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Prinzipien der Chemotherapie und der hormonalen Therapie maligner Tumoren

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Praxis der Viszeralchirurgie

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Zusammenfassung

Es werden ausgewählte Grundlagen über die Chemotherapie und die hormonale Therapie maligner Tumoren dargestellt. Darüber hinaus wird aufgezeigt, dass ein neuer Entwicklungsabschnitt in der medikamentösen Therapie maligner Tumoren begonnen hat, in welchem die Modulation apoptosefördernder und -verhindernder Mechanismen eine wesentliche Rolle spielt.

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Literatur

  • Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J (1996) Human ICE/CED-3 protease nomenclature. Cell 87: 171

    Article  CAS  PubMed  Google Scholar 

  • Bardeesy N, Falkoff D, Petruzzi MJ et al. (1994) Anaplastic Wilms’ tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet 7: 91–97

    Article  CAS  PubMed  Google Scholar 

  • Bhuyan BK, Groppi VE (1989) Cell cycle specific inhibitors. Pharmacol Ther 42: 307–348

    Article  CAS  PubMed  Google Scholar 

  • Brown JM, Wouters BG (1999) Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59: 1391–1399

    CAS  PubMed  Google Scholar 

  • Chen G-Q, Zhu J, Shi X-G et al. (1996) In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4, cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARα/PML proteins. Blood 88: 1052–1061

    CAS  PubMed  Google Scholar 

  • Chu E, DeVita VT Jr (2001) Principles of cancer management: Chemotherapy. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer, Principles and practice of oncology. Lippincott, Philadelphia, pp 289–306

    Google Scholar 

  • Deigner HP, Kinscherf R (1999) Modulating apoptosis: current applications and prospects for future drug development. Curr Med Chem 6: 399–414

    CAS  PubMed  Google Scholar 

  • Eilers M (1999) Control of cell proliferation by Myc family genes. Mol Cells 9: 1–6

    CAS  PubMed  Google Scholar 

  • El Rouby S, Thomas A, Costin D et al. (1993) p 53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 82: 3452–3459

    PubMed  Google Scholar 

  • El-Deiry WS (1998) Regulation of p53 downstream genes. Semin Cancer Biol 8: 345–357

    CAS  PubMed  Google Scholar 

  • Gallagher WM, Brown R (1999) p 53-oriented cancer therapies: Current progress. Ann Oncol 10: 139–150

    Article  CAS  PubMed  Google Scholar 

  • Gasparini G, Barbareschi M, Doglioni C et al. (1995) Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node positive breast cancer. Clin Cancer Res 1: 189–198

    CAS  PubMed  Google Scholar 

  • Gilewski TA, Norton L (2001) Norton-Simon Hypothesis. In: Perry MC (ed) The Chemotherapy Source Book, Lippincott Williams & Wilkins, Philadelphia, pp 23–37

    Google Scholar 

  • Goldie JH (1987) Scientific basis for adjuvant and primary (neoadjuvant) chemotherapy. Semin Oncol 14: 1–7

    CAS  PubMed  Google Scholar 

  • Hannun YA (1997) Apoptosis and the dilemma of cancer chemotherapy. Blood 98: 1845–1852

    Google Scholar 

  • Held J, Schulze-Osthoff K (2001) Potential and caveats of TRAIL in cancer therapy. Drug Resist Update 4: 243–252

    CAS  Google Scholar 

  • Herr I, Debatin K-M (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98: 2603–2614

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann J, Sommer A, Schneider MR (2004) Hormonale Therapie maligner Tumoren. In: Zeller WJ, zur Hausen H (Hrsg) Onkologie IV. 5. ecomed, Landsberg, S 1–74

    Google Scholar 

  • Hryniuk WM (1988) The importance of dose intensity in the outcome of chemotherapy. In: DeVita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology. Lippincott, Philadelphia, pp 121–142

    Google Scholar 

  • Huppertz B, Frank H-G, Kaufmann P (1999) The apoptosis cascade — morphological and immunohistochemical methods for its visualization. Anat Embryol 200: 1–18

    Article  CAS  PubMed  Google Scholar 

  • Khanna N, Singh N (1999) Role of caspases in apoptosis and disease. Indian J Physiol Pharmacol 43: 151–159

    CAS  PubMed  Google Scholar 

  • Kinloch RA, Treherne JM, Furness LM, Hajimohamadreza I (1999) The pharmacology of apoptosis. Trends Pharmacol Sci 20: 35–42

    Article  CAS  PubMed  Google Scholar 

  • Kliche K-O, Höffken K (1999) The role of apoptosis in hematologic malignancies and modulation of apoptosis as a new therapeutic approach. J Cancer Res Clin Oncol 125: 226–231

    Article  CAS  PubMed  Google Scholar 

  • Korsmeyer SJ, Zinkel SS (2001) Molecular biology of cancer: Apoptosis. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer, Principles and practice of oncology. Lippincott, Philadelphia, pp 111–122

    Google Scholar 

  • Krajewski S, Blomqvist C, Franssila K et al. (1995) Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapys and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55: 4471–4478

    CAS  PubMed  Google Scholar 

  • Krammer PH et al. (2003) Apoptosis in the APO-1 (Cd95/FAS) system. In: DKFZ Heidelberg (ed) Research report, 2001/2002 DKFZ, pp 357–360

    Google Scholar 

  • Lamkanfi M, Declercq W, Depuydt B et al. (2002) The Caspases familiy. In: Los M, Walczak H (eds) Caspases — their role in cell death and cell survival. Mol Biol Intelligence Unit 24, Landes Bioscience, pp 1–40

    Google Scholar 

  • Los M, Walczak H (eds) (2002) Caspases — their role in cell death and cell survival. Mol Biol Intelligence Unit 24, Landes Bioscience

    Google Scholar 

  • McConkey DJ (1998) Biochemical determinants of apoptosis and necrosis. Toxicol Lett 99: 157–168

    Article  CAS  PubMed  Google Scholar 

  • Mesner PW Jr, Budihardjo II, Kaufmann SH (1997) Chemotherapy-induced apoptosis. Adv Pharmacol 41: 461–499

    CAS  PubMed  Google Scholar 

  • Meterissian SH (1997) Apoptosis: its role in the progression of and chemotherapy for carcinoma. J Am Coll Surgeons 184: 658–666

    CAS  Google Scholar 

  • Norton L (1987) Synopsis of cancer growth kinetics and chemotherapy. In Silver RT, Lauper RD, Jarowski C (eds) A synopsis of cancer chemotherapy Yorke Medical Books, New York, pp XI–XXV

    Google Scholar 

  • Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax that accelerates programmed cell death. Cell 74: 609–619

    CAS  PubMed  Google Scholar 

  • Pellegrini M, Strasser A (2002) Bcl-2 family proteins and other components of the death machinery: their role in the regulation of the immune response. In: Los M, Walczak H (eds) Caspases — their role in cell death and cell survival. Mol Biol Intelligence Unit 24, Landes Bioscience, pp 155–174

    Google Scholar 

  • Prendergast GC (1999) Mechanisms of apoptosis by c-Myc. Oncogene 18: 2967–2987

    CAS  PubMed  Google Scholar 

  • Schmitt CA, Lowe SW (1999) Apoptosis and therapy. J Pathol 187: 127–137

    Article  CAS  PubMed  Google Scholar 

  • Schwartz D, Rotter V (1998) p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol 8: 325–336

    CAS  PubMed  Google Scholar 

  • Schwerk C, Schulze-Osthoff K (2003) Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol 66: 1453–1458

    Article  CAS  PubMed  Google Scholar 

  • Soddu S, Sacchi A (1998) p53: Prospects for cancer gene therapy. Cytokines Cell Mol Ther 4: 177–185

    CAS  PubMed  Google Scholar 

  • Walczak H, Miller RE, Ariail K et al. (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature Med 5: 157–163

    CAS  PubMed  Google Scholar 

  • Walczak H, Krammer PH (2000) The CD95 (APO-1/Fas) and TRAIL (APO-2L) apoptosis systems. Exp Cell Res 356: 58–66

    Google Scholar 

  • Walczak H et al. (2003) Apoptosis regulation. In: DKFZ Heidelberg (ed) Research report 2001/2002 DKFZ, pp 361–365

    Google Scholar 

  • Wang C-Y, Cusack JC Jr, Liu R, Baldwin AS Jr. (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nature Med 5: 412–417

    PubMed  Google Scholar 

  • Weller M (1998) Predicting response to cancer chemotherapy: the role of p53. Cell Tissue Res 292: 435–445

    Article  CAS  PubMed  Google Scholar 

  • Wilson MR (1998) Apoptotic signal transduction: emerging pathways. Biochem Cell Biol 76: 573–582

    Article  CAS  PubMed  Google Scholar 

  • Yarbro JW (1992) The scientific basis of cancer chemotherapy. In: Perry MC (ed) The chemotherapy source book. Williams & Wilkins, Baltimore, pp 2–14

    Google Scholar 

  • Zeller WJ (1982) Probleme des Metastasenwachstums. In: Schmähl D (Hrsg) Krebsmetastasen, Thieme, Stuttgart, New York, S 27–32

    Google Scholar 

  • Zeller WJ (1995) Krebschemotherapie — Theoretische Grundlagen. In: Zeller WJ, zur Hausen H (Hrsg) Onkologie, IV-1. ecomed, Landsberg, S 1–17

    Google Scholar 

  • Zeller WJ (1995) Zytostatika (klinisch etablierte Verbindungen). In: Zeller WJ, zur Hausen H (Hrsg) Onkologie, IV-3, ecomed, Landsberg

    Google Scholar 

  • Zhivotovsky B, Joseph B, Orrenius S (1999) Tumor radiosensitivity and apoptosis. Exp Cell Res 248: 10–17

    Article  CAS  PubMed  Google Scholar 

  • Ziegler A, Luedke GH, Fabbro D, Altmann KH, Stahel RA, Zangemeister-Wittke U (1997) Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence. J Natl Cancer Inst 89: 1027–1036

    CAS  PubMed  Google Scholar 

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Authors
  1. W. J. Zeller
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Editors and Affiliations

  1. Chirurgische Klinik und Poliklinik, Technische Universität München Klinikum rechts der Isar, Ismaninger Str. 22, 81657, München, Germany

    Jörg Rüdiger Siewert

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg, Germany

    Matthias Rothmund

  3. Medizinische Fakultät der RWTH, Universitätsklinik und Poliklinik, Pauwelsstr. 30, 52057, Aachen, Germany

    Volker Schumpelick

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Zeller, W.J. (2006). Prinzipien der Chemotherapie und der hormonalen Therapie maligner Tumoren. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30036-8_20

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  • DOI: https://doi.org/10.1007/3-540-30036-8_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21914-9

  • Online ISBN: 978-3-540-30036-6

  • eBook Packages: Medicine (German Language)

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