Kolbe-Schmitt reaction

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Kolbe, H. Justus Liebigs Ann. Chem. 1860, 113, 1125. Hermann Kolbe (1818–1884) was born in Elliehausen, Germany. In 1860, at Marburg University, he developed a reaction to synthesize salicylic acid by simply treating phenol with carbon dioxide under high pressure at 180–200 °C. Like Wöhler’s urea synthesis, Kolbe’s synthesis of acetic acid by treating trichloroacetic acid with potassium amalgam is considered one of the first total syntheses in organic chemistry. One of his students, Friedrich von Heyden, founded a company to profit from the Kolbe reaction with much financial success.
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(2006). Kolbe-Schmitt reaction. In: Name Reactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30031-7_150

DOI: https://doi.org/10.1007/3-540-30031-7_150
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-30030-4
Online ISBN: 978-3-540-30031-1
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