Unusual Kidney Cancers

  • Kyeong Ah Kim
  • Cheol Min Park
Part of the Medical Radiology book series (MEDRAD)

14.5 Conclusion

There are various unusual manifestations of RCCs. Sometimes they mimic other benign or malignant renal tumors or inflammation. Familiarity with these radiologic features of unusual RCCs can help ensure correct diagnosis and proper management.


Renal Cell Carcinoma Renal Mass Papillary Renal Cell Carcinoma Excretory Phase Nephrographic Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ambos MA, Bosniak MA, Madayag MA et al. (1977) Infiltrating neoplasms of the kidney. Am J Roentgenol 129:859–864Google Scholar
  2. Bjornsson J, Short MP, Kwiatkowski DJ et al. (1996) Tuberous sclerosis-assocated renal cell carcinoma. Clinical, pathological, and genetic features. Am J Pathol 149:1201–1208PubMedGoogle Scholar
  3. Bosniak MA (1986) The current radiological approach to renal cysts. Radiology 158:1–10PubMedGoogle Scholar
  4. Bosniak MA (1991) Difficulties in classifying cystic lesions of the kidney. Urol Radiol 13:91–93PubMedCrossRefGoogle Scholar
  5. Bosniak MA (1997a) Diagnosis and management of patients with complicated cystic lesions of the kidney. Am J Roentgenol 169:819–821Google Scholar
  6. Bosniak MA (1997b) The use of the Bosniak classification system for renal cysts and cystic tumors. J Urol 157:1852–1853PubMedGoogle Scholar
  7. Bosnib SM (1999) Risk and prognosis in renal neoplasm: a pathologist’s prospective. Urol Clin North Am 26:643–660Google Scholar
  8. Bostwick DG (1997) Spermatic cord and testicular adnexa. In: Bostwick DG, Eble JN (eds) Urologic surgical pathology. Mosby, St. Louis, pp 647–674Google Scholar
  9. Brinker DA, Amin MB, de Peralta-Venturina M et al. (2000) Extensively necrotic cystic renal cell carcinoma: a clinico-pathologic study with comparison to other cytic and necrotic renal cancers. Am J Surg Pathol 24:988–995PubMedCrossRefGoogle Scholar
  10. Castoldi MC, Dellafiore L, Renne G et al. (1995) CT demonstration of liquid intratumoral fat layering in a necrotic renal cell carcinoma. Abdom Imaging 20:483–485PubMedCrossRefGoogle Scholar
  11. Cheuk W, Lo ES, Chan AK et al. (2002) Atypical epithelial pro-liferations in acquired renal cystic disease harbor cytogenetic aberration. Hum Pathol 33:761–765PubMedCrossRefGoogle Scholar
  12. Cho KR, Park CM, Chung HH et al. (2002) Spiral CT findings of chromophobe renal cell carcinoma: correlation with pathologic features and prognosis. J Korean Radiol Soc 46:57–62Google Scholar
  13. Choyke PL, Glenn GM, Walther MM et al. (2003) Hereditary renal cancers. Radiology 226:33–46PubMedGoogle Scholar
  14. Curry NS, Schabel SI, Garvin AJ et al. (1990) Intratumoral fat in a renal oncocytoma mimicking angiomyolipoma. Am J Roentgenol 154:307–308Google Scholar
  15. Daniel WW Jr, Hartman GW, Witten DM et al. (1972) Calcified renal masses. A review of ten years experience at the Mayo Clinic. Radiology 103:503–508PubMedGoogle Scholar
  16. Davidson AJ, Choyke PL, Hartman DS et al. (1995) Renal medullary carcinoma associated with sickle cell trait: radiologic findings. Radiology 195:83–85PubMedGoogle Scholar
  17. Davis CJ, Mostofi FK, Sesterhenn IA (1995) Renal medullary carcinoma: the seventh sickle nephropathy. Am J Surg Pathol 19:1–11PubMedGoogle Scholar
  18. Dimopoulos MA, Logothetis CJ, Markowitz A et al. (1993) Collecting duct carcinoma of the kidney. Br J Urol 71:388–391PubMedGoogle Scholar
  19. Eble JN, Bosnib SM (1998) Extensively cystic renal neoplasm: cystic nephroma, cystic partially differentiated nephro-blastoma, multilocular cystic renal cell carcinoma and cystic hamartoma of the renal pelvis. Semin Diagn Pathol 15:2–20PubMedGoogle Scholar
  20. Eble JN, Sauter G, Epstein JI et al. (2004) World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, LyonsGoogle Scholar
  21. Fukuoka T, Honda M, Namiki M et al. (1987) Renal cell carcinoma with heterotopic bone formation. Case report and review of the Japanese liteature. Urol Int 42:458–460PubMedCrossRefGoogle Scholar
  22. Fukuya T, Honda H, Goto K et al. (1996) Computed tomographic findings of Bellini duct carcinoma of the kidney. J Comput Assist Tomogr 20:399–403PubMedCrossRefGoogle Scholar
  23. Glenn GM, Gnarra JR, Choyke PL et al. (1997) The molecular genetics of renal cell carcinoma. In: Raghaven D, Scher HI, Lange PH (eds) Principles and practice of genitourinary oncology. Lippincott-Raven, Philadelphia, pp 85–97Google Scholar
  24. Gregoire JR, Torres VE, Holley KE et al. (1987) Renal epithelial hyperplastic and neoplastic proliferation in autosomal dominant polycystic kidney disease. Am J Kidney Dis 9:27–38PubMedGoogle Scholar
  25. Hartman DS, Davis CJ Jr, Johns T et al. (1986) Cystic renal cell carcinoma. Urol 28:199–216CrossRefGoogle Scholar
  26. Hartman DS, Davidson AJ, Davis CJ et al. (1988) Infiltrative renal lesions: CT-sonographic-pathologic correlation. Am J Roentgenol 150:1061–1064Google Scholar
  27. Helenon O, Chretien Y, Paraf F et al. (1993) Renal cell carcinoma containing fat: demonstration with CT. Radiology 188:429–430PubMedGoogle Scholar
  28. Helenon O, Merran S, Paraf F et al. (1997) Unusual fat-containing tumors of the kidney: a diagnostic dilemma. Radiographics 17:129–144PubMedGoogle Scholar
  29. Herts BR, Coll DM, Novick AC et al. (2002) Enhancement characteristics of papillary renal neoplasms revealed on triphasic helical CT of the kidneys. Am J Roentgenol 178:367–372Google Scholar
  30. Hughson MD, Buchwald D, Fox M (1986) Renal neoplasia and acquired cystic kidney disease in patients receiving longterm dialysis. Arch Pathol Lab Med 110:592–601PubMedGoogle Scholar
  31. Ishigawa I, Saito Y, Shikura N et al. (1990) Ten-year prospective study on the development of renal cell carcinoma in dialysis patients. Am J Kidney Dis 16:452–458Google Scholar
  32. Israel GM, Bosniak MA (2003) Calcification in cystic renal masses: Is it important in diagnosis? Radiology 226:47–52PubMedGoogle Scholar
  33. Jacobs SC, Berg SI, Lawson RK (1980) Synchronous bilateral renal cell carcinoma: total surgical excision. Cancer 46:2341–2345PubMedGoogle Scholar
  34. Kikkawa K, Lasser EC (1969) “Ring-like” or “rim-like” calcification in renal cell carcinoma. Am J Roentgenol Radium Ther Nucl Med 107:737–742PubMedGoogle Scholar
  35. Kim JC, Kim KH, Lee JW (2000) CT and US findings of multilocular cystic renal cell carcinoma. Korean J Radiol 1:104–109PubMedGoogle Scholar
  36. Kim JK, Kim TK, Ahn HJ et al. (2002) Differentiation of sub-types of renal cell carcinoma on helical CT scans. Am J Roentgenol 178:1499–1506Google Scholar
  37. Koga S, Nishikido M, Inuzuka S et al. (2000) An evaluation of Bosniak’s radiological classification of cystic renal masses. BJU Int 86:607–609PubMedCrossRefGoogle Scholar
  38. Krieger JN, Sniderman KW, Seligson GR et al. (1979) Calcified renal cell carcinoma: a clinical, radiographic and pathologic study. J Urol 121:575–580PubMedGoogle Scholar
  39. Kumar S, Cederbaum AI, Pletka PG (1980) Renal cell carcinoma in polycystic kidneys: case report and review of literature. J Urol 124:708–709PubMedGoogle Scholar
  40. Lemaitre L, Robert Y, Dubrulle F et al. (1995) Renal angiomyo-lipoma: growth followed up with CT and/or US. Radiology 197:598–602PubMedGoogle Scholar
  41. Lemaitre L, Claudon M, Dubrulle F et al. (1997) Imaging of angiomyolipomas. Semin Ultrasound CT MR 18:100–114PubMedCrossRefGoogle Scholar
  42. London NJ, Messions N, Kinder RB et al. (1989) A prospective study of the value of conventional CT, dynamic CT, ultra-sonography and arteriography for staging renal carcinoma. Br J Urol 64:209–217PubMedCrossRefGoogle Scholar
  43. Matas AJ, Simmons RI, Kjellstrand CM et al. (1975) Increased incidence of malignancy during chronic renal failure. Lancet 1:883–885PubMedGoogle Scholar
  44. Matson MA, Cohen EP (1990) Acquired cystic kidney disease: occurrence, prevalence, and renal cancers. Medicine 69:217–226PubMedGoogle Scholar
  45. Mehanna D, Abu-Zidan FM, Rao S (2004) Liver metastasis in renal chondrosarcoma. Singapore Med J 45:183–185PubMedGoogle Scholar
  46. Melmon KL, Rosen SW (1964) Lindau’s disease. Am J Med 36:595–617PubMedCrossRefGoogle Scholar
  47. Murad T, Komaiko W, Oyasu R et al. (1991) Multilocular cystic renal cell carcinoma. Am J Clin Pathol 95:633–637PubMedGoogle Scholar
  48. Muram TM, Aisen A (2003) Fatty metastatic lesions in 2 patients with renal clear-cell carcinoma. J Comput Assist Tomogr 27:869–870PubMedGoogle Scholar
  49. Murphy WM, Grignon DJ, Perlman EJ (2004) Tumors of the kidney, bladder, and related urinary structures. Armed Forces Institute of Pathology Atlas of Tumor Pathology, Fourth Series, Washington, DCGoogle Scholar
  50. Onishi T, Ohishi Y, Iizuka N et al. (1996) Clinicopathological study on patients with chromophobe cell renal carcinoma. Nippon Hinyokika Gakkai Zasshi 87:1167–1174PubMedGoogle Scholar
  51. Onishi T, Oishi Y, Goto H et al. (2002) Histological features of hypovascular or avascular renal cell carcinoma: the experience at four university hospitals. Int J Clin Oncol 7:159–164PubMedCrossRefGoogle Scholar
  52. Outwater EK, Bhatia M, Siegelman ES et al. (1997) Lipid in renal clear cell carcinoma: detection on opposed-phase gradient-echo MR images. Radiology 205:103–107PubMedGoogle Scholar
  53. Parvey LS, Warner RM, Callihan TR et al. (1981) CT demonstration of fat tissue in malignant renal neoplasms: atypical Wilms’ tumors. J Comput Assist Tomogr 5:851–854PubMedGoogle Scholar
  54. Patterson J, Lohr D, Briscoe C et al. (1987) Calcified renal masses. Urology 29:353–356PubMedCrossRefGoogle Scholar
  55. Peralta-Venturina M de, Moch H, Amin M et al. (2001) Sarco-matoid differentiation in renal cell carcinoma: a study of 101 cases. Am J Surg Pathol 25:275–284PubMedGoogle Scholar
  56. Pickhardt PJ, Lonergan GJ, Davis CJ et al. (2000) Infiltrative renal lesions: radiologic-pathologic correlation. Radiographics 20:215–243PubMedGoogle Scholar
  57. Pickhardt PJ, Siegel CL, McLarney JK (2001) Collecting duct carcinoma of the kidney: Are imaging findings suggestive of the diagnosis? Am J Roentgenol 176:627–633Google Scholar
  58. Poston CD, Jaffe GS, Lubensky IA et al. (1995) Characterization of the renal pathology of a familial form of renal cell carcinoma associated with von Hippel-Lindau disease: clinical and molecular genetic implications. J Urol 153:22–26PubMedCrossRefGoogle Scholar
  59. Press GA, McClennan BL, Melson GL et al. (1984) Papillary renal cell carcinoma: CT and sonographic evaluation. Am J Roentgenol. 143:1005–1009Google Scholar
  60. Reuter VE, Presti JC Jr. (2000) Contemporary approach to the classification of renal epithelial tumors. Semin Oncol 27:124–137PubMedGoogle Scholar
  61. Roy C, Tuchmann C, Linder V et al. (1998) Renal cell carcinoma with a fatty component mimicking angiomyolipoma on CT. Br J Radiol 71:977–979PubMedGoogle Scholar
  62. Shinozaki K, Yoshinitsu K, Honda H et al. (2001) Metastatic adrenal tumor from clear-cell renal cell carcinoma: a pit-fall of chemical shift MR imaging. Abdom Imaging 26:439–442PubMedGoogle Scholar
  63. Solomon D, Schwartz A (1988) Renal pathology in von Hippel-Lindau disease. Hum Pathol 19:1012–1029Google Scholar
  64. Srigley JR, Eble JN (1998) Collecting duct carcinoma of the kidney. Semin Diagn Pathol 15:54–67PubMedGoogle Scholar
  65. Storkel S, Eble JN, Adlakha K et al. (1997) Classification of renal cell carcinoma:Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 80:987–989PubMedGoogle Scholar
  66. Strotzer M, Lehner KB, Becker K (1993) Detection of fat in a renal cell carcinoma mimicking angiomyolipoma. Radiology 188:427–428PubMedGoogle Scholar
  67. Swartz MA, Karth J, Schneider DT et al. (2002) Renal medullary carcinoma; clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology 60:1083–1089PubMedCrossRefGoogle Scholar
  68. Szolar DH, Kammerhuber F, Altziebler S et al. (1997) Multiphasic helical CT of the kidney: increased conspicuity for detection and characterization of small (>3 cm) renal masses. Radiology 202:211–217PubMedGoogle Scholar
  69. Takase K, Takahashi S, Tazawa S et al. (1994) Renal cell carcinoma associated with chronic renal failure: evaluation with sonographic angiography. Radiology 192:787–792PubMedGoogle Scholar
  70. Takebayashi S, Hidai H, Chiba T et al. (1999) Using helical CT to evaluate renal cell carcinoma in patients undergoing hemodialysis: value of early enhanced images. Am J Roentgenol 172:429–433Google Scholar
  71. Thoenes W, Storkel S, Rumpelt HJ (1988) Chromophobe cell renal carcinoma and its variant: a report on 32 cases. J Pathol 155:277–287PubMedCrossRefGoogle Scholar
  72. Walther MM, Lubensky IA, Venzon D et al. (1995) Prevalence of microscopic lesions in grossly normal renal parenchyma from patients with von Hippel-Lindau disease, sporadic renal cell carcinoma and no renal disease: clinical implications. J Urol 154:2010–2014PubMedGoogle Scholar
  73. Weyman PJ, McClennan BL, Stabley RJ et al. (1980) Comparison of computed tomography and angiography in the evaluation of renal cell carcinoma. Radiology 137:417–424PubMedGoogle Scholar
  74. Woodward PJ, Schwab CM, Sesterhenn IA (2003) From the archives of the AFIP: extratesticular scrotal masses: radiologic-pathologic correlation. Radiographics 23:215–240PubMedGoogle Scholar
  75. Yamashita Y, Takahashi M, Watanabe O et al. (1992) Small renal cell carcinoma: pathologic and radiologic correlation. Radiology 184:493–498PubMedGoogle Scholar
  76. Yamashita Y, Watanabe O, Miyazaki T et al. (1994) Cystic renal cell carcinoma. Imaging findings with pathologic correlation. Acta Radiol 35:19–24PubMedCrossRefGoogle Scholar
  77. Yamashita Y, Miyazaki T, Ishii A et al. (1995) Multilocular cystic renal cell carcinoma presenting as a solid mass: radiologic evaluation. Abdom Imaging 20:164–168PubMedCrossRefGoogle Scholar
  78. Zagoria RJ, Wolfman NT, Karstaedt N et al. (1990) CT features of renal cell carcinoma with emphasis on relation to tumor size. Invest Radiol 25:261–266PubMedGoogle Scholar
  79. Zincke H, Swanson SK (1982) Bilateral renal cell carcinoma: influence of synchronous and asynchronous occurrence on patient survival. J Urol 128:913–915PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Kyeong Ah Kim
    • 1
  • Cheol Min Park
    • 2
  1. 1.Department of RadiologyKorea University Guro HospitalSeoulSouth Korea
  2. 2.Department of RadiologyKorea University Guro HospitalSeoulSouth Korea

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