Perfusion MRI of Acute Stroke

  • Pamela W. Schaefer
  • William A. Copen
  • R. Gilberto González

8.7 Conclusion

Perfusion MRI allows evaluation of the hemodynamic status of acutely ischemic tissue and has greatly improved evaluation of acute stroke. The CBV abnormality correlates highly with the DWI abnormality, which is thought to represent the ischemic core. With proximal emboli, CBF and tissue transit time maps demonstrate the operational ischemic penumbra, additional tissue with altered perfusion that is at risk of progressing to infarction. Diffusion and perfusion MRI are useful in predicting tissue viability, and are also useful in predicting HT and clinical outcome. Most importantly, it has now been shown how DWI-PWI mismatch criteria may be used to successfully guide thrombolytic therapy.


Arterial Spin Label Mean Transit Time Arterial Input Function Hemorrhagic Transformation Ischemic Penumbra 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Pamela W. Schaefer
    • 1
  • William A. Copen
    • 2
  • R. Gilberto González
    • 2
  1. 1.NeuroradiologyMassachusetts General HospitalBoston
  2. 2.Neuroradiology DivisionMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

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