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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery pp 137–157Cite as

Resolution of Inflammation

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Part of the Update in Intensive Care and Emergency Medicine book series (UICMSOFT,volume 44)

Conclusion

Inflammation requires clearance of the inciting pathogen, then orchestrated removal of the burden of leukocytes and other cells influxed into the inflamed site along with dissipation of the pro (or anti) inflammatory mediator cascades. We now recognize that this resolution process is strictly controlled by a number of mediators and adhesion molecules. Apoptotic cell death, when timed appropriately, allows the non-phlogistic clearance of PMNs, monocytes and eosinophils. Macrophage engulfment of these apoptotic cells signals further anti-inflammatory processes, including additional programmed cell death, anti-inflammatory mediator release, and promotes active macrophage emigration which is the final route by which cell clearance is effected. Should these processes evolve successfully, then the tissue will return to its normal structure and function, but should this not proceed effectively then the body will limit further damage by evoking a fibrotic response to ‘heal and seal’ the damaged tissue.

Keywords

  • Apoptotic Cell
  • Leukoc Biol
  • Gamma Delta
  • Milky Spot
  • Prostaglandin Leukot Essent Fatty Acid

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. Center for Respiratory Research, University College London Rayne Institute, University St, London, WC1E 6JJ, UK

    G. Bellingan

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  1. G. Bellingan
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  1. Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, E. Ninth Avenue 4200, 80262, Denver, CO, USA

    Edward Abraham MD

  2. Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, Gower Street, WC1E 6BT, London, UK

    Mervyn Singer MD

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Bellingan, G. (2007). Resolution of Inflammation. In: Abraham, E., Singer, M. (eds) Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Update in Intensive Care and Emergency Medicine, vol 44. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30328-6_10

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  • DOI: https://doi.org/10.1007/3-540-30328-6_10

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  • Online ISBN: 978-3-540-30328-2

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