Skip to main content
SpringerLink
Log in

Introduction: Epidemiology, Risk Factors, Pathology, and Natural History of Head and Neck Neoplasms

  • Chapter
Head and Neck Cancer Imaging

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 1783 Accesses

Abstract

The most frequent malignant head and neck neoplasms can be grouped under two major headings. The most abundant are the epithelial malignancies of the mucous membranes of the upper aerodigestive tract, so-called head and neck squamous cell carcinoma (HNSCC), accounting for about 90% of all head and neck neoplasms (Greenlee et al. 2001). The second largest group of neoplasms can be described as “glandular neoplasms”, the majority arising in the thyroid, a minority in the salivary glands.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Acheson ED, Cowdell RH, Hadfield E et al (1968) Nasal cancer in woodworkers in the furniture industry. Br Med J 2:587–596

    PubMed  CAS  Google Scholar 

  • Armstrong JG, Harrison LB, Spiro RH et al (1990) Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy. Arch Otolaryngol Head Neck Surg 116:290–293

    PubMed  CAS  Google Scholar 

  • Batsakis JG (2003) Clinical pathology of oral cancer. In: Shah JP, Johnson NW, and Batsakis JG (eds) Oral cancer, 1st edn. Martin Dunitz, Taylor and Francis Group, London, pp 77–123

    Google Scholar 

  • Batsakis JG, el Naggar AK, Luna MA (1994) Hyalinizing clear cell carcinoma of salivary origin.Ann Otol Rhinol Laryngol 103:746–748

    PubMed  CAS  Google Scholar 

  • Blot WJ, McLaughlin JK, Winn DM et al (1988) Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 48:3282–3287

    PubMed  CAS  Google Scholar 

  • Boffetta P, Trichopoulos D (2002) Cancer of the lung, larynx and pleura. In: Adami HO, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology. Oxford University Press, Oxford, pp 268–272

    Google Scholar 

  • Brugere J,Guenel P,Leclerc A et al (1986) Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer 57:391–395

    Article  PubMed  CAS  Google Scholar 

  • Colmenero C, Patron M, Sierra I (1991) Acinic cell carcinoma of the salivary glands. A review of 20 new cases. J Craniomaxillofac Surg 19:260–266

    PubMed  CAS  Google Scholar 

  • Day GL, Blot WJ, Austin DF et al (1993) Racial differences in risk of oral and pharyngeal cancer: alcohol, tobacco, and other determinants. J Natl Cancer Inst 85:465–473

    Article  PubMed  CAS  Google Scholar 

  • De Rienzo DP, Greenberg SD, Fraire AE (1991) Carcinoma of the larynx. Changing incidence in women. Arch Otolaryngol Head Neck Surg 117:681–684

    Google Scholar 

  • De Stefani E, Ronco A, Mendilaharsu M et al (1999) Diet and risk of cancer of the upper aerodigestive tract – II. Nutrients. Oral Oncol 35:22–26

    Article  PubMed  Google Scholar 

  • Delange F (2000) Iodine deficiency. In: Braverman LE, Utiger RD (eds) Werner and Ingbar’s the thyroid, 8th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 295–296

    Google Scholar 

  • Deveci MS, Deveci G, Gunhan O (2000) Oncocytic mucoepidermoid carcinoma of the parotid gland: report of a case with DNA ploidy analysis and review of the literature. Pathol Int 50:905–909

    Article  PubMed  CAS  Google Scholar 

  • Ellis GL, Auclair PL (1996a) Salivary gland tumors: general considerations: site specific tumor differences. In: Ellis GL, Auclair PL (eds) Tumors of the salivary glands. Third Series. Armed Forces Institute of Pathology, Washington DC, p 32

    Google Scholar 

  • Ellis GL, Auclair PL (1996b) The normal salivary glands. In: Ellis GL, Auclair PL (eds) Tumors of the salivary glands. Third Series. Armed Forces Institute of Pathology, Washington DC, pp 1–23

    Google Scholar 

  • Eneroth CM, Zetterberg A (1974) Malignancy in pleomorphic adenoma. A clinical and microspectrophotometric study. Acta Otolaryngol 77:426–432

    Article  PubMed  CAS  Google Scholar 

  • Franceschi S, Munoz N, Bosch XF et al (1996) Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence. Cancer Epidemiol Biomarkers Prev 5:567–575

    PubMed  CAS  Google Scholar 

  • Gallo O (2001) Aetiology and molecular changes in salivary gland tumours. In: Mc Gurk M, Renehan AG (eds) Controversies in the management of salivary gland tumours, 1st edn. Oxford University Press, Oxford, pp 13–23

    Google Scholar 

  • Gallo O, Bocciolini C (1997)Warthin’s tumour associated with autoimmune diseases and tobacco use. Acta Otolaryngol 117:623–627

    Article  PubMed  CAS  Google Scholar 

  • Gnepp DR (1993) Malignant mixed tumors of the salivary glands: a review. Pathol Annu 28:279–328

    PubMed  Google Scholar 

  • Greenlee RT, Hill-Harmon MB, Murray T et al (2001) Cancer statistics, 2001. CA Cancer J Clin 51:15–36

    Article  PubMed  CAS  Google Scholar 

  • Hay ID,Klee GG (1993) Thyroid cancer diagnosis and management. Clin.Lab Med 13:725–734

    PubMed  CAS  Google Scholar 

  • Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Classification, clinicalpathologic correlation, and results of treatment. Cancer 26:368–388

    Article  PubMed  CAS  Google Scholar 

  • Heller KS, Attie JN (1988) Treatment of Warthin’s tumor by enucleation. Am J Surg 156:294–296

    Article  PubMed  CAS  Google Scholar 

  • Hoffman HT, Karnell LH, Robinson RA et al (1999) National Cancer Data Base report on cancer of the head and neck: acinic cell carcinoma. Head Neck 21: 297–309

    Article  PubMed  CAS  Google Scholar 

  • IARC (1997) Cancer incidence in five continents,vol.VII.IARC Sci Publ (143):i–xxxiv, 1–1240

    Google Scholar 

  • IARC CancerBase N°4. EUCAN (1999) Cancer incidence, mortality and prevalence in the European Union 1997, version 4.0. IARC Press, Lyon

    Google Scholar 

  • Jeannel D, Bouvier G, Hubert A (1999) Nasopharyngeal cancer. In: Newton R, Beral V, Weiss RA (eds) Infections and human cancer. Cold Spring Harbor Press, Plainview, New York, pp 125–156

    Google Scholar 

  • Kane WJ,McCaffrey TV,Olsen KD et al (1991) Primary parotid malignancies. A clinical and pathologic review. Arch Otolaryngol Head Neck Surg 117:307–315

    PubMed  CAS  Google Scholar 

  • Kopp P, Kimura ET, Aeschimann S et al (1994) Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters. J Clin Endocrinol Metab 79:134–139

    Article  PubMed  CAS  Google Scholar 

  • LaVecchia C,Tavani A,Franceschi S et al.(1997) Epidemiology and prevention of oral cancer. Oral Oncol. 33:302–312

    Article  CAS  Google Scholar 

  • Lefebvre J, Lartigau E, Kara A et al (2001) Oral cavity, pharynx and larynx cancer.Environment-related prognostic factors. In: Gospodarowicz MK,Henson DE,Hutter RVP,O’Sullivan BO, Sobin LH,Wittekind Ch (eds) UICC prognostic factors in cancer, 2nd edn. Wiley-Liss, New York, pp 151–165

    Google Scholar 

  • Lydiatt WM, Lydiatt DD (2001) The larynx: early stage disease. In: Shah JP (ed) Cancer of the head and neck, 1st edn. BC Decker Inc., Hamilton, London, pp 169–184

    Google Scholar 

  • Maruya S, Kurotaki H, Fujita S et al (2001) Primary chondrosarcoma arising in the parotid gland.ORL J Otorhinolaryngol Relat Spec 63:110–113

    PubMed  CAS  Google Scholar 

  • Medina JE, Dichtel W, Luna MA (1984) Verrucous-squamous carcinomas of the oral cavity. A clinicopathologic study of 104 cases. Arch Otolaryngol 110:437–440

    PubMed  CAS  Google Scholar 

  • Moley JF (1995) Medullary thyroid cancer. Surg Clin North Am 75:405–420

    PubMed  CAS  Google Scholar 

  • Morse DE, Katz RV, Pendrys DG et al (1996) Smoking and drinking in relation to oral epithelial dysplasia. Cancer Epidemiol Biomarkers Prev 5:769–777

    PubMed  CAS  Google Scholar 

  • Parkin DM, Pisani P, Ferlay J (1999) Global cancer statistics. CA Cancer J Clin 49:33–64, 1

    Article  PubMed  Google Scholar 

  • Pedersen EA, Hogetveit C, Andersen A (1973) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 12:32–41

    Article  PubMed  CAS  Google Scholar 

  • Russell WO, Ibanez ML, Clark RL (1963) Thyroid carcinoma. Classification, intraglandular dissemination, and clinicopathological study based upon whole organ sections of 80 glands. Cancer 16:1425–1460

    Article  PubMed  CAS  Google Scholar 

  • Saku T, Hayashi Y, Takahara O et al (1997) Salivary gland tumors among atomic bomb survivors, 1950–1987. Cancer 79:1465–1475

    Article  PubMed  CAS  Google Scholar 

  • Seifert G, Sobin LH (1992) The World Health Organization’s histological classification of salivary gland tumors.A commentary on the second edition. Cancer 70:379–385

    Article  PubMed  CAS  Google Scholar 

  • Shaha AR, Loree TR, Shah JP (1995) Prognostic factors and risk group analysis in follicular carcinoma of the thyroid. Surgery 118:1131–1136

    Article  PubMed  CAS  Google Scholar 

  • Silverman S Jr,Gorsky M,Kaugars GE (1996) Leukoplakia,dysplasia, and malignant transformation. Oral Surg Oral Med Oral Pathol 82:117

    Google Scholar 

  • Spiro JD, Spiro RH (2001) Salivary tumors. In: Shah JP, Patel SG (eds) Cancer of the head and neck, 1st edn. Decker BC Inc, Hamilton, London, pp 240–250

    Google Scholar 

  • Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck 8:177–184

    Article  CAS  Google Scholar 

  • Spiro RH, Huvos AG (1992) Stage means more than grade in adenoid cystic carcinoma. Am J Surg 164:623–628

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Huvos AG, Strong EW (1978) Acinic cell carcinoma of salivary origin. A clinicopathologic study of 67 cases. Cancer 41:924–935

    Article  PubMed  CAS  Google Scholar 

  • Tezelman S, Clark OH (1995) Current management of thyroid cancer. Adv Surg 28:191–221

    PubMed  CAS  Google Scholar 

  • UNSCEAR (2000) The United Nations Scientific Committee on the Effects of Atomic Radiation. Health Phys 79: 314

    Article  Google Scholar 

  • Vander Poorten VLM, Balm AJM, Hilgers FJM et al (1999a) Prognostic factors for long term results of the treatment of patients with malignant submandibular gland tumors. Cancer 85:2255–2264

    Article  CAS  Google Scholar 

  • Vander PoortenVLM,Balm AJM,Hilgers FJM et al (1999b) The development of a prognostic score for patients with parotid carcinoma. Cancer 85:2057–2067

    CAS  Google Scholar 

  • Vander Poorten VLM, Balm AJM, Hilgers FJM et al (2000). Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer 89:1195–1204

    Article  PubMed  CAS  Google Scholar 

  • Vander Poorten VLM, Hart AA, van der Laan BF et al. (2003) Prognostic index for patients with parotid carcinoma: external validation using the nationwide 1985–1994 Dutch Head and Neck Oncology Cooperative Group database. Cancer 97:1453–1463

    Article  PubMed  Google Scholar 

  • World Health Organization Collaborating Centre for Oral Precancerous Lesions (1978) Definitions of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 46:518–539

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Vincent Vander Poorten

Authors
  1. Vincent Vander Poorten
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Robert Hermans

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Vander Poorten, V. (2008). Introduction: Epidemiology, Risk Factors, Pathology, and Natural History of Head and Neck Neoplasms. In: Hermans, R. (eds) Head and Neck Cancer Imaging. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-33066-6_1

Download citation

  • DOI: https://doi.org/10.1007/3-540-33066-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-68439-8

  • Online ISBN: 978-3-540-33066-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation