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Hepatitis Delta Virus pp 187–209Cite as

Immunology of HDV Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 307))

Abstract

Hepatitis delta virus (HDV) infection may occur as coinfection with hepatitis B virus (HBV) or as superinfection of a chronically HBV-infected patient. A strong antibody response is mounted, which persists for many years; however, it is not able to modulate the course of infection. In most cases the superinfection takes a chronic course. In patients with inactive disease (HDV PCR negative) an oligospecific T-helper cell immune response and a cytotoxic T-cell response were found, which were absent in patients with persistent viremia. The role of the cellular immune response in liver injury during acute infection has not been investigated. Vaccination strategies tested in the woodchuck model induced specific B- and T-cell responses but failed to protect from HDV infection.

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Authors and Affiliations

  1. Institute of Virology, University Clinic Essen, Hufelandstrasse 55, 45122, Essen, Germany

    M. Fiedler & M. Roggendorf

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  1. M. Fiedler
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  2. M. Roggendorf
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    John L. Casey Ph.D.

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© 2006 Springer-Verlag Berlin Heidelberg

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Fiedler, M., Roggendorf, M. (2006). Immunology of HDV Infection. In: Casey, J.L. (eds) Hepatitis Delta Virus. Current Topics in Microbiology and Immunology, vol 307. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29802-9_10

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