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Pulmonary Edema in Organ Donors and Lung Transplant Recipients: Is there a Role for Beta-adrenergic Agonists?

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Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2006))

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Conclusion

Pulmonary edema is a common problem in both brain dead organ donors and lung transplant recipients. Based on prior studies of the physiology of the donor lung, there is strong scientific rationale for rigorously testing a strategy aimed at accelerating alveolar fluid clearance and reducing pulmonary edema in organ donors. Use of β-agonists to accelerate alveolar fluid clearance in lung recipients might also be therapeutic but further study is needed. Other therapeutic options that warrant investigation include protective ventilatory strategies, diuretics, anti-inflammatory agents, and medications or preservation techniques that preserve or stimulate alveolar fluid clearance in the organ donor. Along with improving donor lung utilization rates, these measures might result in better lung transplant recipient outcomes.

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Author information

Authors and Affiliations

  1. Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Room T-1218 Medical Center North, 1161 South 21st Avenue, Nashville, TN, 37232-2650, USA

    M. B. Covarrubias & L. B. Ware

Authors
  1. M. B. Covarrubias
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  2. L. B. Ware
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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© 2006 Springer-Verlag Berlin Heidelberg

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Covarrubias, M.B., Ware, L.B. (2006). Pulmonary Edema in Organ Donors and Lung Transplant Recipients: Is there a Role for Beta-adrenergic Agonists?. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2006. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33396-7_34

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  • DOI: https://doi.org/10.1007/3-540-33396-7_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30155-4

  • Online ISBN: 978-3-540-33396-8

  • eBook Packages: MedicineMedicine (R0)

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