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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery pp 1–14Cite as

Setting the Scene

  • Conference paper

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Part of the Update in Intensive Care and Emergency Medicine book series (UICMSOFT,volume 44)

Keywords

  • Septic Shock
  • Severe Sepsis
  • Acute Lung Injury
  • Organ Dysfunction
  • Acute Respiratory Distress Syndrome

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gajewska K, Schroeder M, de Marre F, et al (2004) Analysis of terminal events in 109 successive deaths in a Belgian intensive care unit. Intensive Care Med 30:1224–1227

    CrossRef  PubMed  Google Scholar 

  2. Rivers E, Nguyen B, Havstad S, et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377

    CrossRef  PubMed  CAS  Google Scholar 

  3. Vincent JL, Bernard GR, Beale R, et al (2005) Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE. Crit Care Med 33:2266–2277

    CrossRef  PubMed  CAS  Google Scholar 

  4. Lopes Ferreira F, Peres Bota D, Bross A, et al (2001) Serial evaluation of the SOFA score to predict outcome. J A M A 286:1754–1758

    Google Scholar 

  5. Levy MM, Macias WL, Vincent JL, et al (2005) Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 33:2194–2201

    CrossRef  PubMed  Google Scholar 

  6. Jain M, Sznajder JI (2005) Effects of hypoxia on the alveolar epithelium. Proc Am Thorac Soc 2:202–205

    CrossRef  PubMed  CAS  Google Scholar 

  7. Schumacker PT (2005) Hypoxia-inducible factor-1 (HIF-1). Crit Care Med 33:S423–S425

    CrossRef  PubMed  Google Scholar 

  8. Peyssonnaux C, Datta V, Cramer T, et al (2005) HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 115:1806–1815

    CrossRef  PubMed  CAS  Google Scholar 

  9. Lahiri S, Roy A, Baby SM, et al (2005) Oxygen sensing in the body. Prog Biophys Mol Biol

    Google Scholar 

  10. Boekstegers P, Weidenhofer S, Kapsner T, et al (1994) Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 22:640–650

    PubMed  CAS  Google Scholar 

  11. Rosser DM, Stidwill RP, Jacobson D, et al (1995) Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis. J Appl Physiol 79:1878–1882

    PubMed  CAS  Google Scholar 

  12. Levy RJ, Piel DA, Acton PD, et al (2005) Evidence of myocardial hibernation in the septic heart. Crit Care Med 33:2752–2756

    CrossRef  PubMed  Google Scholar 

  13. Hubbard WJ, Bland KI, Chaudry IH (2004) The role of the mitochondrion in trauma and shock. Shock 22:395–402

    CrossRef  PubMed  CAS  Google Scholar 

  14. Brealey D, Brand M, Hargreaves I, et al (2002) Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 360:219–223

    CrossRef  PubMed  CAS  Google Scholar 

  15. Crouser ED, Julian MW, Huff JE, et al (2004) Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia. Crit Care Med 32:478–488

    CrossRef  PubMed  CAS  Google Scholar 

  16. Callahan LA, Supinski GS (2005) Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis. J Appl Physiol 99:1120–1126

    CrossRef  PubMed  Google Scholar 

  17. Boulos M, Astiz ME, Barua RS, et al (2003) Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase. Crit Care Med 31:353–358

    CrossRef  PubMed  CAS  Google Scholar 

  18. Sedlak TW, Snyder SH (2006) Messenger molecules and cell death: therapeutic implications. JAMA 295:81–89

    CrossRef  PubMed  CAS  Google Scholar 

  19. Kiechle FL, Zhang X (2002) Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta 326:27–45

    CrossRef  PubMed  CAS  Google Scholar 

  20. McDonald TE, Grinman MN, Carthy CM, et al (2000) Endotoxin infusion in rats induces apoptotic and survival pathways in hearts. Am J Physiol Heart Circ Physiol 279:H2053–H2061

    PubMed  CAS  Google Scholar 

  21. Hiramatsu M, Hotchkiss RS, Karl IE, et al (1997) Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7:247–253

    CrossRef  PubMed  CAS  Google Scholar 

  22. Kumar A, Kumar A, Michael P, et al (2005) Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaBandinduces apoptosis inhuman cardiac myocytes. J Biol Chem 280:42619–42626

    CrossRef  PubMed  CAS  Google Scholar 

  23. Hotchkiss RS, Swanson PE, Freeman BD, et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230–1251

    CrossRef  PubMed  CAS  Google Scholar 

  24. Coutinho HB, Robalinho TI, Coutinho VB, et al (1997) Intra-abdominal sepsis: an immunocytochemical study of the small intestine mucosa. J Clin Pathol 50:294–298

    PubMed  CAS  Google Scholar 

  25. Kellum JA, Song M, Li J (2004) Science review: extracellular acidosis and the immune response: clinical and physiologic implications. Crit Care 8:331–336

    CrossRef  PubMed  Google Scholar 

  26. Bellocq A, Suberville S, Philippe C, et al (1998) Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation. J Biol Chem 273:5086–5092

    CrossRef  PubMed  CAS  Google Scholar 

  27. Heming TA, Dave SK, Tuazon DM, et al (2001) Effects of extracellular pH on tumour necrosis factor-alpha production by resident alveolar macrophages. Clin Sci (Lond) 101:267–274

    CrossRef  PubMed  CAS  Google Scholar 

  28. Gehlbach BK, Schmidt GA (2004) Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit-the role of buffers. Crit Care 8:259–265

    CrossRef  PubMed  Google Scholar 

  29. Bonventre JV, Cheung JY (1985) Effects of metabolic acidosis on viability of cells exposed to anoxia. Am J Physiol 249:C149–C159

    PubMed  CAS  Google Scholar 

  30. Gores GJ, Nieminen A-L, Wray BE, et al (1989) Intracellular pH during “chemical hypoxia” in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. J Clin Invest 83:386–396

    PubMed  CAS  Google Scholar 

  31. Kitakaze M, Takashima S, Funaya H, et al (1997) Temporary acidosis during reperfusion limits myocardial infarct size in dogs. Am J Physiol 272:H2071–H2078

    PubMed  CAS  Google Scholar 

  32. Kregenow DA, Rubenfeld GD, Hudson LD, et al (2006) Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med 34:1–7

    CrossRef  PubMed  Google Scholar 

  33. Macdonald J, Galley HF, Webster NR (2003) Oxidative stress and gene expression in sepsis. Br J Anaesth 90:221–232

    CrossRef  PubMed  CAS  Google Scholar 

  34. Spapen HD, Diltoer MW, Nguyen DN, et al (2005) Effects of N-acetylcysteine on microalbuminuria and organ failure in acute severe sepsis: results of a pilot study. Chest 127:1413–1419

    CrossRef  PubMed  CAS  Google Scholar 

  35. Ortolani O, Conti A, De Gaudio AR, et al (2000) The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 161:1907–1911

    PubMed  CAS  Google Scholar 

  36. Vincent JL, Zhang H, Szabo C, et al (2000) Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 161:1781–1785

    PubMed  CAS  Google Scholar 

  37. Clancy RM, Leszczynska-Piziak J, Abramson SB (1992) Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 90:1116–1121

    CrossRef  PubMed  CAS  Google Scholar 

  38. Morse D, Choi AM (2005) Heme oxygenase-1: from bench to bedside. AmJ Respir Crit Care Med 172:660–670

    CrossRef  Google Scholar 

  39. Otterbein LE, Bach FH, Alam J, et al (2000) Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6:422–428

    CrossRef  PubMed  CAS  Google Scholar 

  40. Camhi SL, Alam J, Otterbein L, et al (1995) Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13:387–398

    PubMed  CAS  Google Scholar 

  41. Zegdi R, Fabre O, Lila N, et al (2003) Exhaled carbon monoxide and inducible heme oxygenase expression in a rat model of postperfusion acute lung injury. J Thorac Cardiovasc Surg 126:1867–1874

    CrossRef  PubMed  CAS  Google Scholar 

  42. Mumby S, Upton RL, Chen Y, et al (2004) Lung heme oxygenase-1 is elevated in acute respiratory distress syndrome. Crit Care Med 32:1130–1135

    CrossRef  PubMed  CAS  Google Scholar 

  43. Morse D, Choi AM (2002) Heme oxygenase-1: the “emerging molecule” has arrived. Am J Respir Cell Mol Biol 27:8–16

    PubMed  CAS  Google Scholar 

  44. Jin Y, Choi AM (2005) Cytoprotection of heme oxygenase-1/carbonmonoxide in lung injury. Proc Am Thorac Soc 2:232–235

    CrossRef  PubMed  CAS  Google Scholar 

  45. Otterbein LE, Mantell LL, Choi AM (1999) Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol 276:L688–L694

    PubMed  CAS  Google Scholar 

  46. Fujita T, Toda K, Karimova A, et al (2001) Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med 7:598–604

    CrossRef  PubMed  CAS  Google Scholar 

  47. Sato K, Balla J, Otterbein L, et al (2001) Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 166:4185–4194

    PubMed  CAS  Google Scholar 

  48. Mazzola S, Forni M, Albertini M, et al (2005) Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs. FASEB J 19:2045–2047

    PubMed  CAS  Google Scholar 

  49. Matarese G, Moschos S, Mantzoros CS (2005) Leptin in immunology. J Immunol 174:3137–3142

    PubMed  CAS  Google Scholar 

  50. Dal Pizzol F, Di Leone LP, Ritter C, et al (2006) Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis. Am J Respir Crit Care Med 173:84–90

    CrossRef  CAS  Google Scholar 

  51. Dugo L, Collin M, Allen DA, et al (2005) GSK-3beta inhibitors attenuate the organ injury/ dysfunction caused by endotoxemia in the rat. Crit Care Med 33:1903–1912

    CrossRef  PubMed  CAS  Google Scholar 

  52. Van der Poll T, Bueller HR, ten Cate H, et al (1990) Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 322:1622–1626

    CrossRef  PubMed  Google Scholar 

  53. Sfeir T, Saha DC, Astiz M, et al (2001) Role of interleukin-10 in monocyte hyporesponsiveness associated with septic shock. Crit Care Med 29:129–133

    CrossRef  PubMed  CAS  Google Scholar 

  54. von Knethen A, Tautenhahn A, Link H, et al (2005) Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis. J Immunol 174:4960–4965

    Google Scholar 

  55. Wesselkamper SC, Case LM, Henning LN, et al (2005) Gene expression changes during the development of acute lung injury: role of transforming growth factor beta. Am J Respir Crit Care Med 172:1399–1411

    CrossRef  PubMed  Google Scholar 

  56. Yang H, Tracey KJ (2005) High mobility group box 1 (HMGB1). Crit Care Med 33:S472–S474

    CrossRef  PubMed  Google Scholar 

  57. Leng L, Bucala R (2005) Macrophage migration inhibitory factor. Crit Care Med 33:S475–S477

    CrossRef  PubMed  Google Scholar 

  58. Marshall JC (2005) Neutrophils in the pathogenesis of sepsis. Crit Care Med 33:S502–S505

    CrossRef  PubMed  Google Scholar 

  59. Rice P, Martin E, He JR, et al (2005) Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia. J Immunol 174:3676–3685

    PubMed  CAS  Google Scholar 

  60. Schulman CI, Namias N, Doherty J, et al (2005) The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg Infect (Larchmt) 6:369–375

    CrossRef  Google Scholar 

  61. Clifton GL, Miller ER, Choi SC, et al (2001) Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 344:556–563

    CrossRef  PubMed  CAS  Google Scholar 

  62. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349

    CrossRef  PubMed  CAS  Google Scholar 

  63. De Backer D, Creteur J, Preiser JC, et al (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98–104

    CrossRef  PubMed  Google Scholar 

  64. McVerry BJ, Peng X, Hassoun PM, et al (2004) Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med 170:987–993

    CrossRef  PubMed  Google Scholar 

  65. Mura M, Dos Santos CC, Stewart D, et al (2004) Vascular endothelial growth factor and related molecules in acute lung injury. J Appl Physiol 97:1605–1617

    CrossRef  PubMed  CAS  Google Scholar 

  66. Burnham EL, Taylor WR, Quyyumi AA, et al (2005) Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med 172:854–860

    CrossRef  PubMed  Google Scholar 

  67. Imai Y, Kuba K, Rao S, et al (2005) Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 436:112–116

    CrossRef  PubMed  CAS  Google Scholar 

  68. Brell B, Hippenstiel S, David I, et al (2005) Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin — an intravital microscopic study on an isolated rat ileum. Crit Care Med 33:2810–016

    CrossRef  PubMed  CAS  Google Scholar 

  69. Scherpereel A, Depontieu F, Grigoriu B, et al (2006) Endocan, a new endothelial marker in human sepsis. Crit Care Med 34:532–537

    CrossRef  PubMed  CAS  Google Scholar 

  70. Dixon B, Santamaria J, Campbell D (2005) Coagulation activation and organ dysfunction following cardiac surgery. Chest 128:229–236

    CrossRef  PubMed  Google Scholar 

  71. Vadasz I, Morty RE, Olschewski A, et al (2005) Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol 33:343–354

    CrossRef  PubMed  CAS  Google Scholar 

  72. Bernard GR, Vincent JL, Laterre PF, et al (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709

    CrossRef  PubMed  CAS  Google Scholar 

  73. Warren BL, Eid A, Singer P, et al (2001) Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. J A M A 286:1869–1878

    PubMed  CAS  Google Scholar 

  74. Abraham E, Reinhart K, Opal S, et al (2003) Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. J A M A 290:238–247

    PubMed  CAS  Google Scholar 

  75. Macias WL, Yan SB, Williams MD, et al (2005) New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care 9Suppl 4:S38–S45

    CrossRef  PubMed  Google Scholar 

  76. Mosnier LO, Gale AJ, Yegneswaran S, et al (2004) Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood 104:1740–1744

    CrossRef  PubMed  CAS  Google Scholar 

  77. Matthay MA, Robriquet L, Fang X (2005) Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc 2:206–213

    CrossRef  PubMed  CAS  Google Scholar 

  78. Fink MP, Delude RL (2005) Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 21:177–196

    CrossRef  PubMed  CAS  Google Scholar 

  79. Martin TR, Hagimoto N, Nakamura M, et al (2005) Apoptosis and epithelial injury in the lungs. Proc Am Thorac Soc 2:214–220

    CrossRef  PubMed  CAS  Google Scholar 

  80. Carrico CJ, Meakins JL, Marshall JC, et al (1986) Multiple organ failure syndrome. Arch Surg 121:196–208

    PubMed  CAS  Google Scholar 

  81. Holland J, Carey M, Hughes N, et al (2005) Intraoperative splanchnic hypoperfusion, increased intestinal permeability, down-regulation of monocyte class II major histocom-patibility complex expression, exaggerated acute phase response, and sepsis. Am J Surg 190:393–400

    CrossRef  PubMed  CAS  Google Scholar 

  82. De Backer D, Creteur J, Silva E, et al (2003) Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Crit Care Med 31:1659–1667

    CrossRef  PubMed  CAS  Google Scholar 

  83. de Jonge E, Schultz MJ, Spanjaard L, et al (2003) Effects of selective decontamination of the digestive tract on mortality and the acquisition of resistant bacteria in intensive care patients. Lancet 362:1011–1016

    CrossRef  PubMed  CAS  Google Scholar 

  84. Lopau K, Mark J, Schramm L, et al (2000) Hormonal changes in brain death and immune activation in the donor. Transpl Int 13Suppl 1:S282–S285

    CrossRef  PubMed  Google Scholar 

  85. Trentz OA, Handschin AE, Bestmann L, et al (2005) Influence of brain injury on early posttraumatic bone metabolism. Crit Care Med 33:399–406

    CrossRef  PubMed  CAS  Google Scholar 

  86. Lopez-Aguilar J, Villagra A, Bernabe F, et al (2005) Massive brain injury enhances lung damage in an isolated lung model of ventilator-induced lung injury. Crit Care Med 33:1077–1083

    CrossRef  PubMed  Google Scholar 

  87. Luyer MD, Greve JW, Hadfoune M, et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med 202:1023–1029

    CrossRef  PubMed  CAS  Google Scholar 

  88. Annane D, Sebille V, Charpentier C, et al (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. J A M A 288:862–871

    PubMed  CAS  Google Scholar 

  89. Van den Berghe G, Wouters P, Weekers F, et al (2001) Intensive insulin therapy in the critically ill patient. N Engl J Med 345:1359–1367

    CrossRef  PubMed  Google Scholar 

  90. Turina M, Fry DE, Polk HC, Jr. (2005) Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med 33:1624–1633

    CrossRef  PubMed  Google Scholar 

  91. Catalan MP, Reyero A, Egido J, et al (2001) Acceleration of neutrophil apoptosis by glucose-containing peritoneal dialysis solutions: role of caspases. J Am Soc Nephrol 12:2442–2449

    PubMed  CAS  Google Scholar 

  92. Altannavch TS, Roubalova K, Kucera P, et al (2004) Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. Physiol Res 53:77–82

    PubMed  CAS  Google Scholar 

  93. Zuurbier CJ, Demirci C, Koeman A, et al (2005) Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells. J Appl Physiol 99:1471–1476

    CrossRef  PubMed  Google Scholar 

  94. Vanhorebeek I, de Vos R, Mesotten D, et al (2005) Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365:53–59

    CrossRef  PubMed  CAS  Google Scholar 

  95. Langouche L, Vanhorebeek I, Vlasselaers D, et al (2005) Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115:2277–2286

    CrossRef  PubMed  CAS  Google Scholar 

  96. Dandona P, Aljada A, Mohanty P, et al (2001) Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 86:3257–3265

    CrossRef  PubMed  CAS  Google Scholar 

  97. Siore AM, Parker RE, Stecenko AA, et al (2005) Endotoxin-induced acute lunginjury requires interaction with the liver. Am J Physiol Lung Cell Mol Physiol 289:L769–L776

    CrossRef  PubMed  CAS  Google Scholar 

  98. Hayes MA, Timmins AC, Yau EH, et al (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717–1722

    CrossRef  PubMed  CAS  Google Scholar 

  99. The ARDS Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308

    CrossRef  Google Scholar 

  100. Ranieri VM, Suter PM, Tortorella C, et al (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. J A M A 282:54–61

    PubMed  CAS  Google Scholar 

  101. Charles PE, Etienne M, Croisier D, et al (2005) The impact of mechanical ventilation on the moxifloxacin treatment of experimental pneumonia caused by Streptococcus pneumoniae. Crit Care Med 33:1029–1035

    CrossRef  PubMed  Google Scholar 

  102. Ploppa A, Kiefer RT, Nohe B, et al (2006) Dose-dependent influence of barbiturates but not of propofol on human leukocyte phagocytosis of viable Staphylococcus aureus. Crit Care Med 34:478–483

    CrossRef  PubMed  CAS  Google Scholar 

  103. Mehta RL, Pascual MT, Soroko S, et al (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. J A M A 288:2547–2553

    CrossRef  PubMed  CAS  Google Scholar 

  104. Yende S, Tuomanen EI, Wunderink R, et al (2005) Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am J Respir Crit Care Med 172:1440–1446

    CrossRef  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Intensive Care Medicine, Erasme University of Brussels Hospital, Route de Lennik 808, 1070, Brussels, Belgium

    J. L. Vincent

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  1. J. L. Vincent
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Editors and Affiliations

  1. Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, E. Ninth Avenue 4200, 80262, Denver, CO, USA

    Edward Abraham MD

  2. Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, Gower Street, WC1E 6BT, London, UK

    Mervyn Singer MD

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Vincent, J.L. (2007). Setting the Scene. In: Abraham, E., Singer, M. (eds) Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Update in Intensive Care and Emergency Medicine, vol 44. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30328-6_1

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  • DOI: https://doi.org/10.1007/3-540-30328-6_1

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