Nucleus Reconstruction by Autologous Chondrocyte Transplantation

  • H.-J. Meisel
  • T. Ganey


Nucleus Pulposus Disc Degeneration Lumbar Disc Herniation Disc Height Good Manufacturing Practice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Annunen S, Paassilta P, Lohiniva J, Perala M, Pihlajamaa T, Karppinen J, et al (1999) An allele of COL9A2 associated with intervertebral disc disease. Science 285:409–412CrossRefPubMedGoogle Scholar
  2. 2.
    Baba H, Chen Q, Kamitani K, Imura S, Tomita K (1995) Revision surgery for lumbar disc herniation. An analysis of 45 patients. Int Orthop 19:98–102PubMedGoogle Scholar
  3. 3.
    Bibby SRS, Jones DA, Lee RB, Yu J, Urban JPG (2001) The pathophysiology of the intervertebral disc. Joint Bone Spine 68:537–542CrossRefPubMedGoogle Scholar
  4. 4.
    Boden SD, Davis DO, Dina TS, Mark AS, Wiesel S (1990) Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects: a prospective investigation. J Bone Joint Surg Am 72:1178–1184PubMedGoogle Scholar
  5. 5.
    Brock M, Gorge HH, Curio G (1984) Intradiscal pressurevolume response: a methodological contribution to chemonucleolysis. eliminary results. J Neurosurg 60:1029–1032PubMedGoogle Scholar
  6. 7.
    Doers TM, Kang JD (1999) The biomechanics and biochemistry of disc degeneration. Curr Opin Orthop 10:117–121Google Scholar
  7. 8.
    Ganey TM, Libera J, Moos V, Alasevic O, Fritsch KG, Meisel HJ, Hutton WC (2003) Disc chondrocyte transplantation in a canine model: a treatment for damaged or degenerated intervertebral disc. Spine 28:2609–2620PubMedGoogle Scholar
  8. 9.
    Gruber HE, Johnson T, Norton HJ, Hanley EN Jr (2002) The sand rat model for disc degeneration: radiologic characterization of age-related changes: cross-sectional and prospective analyses. Spine 27:230–234PubMedGoogle Scholar
  9. 10.
    Holzhausen HJ, Bilkenroth U (2004) Independent audit: canine pre-clinical ADCT study. Martin Luther University, Halle, Germany. Documents on file, co.don AG, Teltow, GermanyGoogle Scholar
  10. 11.
    Hutton WC, Elmer WA, Boden SD, Hyon S, Toribatake Y, Tomita K, Hair GA (1999) The effect of hydrostatic pressure on intervertebral disc metabolism. Spine 24:1507–1515CrossRefPubMedGoogle Scholar
  11. 12.
    Hutton WC, Ganey TM, Elmer WA, Kozlowska E, Ugbo JL, Doh ES, Whitesides TE Jr (2000) Does long-termcompressive loading on the intervertebral disc cause degeneration? Spine 25:2993–3004PubMedGoogle Scholar
  12. 13.
    Kawaguchi Y, Osada R, Kanamori M, Ishihara H, Ohmori K, Matsui H, et al (1999) Association between an aggrecan gene polymorphism and lumbar disc degeneration. Spine 24:2456–2460CrossRefPubMedGoogle Scholar
  13. 14.
    Meisel HJ, Alasevic O, Prosenc N, Fritsch KG, Siodla V, Brock M (1997) Three dimensional cultures of cells derived from fibrous disc cartilage for treatment of discopathy. 2nd ICRS meeting, FribourgGoogle Scholar
  14. 15.
    Meisel HJ, Ganey T, Fritsch KG, Alasevic O, Hutton W (2003) Disc repair with autologous chondrocytes: a pilot clinical study. Spine J 55:71–72Google Scholar
  15. 16.
    Miller JA, Schmatz C, Schultz AB (1988) Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine 13:173–178PubMedGoogle Scholar
  16. 17.
    Norwig J, Josimovic-Alasevic O, Fritsch KG, Steiof K, Siodla W (2000) Integrated isolator technology-based sterile production of cell-based drugs. Pharm Ind 63:780–784Google Scholar
  17. 18.
    Okuma M, Mochida J, Nishimura K, Sakabe K, Seiki K (2000) Reinsertion of stimulated nucleus pulposus cells retards intervertebral disc degeneration: an in vitro and in vivo experimental study. J Orthop Res 18:988–997CrossRefPubMedGoogle Scholar
  18. 19.
    Paassilta P, Lohiniva J, Goring HH, Perala M, Raina SS, Karppinen J, et al. (2000) Identification of a common risk factor for lumbar disk disease. JAMA 285:1843–1849Google Scholar
  19. 20.
    Urban JP, Holm S, Maroudas A, Nachemson A (1977) Nutrition of the intervertebral disk. An in vivo study of solute transport. Clin Orthop 129:101–114PubMedGoogle Scholar
  20. 21.
    Videman T, Leppavuori J, Kaprio J, Battie MC, Gibbons L, Peltonen L, Koskenvuo M (1998) Intragenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration. Spine 23:2477–2485PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • H.-J. Meisel
  • T. Ganey

There are no affiliations available

Personalised recommendations