Skip to main content
SpringerLink
Log in
Book cover

Pädiatrische Dermatologie pp 121–143Cite as

Melanozytäre Nävi und maligne Melanome

  • Chapter

  • 2419 Accesses

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abramovits W, Gonzalez-Serva A (1993) Multiple agminated pigmented Spitz nevi (mimicking acral lentiginous malignant melanoma and dysplastic nevus) in an African-American girl. Int J Dermatol 32: 280–285

    Article  PubMed  CAS  Google Scholar 

  • Ackerman AB (1988) What naevus is dysplastic, a syndrome and the commonest precursor of malignant melanoma? A riddle and an answer. Histopathology 13: 241–256

    Article  PubMed  CAS  Google Scholar 

  • Ackerman AB (1991) Histologic atypia in clinically benign nevi. J Am Acad Dermatol 24: 795–796

    PubMed  CAS  Google Scholar 

  • Allcutt D, Michowiz S, Weitzman S, Becker L, Blaser S, Hoffman HJ, Humphreys RP, Drake JM, Rutka JT (1993) Primary leptomeningeal melanoma: an unusually aggressive tumor in childhood. Neurosurgery 32: 721–729

    Article  PubMed  CAS  Google Scholar 

  • Annessi G, Cattaruzza MS, Abeni D, Baliva G, Laurenza M, Macchini V, Melchi F, Ruatti P, Puddu P, Faraggiana T (2001) Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi. J Am Acad Dermatol 45: 77–85

    Article  PubMed  CAS  Google Scholar 

  • Arnsmeier SL, Paller AS (1996) Pigmentary anomalies in the multiple lentigines syndrome: Is it distinct from LEOPARD syndrome? Pediatr Dermatol 13: 100–104

    PubMed  CAS  Google Scholar 

  • Augustsson A, Stierner U, Rosdahl I, Suurkula M (1992) Regional distribution of melanocytic naevi in relation to sun exposure, and site-specific counts predicting total number of naevi. Acta Derm Venereol 72: 123–127

    PubMed  CAS  Google Scholar 

  • Balmaceda CM, Fetell MR, O’Brien JL, Housepian EH (1993) Nevus of Ota and leptomeningeal melanocytic lesions. Neurology 43: 381–386

    PubMed  CAS  Google Scholar 

  • Barnhill RL, Flotte TJ, Fleischli M, Perez-Atayde A (1995) Cutaneous melanoma and atypical Spitz tumors in childhood. Cancer 76: 1833–1845

    Article  PubMed  CAS  Google Scholar 

  • Bauer J, Buettner P, Wiecker TS, Luther H, Garbe C (2005) Effect of sunscreen and clothing on the number of melanocytic nevi in 1,812 German children attending day-care. Am J Epidemiol (in press)

    Google Scholar 

  • Bauer J, Garbe C (2003) Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data. Pigment Cell Res 16: 297–306

    Article  PubMed  Google Scholar 

  • Bauer J, Garbe C (2004) Risk estimation for malignant transformation of melanocytic nevi. Arch Dermatol 140: 127

    Article  PubMed  Google Scholar 

  • Binder SW, Asnong C, Paul E, Cochran AJ (1993) The histology and differential diagnosis of Spitz nevus. Semin Diagn Pathol 10: 36–46

    PubMed  CAS  Google Scholar 

  • Bortolani A, Barisoni D, Scomazzoni G (1994) Benign “metastatic„ cellular blue nevus. Ann Plast Surg 33: 426–431

    Article  PubMed  CAS  Google Scholar 

  • Bumbic S, Stepanovic R, Nestorovic B (1986) Peutz-Jeghers’ syndrome-juvenile intestinal polyposis-review of five cases. 41: 178–180

    CAS  Google Scholar 

  • Carey WP, Jr., Thompson CJ, Synnestvedt M, Guerry D, Halpern A, Schultz D, Elder DE (1994) Dysplastic nevi as a melanoma risk factor in patients with familial melanoma. Cancer 74: 3118–3125

    Article  PubMed  Google Scholar 

  • Carli P, Biggeri A, Giannotti B (1995) Malignant melanoma in Italy: risks associated with common and clinically atypical melanocytic nevi. J Am Acad Dermatol 32: 734–739

    Article  PubMed  CAS  Google Scholar 

  • Casso EM, Grin-Jorgensen CM, Grant-Kels JM (1992) Spitz nevi. J Am Acad Dermatol 27: 901–913

    PubMed  CAS  Google Scholar 

  • Clark WH, Jr. (1988) The dysplastic nevus syndrome. Arch Dermatol 124: 1207–1210

    Article  PubMed  Google Scholar 

  • Clark WH, Jr., Ackerman AB (1989) An exchange of views regarding the dysplastic nevus controversy. Semin Dermatol 8: 229–250

    PubMed  Google Scholar 

  • Clark WH, Jr., Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ (1978) Origin of familial malignant melanomas from heritable melanocytic lesions. „The B-K mole syndrome“. Arch Dermatol 114: 732–738

    Article  PubMed  Google Scholar 

  • Cochran AJ, Bailly C, Paul E, Dolbeau D (1993) Nevi, other than dysplastic and Spitz nevi. Semin Diagn Pathol 10: 3–17

    PubMed  CAS  Google Scholar 

  • Connelly J, Smith JL, Jr. (1991) Malignant blue nevus. Cancer 67: 2653–2657

    Article  PubMed  CAS  Google Scholar 

  • Conti EM, Cercato MC, Gatta G, Ramazzotti V, Roscioni S (2001) Childhood melanoma in Europe since 1978: a population-based survival study. Eur J Cancer 37: 780–784

    Article  PubMed  CAS  Google Scholar 

  • Coppin BD, Temple IK (1997) Multiple lentigines syndrome (LEOPARD syndrome or progressive cardiomyopathic lentiginosis). J Med Genet 34: 582–586

    PubMed  CAS  Google Scholar 

  • Cullity G (1984) Intra-epithelial changes in childhood nevi simulating malignant melanoma. Pathology 16: 307–311

    Article  PubMed  CAS  Google Scholar 

  • Davidoff AM, Cirrincione C, Seigler HF (1994) Malignant melanoma in children. Ann Surg Oncol 1: 278–282

    Article  PubMed  CAS  Google Scholar 

  • Ducker P, Pfeiff B, Pullmann H (1990) Malignes Melanom in Cafe-au-lait-Fleck. Z Hautkr 65: 751–753

    PubMed  CAS  Google Scholar 

  • Duve S, Rakoski J (1994) Cutaneous melanoma in a patient with neurofibromatosis: a case report and review of the literature. Br J Dermatol 131: 290–294

    PubMed  CAS  Google Scholar 

  • Clark WH, Jr., Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ (1978) Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer 46: 1787–1794

    Google Scholar 

  • Elder DE, Green MH, Guerry D, Kraemer KH, Clark WH, Jr. (1982) The dysplastic nevus syndrome: our definition. Am J Dermatopathol 4: 455–460

    PubMed  CAS  Google Scholar 

  • Eller MS, Gilchrest BA (2000) Tanning as part of the eukaryotic SOS response. Pigment Cell Res 13Suppl 8: 94–97

    Article  PubMed  Google Scholar 

  • Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA (1997) Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci U S A 94: 12627–12632

    Article  PubMed  CAS  Google Scholar 

  • Eller MS, Ostrom K, Gilchrest BA (1996) DNA damage enhances melanogenesis. Proc Natl Acad Sci U S A 93: 1087–1092

    Article  PubMed  CAS  Google Scholar 

  • Flageole H, Raptis S, Trudel JL, Lough JO (1994) Progression toward malignancy of hamartomas in a patient with Peutz-Jeghers syndrome: case report and literature review. Can J Surg 37: 231–236

    PubMed  CAS  Google Scholar 

  • Friedman RJ, Rigel DS, Kopf AW, Lieblich L, Lew R, Harris MN, Roses DF, Gumport SL, Ragaz A, Waldo E, Levine J, Levenstein M, Koenig R, Bart RS, Trau H (1983) Favorable prognosis for malignant melanomas associated with acquired melanocytic nevi. Arch Dermatol 119: 455–462

    Article  PubMed  CAS  Google Scholar 

  • Gallagher RP, McLean DI, Yang CP, Coldman AJ, Silver HK, Spinelli JJ, Beagrie M (1990) Anatomic distribution of acquired melanocytic nevi in white children. A comparison with melanoma: the Vancouver Mole Study. Arch Dermatol 126: 466–471

    Article  PubMed  CAS  Google Scholar 

  • Gallagher RP, McLean DI, Yang CP, Coldman AJ, Silver HK, Spinelli JJ, Beagrie M (1990) Suntan, sunburn, and pigmentation factors and the frequency of acquired melanocytic nevi in children. Similarities to melanoma: the Vancouver Mole Study. Arch Dermatol 126: 770–776

    Article  PubMed  CAS  Google Scholar 

  • Gambini C, Rongioletti F (1994) Recurrent Spitz nevus. Case report and review of the literature. Am J Dermatopathol 16: 409–413

    PubMed  CAS  Google Scholar 

  • Garbe C (1995) Risikofaktoren fur die Entwicklung maligner Melanome und Identifikation von Risikopersonen im deutschsprachigen Raum. Hautarzt 46: 309–314

    Article  PubMed  CAS  Google Scholar 

  • Garbe C (1997) Melanozytäre Nävi und Melanomrisiko: Leitlinien für die Betreuung und Therapie. In: Garbe C, Dummer R, Kaufmann R, Tilgen W (eds) Dermatologische Onkologie. Springer, Berlin, Heidelberg, New York, Tokio: 215–230

    Google Scholar 

  • Garbe C, Büttner P, Weiss J, Soyer HP, Stocker U, Krüger S, Roser M, Weckbecker J, Panizzon R, Bahmer F,. (1994) Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J Invest Dermatol 102: 700–705

    Article  PubMed  CAS  Google Scholar 

  • Garbe C, Büttner P, Weiss J, Soyer HP, Stocker U, Krüger S, Roser M, Weckbecker J, Panizzon R, Bahmer F (1994) Risk factors for developing cutaneous melanoma and criteria for identifying persons at risk: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J Invest Dermatol 102: 695–699

    Article  PubMed  CAS  Google Scholar 

  • Garbe C, Krüger S, Stadler R, Guggenmoos-Holzmann I, Orfanos CE (1989) Markers and relative risk in a German population for developing malignant melanoma. Int J Dermatol 28: 517–523

    Article  PubMed  CAS  Google Scholar 

  • Gartmann H (1978) Zur Dignität der naevoiden Lentigo. Ein Beitrag zur Früherkennung und-erfassung des malignen Melanoms und seiner Vorstufen. Z Hautkr 53: 91–100

    PubMed  CAS  Google Scholar 

  • Gartmann H, Ganser M (1985) Der Spitz-Naevus. Spindelzellen-und/oder Epitheloidzellennaevus-Eine histologische Analyse von 652 Tumoren. Z Hautkr 60: 29–6, 39

    PubMed  CAS  Google Scholar 

  • Goldenhersh MA, Savin RC, Barnhill RL, Stenn KS (1988) Malignant blue nevus. Case report and literature review. J Am Acad Dermatol 19: 712–722

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez-Campora R, Diaz-Cano S, Vazquez-Ramirez F, Ruiz HG, Moreno JC, Camacho F (1996) Cellular blue nevus with massive regional lymph node metastases. Dermatol Surg 22: 83–87

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez-Campora R, Galera-Davidson H, Vazquez-Ramirez FJ, Diaz-Cano S (1994) Blue nevus: classical types and new related entities. A differential diagnostic review. Pathol Res Pract 190: 627–635

    PubMed  CAS  Google Scholar 

  • Goss BD, Forman D, Ansell PE, Bennett V, Swerdlow AJ, Burge S, Ryan TJ (1990) The prevalence and characteristics of congenital pigmented lesions in newborn babies in Oxford. Paediatr Perinat Epidemiol 4: 448–457

    Article  PubMed  CAS  Google Scholar 

  • Greene MH, Clark WH, Jr., Tucker MA, Kraemer KH, Elder DE, Fraser MC (1985) High risk of malignant melanoma in melanoma-prone families with dysplastic nevi. Ann Intern Med 102: 458–465

    PubMed  CAS  Google Scholar 

  • Grob JJ, Gouvernet J, Aymar D, Mostaque A, Romano MH, Collet AM, Noe MC, Diconstanzo MP, Bonerandi JJ (1990) Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma. Cancer 66: 387–395

    Article  PubMed  CAS  Google Scholar 

  • Hafner J (1993) Persistierender Mongolenfleck, Navus Ota und Riesen-Navus bleu: Melanom-Präkursoren? Hautarzt 44: 486–487

    PubMed  CAS  Google Scholar 

  • Halpern AC, Guerry D, Elder DE, Trock B, Synnestvedt M (1993) A cohort study of melanoma in patients with dysplastic nevi. J Invest Dermatol 100: 346S–349S

    Article  PubMed  CAS  Google Scholar 

  • Hamm H, Happle R, Bröcker EB (1987) Multiple agminate Spitz naevi: review of the literature and report of a case with distinctive immunohistological features. Br J Dermatol 117: 511–522

    Article  PubMed  CAS  Google Scholar 

  • Harrison SL, MacKie RM, MacLennan R (2000) Development of melanocytic nevi in the first three years of life. J Natl Cancer Inst 92: 1436–1438

    Article  PubMed  CAS  Google Scholar 

  • Hartmann LC, Oliver GF, Winkelmann RK, Colby TV, Sundt TM, Jr., O’Neill BP (1989) Blue nevus and nevus of Ota associated with dural melanoma. Cancer 64: 182–186

    Article  PubMed  CAS  Google Scholar 

  • Hayes FA, Green AA (1984) Malignant melanoma in childhood: clinical course and response to chemotherapy. J Clin Oncol 2: 1229–1234

    PubMed  CAS  Google Scholar 

  • Herron MD, Vanderhooft SL, Smock K, Zhou H, Leachman SA, Coffin C (2004) Proliferative nodules in congenital melanocytic nevi: a clinico-pathologic and immunohistochemical analysis. Am J Surg Pathol 28: 1017–1025

    Article  PubMed  Google Scholar 

  • Herzfeld PM, Fitzgerald EF, Hwang SA, Stark A (1993) A case-control study of malignant melanoma of the trunk among white males in upstate New York. Cancer Detect Prev 17: 601–608

    PubMed  CAS  Google Scholar 

  • Holly EA, Kelly JW, Shpall SN, Chiu SH (1987) Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol 17: 459–468

    Article  PubMed  CAS  Google Scholar 

  • Hundeiker M (1981) Naevoide Lentigo. Histologische Differentialdiagnose. Pathologe 2: 111–112

    PubMed  CAS  Google Scholar 

  • Illig L, Weidner F, Hundeiker M, Gartmann H, Biess B, Leyh F, Paul E (1985) Congenital nevi less than or equal to 10 cm as precursors to melanoma. 52 cases, a review, and a new conception. Arch Dermatol 121: 1274–1281

    Article  PubMed  CAS  Google Scholar 

  • Kaye VN, Dehner LP (1990) Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy. Arch Dermatol 126: 1581–1583

    Article  PubMed  CAS  Google Scholar 

  • Kelly JW, Holly EA, Shpall SN, Ahn DK (1989) The distribution of melanocytic naevi in melanoma patients and control subjects. Australas J Dermatol 30: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Kelly JW, Rivers JK, MacLennan R, Harrison S, Lewis AE, Tate BJ (1994) Sunlight: a major factor associated with the development of melanocytic nevi in Australian schoolchildren. J Am Acad Dermatol 30: 40–48

    PubMed  CAS  Google Scholar 

  • Khlat M, Vail A, Parkin M, Green A (1992) Mortality from melanoma in migrants to Australia: variation by age at arrival and duration of stay. Am J Epidemiol 135: 1103–1113

    PubMed  CAS  Google Scholar 

  • Khlgatian MK, Hadshiew IM, Asawanonda P, Yaar M, Eller MS, Fujita M, Norris DA, Gilchrest BA (2002) Tyrosinase gene expression is regulated by p53. J Invest Dermatol 118: 126–132

    Article  PubMed  CAS  Google Scholar 

  • Kitagawa S, Townsend BL, Hebert AA (1995) Peutz-Jeghers syndrome. Dermatol Clin 13: 127–133

    PubMed  CAS  Google Scholar 

  • Ko CB, Walton S, Wyatt EH, Bury HP (1993) Spitz nevus. Int J Dermatol 32: 354–357

    Article  PubMed  CAS  Google Scholar 

  • Kopf AW, Levine LJ, Rigel DS, Friedman RJ, Levenstein M (1985a) Congenital-nevus-like nevi, nevi spili, and cafe-au-lait spots in patients with malignant melanoma. J Dermatol Surg Oncol 11: 275–280

    PubMed  CAS  Google Scholar 

  • Kopf AW, Levine LJ, Rigel DS, Friedman RJ, Levenstein M (1985b) Prevalence of congenital-nevus-like nevi, nevi spili, and cafe au lait spots. Arch Dermatol 121: 766–769

    Article  PubMed  CAS  Google Scholar 

  • Koyama T, Ogawa M, Kurata S, Komazawa M, Murakami M (1992) Meningeal malignant melanoma in a child: immunocytological diagnosis. Acta Paediatr Jpn 34: 173–178

    PubMed  CAS  Google Scholar 

  • Krahn G, Thoma E, Peter RU (1992) Zwei superfiziell spreitende maligne Melanome auf Naevus spilus. Hautarzt 43: 32–34

    PubMed  CAS  Google Scholar 

  • Krüger S, Garbe C, Büttner P, Stadler R, Guggenmoos-Holzmann I, Orfanos CE (1992) Epidemiologic evidence for the role of melanocytic nevi as risk markers and direct precursors of cutaneous malignant melanoma. Results of a case control study in melanoma patients and nonmelanoma control subjects. J Am Acad Dermatol 26: 920–926

    PubMed  Google Scholar 

  • Kurban RS, Preffer FI, Sober AJ, Mihm MC, Jr., Barnhill RL (1992) Occurrence of melanoma in „dysplastic“ nevus spilus: report of case and analysis by flow cytometry. J Cutan Pathol 19: 423–428

    Article  PubMed  CAS  Google Scholar 

  • Lambert WC, Brodkin RH (1984) Nodal and subcutaneous cellular blue nevi. A pseudometastasizing pseudomelanoma. Arch Dermatol 120: 367–370

    Article  PubMed  CAS  Google Scholar 

  • Luther H, Altmeyer P, Garbe C, Ellwanger U, Jahn S, Hoffmann K, Segerling M (1996) Increase of melanocytic nevus counts in children during 5 years of follow-up and analysis of associated factors. Arch Dermatol 132: 1473–1478

    Article  PubMed  CAS  Google Scholar 

  • MacKie RM, Freudenberger T, Aitchison TC (1989) Personal risk-factor chart for cutaneous melanoma. Lancet 2: 487–490

    Article  PubMed  CAS  Google Scholar 

  • Mang R, Krutmann J (2003) Sonnenschutz im Urlaub. Hautarzt 54: 498–505

    Article  PubMed  CAS  Google Scholar 

  • Marghoob AA (2002) Congenital melanocytic nevi. Evaluation and management. Dermatol Clin 20: 607–16, viii

    PubMed  Google Scholar 

  • Marghoob AA, Dusza S, Oliveria S, Halpern AC (2004) Number of satellite nevi as a correlate for neurocutaneous melanocytosis in patients with large congenital melanocytic nevi. Arch Dermatol 140: 171–175

    Article  PubMed  Google Scholar 

  • Marghoob AA, Kopf AW, Rigel DS, Bart RS, Friedman RJ, Yadav S, Abadir M, Sanfilippo L, Silverman MK, Vossaert KA (1994) Risk of cutaneous malignant melanoma in patients with „classic“ atypical-mole syndrome. A case-control study. Arch Dermatol 130: 993–998

    Article  PubMed  CAS  Google Scholar 

  • Mastrangelo MJ, Goepp CE, Patel YA, Clark WH, Jr. (1979) Cutaneous melanoma in a patient with neurofibromatosis. Arch Dermatol 115: 864–865

    Article  PubMed  CAS  Google Scholar 

  • McLean DI, Gallagher RP (1995) „Sunburn“ freckles, cafe-au-lait macules, and other pigmented lesions of schoolchildren: the Vancouver Mole Study. J Am Acad Dermatol 32: 565–570

    Article  PubMed  CAS  Google Scholar 

  • Mehregan DA, Gibson LE, Mehregan AH (1992) Malignant blue nevus: a report of eight cases. J Dermatol Sci 4: 185–192

    Article  PubMed  CAS  Google Scholar 

  • Mehregan DA, Mehregan AH (1993) Deep penetrating nevus. Arch Dermatol 129: 328–331

    Article  PubMed  CAS  Google Scholar 

  • Merot Y, Frenk E (1989) Spitz nevus (large spindle cell and/or epithelioid cell nevus). Age-related involvement of the suprabasal epidermis. Virchows Arch A Pathol Anat Histopathol 415: 97–101

    Article  PubMed  CAS  Google Scholar 

  • Meves A, Repacholi MH, Rehfuess EA (2003) Promoting safe and effective sun protection strategies. J Am Acad Dermatol 49: 1203–1204

    Article  PubMed  Google Scholar 

  • Muhlbauer JE, Margolis RJ, Mihm MC, Jr., Reed RJ (1983) Minimal deviation melanoma: a histologic variant of cutaneous malignant melanoma in its vertical growth phase. J Invest Dermatol 80Suppl: 63s–65s

    Article  PubMed  CAS  Google Scholar 

  • Naasan A, al Nafussi A, Quaba A (1996) Cutaneous malignant melanoma in children and adolescents in Scotland, 1979–1991. Plast Reconstr Surg 98: 442–446

    Article  PubMed  CAS  Google Scholar 

  • Niemann TH, Argenyi ZB (1993) Immunohistochemical study of Spitz nevi and malignant melanoma with use of antibody to proliferating cell nuclear antigen. Am J Dermatopathol 15: 441–445

    PubMed  CAS  Google Scholar 

  • Novakovic B, Clark WH, Jr., Fears TR, Fraser MC, Tucker MA (1995) Melanocytic nevi, dysplastic nevi, and malignant melanoma in children from melanoma-prone families. J Am Acad Dermatol 33: 631–636

    Article  PubMed  CAS  Google Scholar 

  • Ortonne JP, Brocard E, Floret D, Perrot H, Thivolet J (1980) Valeur diagnostique des taches café-au-lait (T.C.L.). Ann Dermatol Venereol 107: 313–327

    PubMed  CAS  Google Scholar 

  • Palazzo JP, Duray PH (1988) Congenital agminated Spitz nevi: immunoreactivity with a melanoma-associated monoclonal antibody. J Cutan Pathol 15: 166–170

    Article  PubMed  CAS  Google Scholar 

  • Partoft S, Osterlind A, Hou-Jensen K, Drzewiecki KT (1989) Malignant melanoma of the skin in children (0 to 14 years of age) in Denmark, 1943–1982. Scand J Plast Reconstr Surg Hand Surg 23: 55–58

    Article  PubMed  CAS  Google Scholar 

  • Paties CT, Borroni G, Rosso R, Vassallo G (1987) Relapsing eruptive multiple Spitz nevi or metastatic spitzoid malignant melanoma? Am J Dermatopathol 9: 520–527

    PubMed  CAS  Google Scholar 

  • Peters MS, Goellner JR (1986) Spitz naevi and malignant melanomas of childhood and adolescence. Histopathology 10: 1289–1302

    Article  PubMed  CAS  Google Scholar 

  • Piepkorn M, Meyer LJ, Goldgar D, Seuchter SA, Cannon-Albright LA, Skolnick MH, Zone JJ (1989) The dysplastic melanocytic nevus: a prevalent lesion that correlates poorly with clinical phenotype. J Am Acad Dermatol 20: 407–415

    Article  PubMed  CAS  Google Scholar 

  • Quaba AA, Wallace AF (1986) The incidence of malignant melanoma (0 to 15 years of age) arising in „large“ congenital nevocellular nevi. Plast Reconstr Surg 78: 174–181

    Article  PubMed  CAS  Google Scholar 

  • Ramirez R, Schneider J (2003) Practical guide to sun protection. Surg Clin North Am 83: 97–107, vi

    Article  PubMed  Google Scholar 

  • Rampen FH, van der Meeren HL, Boezeman JB (1986) Frequency of moles as a key to melanoma incidence? J Am Acad Dermatol 15: 1200–1203

    PubMed  CAS  Google Scholar 

  • Reed RJ, Ichinose H, Clark WH, Jr., Mihm MC, Jr. (1975) Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol 2: 119–147

    PubMed  CAS  Google Scholar 

  • Reed RJ, Webb SV, Clark WH, Jr. (1990) Minimal deviation melanoma (halo nevus variant). Am J Surg Pathol 14: 53–68

    PubMed  CAS  Google Scholar 

  • Renfro L, Grant-Kels JM, Brown SA (1989) Multiple agminate Spitz nevi. Pediatr Dermatol 6: 114–117

    Article  PubMed  CAS  Google Scholar 

  • Reynolds N, Kenealy J, Mercer N (2003) Carbon dioxide laser dermabrasion for giant congenital melanocytic nevi. Plast Reconstr Surg 111: 2209–2214

    Article  PubMed  Google Scholar 

  • Rhodes AR, Melski JW (1982) Small congenital nevocellular nevi and the risk of cutaneous melanoma. J Pediatr 100: 219–224

    Article  PubMed  CAS  Google Scholar 

  • Rhodes AR, Melski JW, Sober AJ, Harrist TJ, Mihm MC, Jr., Fitzpatrick TB (1983) Increased intraepidermal melanocyte frequency and size in dysplastic melanocytic nevi and cutaneous melanoma. A comparative quantitative study of dysplastic melanocytic nevi, superficial spreading melanoma, nevocellular nevi, and solar lentigines. J Invest Dermatol 80: 452–459

    Article  PubMed  CAS  Google Scholar 

  • Rhodes AR, Mihm MC, Jr. (1990) Origin of cutaneous melanoma in a congenital dysplastic nevus spilus. Arch Dermatol 126: 500–505

    Article  PubMed  CAS  Google Scholar 

  • Rhodes AR, Mihm MC, Jr., Weinstock MA (1989) Dysplastic melanocytic nevi: a reproducible histologic definition emphasizing cellular morphology. Mod Pathol 2: 306–319

    PubMed  CAS  Google Scholar 

  • Rhodes AR, Sober AJ, Day CL, Melski JW, Harrist TJ, Mihm MC, Jr., Fitzpatrick TB (1982) The malignant potential of small congenital nevocellular nevi. An estimate of association based on a histologic study of 234 primary cutaneous melanomas. J Am Acad Dermatol 6: 230–241

    Article  PubMed  CAS  Google Scholar 

  • Rivers JK, MacLennan R, Kelly JW, Lewis AE, Tate BJ, Harrison S, McCarthy WH (1995) The eastern Australian childhood nevus study: prevalence of atypical nevi, congenital nevus-like nevi, and other pigmented lesions. J Am Acad Dermatol 32: 957–963

    Article  PubMed  CAS  Google Scholar 

  • Roth ME, Grant-Kels JM, Ackerman AB, Elder DE, Friedman RJ, Heilman ER, Maize JC, Sagebiel RW (1991) The histopathology of dysplastic nevi. Continued controversy. Am J Dermatopathol 13: 38–51

    PubMed  CAS  Google Scholar 

  • Sagebiel RW (1993) Melanocytic nevi in histologic association with primary cutaneous melanoma of superficial spreading and nodular types: effect of tumor thickness. J Invest Dermatol 100: 322S–325S

    Article  PubMed  CAS  Google Scholar 

  • Sander B, Karlsson P, Rosdahl I, Westermark P, Boeryd B (1999) Cutaneous malignant melanoma in Swedish children and teenagers 1973–1992: a clinico-pathological study of 130 cases. Int J Cancer 80: 646–651

    Article  PubMed  CAS  Google Scholar 

  • Sau P, Graham JH, Helwig EB (1993) Pigmented spindle cell nevus: a clinico-pathologic analysis of ninety-five cases. J Am Acad Dermatol 28: 565–571

    Article  PubMed  CAS  Google Scholar 

  • Schmid-Wendtner MH, Berking C, Baumert J, Schmidt M, Sander CA, Plewig G, Volkenandt M (2002) Cutaneous melanoma in childhood and adolescence: an analysis of 36 patients. J Am Acad Dermatol 46: 874–879

    Article  PubMed  Google Scholar 

  • Scott GA, Trepeta R (1993) Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in prepubescent children. Report of two cases and review of the literature. Am J Dermatopathol 15: 139–145

    PubMed  CAS  Google Scholar 

  • Seab JA, Jr., Graham JH, Helwig EB (1989) Deep penetrating nevus. Am J Surg Pathol 13: 39–44

    Article  PubMed  Google Scholar 

  • Skender-Kalnenas TM, English DR, Heenan PJ (1995) Benign melanocytic lesions: risk markers or precursors of cutaneous melanoma? J Am Acad Dermatol 33: 1000–1007

    Article  PubMed  CAS  Google Scholar 

  • Soares de Sa BC, Rezze GG, Scramim AP, Landman G, Neves RI (2004) Cutaneous melanoma in childhood and adolescence: retrospective study of 32 patients. Melanoma Res 14: 487–492

    Article  Google Scholar 

  • Spatz A, Ruiter D, Hardmeier T, Renard N, Wechsler J, Bailly C, Avril MF, Kwee H, Bastian BC, Hill C, De Potter C, Prade M (1996) Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects. Int J Cancer 68: 317–324

    Article  PubMed  CAS  Google Scholar 

  • Stadler R, Garbe C (1991) Nävus-assoziierte maligne Melanome-diagnostische Sicherung und Prognose. Hautarzt 42: 424–429

    PubMed  CAS  Google Scholar 

  • Sterchi JM, Muss HB, Weidner N (1987) Cellular blue nevus simulating metastatic melanoma: report of an unusually large lesion associated with nevus-cell aggregates in regional lymph nodes. J Surg Oncol 36: 71–75

    Article  PubMed  CAS  Google Scholar 

  • Stierner U, Augustsson A, Rosdahl I, Suurkula M (1992) Regional distribution of common and dysplastic naevi in relation to melanoma site and sun exposure. A case-control study. Melanoma Res 1: 367–375

    Article  PubMed  CAS  Google Scholar 

  • Stolz W, Schmoeckel C, Landthaler M, Braun-Falco O (1989) Association of early malignant melanoma with nevocytic nevi. Cancer 63: 550–555

    Article  PubMed  CAS  Google Scholar 

  • Swerdlow AJ, English JS, Qiao Z (1995) The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol 32: 595–599

    Article  PubMed  CAS  Google Scholar 

  • Tanaka K, Mihara M, Shimao S, Taniguchi K (1990) The local recurrence of pigmented Spitz nevus after removal. J Dermatol 17: 575–580

    PubMed  CAS  Google Scholar 

  • Tate PS, Ronan SG, Feucht KA, Eng AM, Das Gupta TK (1993) Melanoma in childhood and adolescence: clinical and pathological features of 48 cases. J Pediatr Surg 28: 217–222

    Article  PubMed  CAS  Google Scholar 

  • Tiersten AD, Grin CM, Kopf AW, Gottlieb GJ, Bart RS, Rigel DS, Friedman RJ, Levenstein MJ (1991) Prospective follow-up for malignant melanoma in patients with atypical-mole (dysplastic-nevus) syndrome. J Dermatol Surg Oncol 17: 44–48

    PubMed  CAS  Google Scholar 

  • Ting WW, Vest CD, Sontheimer R (2003) Practical and experimental consideration of sun protection in dermatology. Int J Dermatol 42: 505–513

    Article  PubMed  Google Scholar 

  • Toppe F, Haas N (1987) Zur Klinik des blauen Naevus und seiner Sonderformen. Z Hautkr 62: 1214–1223

    PubMed  CAS  Google Scholar 

  • Tsao H, Bevona C, Goggins W, Quinn T (2003) The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch Dermatol 139: 282–288

    Article  PubMed  Google Scholar 

  • Tu P, Miyauchi S, Miki Y (1993) Proliferative activities in Spitz nevus compared with melanocytic nevus and malignant melanoma using expression of PCNA/cyclin and mitotic rate. Am J Dermatopathol 15: 311–314

    PubMed  CAS  Google Scholar 

  • Tucker MA, Fraser MC, Goldstein AM, Elder DE, Guerry D, Organic SM (1993) Risk of melanoma and other cancers in melanoma-prone families. J Invest Dermatol 100: 350S–355S

    Article  PubMed  CAS  Google Scholar 

  • Vion B, Belaich S, Grossin M, Preaux J (1985) Les aspects evolutifs du naevus sur naevus: revue de la litterature a propos de 7 observations. Ann Dermatol Venereol 112: 813–819

    PubMed  CAS  Google Scholar 

  • Watt AJ, Kotsis SV, Chung KC (2004) Risk of melanoma arising in large congenital melanocytic nevi: a systematic review. Plast Reconstr Surg 113: 1968–1974

    PubMed  Google Scholar 

  • Wechsler J, Bastuji-Garin S, Spatz A, Bailly C, Cribier B, Andrac-Meyer L, Vergier B, Fraitag S, Verola O, Wolkenstein P (2002) Reliability of the histopathologic diagnosis of malignant melanoma in childhood. Arch Dermatol 138: 625–628

    Article  PubMed  Google Scholar 

  • Weiss J, Garbe C, Bertz J, Biltz H, Burg G, Hennes B, Jung EG, Kreysel HW, Orfanos CE, Petzold D,. (1990) Risikofaktoren fur die Entwicklung maligner Melanome in der Bundesrepublik Deutschland. Ergebnises einer multizentrischen Fall-Kontroll-Studie. Hautarzt 41: 309–313

    PubMed  CAS  Google Scholar 

  • Weiss LW, Zelickson AS (1977) Giant melanosomes in multiple lentigines syndrome. Arch Dermatol 113: 491–494

    Article  PubMed  CAS  Google Scholar 

  • Westerdahl J, Olsson H, Ingvar C, Brandt L, Jonsson PE, Moller T (1992) Southern travelling habits with special reference to tumour site in Swedish melanoma patients. Anticancer Res 12: 1539–1542

    PubMed  CAS  Google Scholar 

  • Wiecker TS, Luther H, Buettner P, Bauer J, Garbe C (2003) Moderate sun exposure and nevus counts in parents are associated with development of melanocytic nevi in childhood: a risk factor study in 1,812 kindergarten children. Cancer 97: 628–638

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sektion für Dermatologische Onkologie, Universitäts-Hautklinik, Liebermeisterstr. 25, 72076, Tübingen

    C. Garbe (Prof. Dr. med.)

Authors
  1. C. Garbe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Garbe, C. (2006). Melanozytäre Nävi und maligne Melanome. In: Pädiatrische Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31259-5_9

Download citation

  • DOI: https://doi.org/10.1007/3-540-31259-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25646-5

  • Online ISBN: 978-3-540-31259-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation