedGoogle Scholar
  21. Blaas H-GK (1999) The Embryonic Examination. Ultrasound studies on the development of the human embryo. Thesis, Norwegian University of Science and Technology, Trondheim. TAPIR, Trondheim, NorwayGoogle Scholar
  22. Blaas H-GK, Eik-Nes SH (1996) Ultrasound assessment of early brain development. In: Jurkovic D, Jauniaux E (eds) Ultrasound and Early Pregnancy. Parthenon, New York, pp 3–18Google Scholar
  23. Blaas H-G, Eik-Nes SH (2002) The description of the early development of the human central nervous system using two-dimensional and three-dimensional ultrasound. In: Lagercrantz H, Hanson M, Evrard P, Rodeck CH (eds) The Newborn Brain-Neuroscience and clinical applications. Cambridge University Press, Cambridge, pp 278–288Google Scholar
  24. Blaas H-G, Eik-Nes SH, Kiserud T, Hellevik LR (1994) Early development of the forebrain and midbrain: A longitudinal ultrasound study from 7 to 12 weeks of gestation. Ultrasound Obstet Gynecol 4:183–192PubMedCrossRefGoogle Scholar
  25. Blaas H-G, Eik-Nes SH, Kiserud T, Berg S, Angelsen B, Olstad B (1995a) Three-dimensional imaging of the brain cavities in human embryos. Ultrasound Obstet Gynecol 5:228–232PubMedCrossRefGoogle Scholar
  26. Blaas H-G, Eik-Nes SH, Kiserud T, Hellevik LR (1995b) Early development of the hindbrain: A longitudinal ultrasound study from 7 to 12 weeks of gestation. Ultrasound Obstet Gynecol 5:151–160PubMedCrossRefGoogle Scholar
  27. Brazel CY, Romanko MJ, Rothstein RP, Levison SW (2003) Roles of the mammalian subventricular zone in brain development. Prog Neurobiol 69:49–69PubMedCrossRefGoogle Scholar
  28. Brody BA, Kinney HC, Kloman AS, Gilles FH (1987) Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 46:283–301PubMedGoogle Scholar
  29. Brun A (1965) The subpial granular layer of the foetal cerebral cortex in man. Its ontogeny and significance in congenital cortical malformations. Acta Pathol Microbiol Scand 179(Suppl):1–98Google Scholar
  30. Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubinstein JLR (1993) Spatially restricted expression of Dlx-1, Dlx-2, (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal boundaries. J Neurosci 13:3155–3172PubMedGoogle Scholar
  31. Carlson BM (1999) Human Embryology & Development, 2nd ed. Mosby, St. Louis, MOGoogle Scholar
  32. Collins P, Billett FS (1995) The terminology of early development. Clin Anat 8:418–425PubMedCrossRefGoogle Scholar
  33. Congdon ED (1922) Transformation of the aortic-arch system during the development of the human embryo. Contrib Embryol Carnegie Instn 14:47–110Google Scholar
  34. Corner GW (1929) A well-preserved human embryo of 10 somites. Contrib Embryol Carnegie Instn 20:81–102Google Scholar
  35. Crelin EA (1973) Functional Anatomy of the Newborn. Yale University Press, LondonGoogle Scholar
  36. de Carlos JA, Lopez-Mascaraque L, Valverde F (1996) Dynamics of cell migration from the lateral ganglionic eminence in the rat. J Neurosci 16:6146–6156PubMedGoogle Scholar
  37. de Souza FSJ, Niehrs C (2000) Anterior endoderm and head induction in early vertebrate embryos. Cell Tissue Res 300:207–217PubMedCrossRefGoogle Scholar
  38. De Reuck J, Chattha AS, Richardson EPJ (1972) Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch Neurol 27:229–236Google Scholar
  39. de Vries JIP, Visser GHA, Prechtl HFR (1982) The emergence of fetal behaviour. I. Qualitative aspects. Early Hum Dev 7:301–322PubMedCrossRefGoogle Scholar
  40. Doetsch F, GarcÍa-Verdugo JM, Alvarez-Buylla A (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17:5046–5061PubMedGoogle Scholar
  41. Duckett S (1971) The establishment of internal vascularization in the human telencephalon. Acta Anat (Basel) 80:107–113Google Scholar
  42. Duvernoy HM (1998) The Human Hippocampus. Functional anatomy, vascularization and serial sections with MRI, 2nd ed. Springer, Berlin Heidelberg New YorkGoogle Scholar
  43. Essick CR (1912) The development of the nuclei pontis and the nucleus arcuatus in man. Am J Anat 13:25–54CrossRefGoogle Scholar
  44. Evans HM (1911) Die Entwicklung des Blutgefäßsystems. In:Keibel F, Mall FP (Hrsg) Handbuch der Entwicklungsgeschichte des Menschen, Zweiter Band. Hirzel, Leipzig, pp 551–688Google Scholar
  45. Evans HM (1912) The development of the vascular system. In: Keibel F, Mall FP (eds) Manual of Human Embryology, Vol 2. Lippincott, Philadelphia, PA, pp 570–709Google Scholar
  46. Favier B, Dollé P (1997) Developmental functions of mammalian Hox genes. Mol Hum Reprod 3:115–131PubMedCrossRefGoogle Scholar
  47. Feess-Higgins A, Larroche J-C (1987) Le développement du cerveau foetal humain. Atlas anatomique. Masson, ParisGoogle Scholar
  48. Flechsig PE (1920) Anatomie des menschlichen Gehirns und Rückenmarks auf myelogenetischer Grundlage. Thieme, LeipzigGoogle Scholar
  49. Gadisseux J-F, Goffinet AM, Lyon G, Evrard P (1992) The human transient subpial granular layer: An optical, immunohistochemical, and ultrastructural analysis. J Comp Neurol 324:94–114PubMedCrossRefGoogle Scholar
  50. Garel C (2004) MRI of the Fetal Brain. Normal development and cerebral pathologies. Springer, Berlin Heidelberg New YorkGoogle Scholar
  51. Gardner RJM, Coleman LT, Mitchell LA, Smith LJ, Harvey AS, Scheffer IE, Storey E, Nowotny MJ, Sloane RA, Lubitz L (2001) Neartotal absence of the cerebellum. Neuropediatrics 32:62–68PubMedCrossRefGoogle Scholar
  52. Gilles FH, Shankle W, Dooling EC (1983) Myelinated tracts. In: Gilles FH, Leviton A, Dooling EC (eds) The Developing Human Brain. Wright, Bristol, pp 117–183Google Scholar
  53. Gillilan LA (1972) Anatomy and embryology of the arterial system of the brain stem and cerebellum. Handb Clin Neurol 11:24–44Google Scholar
  54. Gleeson JG, Walsh CA (2000) Neuronal migration disorders: From genetic diseases to developmental mechanisms. Trends Neurosci 23:352–359PubMedCrossRefGoogle Scholar
  55. Golden JA (1998) Holoprosencephaly: A defect in brain patterning. J Neuropathol Exp Neurol 57:991–999PubMedGoogle Scholar
  56. Gribnau AAM, Geijsberts LGM (1985) Morphogenesis of the brain in staged rhesus monkey embryos. Adv Anat Embryol Cell Biol 91:1–69PubMedGoogle Scholar
  57. Hadders-Algra M, Forssberg H (2002) Development of motor functions in health and disease. In: Lagercrantz H, Hanson M, Evrard P, Rodeck CH (eds) The Newborn Brain-Neuroscience and clinical applications. Cambridge University Press, Cambridge, pp 479–507Google Scholar
  58. Hall JG (1986) Analysis of Pena Shokeir phenotype. Am J Med Genet 25:99–117PubMedCrossRefGoogle Scholar
  59. Hambleton G, Wigglesworth JS (1976) Origin of intraventricular haemorrhage in the preterm infant. Arch Child Dis 51:651–659Google Scholar
  60. Hamburger V, Wenger E, Oppenheim RW (1966) Motility in the chick embryo in the absence of sensory input. J Exp Zool 162:133–160CrossRefGoogle Scholar
  61. Hamilton WJ, Mossman HW (1972) Hamilton, Boyd and Mossman’s Human Embryology. Prenatal development of form and function, 4th ed. Heffer, CambridgeGoogle Scholar
  62. Hatten ME (1999) Central nervous system neuronal migration. Annu Rev Neurosci 22:511–539PubMedCrossRefGoogle Scholar
  63. Hatten ME, Alder J, Zimmerman K, Heintz N (1997) Genes involved in cerebellar cell specification and differentiation. Curr Opin Neurobiol 7:40–47PubMedCrossRefGoogle Scholar
  64. Heuser CH, Corner GW (1957) Developmental horizons in human embryos. Description of age group X, 4 to 12 somites. Contrib Embryol Carnegie Instn 36:29–39Google Scholar
  65. Hevner RF, Kinney HC (1996) Reciprocal entorhinal-hippocampal connections established by human fetal midgestation. J Comp Neurol 372:384–394PubMedCrossRefGoogle Scholar
  66. Hewitt W (1961) The development of the human internal capsule and lentiform nucleus. J Anat (Lond) 95:191–199Google Scholar
  67. His W (1880) Anatomie menschlicher Embryonen. I. Embryonen des ersten Monats. Vogel, LeipzigCrossRefGoogle Scholar
  68. His W (1889) Die Formentwickelung des menschlichen Vorderhirns vom Ende des ersten bis zum Beginn des dritten Monats. Abh Kön Sächs Ges Wiss, Math Phys Kl 15:675–735Google Scholar
  69. His W (1890) Die Entwickelung des menschlichen Rautenhirns vom Ende des ersten bis zum Beginn des dritten Monats. I.Verlängertes Mark. Abh Kön Sächs Ges Wiss, Math Phys Kl 29:1–74Google Scholar
  70. His W (1904) Die Entwickelung des menschlichen Gehirns während der ersten Monate. Hirzel, LeipzigGoogle Scholar
  71. Hochstetter F (1919) Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns, I. Teil. Deuticke, ViennaGoogle Scholar
  72. Hochstetter F (1929) Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns, II. Teil, 3. Lieferung. Die Entwicklung des Mittel-und Rautenhirns. Deuticke, ViennaGoogle Scholar
  73. Hochstetter F (1934) Über die Entwicklung und Differenzierung der Hüllen des Rückenmarkes beim Menschen. Morphol Jahrb 74:1–104Google Scholar
  74. Hochstetter F (1939) Über die Entwicklung und Differenzierung der Hüllen des menschlichen Gehirns. Morphol Jahrb 83:359–494Google Scholar
  75. Hori A, Friede RL, Fischer G (1983) Ventricular diverticles with localized dysgenesis of the temporal lobe in a cloverleaf skull anomaly. Acta Neuropathol (Berl) 60:132–136PubMedCrossRefGoogle Scholar
  76. Hori A, Eubel R, Ulbrich R (1984a) Congenital ventricular diverticulum in the brainstem. Report of four cases. Acta Neuropathol (Berl) 63:330–333PubMedCrossRefGoogle Scholar
  77. Hori A, Bardosi A, Tsuboi K, Maki Y (1984b) Accessory cerebral ventricle of the occipital lobe. Morphogenesis and clinical and pathological appearance. J Neurosurg 61:767–771PubMedCrossRefGoogle Scholar
  78. Humphrey T (1960) The development of the pyramidal tracts in human fetuses, correlated with cortical differentiation. In:Tower DB, Schadé JP (eds) Structure and Function of the Cerebral Cortex. Elsevier, Amsterdam, pp 93–103Google Scholar
  79. Humphrey T (1966) The development of the human hippocampal formation correlated with some aspects of its phylogenetic history. In: Hassler R, Stephan H (eds) Evolution of the Forebrain. Thieme, Stuttgart, pp 104–116Google Scholar
  80. Ianniruberto A, Tajani E (1981) Ultrasonographic study of fetal movements. Sem Perinatol 5:175–181Google Scholar
  81. Inoue T, Nakamura S, Osumi N (2000) Fate mapping of the mouse prosencephalic neural plate. Dev Biol 219:373–383PubMedCrossRefGoogle Scholar
  82. Jakob A (1928) Das Kleinhirn. In: von Möllendorf W (ed) Handbuch der mikroskopischen Anatomie des Menschen, Vol 4, Teil 1. Springer, Berlin Heidelberg New York, pp 674–916Google Scholar
  83. Jeffery N (2002) Differential regional brain growth and rotation of the prenatal human tentorium cerebelli. J Anat (Lond) 200:135–144PubMedCrossRefGoogle Scholar
  84. Jirásek JE (1983) Atlas of Human Prenatal Morphogenesis. Nijhoff, Baltimore, MDGoogle Scholar
  85. Jirásek JE (2001) An Atlas of the Human Embryo and Fetus. Parthenon, New YorkGoogle Scholar
  86. Jirásek JE (2004) An Atlas of Human Prenatal Developmenta Mechanisms. Anatomy and staging. Taylor & Francis, London, New YorkGoogle Scholar
  87. Kahle W (1969) Die Entwicklung der menschlichen Grosshirnhemisphäre. Schriftenr Neurol 1:1–116Google Scholar
  88. Keibel F, Elze C (1908) Normentafeln zur Entwicklungsgeschichte des Menschen. Hirzel, LeipzigGoogle Scholar
  89. Keyser AJM (1972) The development of the diencephalon of the Chinese hamster. Acta Anat (Basel) 83(Suppl 59):1–178Google Scholar
  90. Kinney HC, Brody BA, Kloman AS, Gilles FH (1988) Sequence of central nervous system myelination in human infancy. II. Patterns of myelination in autopsied infants. J Neuropathol Exp Neurol 47:217–234PubMedGoogle Scholar
  91. Klintworth GK (1967) The ontogeny and growth of the human tentorium cerebelli. Anat Rec 158:433–442PubMedCrossRefGoogle Scholar
  92. Kollias SS, Ball WS (1997) Congenital malformations of the brain. In: Ball WS (ed) Pediatric Neuroradiology. Lippincott, Philadelphia, PA, pp 91–174Google Scholar
  93. Konstantinidou AD, Silos-Santiago I, Flaris N, Snider WD (1995) Development of the primary afferent projection in human spinal cord. J Comp Neurol 354:1–12CrossRefGoogle Scholar
  94. Kornack DR, Rakic P (2001) The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proc Natl Acad Sci USA 98:4752–4757PubMedCrossRefGoogle Scholar
  95. Kraus I, Jirásek JE (2002) Some observations of the structure of the choroid plexus and its cysts. Prenat Diagn 22:1223–1228PubMedCrossRefGoogle Scholar
  96. Kuban KCK, Gilles FH (1985) Human telencephalic angiogenesis. Ann Neurol 17:539–548PubMedCrossRefGoogle Scholar
  97. Lammens M, Moerman P, Fryns JP, Lemmens F, van de Kamp GM, Goemans N, Dom R (1997) Fetal akinesia sequence caused by nemaline myopathy. Neuropediatrics 28:116–119PubMedGoogle Scholar
  98. Langman J (1963) Medical Embryology. Williams & Wilkins, Baltimore, MDGoogle Scholar
  99. Lavdas AA, Grigoriou M, Pachnis V, Parnavelas JG (1999) The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci 19:7881–7888PubMedGoogle Scholar
  100. Le Douarin NM, Kalcheim C (1999) The Neural Crest, 2nd ed. Cambridge University Press, CambridgeGoogle Scholar
  101. Lemire RJ, Loeser JD, Leech RW, Alvord EC (1975) Normal and Abnormal Development of the Human Nervous System. Harper & Row, Hagerstown, MDGoogle Scholar
  102. Letinić K, Kostović I (1997) Transient fetal structure, the gangliothalamic body, connects telencephalic germinal zone with all thalamic regions in the developing human brain. J Comp Neurol 384:373–395PubMedCrossRefGoogle Scholar
  103. Letinić K, Rakic P (2001) Telencephalic origin of human thalamic GABAergic neurons. Nat Neurosci 9:931–936CrossRefGoogle Scholar
  104. Lie KTA (1968) Congenital Anomalies of the Carotid Arteries. Thesis, University of Amsterdam. Excerpta Medica Foundation, AmsterdamGoogle Scholar
  105. Lindenberg R (1956) Die Gefässversorgung und ihre Bedeutung für Art und Ort von kreislaufgedingten Gewebsschäden und Gefässprozessen. In: Lubarsch-Henke-Rössle’s Handbuch der speziellen pathologischen Anatomie und Histologie, Vol 13 (Scholz W, Hrsg), Teil 1B. Springer, Berlin Heidelberg New York, pp 1071–1164Google Scholar
  106. Luckett WP (1978) Origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos. Am J Anat 152:59–97PubMedCrossRefGoogle Scholar
  107. Lumsden A, Krumlauf AR (1996) Patterning the vertebrate neuraxis. Science 274:1109–1115PubMedCrossRefGoogle Scholar
  108. Macchi G (1951) The ontogenetic development of the olfactory telencephalon in man. J Comp Neurol 95:245–305PubMedCrossRefGoogle Scholar
  109. Marín O, Rubinstein JLR (2001) A long, remarkable journey: Tangential migration in the telencephalon. Nat Rev Neurosci 2:780–790PubMedCrossRefGoogle Scholar
  110. Marín O, Rubinstein JLR (2002) Patterning, regionalization, and cell differentiation in the forebrain. In: Rossant J, Tam PPL (eds) Mouse Development-Patterning, Morphogenesis, and Organogenesis. Academic, San Diego CA, pp 75–106Google Scholar
  111. Marín O, Anderson SA, Rubinstein JLR (2000) Origin and molecular specification of striatal interneurons. J Neurosci 20:6063–6076PubMedGoogle Scholar
  112. Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubinstein JLR (2001) Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science 293:872–875PubMedCrossRefGoogle Scholar
  113. Marín-Padilla M (1990) Origin, formation, and prenatal maturation of the human cerebral cortex: An overview. J Craniofac Genet Dev Biol 10:137–146PubMedGoogle Scholar
  114. Marín-Padilla M (1996) Developmental neuropathology and impact of perinatal brain damage. I. Hemorrhagic lesions of neocortex. J Neuropathol Exp Neurol 55:758–773PubMedGoogle Scholar
  115. Marín-Padilla M (1997) Developmental neuropathology and impact of perinatal brain damage. II. White matter lesions of the neocortex. J Neuropathol Exp Neurol 56:219–235PubMedGoogle Scholar
  116. Marín-Padilla M (1998) Cajal-Retzius cells and the development of the neocortex. Trends Neurosci 21:64–71PubMedCrossRefGoogle Scholar
  117. Marín-Padilla M (1999) Developmental neuropathology and impact of perinatal brain damage. III. Gray matter lesions of the neocortex. J Neuropathol Exp Neurol 58: 407–429PubMedGoogle Scholar
  118. Marti E, Bovolenta P (2002) Sonic hedgehog in CNS development: One signal, multiple outputs. Trends Neurosci 25:89–96PubMedCrossRefGoogle Scholar
  119. Mehler MF, Mabie PC, Zhang D, Kessler JA (1997) Bone morphogenetic proteins in the nervous system. Trends Neurosci 20:309–317PubMedCrossRefGoogle Scholar
  120. Meyer G, Goffinet AM (1998) Prenatal development of reelin-immunoreactive neurons in the human neocortex. J Comp Neurol 397:29–40PubMedCrossRefGoogle Scholar
  121. Meyer G, Wahle P (1999) The paleocortical ventricle is the origin of reelin-expressing neurons in the marginal zone of the foetal human neocortex. Eur J Neurosci 11:3937–3944PubMedCrossRefGoogle Scholar
  122. Meyer G, Goffinet AM, Fairén A (1999) What is a Cajal-Retzius cell? A reassessment of a classical cell type based on recent observations in the developing neocortex. Cereb Cortex 9:765–775PubMedCrossRefGoogle Scholar
  123. Meyer G, Schaaps JP, Moreau L, Goffinet AM (2000) Embryonic and early fetal development of the human neocortex. J Neurosci 20:1858–1868PubMedGoogle Scholar
  124. Millen KJ, Millonig JH, Wingate RJT, Alder J, Hatten ME (1999) Neurogenetics of the cerebellar system. J Child Neurol 14:574–582PubMedGoogle Scholar
  125. Moessinger AC (1983) Fetal akinesia deformation sequence: An animal model. Pediatrics 72:857–863PubMedGoogle Scholar
  126. Monuki ES, Walsh CA (2001) Mechanisms of cerebral cortical patterning in mice and human. Nat Neurosci 4:1199–1206PubMedCrossRefGoogle Scholar
  127. Moore KL, Persaud TVN, Shiota K (2000) Color Atlas of Clinical Embryology, 2nd ed. Saunders, Philadelphia, PAGoogle Scholar
  128. Muenke M, Beachy PA (2000) Genetics of ventral forebrain development and holoprosencephaly. Curr Opin Genet Dev 10:262–269PubMedCrossRefGoogle Scholar
  129. Müller F, O’Rahilly R (1983) The first appearance of the major divisions of the human brain at stage 9. Anat Embryol (Berl) 168:419–432PubMedCrossRefGoogle Scholar
  130. Müller F, O’Rahilly R (1985) The first appearance of the neural tube and optic primordium in the human embryo at stage 10. Anat Embryol (Berl) 172:157–169PubMedCrossRefGoogle Scholar
  131. Müller F, O’Rahilly R (1988a) The development of the human brain from a closed neural tube at stage 13. Anat Embryol (Berl) 177:203–224PubMedCrossRefGoogle Scholar
  132. Müller F, O’Rahilly R (1988b) The first appearance of the future cerebral hemispheres in the human embryo at stage 14. Anat Embryol (Berl) 177:495–511PubMedCrossRefGoogle Scholar
  133. Müller F, O’Rahilly R (1989) The human brain at stage 16, including the initial evagination of the neurohypophysis. Anat Embryol (Berl) 179:551–569PubMedCrossRefGoogle Scholar
  134. Müller F, O’Rahilly R (1990a) The human brain at stages 18–20, including the choroid plexuses and the amygdaloid and septal nuclei. Anat Embryol (Berl) 182:285–306PubMedGoogle Scholar
  135. Müller F, O’Rahilly R (1990b) The human brain at stages 21–23, with particular reference to the cerebral cortical plate and to the development of the cerebellum. Anat Embryol (Berl) 182:375–400PubMedCrossRefGoogle Scholar
  136. Müller F, O’Rahilly R (1990c) The human rhombencephalon at the end of the embryonic period proper. Am J Anat 189:127–145PubMedCrossRefGoogle Scholar
  137. Müller F, O’Rahilly R (1997) The timing and sequence of appearance of neuromeres and their derivatives in staged human embryos. Acta Anat (Basel) 158:83–99PubMedCrossRefGoogle Scholar
  138. Nakamura M, Roser F, Rundschuh O, Vorkapic P, Samii M (2003) Intraventricular meningiomas: A review of 16 cases with reference to the literature. Surg Neurol 59:491–503PubMedCrossRefGoogle Scholar
  139. Nakatsu T, Uwabe C, Shiota K (2000) Neural tube closure in humans initiates at multiple sites: Evidence from human embryos and implications for the pathogenesis of neural tube defects. Anat Embryol (Berl) 201:455–466PubMedCrossRefGoogle Scholar
  140. Nelson MD, Gonzalez-Gomez I, Gilles FH (1991) The search for human telencephalic ventriculofugal arteries. Am J Neuroradiol 12:215–222PubMedGoogle Scholar
  141. Niemann G, Wakat JP, Krägeloh-Mann I, Grodd W, Michaelis R (1994) Congenital hemiparesis and periventricular leukomalacia: Pathogenetic aspects on magnetic resonance imaging. Dev Med Child Neurol 36:943–950PubMedCrossRefGoogle Scholar
  142. Nieuwenhuys R (1998) Morphogenesis and general structure. In: Nieuwenhuys R, ten Donkelaar HJ, Nicholson C The Central Nervous System of Vertebrates. Springer, Berlin Heidelberg New York, pp 159–228Google Scholar
  143. Nieuwkoop PD, Albers B (1990) The role of competence in the craniocaudal segregation of the central nervous system. Dev Growth Diff 32:23–31CrossRefGoogle Scholar
  144. Nishimura H, Semba R, Tanimura T, Tanaka O (1977) Prenatal Development of the Human with Special Reference to Craniofacial Structures. An atlas. Department of Health, Education & Welfare, National Institute of Health, Bethesda, MDGoogle Scholar
  145. Noden DM (1991) Cell movements and control of patterned tissue assembly during craniofacial development. J Craniofac Genet Dev Biol 11:192–213PubMedGoogle Scholar
  146. Norman MG, O’Kusky JR (1986) The growth and development of microvasculature in human cerebral cortex. J Neuropathol Exp Neurol 45:222–232PubMedGoogle Scholar
  147. Norman MG, McGillivray BC, Kalousek DK, Hill A, Poskitt KJ (1995) Congenital Malformations of the Brain. Pathological, embryological, clinical, radiological and genetic aspects. Oxford University Press, New YorkGoogle Scholar
  148. Okado N (1981) Onset of synapse formation in the human spinal cord. J Comp Neurol 201:211–219PubMedCrossRefGoogle Scholar
  149. Okado N, Kojima T (1984) Ontogeny of the central nervous system: Neurogenesis, fibre connections, synaptogenesis and myelination in the spinal cord. In: Prechtl HFR (ed) Continuity of Neural Functions from Prenatal to Postnatal Life. Blackwell, Oxford, pp 31–45Google Scholar
  150. Okado N, Kahimi S, Kojima T (1979) Synaptogenesis in the cervical cord of the human embryo: Sequence of synapse formation in a spinal reflex pathway. J Comp Neurol 184:491–517PubMedCrossRefGoogle Scholar
  151. Okudera T, Ohta T, Huang YP, Yokota A (1988) Development and radiological anatomy of the superficial cerebral convexity vessels in the human fetus. J Neuroradiol 15:205–224PubMedGoogle Scholar
  152. Olson EC, Walsh CA (2002) Smooth, rough and upside-down neocortical development. Curr Opin Genet Dev 12:320–327PubMedCrossRefGoogle Scholar
  153. Opitz JM (1993) Blastogenesis and the “primary field” in human development. Birth Defects 29:3–37PubMedGoogle Scholar
  154. Opitz JM, Wilson GN, Gilbert-Barness E (1997) Abnormalities of blastogenesis, organogenesis, and phenogenesis. In: Gilbert-Barness E (ed) Potter’s Pathology of the Fetus and Infant. Mosby, St. Louis, pp 65–105Google Scholar
  155. O’Rahilly R (1973) Developmental Stages in Human Embryos. Part A: Embryos of the first three weeks (stages 1 to 9). Carnegie Institution of Washington Publication 631, Washington, DCGoogle Scholar
  156. O’Rahilly R (1975) A Color Atlas of Human Embryology. A slide presentation. Saunders, Philadelphia, PAGoogle Scholar
  157. O’Rahilly R, Gardner E (1979) The initial development of the human brain. Acta Anat (Basel) 104:123–133PubMedGoogle Scholar
  158. O’Rahilly R, Müller F (1981) The first appearance of the human nervous system at stage 8. Anat Embryol (Berl) 163:1–13PubMedCrossRefGoogle Scholar
  159. O’Rahilly R, Müller F (1986) The meninges in human development. J Neuropathol Exp Neurol 45:588–608PubMedGoogle Scholar
  160. O’Rahilly R, Müller F (1987) Developmental Stages in Human Embryos. Carnegie Institution of Washington Publication 637, Washington, DCGoogle Scholar
  161. O’Rahilly R, Müller F (1999) The Embryonic Human Brain. An atlas of developmental stages, 2nd ed. Wiley-Liss, New YorkGoogle Scholar
  162. O’Rahilly R, Müller F (2001) Human Embryology & Teratology, 3rd ed. Wiley-Liss, New YorkGoogle Scholar
  163. Padget DH (1948) The development of the cranial arteries in the human embryo. Contrib Embryol Carnegie Instn 32:205–261Google Scholar
  164. Padget DH (1957) The development of the cranial venous system in man, from the viewpoint of comparative anatomy. Contrib Embryol Carnegie Instn 36:79–140Google Scholar
  165. Parnavelas JG (2000) The origin and migration of cortical neurones: New vistas. Trends Neurosci 23:126–131PubMedCrossRefGoogle Scholar
  166. Paus T, Collins DL, Evans AC, Leonard G, Pike B, Zijdenbos A (2001) Maturation of white matter in the human brain: A review of magnetic resonance studies. Brain Res Bull 54:255–266PubMedCrossRefGoogle Scholar
  167. Pearce WJ (2002) Cerebrovascular regulation in the neonate. In: Lagercrantz H, Hanson M, Evrard P, Rodeck CH (eds) The Newborn Brain-Neuroscience and clinical applications. Cambridge University Press, Cambridge, pp 252–277Google Scholar
  168. Pearlman AL, Faust PL, Hatten ME, Brunstrom JE (1998) New directions for neuronal migration. Curr Opin Neurobiol 8:45–54PubMedCrossRefGoogle Scholar
  169. Pearson AA (1941) The development of the olfactory nerve in man. J Comp Neurol 75:199–217CrossRefGoogle Scholar
  170. Pilz D, Stoodley N, Golden JA (2002) Neuronal migration, cerebral cortical development, and cerebral cortical anomalies. J Neuropathol Exp Neurol 61:1–11PubMedGoogle Scholar
  171. Pooh RK, Maeda K, Pooh K (2003) An Atlas of Fetal Central Nervous System Diseases. Diagnosis and treatment. Parthenon, Boca Raton, FLGoogle Scholar
  172. Puelles L, Rubinstein JLR (1993) Expression patterns of homeobox and other putative regulatory genes in the embryonic forebrain suggest a neuromeric organization. Trends Neurosci 16:472–479PubMedCrossRefGoogle Scholar
  173. Puelles L, Rubinstein JLR (2003) Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci 26:469–476PubMedCrossRefGoogle Scholar
  174. Puelles L, Verney C (1998) Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos. J Comp Neurol 394:283–308PubMedCrossRefGoogle Scholar
  175. Puelles L, Kuwana E, Puelles E, Bulfone A, Shimamura K, Keleher J, Smiga S, Rubinstein JLR (2000) Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1. J Comp Neurol 424:409–438PubMedCrossRefGoogle Scholar
  176. Rakic P (1972) Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol 145:61–84PubMedCrossRefGoogle Scholar
  177. Rakić P, Sidman RL (1969) Telencephalic origin of pulvinar neurons in the fetal human brain. Z Anat Entw Gesch 129:53–82CrossRefGoogle Scholar
  178. Rakic P, Sidman RL (1970) Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J Comp Neurol 139:473–500PubMedCrossRefGoogle Scholar
  179. Rakic P, Yakovlev PI (1968) Development of the corpus callosum and cavum septi in man. J Comp Neurol 132:45–72PubMedCrossRefGoogle Scholar
  180. Ramaekers VT, Heimann G, Reul J, Thron A, Jaeken J (1997) Genetic disorders and cerebellar structural abnormalities in childhood. Brain 120:1739–1751PubMedCrossRefGoogle Scholar
  181. Ranke G (1910) Beiträge zur Kenntnis der normalen und pathologischen Hirnrindenbildung. Ziegl Beitr Path Anat 47:51–125Google Scholar
  182. Rhinn M, Brand M (2001) The midbrain-hindbrain boundary organizer. Curr Opin Neurobiol 11:34–42PubMedCrossRefGoogle Scholar
  183. Rijli FM, Gavalas A, Chambon P (1998) Segmentation and specification in the branchial region of the head: The role of the Hox selector genes. Int J Dev Biol 42:393–401PubMedGoogle Scholar
  184. Rorke LB (1992) Anatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury. Brain Pathol 2:211–221PubMedGoogle Scholar
  185. Rubinstein JLR, Beachy PA (1998) Patterning of the embryonic forebrain. Curr Opin Neurobiol 8:18–26CrossRefGoogle Scholar
  186. Rubinstein JLR, Shimamura K, Martinez S, Puelles L (1998) Regionalization of the prosencephalic neural plate. Annu Rev Neurosci 21:445–477CrossRefGoogle Scholar
  187. Ruggieri PM (1997) Metabolic and neurodegenerative disorders and disorders with abnormal myelination. In: Ball WS (ed) Pediatric Neuroradiology. Lippincott, Philadelphia, PA, pp 175–237Google Scholar
  188. Salas E, Ziyal IM, Sekhar LN, Wright DC (1998) Persistent trigeminal artery: An anatomic study. Neurosurgery 43:557–562PubMedCrossRefGoogle Scholar
  189. Sarnat HB (2000) Molecular genetic classification of central nervous system malformations. J Child Neurol 15:675–687PubMedGoogle Scholar
  190. Sarnat HB, Flores-Sarnat L (2001) Neuropathologic research strategies in holoprosencephaly. J Child Neurol 16:918–931PubMedGoogle Scholar
  191. Schuurmans C, Guillemot F (2002) Molecular mechanisms underlying cell fate specification in the developing telencephalon. Curr Opin Neurobiol 12:26–34PubMedCrossRefGoogle Scholar
  192. Sensenig EC (1951) The early development of the meninges of the spinal cord in human embryos. Contrib Embryol Carnegie Instn 34:145–157Google Scholar
  193. Seress L, Ábrahám H, Tornóczky T, Kosztolányi G (2001) Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period. Neuroscience 105:831–843PubMedCrossRefGoogle Scholar
  194. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubinstein JLR (1995) Longitudinal organization of the anterior neural plate and neural tube. Development 121:3923–3933PubMedGoogle Scholar
  195. Sidman RL, Rakic P (1982) Development of the human central nervous system. In: Haymaker W, Adams RD (eds) Histology and Histopathology of the Nervous System. Thomas, Springfield, IL, pp 3–145Google Scholar
  196. Sie LTL, van der Knaap MS, van Wezel-Meijler G, Valk J (1997) MRI assessment of myelination of motor and sensory pathways in the brain of preterm and term-born infants. Neuropediatrics 28:97–105PubMedGoogle Scholar
  197. Spreafico R, Arcelli P, Frassoni C, Canetti P, Giaccone G, Rizzutti T, Mastrangelo M, Bentivoglio M (1999) Development of layer I of the human cerebral cortex after midgestation: Architectonic findings, immunocytochemical identification of neurons and glia, and in situ labeling of apoptotic cells. J Comp Neurol 410:126–142PubMedCrossRefGoogle Scholar
  198. Squier W (2002) Pathology of fetal and neonatal brain development: Identifying the timing. In: Squier W (ed) Acquired Damage to the Developing Brain: Timing and causation. Arnold, London, pp 110–127Google Scholar
  199. Staudt M, Niemann G, Grodd W, Krägeloh-Mann I (2000) The pyramidal tract in congenital hemiparesis: Relationship between morphology and function in periventricular lesions. Neuropediatrics 31:257–264PubMedCrossRefGoogle Scholar
  200. Stephan H (1975) Allocortex. Handbuch der mikroskopischen Anatomie des Menschen, Band 4, Teil 9. Springer, Berlin Heidelberg New YorkGoogle Scholar
  201. Streeter GL (1911) Die Entwicklung des Nervensystems. In: Keibel F, Mall FP (Hrsg) Handbuch der Entwicklungsgeschichte des Menschen, Zweiter Band. Hirzel, Leipzig, pp 1–156Google Scholar
  202. Streeter GL (1912) The development of the nervous system. In: Keibel F, Mall FP (eds) Manual of Human Embryology, Vol 2. Lippincott, Philadelphia, PA, pp 1–156Google Scholar
  203. Streeter GL (1915) The development of the venous sinuses in the dura mater in the human embryo. Am J Anat 18:145–178CrossRefGoogle Scholar
  204. Streeter GL (1918) The developmental alterations in the vascular system of the brain of the human embryo. Contrib Embryol Carnegie Instn 8:5–38Google Scholar
  205. Streeter GL (1951) Developmental Horizons in Human Embryos. Age groups XI to XXIII. Carnegie Institution of Washington, Washington, DCGoogle Scholar
  206. Supèr H, Soriano E, Uylings HBM (1998) The functions of the preplate in development and evolution of the neocortex and hippocampus. Brain Res Rev 27:40–64PubMedCrossRefGoogle Scholar
  207. Suttner N, Mura J, Tedeschi H, Ferreira MAT, Wen HT, de Oliveira E, Rhoton AL Jr (2000) Persistent trigeminal artery: A unique anatomic specimen-Analysis and therapeutic implications. Neurosurgery 47:428–434PubMedCrossRefGoogle Scholar
  208. Takashima S, Tanaka K (1978) Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch Neurol 35:11–16PubMedGoogle Scholar
  209. ten Donkelaar HJ (2000) Development and regenerative capacity of descending supraspinal pathways in tetrapods: A comparative approach. Adv Anat Embryol Cell Biol 154:1–145Google Scholar
  210. ten Donkelaar HJ, Lammens M, Wesseling P, Thijssen HOM, Renier WO (2003) Development and developmental disorders of the human cerebellum. J Neurol 250:1025–1036PubMedCrossRefGoogle Scholar
  211. ten Donkelaar HJ, Lammens M, Wesseling P, Hori A, Keyser A, Rotteveel J (2004) Development and malformations of the human pyramidal tract. J Neurol 251:1429–1442PubMedCrossRefGoogle Scholar
  212. Tsuboi K, Maki Y, Hori A, Ebihara R (1984) Accessory ventricles of the posterior horn. Prog Comp Tomogr 6:529–534Google Scholar
  213. Van den Bergh R, Vander Eecken H (1968) Anatomy and embryology of cerebral circulation. Prog Brain Res 30:1–25CrossRefGoogle Scholar
  214. van der Knaap MS, Valk J (1988) Classification of congenital abnormalities of the CNS. AJNR Am J Neuroradiol 9:315–326PubMedGoogle Scholar
  215. van der Knaap MS, Valk J (1990) MR imaging of the various stages of normal myelination during the first year of life. Neuroradiology 31:459–470PubMedCrossRefGoogle Scholar
  216. van der Knaap MS, Valk J (1995) Magnetic Resonance of Myelin, Myelination and Myelin Disorders, 2nd ed. Springer, Berlin Heidelberg New YorkGoogle Scholar
  217. van Wezel-Meijler G, van der Knaap MS, Sie LTL, Oosting J, Taets van Amerongen AHM, Cranendonk A, Lafeber HN (1998) Magnetic resonance imaging of the brain in premature infants during the neonatal period. Normal phenomena and reflection of mild ultrasound abnormalities. Neuropediatrics 29:89–96PubMedGoogle Scholar
  218. van Zalen-Sprock RM, van Vugt JMG, van Geijn HPM (1996) Firsttrimester sonographic detection of neurodevelopmental abnormalities in some single-gene defects. Prenat Diagn 16:199–202PubMedCrossRefGoogle Scholar
  219. Vieille-Grosjean I, Hunt P, Gulisano M, Boncinelli E, Thorogood P (1997) Branchial HOX gene expression and human craniofacial development. Dev Biol 183:49–60PubMedCrossRefGoogle Scholar
  220. Volpe JJ (1987) Neurology of the Newborn, 2nd ed. Saunders, Philadelphia, PAGoogle Scholar
  221. Volpe JJ (1998) Neurologic outcome of prematurity. Arch Neurol 55:297–300PubMedCrossRefGoogle Scholar
  222. Volpe JJ (2001) Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 50:553–562PubMedGoogle Scholar
  223. von Baer KE (1828) Über die Entwickelungsgeschichte der Thiere, Beobachtung und Reflexion. Bornträger, KönigsbergGoogle Scholar
  224. Wang VY, Zoghbi HY (2001) Genetic regulation of cerebellar development. Nat Rev Neurosci 2:484–491PubMedCrossRefGoogle Scholar
  225. Wechsler-Reya RJ, Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog. Neuron 22:103–114PubMedCrossRefGoogle Scholar
  226. Weindling M (2002) Clinical aspects of brain injury of the preterm brain. In: Lagercrantz H, Hanson M, Evrard P, Rodeck CH (eds) The Newborn Brain — Neuroscience and clinical applications. Cambridge University Press, Cambridge, pp 443–478Google Scholar
  227. Wigglesworth JS, Pape KE (1980) Pathophysiology of intracranial haemorrhage in the newborn. J Perinat Med 8:119–133PubMedCrossRefGoogle Scholar
  228. Wilkie AOM, Morriss-Kay GM (2001) Genetics of craniofacial development and malformation. Nat Rev Genet 2:458–468PubMedCrossRefGoogle Scholar
  229. Windle WF (1970) Development of neural elements in human embryos of four to seven weeks gestation. Exp Neurol Suppl 5:44–83Google Scholar
  230. Windle WF, Fitzgerald JE (1937) Development of the spinal reflex mechanism in human embryos. J Comp Neurol 67:493–509CrossRefGoogle Scholar
  231. Wingate RJT (2001) The rhombic lip and early cerebellar development. Curr Opin Neurobiol 11:82–88PubMedCrossRefGoogle Scholar
  232. Witters I, Moerman P, Devriendt K, Braet P, Van Schoubroeck D, Van Assche FA, Fryns JP (2002) Two siblings with early onset fetal akinesia deformation wequence and hydranencephaly: Further evidence for autosomal recessive inheritance of hydranencephaly, Fowler type. Am J Med Genet 108:41–44PubMedCrossRefGoogle Scholar
  233. Wollschlaeger G, Wollschlaeger PB (1964) The primitive trigeminal artery as seen angiographically and at postmortem examination. AJR Am J Roentgenol 92:761–768Google Scholar
  234. Wurst W, Bally-Cuif L (2001) Neural plate patterning: Upstream and downstream of the isthmic organizer. Nat Rev Neurosci 2:99–108PubMedCrossRefGoogle Scholar
  235. Yakovlev PI, Lecours AR (1967) The myelogenetic cycles of regional maturation of the brain. In: Minkowski A (ed) Regional Development of the Brain in Early Life. Blackwell, Oxford, pp 3–70Google Scholar
  236. Yamadori T (1965) Die Entwicklung des Thalamuskerns mit ihren ersten Fasersystemen bei menschlichen Embryonen. J Hirnforsch 7:393–413PubMedGoogle Scholar
  237. Zecevic N, Milosevic A, Rakic S, Marín-Padilla M (1999) Early development and composition of the human primordial plexiform layer: An immunohistochemical study. J Comp Neurol 412: 241–254PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Hans J. ten Donkelaar
    • 1
  • Ton van der Vliet
    • 2
  1. 1.935 Department of NeurologyRadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  2. 2.667 Department of RadiologyRadboud University Nijmegen Medical CentreNijmegenThe Netherlands

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