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Molekulare Pathogenese, Diagnostik und Therapie hereditärer Tumoren des Gastrointestinaltrakts

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Praxis der Viszeralchirurgie

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Zusammenfassung

Die Aufklärung der molekulargenetischen Grundlagen der Krebsentsstehung hat in den letzten Jahren wesentliche neue Erkenntnisse erbracht, durch die es möglich geworden ist, Patienten mit einem familiär bedingten erhöhten Krebsrisiko aufgrund genetischer Untersuchungsmethoden zu identifizieren. Insbesondere bei den erblichen gastrointestinalen Karzinomen, allen voran der familiären polypösen Adenomatose (FAP) und dem nichtpolypösen kolorektalen Karzinom (HNPCC) konnten so neue interdisziplinäre klinische Konzepte entwickelt werden, die zu einer wesentlichen Verbesserung der Krebsvorsorge und -früherkennung beitragen.

Durch diese Maßnahmen können die betroffenen Risikopersonen eindeutig erkannt werden, invasive klinische Maßnahmen auf diese Personen beschränkt und operative Maßnahmen prophylaktisch durchgeführt werden, noch bevor eine Tumorer krankung sich manifestiert hat. Andererseits können die oft belastenden invasiven Vorsorgemaßnahmen den nicht betroffenen Personen in den belasteten Familien aufgrund der molekulargenetischen Diagnosemöglichkeiten erspart werden. So kann für diese Patienten ein höheres Maß an Sicherheit geschaffen und die klinische Versorgung der Betroffenen kann deutlich verbessert werden.

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Authors
  1. J. Gebert
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  2. C. von Knebel Doeberitz
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  3. M. von Knebel Doeberitz
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Editors and Affiliations

  1. Chirurgische Klinik und Poliklinik, Technische Universität München Klinikum rechts der Isar, Ismaninger Str. 22, 81657, München, Germany

    Jörg Rüdiger Siewert

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg, Germany

    Matthias Rothmund

  3. Medizinische Fakultät der RWTH, Universitätsklinik und Poliklinik, Pauwelsstr. 30, 52057, Aachen, Germany

    Volker Schumpelick

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© 2006 Springer Medizin Verlag Heidelberg

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Gebert, J., von Knebel Doeberitz, C., von Knebel Doeberitz, M. (2006). Molekulare Pathogenese, Diagnostik und Therapie hereditärer Tumoren des Gastrointestinaltrakts. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30036-8_5

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  • DOI: https://doi.org/10.1007/3-540-30036-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21914-9

  • Online ISBN: 978-3-540-30036-6

  • eBook Packages: Medicine (German Language)

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