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Clinical Implications of Anti-cardiac Immunity in Dilated Cardiomyopathy

  • Conference paper
Chronic Viral and Inflammatory Cardiomyopathy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 55))

Abstract

Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in such patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expressed in the heart (organ-specific), others in heart and some skeletal muscle fibres (partially heart-specific) or in heart and skeletal muscle (muscle-specific). Distinct autoantibodies have different frequency in disease and normal controls. Different techniques detect one or more antibodies, thus they cannot be used interchangeably for screening. It is unknown whether the same patients produce more antibodies or different patient groups develop autoimmunity to distinct antigens. IgG antibodies, shown to be cardiac- and disease-specific for myocarditis/DCM, can be used as autoimmune markers for relatives at risk as well as for identifying patients in whom immunosuppression may be beneficial. Some autoantibodies may also have a functional role, but further work is needed.

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Authors and Affiliations

  1. Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences Centro “V. Gallucci”, Policlinico University of Padua, Via Giustiniani, 2, 35128, Padova, Italy

    A. L. P. Caforio

  2. Cardiovascular Department, Mater Misericordiae Hospital, Dublin, Ireland

    N. G. Mahon

  3. The Heart Hospital, University College London Hospitals NHS Foundation Trust, London, UK

    W. J. McKenna

Authors
  1. A. L. P. Caforio
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  2. N. G. Mahon
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  3. W. J. McKenna
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Editor information

Editors and Affiliations

  1. Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité University Medicine Berlin, Hindenburgdamm 30, Germany

    H. -P. Schultheiss

  2. Specialized Therapeutics, M1/3-9, Berlex Inc., Montville, NJ, 07045, USA

    J. -F. Kapp

  3. Medical Development, Specialized Therapeutics, Cardiovascular Europe, Schering AG, 13342, Berlin, Germany

    G. Grötzbach

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Caforio, A.L.P., Mahon, N.G., McKenna, W.J. (2006). Clinical Implications of Anti-cardiac Immunity in Dilated Cardiomyopathy. In: Schultheiss, H.P., Kapp, J.F., Grötzbach, G. (eds) Chronic Viral and Inflammatory Cardiomyopathy. Ernst Schering Research Foundation Workshop, vol 55. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30822-9_11

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  • DOI: https://doi.org/10.1007/3-540-30822-9_11

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