Advertisement

The Role of Scintigraphy in the Management of Children with Neurogenic Bladder Dysfunction

  • Luigi Mansi
  • Carlo Rambaldi
  • Guiseppe Lucio Cascini
  • Gianfranco Vallone

15.9 Conclusion

In conclusion, although only few papers extensively evaluated the clinical relevance of radionuclide procedures in patients with NBSD, their usefulness can be demonstrated both in diagnosis and in the prognostic definition. The most important issues deriving from nuclear medicine are related to its capability of providing reliable functional information, often quantitative, original, and/or complementary with respect to the other diagnostic approaches; therefore, in the presence of major advantages in comparison with traditional Rx, having capability to integrate morphostructural information achievable by US and waiting for a wider diffusion and a further validation of data obtained using newer procedures allowed by multislice CT and MRI, nuclear medicine can certainly find a clinical relevance in patients with NBSD.

Keywords

Neurogenic Bladder Neurogenic Bladder Dysfunction QBUJFOUT XJUI IBWF CFFO DPNQBSFE XJUI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ataei N et al (2005) Evaluation of acute pyelonephritis with DMSA scans in children presenting after the age of 5 years. Pediatr Nephrol 20: 1439–1444PubMedCrossRefGoogle Scholar
  2. 2.
    Bauer SB (1998) Neurogenic dysfunction of the lower urinary tract in children. In:Walsh PC, Retik AB, Vaughan ED, et al (eds) Campbell’s uology, ed 7, vol 2. Philadelphia, Saunders, pp 2022Google Scholar
  3. 3.
    Bjorgvinson E et al (1991) Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. Am J Roentgenol 157: 539–543Google Scholar
  4. 4.
    Blaufox MD (1991) Procedures of choice in renal nuclear medicine. J Nucl Med 32: 1301–1309PubMedGoogle Scholar
  5. 5.
    Boubaker A et al (2001) F+0 renography in neonates and infants younger than 6 months: an accurate method to diagnose severe obstructive uropathy. J Nucl Med 42: 1780–1788PubMedGoogle Scholar
  6. 6.
    Braren V et al (1982) A microtechnique for radioisotopic determination of glomerular filtration rate in infants and children. Clin Pediatr 21: 225–227Google Scholar
  7. 7.
    Christian MT et al (2000) Risk assessment of renal cortical scarring with urinary tract infection by clinical features and ultrasonography. Arch Dis Child 82: 376–380PubMedCrossRefGoogle Scholar
  8. 8.
    Churchill BM et al (2001) Dysfunction of the lower urinary and distal gastrointestinal tracts in pediatric patients with know spinal cord problems. Pediatr Clin North Am 48: 1587–1629PubMedCrossRefGoogle Scholar
  9. 9.
    Del Gado R et al (2003) Renal size and function in patients with neurophatic bladder due to myelomeningocele: the role of growth hormone. J Urol 170: 1960–1961PubMedCrossRefGoogle Scholar
  10. 10.
    Eskild-Jensen A et al (2004) Interpretation of the renogram: problems and pitfalls in hydronephrosis in children. BJU Int 94: 887–892PubMedCrossRefGoogle Scholar
  11. 11.
    Fettich J et al (2003) Guidelines for direct radionuclide cystography in children. Eur J Nucl Med Mol Imaging 30: 39–44CrossRefGoogle Scholar
  12. 12.
    Goonasekera CD et al (1998) 15-year follow-up of reflux nephropathy by imaging. Clin Nephrol 50: 224–231PubMedGoogle Scholar
  13. 13.
    Gordon I et al (2003) Guidelines for standard and diuretic renography in children. Eur J Nucl Med 28: 21–30Google Scholar
  14. 14.
    Gordon I (2004) Pathophysiology of renal function and its effect on isotope studies in the workup of hydronephrosis. World J Urol 22: 411–414PubMedCrossRefGoogle Scholar
  15. 15.
    Hopps CV et al (2003) Preservation of renal function in children with myelomeningocele managed with basic newborn evaluation and close follow up 169: 305–308Google Scholar
  16. 16.
    Jakobsson B (1994) The role of Tc-99m DMSA scan in urinary tract infection in children. In: O’Reilly PH, Taylor A, Nally JV (eds) Radionuclides in nephrology. Fields and Wood, Blue Bell, pp 91–97Google Scholar
  17. 17.
    Kaplan WE et al (1983) Management of reflux in the myelodysplastic child. J Urol 129: 1195–1197PubMedGoogle Scholar
  18. 18.
    Levart TK et al (2002) Sensitivity of ultrasonography in detecting renal parenchymal defects in children. Pediatr Nephrol 17: 1059–1062PubMedCrossRefGoogle Scholar
  19. 19.
    Lie HR et al (1991) Bowel and bladder control of children with myelomeningocele. Dev Med Child Neurol 33: 1053–1061PubMedCrossRefGoogle Scholar
  20. 20.
    Lythgoe MF et al (1999) Assessment of various parameters in the estimation of differential renal function using technetium-99m mercaptoacetyltriglycine. Eur J Nucl Med 26: 155–162PubMedCrossRefGoogle Scholar
  21. 21.
    Majd M et al (2001) Acute pyelonephritis: comparison of diagnosis with 99mTc-DMSA, SPECT, spiral CT, MR imaging, and power Doppler US in an experimental pig model. Radiology 218: 101–108.PubMedGoogle Scholar
  22. 22.
    Mandell GA et al (1997) Procedure guideline for radionuclide cystography in children. J Nucl Med 38: 1650–1654PubMedGoogle Scholar
  23. 23.
    Moorthy I et al (2004) Ultrasonography in the evaluation of renal scarring using DMSA scan as the gold standard. Pediatr Nephrol 19: 153–156PubMedCrossRefGoogle Scholar
  24. 24.
    Parkhouse HF et al (1989) Renal imaging with 99mTc-labelled DMSA in the detection of acute pyelonephritis: an experimental study in the pig. Nucl Med Commun 10: 63–70.PubMedGoogle Scholar
  25. 25.
    Piepsz A et al (1978) A simple method for measuring separate glomerular filtration rate using a single injection of 99mTc-DTPA and scintillation camera. J Pediatr 93: 769–774PubMedCrossRefGoogle Scholar
  26. 26.
    Piepsz A et al (2001) Guidelines for glomerular filtration rate determination in children. Eur J Nucl Med 28: 31–36Google Scholar
  27. 27.
    Piepsz A et al (2001) Guidelines for 99mTc-DMSA scintigraphy in children. Eur J Nucl Med 2001 28: 37–41Google Scholar
  28. 28.
    Polito C et al (2000) Enhanced detection of vesicoureteric re-flux with isotopic scintigraphy. Pediatr Nephrol 14: 827–830PubMedCrossRefGoogle Scholar
  29. 29.
    Raptopoulos V et al (2005) Improved pelvicalyceal visualization with multidetector tomography urography; comparison with helical computed tomography. Eur Radiol 15: 1834–1840PubMedCrossRefGoogle Scholar
  30. 30.
    Rossleigh MA (2002) Urinary tract infection and other pediatric considerations. Q J Nucl Med 46: 304–310PubMedGoogle Scholar
  31. 31.
    Smith ED (1972) Urinary prognosis in spina bifida. J Urol 108: 815–818PubMedGoogle Scholar
  32. 32.
    Van Gool JD et al (1984) Vesico-ureteral reflux in children with spina bifida and detrusor-sphincter dyssynergia. Contr Nephrol 39: 221–237Google Scholar
  33. 33.
    Van Gool JD et al (1994) Non-neurophatic and neurophatic bladder-sphincter dysfunction in children. J Pediatr Adolesc Med 5: 178–192Google Scholar
  34. 34.
    Van Gool JD et al (2001) Bladder-sphincter dysfunction in myelomeningocele. Eur J Pediatr 160: 414–420PubMedCrossRefGoogle Scholar
  35. 35.
    Wilcock AR (1970) Deformities of the renal tract in children with myelomeningocele and hydrocephalus, compared with those of children showing no such deformities. Br J Urol 42: 152–159PubMedCrossRefGoogle Scholar
  36. 36.
    Wong DC et al (2000) Diuretic renography with the addition of quantitative gravity-assisted drainage in infants and children. J Nucl Med 41: 1030–1036PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Luigi Mansi
    • 1
  • Carlo Rambaldi
    • 1
  • Guiseppe Lucio Cascini
    • 1
  • Gianfranco Vallone
    • 2
  1. 1.Department of RadiologyChair of Nuclear Medicine Second University of NaplesNaplesItaly
  2. 2.Department of RadiologyFederico II University of NaplesNaplesItaly

Personalised recommendations