Nomenclature
EC number
1.14.99.20
Systematic name
phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
Recommended name
phylloquinone monooxygenase (2,3-epoxidizing)
Synonyms
epoxidase, phylloquinone
oxygenase, phylloquinone mono- (2,3-epoxidizing)
phylloquinone epoxidase
vitamin K 2,3-epoxidase
vitamin K epoxidase
CAS registry number
54596-37-1
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References
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Roth, D.A.; Whirl, M.L.; Velazquez-Estades, L.J.; Walsh, CT.; Furie, B.; Furie, B.C.: Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone. J. Biol. Chem., 270, 5305–5311 (1995)
Sugiura, I.; Furie, B.; Walsh, C.T.; Furie, B.C.: Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis. J. Biol. Chem., 271, 17837–17844 (1996)
Sugiura, I.; Furie, B.; Walsh, C.T.; Furie, B.C.: Propeptide and glutamatecontaining substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state. Proc. Natl. Acad. Sci. USA, 94, 9069–9074 (1997)
Itoh, S.; Onishi, S.: Developmental changes of vitamin K epoxidase and reductase activities involved in the vitamin K cycle in human liver. Early Hum. Dev., 57, 15–23 (2000)
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(2006). Phylloquinone monooxygenase (2,3-epoxidizing). In: Schomburg, D., Schomburg, I. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30439-8_47
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DOI: https://doi.org/10.1007/3-540-30439-8_47
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