Oxidative Stress

  • Christina S. Sander
  • Jens J. Thiele


Reactive Oxygen Species Stratum Corneum Contact Dermatitis Allergic Contact Dermatitis Sulphur Mustard 
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  1. 1.
    Aioi A, Shimizu T, Kuriyama K. Effect of squalene on superoxide anion generation induced by a skin irritant, laurylsarcosine. Int J Pharmaceut 1995; 113:159–164CrossRefGoogle Scholar
  2. 2.
    Akerboom TPM, Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. In: Jakoby W (ed) Detoxication and drug metabolism: conjugation and related systems, Vol. 77. Academic Press, New York, 1981; pp 373–382Google Scholar
  3. 3.
    Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000; 28:463–499PubMedCrossRefGoogle Scholar
  4. 4.
    Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci 1981; 78:6858–6862PubMedCrossRefGoogle Scholar
  5. 5.
    Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997; 272:20313–20316PubMedCrossRefGoogle Scholar
  6. 6.
    Briviba K, Sies H. Nonenzymatic antioxidant defense systems. In: Frei B (ed) Natural antioxidants in human health and disease. Academic Press, New York, 1994Google Scholar
  7. 7.
    Darr D, Fridovich I. Free radicals in cutaneous biology. J Invest Dermatol 1994; 102:671–675PubMedCrossRefGoogle Scholar
  8. 8.
    Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997; 324:1–18PubMedGoogle Scholar
  9. 9.
    Dimon-Gadal S, Gerbaud P, Therond P, Guibourdenche J, Anderson WB, Evain-Brion D, Raynaud F. Increased oxidative damage to fibroblasts in skin with and without lesions in psoriasis. J Invest Dermatol 2000; 114:984–989PubMedCrossRefGoogle Scholar
  10. 10.
    Elias PM. Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp Dermatol 1996; 5:191–201PubMedCrossRefGoogle Scholar
  11. 11.
    Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr 1986; 6:365–406PubMedCrossRefGoogle Scholar
  12. 12.
    Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci 1988; 85:9748–9752PubMedCrossRefGoogle Scholar
  13. 13.
    Fridovich I. Superoxide dismutases. Annu Rev Biochem 1975; 44:147–159PubMedCrossRefGoogle Scholar
  14. 14.
    Fuchs J (1992) Oxidative injury in dermatopathology. Springer, BerlinGoogle Scholar
  15. 15.
    Fuchs J, Milbradt R. Antioxidant inhibition of skin inflammation induced by reactive oxidants: evaluation of the redox couple dihydrolipoate/lipoate. Skin Pharmacol 1994; 7:278–284PubMedCrossRefGoogle Scholar
  16. 16.
    Fuchs J, Packer L. Investigations of anthralin free radicals in model systems and in skin of hairless mice. J Invest Dermatol 1989; 92:677–682PubMedCrossRefGoogle Scholar
  17. 17.
    Fuchs J, Packer L (1993) Oxidative stress in dermatology, Vol. 8. Marcel Dekker, New YorkGoogle Scholar
  18. 18.
    Fuchs J, Zollner TM, Kaufmann R, Podda M. Redox-modulated pathways in inflammatory skin diseases. Free Radic Biol Med 2001; 30:337–353PubMedCrossRefGoogle Scholar
  19. 19.
    Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in mammalian cells. FASEB J 1997; 11:526–534PubMedGoogle Scholar
  20. 20.
    Gupta A, Rosenberger SF, Bowden GT. Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 1999; 20:2063–2073PubMedCrossRefGoogle Scholar
  21. 21.
    Gutman M. Electron flux through the mitochondrial ubiquinone. Biochem Biophys Acta 1980; 594:53–84PubMedGoogle Scholar
  22. 22.
    Hanselmann C, Mauch C, Werner S. Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? Biochem J 2001; 353:459–466PubMedCrossRefGoogle Scholar
  23. 23.
    Hsieh GC, Acosta D. Dithranol-induced cytotoxicity in primary cultures of rat epidermal keratinocytes. I. The role of reactive oxygen species. Toxicol Appl Pharmacol 1991;107:16–26PubMedCrossRefGoogle Scholar
  24. 24.
    Husain K, Dube SN, Sugendran K, Singh R, Das Gupta S, Somani SM. Effect of topically applied sulphur mustard on antioxidant enzymes in blood cells and body tissues of rats. J Appl Toxicol 1996; 16:245–248PubMedCrossRefGoogle Scholar
  25. 25.
    Katsarou A, Davoy E, Xenos K, Armenaka M, Theoharides TC. Effect of an antioxidant (quercetin) on sodium-laurylsulfate-induced skin irritation. Contact Dermatitis 2000;42:85–89PubMedCrossRefGoogle Scholar
  26. 26.
    Kaur S, Zilmer M, Eisen M, Kullisaar T, Rehema A, Vihalemm T. Patients with allergic and irritant contact dermatitis are characterized by striking change of iron and oxidized glutathione status in nonlesional area of the skin. J Invest Dermatol 2001; 116:886–890PubMedCrossRefGoogle Scholar
  27. 27.
    Kirkman HN, Gaetani GF. Catalase: a tetrameric enzyme with four tightly bound molecules of NADPH. Proc Natl Acad Sci U S A 1984; 81:4343–4347PubMedCrossRefGoogle Scholar
  28. 28.
    Kobayashi T, Matsumoto M, Ilzuka H, Suzuki K, Taniguchi N. Superoxide dismutase in psoriasis, squamous cell carcinoma and basal cell epithelioma: an immunohistochemical study. Br J Dermatol 1991; 124:555–559PubMedGoogle Scholar
  29. 29.
    Krinsky NI. Antioxidant functions of carotenoids. Free Radic Biol Med 1989; 7:617–635PubMedCrossRefGoogle Scholar
  30. 30.
    Lange RW, Germolec DR, Foley JF, Luster MI. Antioxidants attenuate anthralin-induced skin inflammation in BALB/c mice: role of specific proinflammatory cytokines. J Leukoc Biol 1998; 64:170–176PubMedGoogle Scholar
  31. 31.
    Lange RW, Hayden PJ, Chignell CF, Luster MI. Anthralin stimulates keratinocyte-derived proinflammatory cytokines via generation of reactive oxygen species. Inflamm Res 1998; 47:174–181PubMedCrossRefGoogle Scholar
  32. 32.
    Levine RL, Williams JA, Stadtman EA, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Meth Enzymol 1994; 233:346–357PubMedGoogle Scholar
  33. 33.
    Lopez-Torres M, Shindo Y, Packer L. Effect of age on antioxidants and molecular markers of oxidative damage in murine epidermis and dermis. J Invest Dermatol 1994;102:476–480PubMedCrossRefGoogle Scholar
  34. 34.
    Marklund SL. Properties of extracellular superoxide dismutase from human lung. Biochem J 1984; 220:269–272PubMedGoogle Scholar
  35. 35.
    Muller K, Wiegrebe W, Younes M. Formation of active oxygen species by dithranol, III. Dithranol, active oxygen species and lipid peroxidation in vivo. Arch Pharm (Weinheim) 1987; 320:59–66Google Scholar
  36. 36.
    Niki E. Interaction of ascorbate and alpha-tocopherol. Ann N Y Acad Sci 1987; 498:186–199PubMedGoogle Scholar
  37. 37.
    Niwa Y, Iizawa O. Abnormalities in serum lipids and leukocyte superoxide dismutase and associated cataract formation in patients with atopic dermatitis. Arch Dermatol 1994; 130:1387–1392PubMedCrossRefGoogle Scholar
  38. 38.
    Ohkuma N, Izka H, Mizumoto T, Ohkawara A. Superoxide dismutase in epidermis: its relation to keratinocyte proliferation. In: Hayaishi O, Immamura S, Miyachi Y (eds) The biological role of reactive oxygen species in skin. Elsevier, New York, 1987; pp 231–237Google Scholar
  39. 39.
    Packer JE, Slater TF, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979; 278:737–738PubMedCrossRefGoogle Scholar
  40. 40.
    Pasche-Koo F, Arechalde A, Arrighi JF, Hauser C. Effect of N-acetylcysteine, an ihibitor of tumor necrosis factor, on irritant contact dermatitis in the human. In: Elsner P, Maibach HI (eds) Irritant dermatitis. Karger, Freiburg, 1995; pp 198–206Google Scholar
  41. 41.
    Peus D, Beyerle A, Rittner HL, Pott M, Meves A, Weyand C, et al. Anti-psoriatic drug anthralin activates JNK via lipid peroxidation: mononuclear cells are more sensitive than keratinocytes. J Invest Dermatol 2000; 114:688–692PubMedCrossRefGoogle Scholar
  42. 42.
    Ponec M, Weerheim A, Kempenaar J, Mulder A, Gooris GS, Bouwstra J, ret al. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 1997; 109:348–355PubMedCrossRefGoogle Scholar
  43. 43.
    Reiners Jr JJ, Thai G, Rupp T, Cantu AR. Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: Quantitation of superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase. Carcinogenesis 1991; 12:2337–2343PubMedGoogle Scholar
  44. 44.
    Schmidt KN, Podda M, Packer L, Baeuerle PA. Anti-psoriatic drug anthralin activates transcription factor NF-kappa B in murine keratinocytes. J Immunol 1996; 156:4514–4519PubMedGoogle Scholar
  45. 45.
    Schroeter C, Chang H, Mueller S, Ekanayake-M S, Elsner P, Thiele JJ. Antioxidant enzyme expression and oxidative stress in chronically UV-exposed human skin. Arch Dermatol Res 2001; 293:84Google Scholar
  46. 46.
    Sekharam M, Cunnick JM, Wu J. Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes. Biochem J 2000; 346:751–758PubMedCrossRefGoogle Scholar
  47. 47.
    Senaldi G, Pointaire P, Piguet PF, Grau GE. Protective effect of N-acetylcysteine in hapten-induced irritant and contact hypersensitivity reactions. J Invest Dermatol 1994;102:934–937PubMedCrossRefGoogle Scholar
  48. 48.
    Sevenian A, Davies KJA, Hochstein P. Serum urate as an antioxidant for ascorbic acid. Am J Clin Nutr 1991;54:1129–1134Google Scholar
  49. 49.
    Sharkey P, Eedy DJ, Burrows D, McCaigue MD, Bell AL. A possible role for superoxide production in the pathogenesis of contact dermatitis. Acta Derm Venereol 1991;71:156–159PubMedGoogle Scholar
  50. 50.
    Shindo Y, Witt E, Packer L. Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 1993; 100:260–265PubMedCrossRefGoogle Scholar
  51. 51.
    Shindo Y, Witt E, Han D, Epstein W, Packer L. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994; 102:122–124PubMedCrossRefGoogle Scholar
  52. 52.
    Sies H (1991) Oxidative stress: Introduction. In: Sies H (ed) Oxidative stress. Vol. xv–xxii. Academic Press, San DiegoGoogle Scholar
  53. 53.
    Sies H. Strategies of antioxidant defense. Eur J Biochem 1993; 215:213–219PubMedCrossRefGoogle Scholar
  54. 54.
    Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Ann NY Acad Sci 1992; 669:7–20PubMedCrossRefGoogle Scholar
  55. 55.
    Sugiura K, Ueda H, Hirano K, Adachi T. Studies on superoxide dismutase in human skin (2). Contents of superoxide dismutase and lipoperoxide in normal human skin. Jpn J Dermatol 1985; 95:1541–1545Google Scholar
  56. 56.
    Thiele JJ, Podda M, Packer L. Tropospheric ozone: an emerging environmental stress to skin. Biol Chem 1997;378:1299–1305PubMedCrossRefGoogle Scholar
  57. 57.
    Thiele JJ, Lodge JK, Choi JH, Packer L. Measurements of antioxidants in cutaneous tissues. In: Sternberg H, Timiras PS (eds) Studies of aging-Springer lab manual. Springer, Heidelberg, 1998Google Scholar
  58. 58.
    Thiele JJ, Traber MG, Packer L. Depletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidation. J Invest Dermatol 1998; 110:756–761PubMedCrossRefGoogle Scholar
  59. 59.
    Thiele JJ, Hsieh SN, Briviba K, Sies H. Protein oxidation in human stratum corneum: susceptibility of keratins to oxidation in vitro and presence of a keratin oxidation gradient in vivo. J Invest Dermatol 1999; 113:335–339PubMedCrossRefGoogle Scholar
  60. 60.
    Thiele JJ, Weber SU, Packer L. Sebaceous gland secretion is a major physiological route of vitamin E delivery to skin. J Invest Dermatol 1999; 113:1006–1010PubMedCrossRefGoogle Scholar
  61. 61.
    Thiele JJ, Dreher F, Packer L. Antioxidant defense systems in skin. In: Elsner P, Maibach H (eds) Drugs vs. cosmetics: cosmeceuticals? Marcel Dekker, New York, 2000; pp 145–188Google Scholar
  62. 62.
    Thiele JJ, Schroeter C, Hsieh SN, Podda M, Packer L. The antioxidant network of the stratum corneum. Curr Probl Dermatol 2001; 29:26–42PubMedCrossRefGoogle Scholar
  63. 63.
    Traber MG, Sies H. Vitamin E in humans—demand and delivery. Ann Rev Nutr 1996; 16:321–347CrossRefGoogle Scholar
  64. 64.
    Trenam CW, Blake DR, Morris CJ. Skin inflammation reactive oxygen species and the role of iron. J Invest Dermatol 1992; 99:675–682PubMedCrossRefGoogle Scholar
  65. 65.
    Trenam CW, Dabbagh AJ, Morris CJ, Blake DR. Skin inflammation induced by reactive oxygen species (ROS): an in-vivo model. Br J Dermatol 1991; 125:325–329PubMedGoogle Scholar
  66. 66.
    Vahlquist A, Lee JB, Michaelsson G, Rollman O. Vitamin A in human skin: II concentrations of carotene, retinol, and dehydroretinol in various components of normal skin. J Invest Dermatol 1982; 79:94–97PubMedCrossRefGoogle Scholar
  67. 67.
    Viluksela M. Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model. Arch Dermatol Res 1991; 283:262–268PubMedCrossRefGoogle Scholar
  68. 68.
    Willis CM, Reiche L, Wilkinson JD. Immunocytochemical demonstration of reduced Cu,Zn-superoxide dismutase levels following topical application of dithranol and sodium lauryl sulphate: an indication of the role of oxidative stress in acute irritant contact dermatitis. Eur J Dermatol 1998; 8:8–12PubMedGoogle Scholar
  69. 69.
    Willis CM, Britton LE, Reiche L, Wilkinson JD. Reduced levels of glutathione S-transferases in patch test reactions to dithranol and sodium lauryl sulphate as demonstrated by quantitative immunocytochemistry: evidence for oxidative stress in acute irritant contact dermatitis. Eur J Dermatol 2001; 11:99–104PubMedCrossRefGoogle Scholar
  70. 70.
    Yohn JJ, Norris DA, Yrastorza DG, Buno IJ, Leff JA, Hake SS, et al. Disparate antioxidant enzyme activities in cultured human cutaneous fibroblasts, keratinocytes, and melanocytes. J Invest Dermatol 1991; 97:405–409PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Christina S. Sander
    • 1
  • Jens J. Thiele
    • 2
  1. 1.Department of Dermatology and AllergologyFriedrich Schiller University JenaJenaGermany
  2. 2.Department of DermatologyFriedrich Schiller University JenaJenaGermany

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