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References

  • Behzadi A, Borgwardt U, Henglein A, Schamberg E, Schnabel W (1970) Pulsradiolytische Untersuchung der Kinetik diffusionkontrollierter Reaktionen des OH-Radikals mit Polymeren und Oligomeren in wäßriger Lösung. Ber Bunsenges Phys Chem 74:649–653

    CAS  Google Scholar 

  • Bourdat A-G, Douki T, Frelon S, Gasparutto D, Cadet J (2000) Tandem base lesions are generated by hydroxyl radical within isolated DNA in aerated aqueous solution. J Am Chem Soc 122:4549–4556

    Article  CAS  Google Scholar 

  • Box HC, Budzinski EE, Freund HG, Evans MS, Patrzyc HB, Wallace JC, Maccubbin AE (1993) Vicinal lesions in X-irradiated DNA? Int J Radiat Biol 64:261–263

    CAS  PubMed  Google Scholar 

  • Box HC, Freund HG, Budzinski EE, Wallace JC, Maccubbin AE (1995) Free radical-induced double base lesions. Radiat Res 141:91–94

    CAS  PubMed  Google Scholar 

  • Brustad T, Jones WBG, Nakken KF (1971) On the binding of an organic nitroxide free radical to radiation-induced deoxyribonucleic acid (DNA) radicals under anoxic conditions. Int J Radiat Phys Chem 3:55–61

    CAS  Google Scholar 

  • Burchill CE, Wollner GP (1972) Radiation-induced oxidation of 2-propanol by nitrous oxide in alkaline aqueous solution. Can J Chem 50:1751–1756

    CAS  Google Scholar 

  • Chatterjee A, Magee JL (1985) Theoretical investigation of the production of strand breaks in DNA by water radicals. Radiat Protect Dosimetry 13:137–140

    CAS  Google Scholar 

  • Deeble DJ, von Sonntag C (1984) γ-Radiolysis of poly(U) in aqueous solution. The role of primary sugar and base radicals in the release of undamaged uracil. Int J Radiat Biol 46:247–260

    CAS  Google Scholar 

  • Deeble DJ, von Sonntag C (1986) Radiolysis of poly(U) in oxygenated solutions. Int J Radiat Biol 49:927–936

    CAS  Google Scholar 

  • Deeble DJ, Schulz D, von Sonntag C (1986) Reactions of OH radicals with poly(U) in deoxygenated solutions: sites of OH radical attack and the kinetics of base release. Int J Radiat Biol 49:915–926

    CAS  Google Scholar 

  • Deeble DJ, Bothe E, Schuchmann H-P, Parsons BJ, Phillips GO, von Sonntag C (1990) The kinetics of hydroxyl-radical-induced strand breakage of hyaluronic acid. A pulse radiolysis study using conductometry and laser-light-scattering. Z Naturforsch 45c:1031–1043

    Google Scholar 

  • Deeble DJ, Phillips GO, Bothe E, Schuchmann H-P, von Sonntag C (1991) The radiation-induced degradation of hyaluronic acid. Radiat Phys Chem 37:115–118

    CAS  Google Scholar 

  • Dizdaroglu M, von Sonntag C, Schulte-Frohlinde D (1975) Strand breaks and sugar release by γ-irradiation of DNA in aqueous solution. J Am Chem Soc 97:2277–2278

    Article  CAS  PubMed  Google Scholar 

  • Fahey RC, Vojnovic B, Michael BD (1991) The effects of counter-ion condensation and co-ion depletion upon the rates of chemical repair of poly(U) radicals by thiols. Int J Radiat Biol 59:885–899

    CAS  PubMed  Google Scholar 

  • Greenstock CL, Banerjee C, Ruddock GW (1977) Interactions of drugs with biological macromolecules as studied by pulse radiolysis. In: Hedvig P, Schiller R (eds) Proceedings of the fourth Tihany symposium on radiation chemistry. Akadémiai Kiadó, Budapest, pp 871–879

    Google Scholar 

  • Gröllmann U, Schnabel W (1980) On the kinetics of polymer degradation in solution, 9. Pulse radiolysis of poly(ethylene oxide). Makromol Chem 181:1215–1226

    Article  Google Scholar 

  • Hildenbrand K, Schulte-Frohlinde D (1989a) ESR studies on the mechanism of •OH-induced strand breakage of poly(U). Free Rad Res Commun 6:137–138

    CAS  Google Scholar 

  • Hildenbrand K, Schulte-Frohlinde D (1989b) E.S.R. studies on the mechanism of hydroxyl radical-induced strand breakage of polyuridylic acid. Int J Radiat Biol 55:725–738

    CAS  PubMed  Google Scholar 

  • Isildar M, Schuchmann MN, Schulte-Frohlinde D, von Sonntag C (1982) Oxygen uptake in the radiolysis of aqueous solutions of nucleic acids and their constituents. Int J Radiat Biol 41:525–533

    CAS  Google Scholar 

  • Janik I, Ulanski P, Rosiak JM, von Sonntag C (2000a) Hydroxyl-radical-induced reactions of the poly(vinyl methyl ether) model 2,4-dimethoxypentane in the absence and presence of dioxygen: a pulse radiolysis and product study. J Chem Soc Perkin Trans 2 2034–2040

    Google Scholar 

  • Janik I, Ulanski P, Hildenbrand K, Rosiak JM, von Sonntag C (2000b) Hydroxyl-radical-induced reactions of poly(vinyl methyl ether): a pulse radiolysis, EPR and product study in deoxygenated and oxygenated aqueous solutions. J Chem Soc Perkin Trans 2 2041–2048

    Google Scholar 

  • Lafleur MVM, Loman H (1986) Radiation damage to Φ X174 DNA and biological effects. Radiat Environ Biophys 25:159–173

    Article  CAS  PubMed  Google Scholar 

  • Lindenau D, Hagen U, Schnabel W (1976) Detachment of segments from DNA double strands as detected by time resolved Rayleigh light scattering. Z Naturforsch 31c:484–485

    CAS  Google Scholar 

  • Loman H, Ebert M (1968) Some pulse radiolytic observations on the reactivity of hydroxyl radicals with DNA and poly A. Int J Radiat Biol 13:549–557

    CAS  Google Scholar 

  • Maccubbin AE, Iijima H, Ersing N, Dawidzik JB, Patrzyc HB, Wallace JC, Budzinski EE, Freund HG, Box HC (2000) Double-base lesions are produced in DNA by free radicals. Arch Biochem Biophys 375:119–123

    Article  CAS  PubMed  Google Scholar 

  • Michaels HB, Hunt JW (1973) Reactions of the hydroxyl radical with polynucleotides. Radiat Res 56:57–70

    CAS  PubMed  Google Scholar 

  • Raap IA, Gröllmann U (1983) The stochastic kinetics of intramolecular reactions in linear polymers. Macromol Chem 184:123–134

    Article  CAS  Google Scholar 

  • Scholes G, Willson RL, Ebert M (1969) Pulse radiolysis of aqueous solutions of deoxyribonucleotides and of DNA: reaction with hydroxy-radicals. Chem Commun 17–18

    Google Scholar 

  • Schuchmann MN, von Sonntag C (1982) Hydroxyl radical induced oxidation of diethyl ether in oxygenated aqueous solution. A product and pulse radiolysis study. J Phys Chem 86:1995–2000

    Article  CAS  Google Scholar 

  • Shragge PC, Michaels HB, Hunt JW (1971) Factors affecting the rate of hydrated electron attack on polynucleotides. Radiat Res 47:598–611

    CAS  PubMed  Google Scholar 

  • Tallman KA, Greenberg MM (2001) Oxygen-dependent DNA damage amplification involving 5,6-dihydrothymin-5-yl in a structurally minimal system. J Am Chem Soc 123:5181–5187

    CAS  PubMed  Google Scholar 

  • Udovicic L, Mark F, Bothe E, Schulte-Frohlinde D (1991) Non-homogeneous kinetics in the competition of single-stranded calf-thymus DNA and low-molecular weight scavengers for OH radicals: a comparison of experimental data and theoretical models. Int J Radiat Biol 59:677–697

    CAS  PubMed  Google Scholar 

  • Udovicic L, Mark F, Bothe E (1994) Single-strand breakage in double-stranded calf-thymus DNA irradiated in aqueous solution in the presence of oxygen and scavengers. Radiat Res 140:166–171

    CAS  PubMed  Google Scholar 

  • Ulanski P, von Sonntag C (2000) OH-radical-induced scission of chitosan in the absence and presence of dioxygen. J Chem Soc Perkin Trans 2 2022–2028

    Google Scholar 

  • Ulanski P, Bothe E, Rosiak JM, von Sonntag C (1994) OH-Radical-induced crosslinking and strand breakage of poly(vinyl alcohol) in aqueous solution in the absence and presence of oxygen. A pulse radiolysis and product study. Makromol Chem 195:1443–1461

    CAS  Google Scholar 

  • Ulanski P, Zainuddin, Rosiak JM (1995) Pulse radiolysis of poly(ethylene oxide) in aqueous solution. I. Formation of macroradicals. Radiat Phys Chem 46:913–916

    CAS  Google Scholar 

  • Ulanski P, Bothe E, Hildenbrand K, Rosiak JM, von Sonntag C (1996a) Hydroxyl-radical-induced reactions of poly(acrylic acid); a pulse radiolysis, EPR and product study, part II. Oxygenated solution. J Chem Soc Perkin Trans 2 23–28

    Google Scholar 

  • Ulanski P, Bothe E, Rosiak JM, von Sonntag C (1996b) Radiolysis of the poly(acrylic acid) model 2,4-dimethylglutaric acid: a pulse radiolysis and product study. J Chem Soc Perkin Trans 2 5–12

    Google Scholar 

  • Ulanski P, Bothe E, Hildenbrand K, Rosiak JM, von Sonntag C (1996c) Hydroxyl-radical-induced reactions of poly(acrylic acid): a pulse radiolysis, EPR and product study. Part I. Deoxygenated aqueous solution. J Chem Soc Perkin Trans 2 13–22

    Google Scholar 

  • Ulanski P, Bothe E, Hildenbrand K, von Sonntag C, Rosiak JM (1997) The influence of repulsive electrostatic forces on the lifetimes of poly(acrylic acid) radicals in aqueous solution. Nukleonika 42:425–436

    CAS  Google Scholar 

  • Ulanski P, Bothe E, von Sonntag C (1999a) Some aspects of the radiolysis of poly(methacrylic acid) in oxygen-free aqueous solution. Radiat Phys Chem 56:467–474

    Article  CAS  Google Scholar 

  • Ulanski P, Bothe E, von Sonntag C (1999b) OH radical induced depolymerization of poly(methacrylic acid). Nucl Instr Methods Phys Res B 151:350–355

    CAS  Google Scholar 

  • Ulanski P, Bothe E, Hildenbrand K, von Sonntag C (2000) Free-radical-induced chain breakage and depolymerization of poly(methacrylic acid). Equilibrium polymerization in aqueous solution at room temperature. Chem Eur J 6:3922–3934

    Article  CAS  Google Scholar 

  • Valota A, Ballarini F, Friedland W, Jacob P, Ottolenghi A, Paretzke HG (2003) Modelling study on the protective role of OH radical scavengers and DNA higher-order structures in induction of single and double strand breaks by gamma-radiation. Int J Radiat Biol 79:643–653

    Article  CAS  PubMed  Google Scholar 

  • Van Rijn K, Mayer T, Blok J, Verberne JB, Loman H (1985) Reaction rate of OH radicals with ΦX174 DNA: influence of salt and scavenger. Int J Radiat Biol 47:309–317

    Google Scholar 

  • Verberne JB, Lafleur MVM, Hummel A, Loman H (1987) Radiation chemistry and biological effects. Non-homogeneous kinetics of reactions of water radicals with biologically active DNA. IAEA Panel Proceedings Series 55–68

    Google Scholar 

  • von Sonntag C, Bothe E, Ulanski P, Adhikary A (1999) Radical transfer reactions in polymers. Radiat Phys Chem 55:599–603

    Google Scholar 

  • von Sonntag C, Bothe E, Ulanski P, Deeble DJ (1995) Pulse radiolysis in model studies toward radiation processing. Radiat Phys Chem 46:527–532

    Google Scholar 

  • Wright HA, Magee JL, Hamm RN, Chatterjee A, Turner JE, Klots CE (1985) Calculations of physical and chemical reactions produced in irradiated water containing DNA. Radiat Protect Dosimetry 13:133–136

    CAS  Google Scholar 

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(2006). Polymer Radicals. In: Free-Radical-Induced DNA Damage and Its Repair. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30592-0_9

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