Skip to main content
SpringerLink
Log in

Neuropeptides and Atopic Eczema

  • Chapter
Handbook of Atopic Eczema

  • 2293 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fantini F, Magnoni C, Pincelli C, Giannetti A (1995) Neurogenic inflammation and the skin: neural modulation of cutaneous inflammatory reactions. Eur J Dermatol 5:349–357

    Google Scholar 

  2. Bruce AN (1913) Vaso-dilator axon reflexes. Q J Exp Physiol 6:339–354

    Google Scholar 

  3. Snyder SH (1980) Brain peptides as neurotransmitters. Science 209:976–983

    CAS  PubMed  Google Scholar 

  4. Johansson O (1987) Pain, motility, neuropeptides and the human skin: immunohistochemical observations. In Bonica J, Eccles J, Tiengo M, Cuello A, Ottoson D, (eds) Advances in pain research and therapy. New York, Raven Press, pp 31–44

    Google Scholar 

  5. Wehie E, Hartschuh W (1987) Multiple peptides in cutaneous nerves: regulators under physiological conditions and a pathogenetic role in skin disease? Semin Dermatol 7: 284–300

    Google Scholar 

  6. Skofitsch G, Savitt JM, Jacobowitz DM (1985) Suggestive evidence for a functional unit between mast cells and substance P fibers the rat diaphragm and mesentery. Histochemistry 82:5–8

    Article  CAS  PubMed  Google Scholar 

  7. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 13;363(6425):159–163

    CAS  Google Scholar 

  8. Lembeck F, Holzer P (1979) Substance P as a neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg’s Arch Pharmacol 310:175–183

    CAS  Google Scholar 

  9. Piotrowski W, Foreman JC (1985) On the action of substance P, somatostatin and vasoactive intestinal polypeptide on rat peritoneal mast cell and in human skin. Naunyn-Schmiedeberg’s Arch Pharmacol 331:364–368

    CAS  Google Scholar 

  10. Wallengren J, Hakanson R (1987) Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses. Eur J Pharmacol 143:267–273

    Article  CAS  PubMed  Google Scholar 

  11. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56

    Article  CAS  PubMed  Google Scholar 

  12. Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Hakanson R, Sundler F (1984) Neuropeptide Y co-exists and cooperates with noradrenaline in perivascular nerve fibres. Regul Pept 8:225–235

    Article  CAS  PubMed  Google Scholar 

  13. Payan DG, McGillis JP, Goetzl EJ (1986) Neuroimmunol Adv Immunol 30:299–323

    Google Scholar 

  14. Asahina A, Hosoi J, Beissert S, Stratigos A, Granstein RD (1995) Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J Immunol 154:3056–3061

    CAS  PubMed  Google Scholar 

  15. Kitazawa T, Streilein JW (2000) Hapten-specific tolerance promoted by calcitonin gene-related peptide. J Invest Dermatol 115:942–948

    Article  CAS  PubMed  Google Scholar 

  16. Amon U, Wolff HH (1994) Healing of chronic atopic dermatitis lesions in skin areas of paraplegia after trauma. J Dermatol 21(12):982–983

    CAS  PubMed  Google Scholar 

  17. Troilius A, Moller H (1989) Unilateral eruption of endogenous eczema after hemiparesis. Acta Derm Venereol (Stockh) 69:256–258

    CAS  Google Scholar 

  18. Dewing SB (1971) Remission of psoriasis associated with cutaneous nerve section. Arch Dermatol 104:220–221

    Article  CAS  PubMed  Google Scholar 

  19. Bettley FR, Marten RH (1956) Unilateral seborrheic dermatitis following nerve lesion. Arch Dermatol 73:110–115

    CAS  Google Scholar 

  20. Lewis T (1927) The blood vessels of the human skin and their responses. London, Shaw and Sons

    Google Scholar 

  21. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003–8008

    CAS  PubMed  Google Scholar 

  22. Tobin D, Nabarro G, Baart de la Faille H, van Vloten WA, van der Putte SC, Schuurman HJ (1992) Increased number of immunoreactive nerve fibers in atopic dermatitis. J Allergy Clin Immunol 90(4):613–622

    Article  CAS  PubMed  Google Scholar 

  23. Sugiura H, Omoto M, Hirota Y, Danno K, Uehara M (1997) Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis. Arch Dermatol Res 289(3):125–131

    Article  CAS  PubMed  Google Scholar 

  24. Urashima R, Mihara M (1998) Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study. Virchows Arch 432(4):363–370

    Article  CAS  PubMed  Google Scholar 

  25. Wallengren J, Ekman R, Moller H (1986) Substance P and vasoactive intestinal peptide in bullous and inflammatory skin diseases. Acta Dermato Venereol 66:23–28

    CAS  Google Scholar 

  26. Pincelli C, Fantini F, Massimi P, Girolomoni G, Seidenari S, Giannetti A (1990) Neuropeptides in skin from patients with atopic dermatitis: an immunohistochemical study. Br J Dermatol 122:745–750

    CAS  PubMed  Google Scholar 

  27. Anand P, Springall DR, Blank MA, Sellu D, Polak JM, Bloom SR (1991) Neuropeptides in skin diseases: increased VIP in eczema and psoriasis but not axillary hyperhidrosis Br J Dermatol 124:547–549

    CAS  PubMed  Google Scholar 

  28. Ostlere LS, Cowen T, Rustin MH (1995) Neuropeptides in the skin of patients with atopic dermatitis. Clin Exp Dermatol 20(6):462–467

    CAS  PubMed  Google Scholar 

  29. Järvikallio A, Harvima IT, Naukkarinen A (2003) Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. Arch Dermatol Res 295:2–7

    PubMed  Google Scholar 

  30. Giannetti A, Fantini F, Cimitan A, Pincelli C (1992) Vasoactive intestinal polypeptide and Substance P in the pathogenesis of atopic dermatitis. Acta Dermato-Venereologica 176:90–92

    CAS  PubMed  Google Scholar 

  31. Toyoda M, Nakamura M, Makino T, Hino T, Kagoura M, Morohashi M (2002) Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol 147(1):71–79

    Article  CAS  PubMed  Google Scholar 

  32. Umemoto N, Kakurai M, Okazaki H, Kiyosawa T, Demitsu T, Nakagawa H (2003) Serumlevels of vasoactive intestinal peptide are elevated in patients with atopic dermatitis, J Dermatol Sci 31(2):161–164

    Article  CAS  PubMed  Google Scholar 

  33. Georgala S, Schulpis KH, Papaconstantinou ED, Stratigos J (1994) Raised beta-endorphin serum levels in children with atopic dermatitis and pruritus. J Dermatol Sci 8(2):125–128

    Article  CAS  PubMed  Google Scholar 

  34. Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D (1995) Increased concentration of beta-endorphin in the sera of patients with severe atopic dermatitis. Acta Derm Venereol 75(1):9–11

    CAS  PubMed  Google Scholar 

  35. Giannetti A, Girolomoni G (1989) Skin reactivity to neuropeptides in atopic dermatitis. Br JDermatol 121(6):681–688

    CAS  Google Scholar 

  36. Coulson IH, Holden CA (1990) Cutaneous reactions to substance P and histamine in atopic dermatitis. Br J Dermatol 122(3):343–349

    CAS  PubMed  Google Scholar 

  37. Heyer G, Hornstein OP, Handwerker HO (1991) Reactions to intradermally injected substance P and topically applied mustard oil in atopic dermatitis patients. Acta Derm Venereol 71(4):291–295

    CAS  PubMed  Google Scholar 

  38. Rukwied R, Heyer G (1998) Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls. Arch Dermatol Res 290(4): 198–204

    Article  CAS  PubMed  Google Scholar 

  39. Gordon DJ, Ostlere LS, Holden CA (1997) Neuropeptide modulation of Th1 and Th2 cytokines in peripheral blood mononuclear leucocytes in atopic dermatitis and non-atopic controls. Br J Dermatol 137(6):921–927

    Article  CAS  PubMed  Google Scholar 

  40. Kang H, Byun DG, Kim JW (2000) Effects of substance P and vasoactive intestinal peptide on interferon-gamma and interleukin-4 production in severe atopic dermatitis. Ann Allergy Asthma Immunol 85(3):227–232

    CAS  PubMed  Google Scholar 

  41. Yokote R, Yagi H, Furukawa F, Takigawa M (1998) Regulation of peripheral blood mononuclear cell responses to Dermatophagoides farinae by substance P in patients with atopic dermatitis. Arch Dermatol Res 290(4):191–197

    Article  CAS  PubMed  Google Scholar 

  42. Ostlere LS, Gordon DJ, Ayliffe MJ, Rustin MH, Pereira RS, Holden CA (1997) Substance P binding to peripheral blood mononuclear leukocytes in atopic dermatitis. Acta Derm Venereol 77(4):260–263

    CAS  PubMed  Google Scholar 

  43. Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A (1996) Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci 19(11):514–520

    Article  CAS  PubMed  Google Scholar 

  44. Aloe L, Bracci-Laudiero L, Bonini S, Manni L (1997) The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy 52(9):883–894

    CAS  PubMed  Google Scholar 

  45. Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci-Laudiero L, Aloe L, Ferrari S, Cossarizza A, Giannetti A (1994) Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol 103(1):13–18

    Article  CAS  PubMed  Google Scholar 

  46. Leon A, Buriani A, Dal Toso R et al (1994) Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci 91:3739–3743

    CAS  PubMed  Google Scholar 

  47. Lambiase A, Bracci-Laudiero L, Bonini S, Bonini S, Starace G, D’Elios MM, De Carli M, Aloe L (1997) Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol 100(3):408–414

    Article  CAS  PubMed  Google Scholar 

  48. Solomon A, Aloe L, Pr’er J, Frucht-Pery J, Bonini S, Levi-Schaffer F (1998) Nerve growth factor is preformed in and activates human peripheral blood eosinophils. J Allergy Clin Immunol 102:454–460

    Article  CAS  PubMed  Google Scholar 

  49. Toyoda M, Nakamura M, Makino T, Morohashi M (2003) Localization and content of nerve growth factor in peripheral blood eosinophils of atopic dermatitis patients. Clin Exp Allergy 33(7):950–955

    Article  CAS  PubMed  Google Scholar 

  50. Grewe M, Vogelsang K, Ruzicka T, Stege H, Krutmann J (2000) Neurotrophin-4 production by human epidermal keratinocytes: increased expression in atopic dermatis. J Invest Dermatol 114:1108–1112

    Article  CAS  PubMed  Google Scholar 

  51. Kannan Y, Bienenstock J, Ohta M, Stanisz AM, Stead RH (1996) Nerve growth factor and cytokines mediate lymphoid tissue-induced neurite outgrowth from mouse superior cervical ganglia in vitro. J Immunol 157:313–320

    CAS  PubMed  Google Scholar 

  52. Lindsay RM, Harmar AJ (1989) Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337:362–364

    Article  CAS  PubMed  Google Scholar 

  53. Donnerer J, Schuligoi R, Stein C (1992) Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo. Neuroscience 49(3):693–698

    Article  CAS  PubMed  Google Scholar 

  54. Leslie TA, Emson PC, Dowd PM, Woolf CJ (1995) Nerve growth factor contributes to the up-regulation of growth-associated protein 43 and preprotachykinin A messenger RNAs in primary sensory neurons following peripheral inflammation. Neuroscience 67:753–761

    Article  CAS  PubMed  Google Scholar 

  55. Gee AP, Boyle MDP, Munger KL, Lawman MJP, Young M (1983) Nerve growth factor: stimulation of polymorphonuclear leukocyte chemotaxis. Proc Natl Acad Sci 80:7215–7218

    CAS  PubMed  Google Scholar 

  56. Albers KM, Wright DE, Davis BM (1994) Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 14:1422–1432

    CAS  PubMed  Google Scholar 

  57. Fantini F, Magnoni C, Bracci-Laudiero L, Pincelli C (1995) Nerve growth factor is increased in psoriatic skin. J Invest Dermatol 105:854–855

    CAS  PubMed  Google Scholar 

  58. Johansson O, Liang Y, Emtestam L (2002) Increased nerve growth factor-and tyrosine kinase A-like immunoreactivities in prurigo nodularis skin: an exploration of the cause of neurohyperplasia. Arch Dermatol Res 293(12):614–619

    Article  CAS  PubMed  Google Scholar 

  59. Kinkelin I, Mötzing S, Koltzenburg M, Bröcker E-B (2000) Increase in NGF content and nerve fiber sprouting in human allergic contact eczema. Cell Tissue Res 302:31–37

    Article  CAS  PubMed  Google Scholar 

  60. Di Marco E, Mathor M, Bondanza S, Cutuli N, Marchisio PC, Cancedda R, De Luca M (1993) Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem 268:22838–22846

    PubMed  Google Scholar 

Download references

Authors
  1. F. Fantini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Pincelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Johannes Ring

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstraße 9-11, 80337, München, Germany

    Bernhard Przybilla

  3. Klinik und Poliklinik für Dermatologie, Heinrich-Heine-Universität, Moorenstraße 5, 40225, Düsseldorf, Germany

    Thomas Ruzicka

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fantini, F., Pincelli, C. (2006). Neuropeptides and Atopic Eczema. In: Ring, J., Przybilla, B., Ruzicka, T. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29856-8_36

Download citation

  • DOI: https://doi.org/10.1007/3-540-29856-8_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23133-2

  • Online ISBN: 978-3-540-29856-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation