Skip to main content
SpringerLink
Log in
Book cover

Neuro-Oncology of CNS Tumors pp 291–302Cite as

Primary CNS Lymphoma

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   249.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrey LE, DeAngelis LM, Yahalom J. Long-term survival in primary CNS lymphoma. J Clin Oncol 1998; 16:859–63

    PubMed  CAS  Google Scholar 

  2. Abrey LE, Yahalom J, DeAngelis LM. Treatment for primary CNS lymphoma: the next step. J Clin Oncol 2000; 18:3144–50

    PubMed  CAS  Google Scholar 

  3. Abrey LE, Moskowitz CH, Mason WP, Crump M, Stewart D, Forsyth P, Paleologos N, Correa DD, Anderson ND, Caron D, Zelenetz A, Nimer SD, DeAngelis LM. Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: an intent-to-treat analysis. J Clin Oncol 2003; 21:4151–6

    Article  PubMed  CAS  Google Scholar 

  4. Antinori A, Cingolani A, Alba L, Ammassari A, Serraino D, Ciancio BC, Palmieri F, De Luca A, Larocca LM, Ruco L, Ippolito G, Cauda R. Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy. AIDS 2001; 15:1483–91

    PubMed  CAS  Google Scholar 

  5. Balmaceda C, Gaynor JJ, Sun M, Gluck JT, DeAngelis LM. Leptomeningeal tumor in primary central nervous system lymphoma: recognition, significance, and implications. Ann Neurol 1995; 38:202–9

    Article  PubMed  CAS  Google Scholar 

  6. Bataille B, Delwail V, Menet E, Vandermarcq P, Ingrand P, Wager M, Guy G, Lapierre F. Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 2000; 92:261–6

    PubMed  CAS  Google Scholar 

  7. Batchelor T, Carson K, O’Neill A, Grossman SA, Alavi J, New P, Hochberg F, Priet R. Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: a report of NABTT 96-07. J Clin Oncol 2003; 21:1044–9

    Article  PubMed  CAS  Google Scholar 

  8. Bessell EM, Lopez-Guillermo A, Villa S, Verger E, Nomdedeu B, Petit J, Byrne P, Montserrat E, Graus F. Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments. J Clin Oncol 2002; 20:231–6

    Article  PubMed  CAS  Google Scholar 

  9. Blay JY, Conroy T, Chevreau C, Thyss A, Quesnel N, Eghbali H, Bouabdallah R, Coiffier B, Wagner JP, Le Mevel A, Dramais-Marcel D, Baumelou E, Chauvin F, Biron P. High-dose methotrexate for the treatment of primary cerebral lymphomas: analysis of survival and late neurologic toxicity in a retrospective series. J Clin Oncol 1998; 16:864–71

    PubMed  CAS  Google Scholar 

  10. Braaten KM, Betensky RA, de Leval L, Okada Y, Hochberg FH, Louis DN, Harris NL, Batchelor TT. BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma. Clin Cancer Res 2003; 9:1063–9

    PubMed  CAS  Google Scholar 

  11. Buhring U, Herrlinger U, Krings T, Thiex R, Weller M, Kuker W. MRI features of primary central nervous system lymphomas at presentation. Neurology 2001; 57:393–6

    PubMed  CAS  Google Scholar 

  12. CBTRUS. Statistical report: Primary brain tumors in the United States, 1992–1997, Chicago II; Central Brain Tumor Registry of the United States, 2000

    Google Scholar 

  13. Chamberlain MC, Kormanik PA. AIDS-related central nervous system lymphomas. J Neurooncol 1999; 43:269–76

    PubMed  CAS  Google Scholar 

  14. Cheng T, Forsyth P, Chaudhry A, Morris D, Gluck S, Russell JA, Stewart DA. High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. Bone Marrow Transplant 2003; 31:679–85

    Article  PubMed  CAS  Google Scholar 

  15. Ciordia R, Henson J, Batchelor T. Intra-ocular concentrations of methotrexate after high dose intravenous methotrexate therapy in patients with primary central nervous system lymphoma. Society of Neuro-Oncology, 1999; Scottsdale, Arizona

    Google Scholar 

  16. Correa DD, DeAngelis LM, Shi W, Thaler H, Glass A, Abrey LE. Cognitive functions in survivors of primary central nervous system lymphoma. Neurology 2004; 62:548–55

    PubMed  CAS  Google Scholar 

  17. Coulon A, Lafitte F, Hoang-Xuan K, Martin-Duverneuil N, Mokhtari K, Blustajn J, Chiras J. Radiographic findings in 37 cases of primary CNS lymphoma in immunocompetent patients. Eur Radiol 2002; 12:329–40

    PubMed  CAS  Google Scholar 

  18. DeAngelis LM, Yahalom J, Thaler HT, Kher U. Combined modality therapy for primary CNS lymphoma. J Clin Oncol 1992; 10:635–43

    PubMed  CAS  Google Scholar 

  19. DeAngelis LM, Seiferheld W, Schold SC, Fisher B, Schultz CJ, Radiation Therapy Oncology Group Study 93-10. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol 2002; 20:4643–8

    Article  PubMed  Google Scholar 

  20. Ferreri AJ, Blay JY, Reni M, Pasini F, Gubkin A, Tirelli U, Calderoni A, Zucca E, Cortelazzo S, Chassagne C, Tinguel M, Borisch B, Berger F, Ponzoni M, Cavalli F; International Extranodal Lymphoma Study Group (IELSG). Relevance of intraocular involvement in the management of primary central nervous system lymphomas. Ann Oncol 2002a; 13:531–8

    Article  PubMed  CAS  Google Scholar 

  21. Ferreri AJ, Reni M, Pasini F, Calderoni A, Tirelli U, Pivnik A, Aondio GM, Ferrarese F, Gomez H, Ponzoni M, Borisch B, Berger F, Chassagne C, Iuzzolino P, Carbone A, Weis J, Pedrinis E, Motta T, Jouvet A, Barbui T, Cavalli F, Blay JY. A multicenter study of treatment of primary CNS lymphoma. Neurology 2002b; 58:1513–20

    PubMed  CAS  Google Scholar 

  22. Ferreri AJ, Abrey LE, Blay JY, Borisch B, Hochman J, Neuwelt EA, Yahalom J, Zucca E, Cavalli F, Armitage J, Batchelor T. Summary statement on primary central nervous system lymphomas from the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002. J Clin Oncol 2003a; 21:2407–14

    PubMed  Google Scholar 

  23. Ferreri AJ, Blay JY, Reni M, Pasini F, Spina M, Ambrosetti A, Calderoni A, Rossi A, Vavassori V, Conconi A, Devizzi L, Berger F, Ponzoni M, Borisch B, Tinguely M, Cerati M, Milani M, Orvieto E, Sanchez J, Chevreau C, Dell’Oro S, Zucca E, Cavalli F. Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol 2003b; 21:266–72

    PubMed  Google Scholar 

  24. Ferreri AJ, Guerra E, Regazzi M, Pasini F, Ambrosetti A, Pivnik A, Gubkin A, Calderoni A, Spina M, Brandes A, Ferrarese F, Rognone A, Govi S, Dell’Oro S, Locatelli M, Villa E, Reni M. Area under the curve of methotrexate and creatinine clearance are outcome-determining factors in primary CNS lymphomas. Br J Cancer 2004; 90:353–8

    Article  PubMed  CAS  Google Scholar 

  25. Fliessbach K, Urbach H, Helmstaedter C, Pels H, Glasmacher A, Kraus JA, Klockgether T, Schmidt-Wolf I, Schlegel U. Cognitive performance and magnetic resonance imaging findings after high-dose systemic and intraventricular chemotherapy for primary central nervous system lymphoma. Arch Neurol 2003; 60:563–8

    Article  PubMed  Google Scholar 

  26. Forsyth PA, DeAngelis LM. Biology and management of AIDS-associated primary CNS lymphomas. Hematol Oncol Clin North Am 1996; 10:1125–34

    Article  PubMed  CAS  Google Scholar 

  27. Gaidano G, Pasqualucci L, Capello D, Berra E, Deambrogi C, Rossi D, et al. Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma. Blood 2003; 102:1833–1841

    Article  PubMed  CAS  Google Scholar 

  28. Gijtenbeek JM, Rosenblum MK, DeAngelis LM. Primary central nervous system T-cell lymphoma. Neurology 2001; 57:716–8

    PubMed  CAS  Google Scholar 

  29. Gleissner B, Siehl J, Korfel A, Reinhardt R, Thiel E. CSF evaluation in primary CNS lymphoma patients by PCR of the CDR III IgH genes. Neurology 2002; 58:390–6

    PubMed  CAS  Google Scholar 

  30. Guha-Thakurta N, Damek D, Pollack C, Hochberg FH. Intravenous methotrexate as initial treatment for primary central nervous system lymphoma: response to therapy and quality of life of patients. J Neurooncol 1999; 43:259–68

    Article  PubMed  CAS  Google Scholar 

  31. Harder H, Holtel H, Bromberg JEC, Poortmans P, Haaxmareiche H, Kluin-Nelemans, Menten J, van den bent MJ. Cognitive status and quality of life after treatment for primary CNS lymphoma. Neurology 2004; 62:544–47

    PubMed  CAS  Google Scholar 

  32. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. The World Health Organization classification of neoplasms of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November, 1997. Hematol J 2000; 1:53–66

    Article  PubMed  CAS  Google Scholar 

  33. Herrlinger U, Schabet M, Brugger W, Kortmann RD, Kuker W, Deckert M, Engel C, Schmeck-Lindenau HJ, Mergenthaler HG, Krauseneck P, Benohr C, Meisner C, Wiestler OD, Dichgans J, Kanz L, Bamberg M, Weller M. German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. Ann Neurol 2002; 51:247–52

    Article  PubMed  CAS  Google Scholar 

  34. Hoang-Xuan K, Taillandier L, Chinot O, Soubeyran P, Bogdhan U, Hildebrand J, Frenay M, De Beule N, Delattre JY, Baron B; European Organization for Research and Treatment of Cancer Brain Tumor Group. Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. J Clin Oncol 2003; 21:2726–31

    Article  PubMed  CAS  Google Scholar 

  35. Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg 1988; 68: 835–853

    PubMed  CAS  Google Scholar 

  36. Hoffmann C, Tabrizian S, Wolf E, Eggers C, Stoehr A, Plettenberg A, Buhk T, Stellbrink HJ, Horst HA, Jager H, Rosenkranz T. Survival of AIDS patients with primary central nervous system lymphoma is dramatically improved by HAART-induced immune recovery. AIDS 2001; 15:2119–27

    Article  PubMed  CAS  Google Scholar 

  37. Illerhaus G, Marks R, Derigs G, Frichhofen N, Guttenberger R, Kubin T, Ostertag BC, Finke J. Primary CNS Lymphoma: Results of a Multicenter Phase II Study Including High-Dose-Chemotherapy with Autologous PBSCT and Hyperfractionated Radiotherapy as First-Line-Therapy. Blood 2003; 102:abstract#1450

    Google Scholar 

  38. Khan RB, Shi W, Thaler HT, DeAngelis LM, Abrey LE. Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma? J Neurooncol 2002; 58(2):175–8

    Article  PubMed  Google Scholar 

  39. Lai R, Abrey LE, Rosenblum MK, DeAngelis LM. Treatmentinduced leukoencephalopathy in primary CNS lymphoma: a clinical and autopsy study. Neurology 2004; 62:451–6

    PubMed  Google Scholar 

  40. Linnebank M, Schmidt S, Kolsch H, Linnebank A, Heun R, Schmidt-Wolf IG, Glasmacher A, Fliessbach K, Klockgether T, Schlegel U, Pels H. The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma. Br J Cancer 2004; 90:1969–71

    Article  PubMed  CAS  Google Scholar 

  41. McAllister LD, Doolittle ND, Guastadisegni PE, Kraemer DF, Lacy CA, Crossen JR, Neuwelt EA. Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma. Neurosurgery 2000; 46:51–60

    PubMed  CAS  Google Scholar 

  42. Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis DN, Cohen H. Pathology with clinical correlations of primary central nervous system non-Hodgkin’s lymphoma. The Massachusetts General Hospital experience 1958–1989. Cancer 1994; 74:1383–1397

    PubMed  CAS  Google Scholar 

  43. Mocroft A, Katlama C, Johnson AM, Pradier C, Antunes F, Mulcahy F, Chiesi A, Phillips AN, Kirk O, Lundgren JD. AIDS across Europe, 1994–98: the EuroSIDA study. Lancet 2000; 356:291–6

    Article  PubMed  CAS  Google Scholar 

  44. Montesinos-Rongen M, Kuppers R, Schluter D, Spieker T, Van Roost D, Schaller C, Reifenberger G, Wiestler OD, Deckert-Schluter M. Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. Am J Pathol 1999; 155:2077–86

    PubMed  CAS  Google Scholar 

  45. Montesinos-Rongen M, Van Roost D, Schaller C, Wiestler OD, Deckert M. Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation. Blood 2004; 103:1869–75

    Article  PubMed  CAS  Google Scholar 

  46. Morgello S. Pathogenesis and classification of primary central nervous system lymphoma: an update. Brain Pathol 1995; 5:383–93

    PubMed  CAS  Google Scholar 

  47. Nakamura M, Kishi M, Sakaki T, Hashimoto H, Nakase H, Shimada K, Ishida E, Konishi N. Novel tumor suppressor loci on 6q22–23 in primary central nervous system lymphomas. Cancer Res 2003; 63:737–41

    PubMed  CAS  Google Scholar 

  48. Nelson DF, Martz KL, Bonner H, Nelson JS, Newall J, Kerman HD, Thomson JW, Murray KJ. Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 1992; 23:9–17

    PubMed  CAS  Google Scholar 

  49. Nelson DF. Radiotherapy in the treatment of primary central nervous system lymphoma (PCNSL). J Neurooncol 1999; 43:241–7

    Article  PubMed  CAS  Google Scholar 

  50. O’Brien P, Roos D, Pratt G, Liew K, Barton M, Poulsen M, Olver I, Trotter G. Phase II multicenter study of brief single-agent methotrexate followed by irradiation in primary CNS lymphoma. J Clin Oncol 2000; 18:519–26

    PubMed  CAS  Google Scholar 

  51. O’Neill BP, Habermann TM, Witzig TE, Rodriguez M. Prevention of recurrence and prolonged survival in primary central nervous system lymphoma (PCNSL) patients treated with adjuvant high-dose methylprednisolone. Med Oncol 1999; 16:211–5

    PubMed  CAS  Google Scholar 

  52. Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R, et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001; 412:341–346

    Article  PubMed  CAS  Google Scholar 

  53. Pels H, Schmidt-Wolf IG, Glasmacher A, Schulz H, Engert A, Diehl V, Zellner A, Schackert G, Reichmann H, Kroschinsky F, Vogt-Schaden M, Egerer G, Bode U, Schaller C, Deckert M, Fimmers R, Helmstaedter C, Atasoy A, Klockgether T, Schlegel U. Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol 2003; 21:4489–95

    Article  PubMed  CAS  Google Scholar 

  54. Pels H, Schulz H, Schlegel U, Engert A. Treatment of CNS lymphoma with the anti-CD20 antibody rituximab: experience with two cases and review of the literature. Onkologie 2003; 26:351–4

    Article  PubMed  CAS  Google Scholar 

  55. Poortmans PM, Kluin-Nelemans HC, Haaxma-Reiche H, Van’t Veer M, Hansen M, Soubeyran P, Taphoorn M, Thomas J, Van den Bent M, Fickers M, Van Imhoff G, Rozewicz C, Teodorovic I, van Glabbeke M, European Organization for Research and Treatment of Cancer Lymphoma Group. High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial20962. J Clin Oncol 2003; 21:4483–8

    Article  PubMed  CAS  Google Scholar 

  56. Reni M, Ferreri AJ. Therapeutic management of refractory or relapsed primary central nervous system lymphomas. Ann Hematol 2001; 80Suppl 3:B113–7

    PubMed  CAS  Google Scholar 

  57. Reni M, Ferreri AJ, Guha-Thakurta N, Blay JY, Dell’Oro S, Biron P, Hochberg FH. Clinical relevance of consolidation radiotherapy and other main therapeutic issues in primary central nervous system lymphomas treated with upfront high-dose methotrexate. Int J Radiat Oncol Biol Phys 2001; 51:419–25

    Article  PubMed  CAS  Google Scholar 

  58. Sacktor N, Lyles RH, Skolasky R, Kleeberger C, Selnes OA, Miller EN, Becker JT, Cohen B, McArthur JC, Multicenter AIDS Cohort Study. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998. Neurology 2001; 56:257–60

    PubMed  CAS  Google Scholar 

  59. Schlegel U, Pels H, Oehring R, Blumcke I. Neurologic sequelae of treatment of primary CNS lymphomas. J Neurooncol 1999; 43:277–86

    Article  PubMed  CAS  Google Scholar 

  60. Schlegel U, Schmidt-Wolf IG, Deckert M. Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment. J Neurol Sci 2000; 81:1–12

    Google Scholar 

  61. Schultz C, Scott C, Sherman W, Donahue B, Fields J, Murray K, Fisher B, Abrams R, Meis-Kindblom J. Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas: initial report of radiation therapy oncology group protocol 88-06. J Clin Oncol 1996; 14:556–64

    PubMed  CAS  Google Scholar 

  62. Smith JR, Rosenbaum JT, Wilson DJ, Doolittle ND, Siegal T, Neuwelt EA, Pe’er J. Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. Ophthalmology 2002; 109:1709–16

    PubMed  Google Scholar 

  63. Soussain C, Suzan F, Hoang-Xuan K, Cassoux N, Levy V, Azar N, Belanger C, Achour E, Ribrag V, Gerber S, Delattre JY, Leblond V. Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma. J Clin Oncol 2001; 19:742–9

    PubMed  CAS  Google Scholar 

  64. Thompsett AR, Ellison DW, Stevenson FK, Zhu D. V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. Blood 1999; 94:1738–1746

    PubMed  CAS  Google Scholar 

  65. Valenzuela RF and Hochberg FH. Methotrexate In: Spencer, Schaumberg, eds. Experimental and Clinical Neurotoxicology Second Edition. Oxford Press, 2000

    Google Scholar 

  66. Weber T, Weber RG, Kaulich K, Actor B, Meyer-Puttlitz B, Lampel S, Buschges R, Weigel R, Deckert-Schluter M, Schmiedek P, Reifenberger G, Lichter P. Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. Brain Pathol 2000; 10:73–84

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Klinik und Poliklinik der Universität Bonn, Siegmund Freud Strasse 25, 53105, Bonn, Germany

    Uwe Schlegel

  2. Brain Tumor/Oncology Center, Massachusetts General Hospital, 100 Blossom Street, COX 315, Boston, MA, 02114-2617, USA

    Fred H. Hochberg

Authors
  1. Uwe Schlegel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fred H. Hochberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Klinikum Großhadern, Marchioninistrasse 15, 81377, Munich, Germany

    Jörg-Christian Tonn MD

  2. Johns Hopkins Oncology Center Neuro-Oncology, Cancer Bldg G-93 1650 Orleans St., Baltimore, MD, 21231, USA

    Stuart A. Grossman

  3. Division of Neurosurgery, The University of Toronto, The Hospital for Sick Children, Suite 1504, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada

    James T. Rutka MD

  4. Neurochirurgische Klinik, Universitätskrankenhaus Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Manfred Westphal MD

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schlegel, U., Hochberg, F.H. (2006). Primary CNS Lymphoma. In: Tonn, JC., Grossman, S.A., Rutka, J.T., Westphal, M. (eds) Neuro-Oncology of CNS Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31260-9_18

Download citation

  • DOI: https://doi.org/10.1007/3-540-31260-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25833-9

  • Online ISBN: 978-3-540-31260-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation