Uncomplicated Malaria

  • M. P. Grobusch
  • P. G. Kremsner
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 295)


All symptoms and signs of uncomplicated malaria are non-specific, as shared with other febrile conditions, and can occur early or later in the course of the disease. In endemic areas, the presence of hepatosplenomegaly, thrombocytopenia and anaemia is clearly associated with malaria, particularly in children. Fever, cephalgias, fatigue, malaise, and musculoskeletal pain constitute the most frequent clinical features in malaria. Following single exposure to Plasmodium falciparum infection, the patient will either die in the acute attack or survive with the development of some immunity. Elderly individuals are prone to a more severe course of disease. The non-fatal P. vivax and P. ovale cause similar initial illnesses, with bouts of fever relapsing periodically, but irregularly over a period of up to 5 years. Renal involvement of a moderate degree is more common in mild falciparum malaria than initially suspected. The liver is also afflicted in mild disease, but organ damage is limited and fully reversible after parasitological cure. Whereas the cardiotoxic adverse effects of antimalarial chemotherapeutics are well known, clinically relevant cardiac involvement in humans is rare in severe disease and even rarer in uncomplicated falciparum malaria. Co-infection can aggravate malaria. There is a growing body of evidence that there is significant interaction in terms of mutual aggravation of the course of disease between HIV and malaria, particularly in pregnant women. Children with a high level of exposure to P. falciparum have a lower risk of developing atopic disorders.


Falciparum Malaria Cerebral Malaria Vivax Malaria Uncomplicated Malaria Placental Malaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adebajo AO, Smith DJ, Hazleman BL, Wreghitt TG (1994) Seroepidemiological associations between tuberculosis, malaria, hepatitis B and AIDS in West Africa. J Med Virol 42:366–368PubMedGoogle Scholar
  2. Ahmad SH, Danish T, Faridi MMA, Ahmad AJ, Fakhir S, Khan AS (1989) Renal function in acute malaria in children. J Trop Pediatr 35:291–294PubMedGoogle Scholar
  3. Allen S, Van de Perre P, Serufilira A, Lepage P, Carael M, DeClercq J, Black D et al (1991) Human deficiency virus and malaria in a representative sample of childbearing women in Kigali, Rwanda. J Infect Dis 164:67–71PubMedGoogle Scholar
  4. Arioshi K, Berry N, Wilkins A, Ricard D, Aaby P, Naucler A, Ngom PT et al (1996) A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa. J Infect Dis 173:245–248Google Scholar
  5. Baird JK, Masbar S, Basri H, Tirtokusumo S, Subianto B, Hoffman SL (1998) Age-dependent susceptibility to severe disease with primary exposure to Plasmodium falciparum. J Infect Dis 178:592–595PubMedGoogle Scholar
  6. Beg MA, Khan R, Baig SM, Gulzar Z, Hussain R, Smego RA Jr (2002) Cerebral involvement in benign tertian malaria. Am J Trop Med Hyg 67:230–232PubMedGoogle Scholar
  7. Berkley J, Mwarumba S, Bramham K, Lowe B, Marsh K (1999) Bacteraemia complicating severe malaria in children. Trans R Soc Trop Med Hyg 93:283–286PubMedCrossRefGoogle Scholar
  8. Bethell DB, Phuong PT, Phuong CX, Nosten F, Waller D, Davis TM, Day NP et al (1996) Electrocardiographic monitoring in severe falciparum malaria. Trans R Soc Trop Med Hyg 90:266–269PubMedCrossRefGoogle Scholar
  9. Borrmann S, Adegnika AA, Missinou MA, Binder RK, Issifou S, Schindler A, Matsiegui PB, Kun JFJ, Krishna S, Lell B, Kremsner PG (2003) Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicr Agents Chemother 47:901–904Google Scholar
  10. Brahmbhatt H, Kigozi G, Wabwire-Mangen F, Serwadda D, Sewankambo N, Lutalo T, Wawer MJ (2003) The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda. AIDS 17:2539–2541PubMedCrossRefGoogle Scholar
  11. Brandts CH, Ndjave M, Graninger W, Kremsner PG (1997) Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Lancet 350:704–709PubMedCrossRefGoogle Scholar
  12. Burchard GD, Ehrhardt S, Mockenhaupt FP, Mathieu A, Agana-Nsiire P, Anemana SD, Otchwemah RN et al (2003) Renal dysfunction in children with uncomplicated Plasmodium falciparum malaria in Tamale, Ghana. Ann Trop Med Parasitol 4:345–350Google Scholar
  13. Carlini ME, White AC Jr, Atmar RL (1999) Vivax malaria complicated by adult respiratory distress syndrome. Clin Infect Dis 28:1182–1183PubMedCrossRefGoogle Scholar
  14. Chadee DD, Tilluckdharry CC, Maharaj P, Sinanan C (2000) Reactivation of Plasmodium malariae infection in a Trinidad man after neurosurgery. N Engl J Med 342:1924PubMedCrossRefGoogle Scholar
  15. Chen X, Xiao B, Shi W, Xu H, Gao K, Rao J, Zhang Z (2003) Impact of acute vivax malaria on the immune system and viral load of HIV-positive subjects. Chin Med J 116:1810–1820PubMedGoogle Scholar
  16. Chotivanich K, Udomsangpetch R, McGrady R, Proux S, Newton P, Pukrittayakamee S, Looareesuwan S et al (2002) Central role of spleen in malaria parasite clearance. J Infect Dis 185:1538–1541PubMedCrossRefGoogle Scholar
  17. Clemens R, Pramoolsinsap C, Lorenz R, Pukrittayakamee S, Bock HL, White NJ (1994) Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway. Brit J Haematol 87:100–105Google Scholar
  18. D’Acremont V, Landry P, Mueller I, Pécoud A, Genton B (2002) Clinical and laboratory predictors of imported malaria in an outpatient setting: an aid to medical decision making in returning travellers with fever. Am J Trop Med Hyg 66:481–486PubMedGoogle Scholar
  19. David PH, Hommel M, Miller LH, Udeinya IJ, Olliaro LD (1983) Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes. Proc Natl Acad Sci USA 80:5075–5079PubMedGoogle Scholar
  20. Ehrich JH, Horstmann RD (1985) Origin of proteinuria in human malaria. Trop Med Parasitol 36:39–42PubMedGoogle Scholar
  21. Erhart LM, Yingyuen K, Chuanak N, Buathong N, Laoboonchai A, Miller RS, Meshnick SR et al (2004) Hematologic and clinical indices of malaria in a semi-immune population of western Thailand. Am J Trop Med Hyg 70:8–14PubMedGoogle Scholar
  22. Facer CA, Rouse D (1991) Spontaneous splenic rupture due to Plasmodium ovale malaria. Lancet 338:896PubMedGoogle Scholar
  23. Faucher JF, Ngou-Milama E, Missinou MA, Ngomo R, Kombila M, Kremsner PG (2002) The impact of malaria on common lipid parameters. Parasitol Res 88:1040–1043PubMedCrossRefGoogle Scholar
  24. Flatau E, Reichman N, Elias M, Raz R (2000) Malaria and Borrelia co-infection. J Travel Med 7:98–99PubMedGoogle Scholar
  25. Franzen D, Curtius JM, Heitz W, Hopp HW, Diehl V, Hilger HH (1992) Cardiac involvement during and after malaria. Clin Invest 70:670–673CrossRefGoogle Scholar
  26. French N, Nakiyingi J, Lugada E, Watera C, Whitworth JAG, Gilks CF (2001) Increasing rates of malarial fever with deteriorating immune status in HIV-1 infected Ugandan adults. AIDS 15:899–906PubMedGoogle Scholar
  27. Garnham PC (1970) The role of the spleen in protozoal infections with special reference to splenectomy. Acta Trop 27:1–14PubMedGoogle Scholar
  28. Ghoshal UC, Somani S, Chetri K, Akhtar P, Aggarwal R, Naik SR (2001) Plasmodium falciparum and hepatitis E virus co-infection in fulminant hepatic failure. Indian J Gastroenterol 20:111PubMedGoogle Scholar
  29. Graham SM, Walsh AL, Molyneux EM, Phiri AJ, Molyneux ME (2000) Clinical presentation of non-typhoidal Salmonella bacteraemia in Malawian children. Trans R Soc Trop Med Hyg 94:310–314PubMedGoogle Scholar
  30. Greenberg AE, Nsa W, Ryder RW, Medi M, Nzeza M, Kitadi N, Baangi M et al (1991) Plasmodium falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in Kinshasa, Zaire. A prospective, longitudinal cohort study of 587 children. New Engl J Med 325:105–109PubMedCrossRefGoogle Scholar
  31. Grobusch MP, Wiese A, Teichmann D (2000) Delayed primary attack of vivax malaria. J Travel Med 7:104–105PubMedGoogle Scholar
  32. Grobusch MP, Krüll M, Teichmann D, Gobels K, Suttorp N (2003a) Falciparummalaria and Tangier disease. Intern J Infect Dis 7:74–75Google Scholar
  33. Grobusch MP, Borrmann S, Omva J, Issifou S, Kremsner PG (2003b) Severe malaria in a splenectomized Gabonese woman. Wien Klin Wochenschr/Middle Eur J Med 115:63–65Google Scholar
  34. Günther A, Burchard GD, Slevogt H, Abel C, Grobusch MP (2002) Renal dysfunction in falciparum-malaria is detected more often when assessed by serum concentration of cystatin C instead of creatinine. Trop Med Intern Health 7:931–934Google Scholar
  35. Günther A, Grobusch MP, Slevogt H, Abel W, Burchard GD (2003) Myocardial damage in falciparum malaria detectable by cardiac troponin T is rare. Trop Med Intern Health 8:30–32Google Scholar
  36. Hänscheid T, Grobusch, MP, Melo Cristino J, Pinto BG (2003) Avoiding misdiagnosis of imported malaria: Screening of emergency department samples with thrombocytopenia detects clinically unsuspected cases. J Travel Med 10:155–159PubMedGoogle Scholar
  37. Hightower M, Kallas EG (2003) Diagnosis, antiretroviral therapy, and emergence of resistance of antiretroviral agents in HIV-2 infection: a review. Brazil J Infect Dis 7:7–15Google Scholar
  38. Ho M, Bannister LH, Looareesuwan S, Suntharasamai P (1992) Cytoadherence and ultrastructure of Plasmodium falciparum-infected erythrocytes from a splenectomized patient. Infect Immun 60:2225–2228PubMedGoogle Scholar
  39. Hoffman IF, Jere CS, Taylor TE, Munthali P, Dyer JR, Wirima JJ, Rogerson SJ et al (1999) The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS 13:487–494PubMedCrossRefGoogle Scholar
  40. Inion I, Mwanyumba F, Gaillard P, Chohan V, Verhofstede C, Claeys P, Kishorchandra M et al (2003) Placental malaria and perinatal transmission of human immunodeficiency virus type 1. J Infect Dis 188:1675–1678PubMedCrossRefGoogle Scholar
  41. Israeli A, Shapiro M, Ephros A (1987) Plasmodium falciparum malaria in an asplenic man. Trans R Soc Trop Med Hyg 81:233–234PubMedCrossRefGoogle Scholar
  42. Jelinek T, Schulte C, Behrens R, Grobusch MP, JP Coulaud, Bisoffi Z, Matteelli A et al (2002) Imported falciparum malaria in Europe: Sentinel surveillance data from the European network on surveillance of imported infectious disease. Clin Infect Dis 34:572–576PubMedCrossRefGoogle Scholar
  43. Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, Winkler S (2004) Platelet kinetics and szintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemost 91:353–357Google Scholar
  44. Kaufmann JS, Asuzu MC, Rotimi CN, Johnson OO, Owoaje EE, Cooper RS (1997) The absence of adult mortality data for sub-Saharan Africa: a practical solution. Bull WHO 75:389–395Google Scholar
  45. Khanna KV, Markham RB (1999) A perspective on cellular immunity in the elderly. Clin Infect Dis 28:710–713PubMedGoogle Scholar
  46. Kittl EM, Diridl G, Lenhart V, Neuwald C, Tomasits J, Pichler H, Bauer K (1992) HDL cholesterol as a sensitive diagnostic parameter in malaria. Wien Klin Wochenschr/Middle Europ J Med 104:21–24Google Scholar
  47. Koibuchi T, Nakamura T, Miura T, Endo T, Nakamura H, Takahashi T, Kim HS et al (2003) Acute disseminated encephalomyelitis following Plasmodium vivax malaria. J Infect Chemother 9:254–256PubMedCrossRefGoogle Scholar
  48. Kremsner PG, Winkler S, Brandts C, Neifer S, Bienzle U, Graninger W (1994) Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon. J Infect Dis 169:467–470PubMedGoogle Scholar
  49. Krishna S, Suparanond W, Pukrittayakamee S, ter Kuile F, Supputamangkol Y, Attatamsoonthorn K, Ruprah M et al (1995a) Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol. Trans R Soc Trop Med Hyg 89:197–199PubMedGoogle Scholar
  50. Krishna S, Pukrittayakamee S, Supanaranond W, ter Kuile F, Ruprah M, Sura T, White NJ (1995b) Fever in uncomplicated Plasmodium falciparum malaria: randomized double-blind comparison of ibuprofen and paracetamol treatment. Trans R Soc Trop Med Hyg 89:507–509PubMedGoogle Scholar
  51. Kun JFJ, Mordmüller B, Lell B, Lehman LG, Luckner D, Kremsner PG (1998) Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 351:265–266PubMedCrossRefGoogle Scholar
  52. Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR (2002) Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 119:839–847PubMedCrossRefGoogle Scholar
  53. Lambrecht AJ, Snoeck J, Timmermans U (1978) Transient an-alpha-lipoproteinaemia in man during infection by Plasmodium vivax. Lancet 8075:1206Google Scholar
  54. Lawn SD (2004) AIDS in Africa: the impact of co-infections on the pathogenesis of HIV-1 infection. J Infect 48:1–12PubMedCrossRefGoogle Scholar
  55. Lell B, Brandts CH, Graninger W, Kremsner PG (2000) The circadian rhythm of body temperature is preserved during malarial fever. Wien Klin Wochenschr/Middle Europ J Med 112:1014–1015Google Scholar
  56. Lell B, Borrmann S, Yazdanbakhsh M, Kremsner PG (2001) Atopy and malaria. Wien Klin Wochenschr/Middle Europ J Med 113:927–929Google Scholar
  57. Long HY, Lell B, Dietz K, Kremsner PG (2001) Plasmodium falciparum: in vitro growth inhibition by febrile temperatures. Parasitol Res 87:553–555PubMedGoogle Scholar
  58. Looareesuwan S, White NJ, Chittama, Bunnag D, Harinasuta T (1987) High rate of Plasmodiumvivax relapse following treatment of falciparummalaria in Thailand. Lancet 8567:1052–1055Google Scholar
  59. Mabey DCW, Brown A, Greenwood BM. Plasmodium falciparum malaria and Salmonella infections in Gambian children (1987) J Infect Dis 155:1319–1321PubMedGoogle Scholar
  60. Mason DP, McKenzie FE (1999) Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections. Am J Trop Med Hyg 61:367–374PubMedGoogle Scholar
  61. Mayxay M, Pukrittayakamee S, Chotivanich K, Imwong M, Looareesuwan S, White NJ (2001) Identification of cryptic co-infection with Plasmodium falciparum in patients presenting with vivax malaria. Am J Trop Med Hyg 65:588–592PubMedGoogle Scholar
  62. Mendis K, Sina BJ, Marchesini P, Carter R (2001) The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64:97–106PubMedGoogle Scholar
  63. Metzger WG, Mordmüller BG, Kremsner PG (1995a) Malaria pigment in leucocytes. Trans R Soc Trop Med Hyg 89:637–638PubMedGoogle Scholar
  64. Metzger W, Mordmüller B, Graninger W, Bienzle U, Kremsner PG (1995b) Sulfadoxine/ pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children with chloroquine resistant malaria. J Antimicrob Chemother 36:723–728PubMedGoogle Scholar
  65. Missinou MA, Lell B, Kremsner PG (2003) Uncommon asymptomatic Plasmodium falciparum infections in Gabonese children. Clin Infect Dis 36:1198–1202PubMedCrossRefGoogle Scholar
  66. Modebe O, Jain S (1999) Multi-system failure in Plasmodium vivax malaria: report of a case. Ann Trop Parasitol 93:409–412Google Scholar
  67. Molyneux ME, Looareesuwan S, Menzies IS, Graniger SL, Phillips RE, Wattanagoon Y, Thomson RP et al (1989) Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria. Am J Trop Med Hyg 40:470–476PubMedGoogle Scholar
  68. Moulin F, Lesage F, Legros AH, Maroga C, Moussavou A, Guyon P, Marc E et al (2003) Thrombocytopenia and Plasmodium falciparum malaria in children with different exposures. Arch Dis Child 88:540–541PubMedCrossRefGoogle Scholar
  69. Mühlberger N, Jelinek T, Behrens RH, Gjorup I, Coulaud JP, Clerinx J, Puente S et al (2003) Age as a riks factor for severe manifestations and fatal outcome of falciparum malaria in European patients: observations from TropNetEurop and SIMPID surveillance data. Clin Infect Dis 36:990–995PubMedGoogle Scholar
  70. Muller O, Moser R (1990) The clinical and parasitological presentation of Plasmodium falciparum malaria in Uganda is unaffected by HIV-1 infection. Trans R Soc Trop Med Hyg 84:336–338PubMedGoogle Scholar
  71. Nacher M (2002) Worms and malaria: noisy nuisances and silent benefits. Parasite Immunol 24:391–393PubMedGoogle Scholar
  72. Nathoo S, Serghides L, Kain KC (2003) Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasited erythrocytes. Lancet 362:1039–1041PubMedCrossRefGoogle Scholar
  73. N’gom PT, Jaffar S, Ricard D, Wilkins A, Ariyoshi K, Morgan G, Da Silva AP et al (1997) Immune stimulation by syphilis and malaria in HIV-2-infected and uninfected villagers in West Africa. Br J Biomed Science 54:251–255Google Scholar
  74. Nierengarten MB (2003) Malariotherapy to treat HIV patients? Lancet Infect Dis 2003; 3:321PubMedGoogle Scholar
  75. Nilsson-Ehle I, Nilsson-Ehle P (1990) Changes in plasma lipoproteins in acute malaria. J Intern Med 227:151–155PubMedCrossRefGoogle Scholar
  76. Norhayati M, Rohani AK, Hayati MI, Halimah AS, Sharom MY, Abidin AH, Fatmah MS (2001) Clinical features of malaria in Orang Asli population in Pos Piah, Malaysia. Med J Malaysia 56:271–274PubMedGoogle Scholar
  77. Nwanyanwu OC, Kumwenda N, Kazembe PN, Jemu S, Ziba C, Nkhoma WC, Redd SC (1997) Malaria and human immunodeficiency virus infection among male employees of a sugar estate in Malawi. Trans R Soc Trop Med Hyg 91:567–569PubMedCrossRefGoogle Scholar
  78. Olaleye BO, Williams LA, d’Alessandro U, Weber MR, Mulholland K, Okorie C, Langerock P et al (1998) Clinical predictors of malaria in Gambian children with fever or a history of fever. Trans R Soc Trop Med Hyg 92:300–304PubMedCrossRefGoogle Scholar
  79. Pongponratn E, Viriyavejakul P, Wilairatana P, Ferguson D, Chaisri U, Turner G, Looareesuwan S (2000) Absence of knobs on parasitized red blood cells in a splenectomized patient in fatal falciparum malaria. Southeast Asian J Trop Med Public Health 31:829–835PubMedGoogle Scholar
  80. Prakash J, Singh AK, Kumar NS, Saxena RK (2003) Acute renal failure in Plasmodium vivax malaria. J Assoc Physicians India 51:265–267PubMedGoogle Scholar
  81. Pukrittayakamee S, White NJ, Davis TM, Looareesuwan S, Supanaranond W, Desakorn V, Chaivisuth B, Williamson DH (1992) Hepatic blood flow and metabolism in severe falciparum malaria: clearance of intravenously administered galactose. Clin Sci (Lond) 82:63–70Google Scholar
  82. Radloff PD, Philipps J, Nkeyi M, Sturchler D, Mittelholzer ML, Kremsner PG (1996) Arteflene compared with mefloquine for treating Plasmodium falciparum malaria in children. Am J Trop Med Hyg 55:259–262PubMedGoogle Scholar
  83. Ree HI (2000) Unstable vivax malaria in Korea. Korean J Parasitol 38:119–138PubMedGoogle Scholar
  84. Reeves JD, Doms RW (2002) Human immunodeficiency virus type 2. J Gen Virol 83:1253–1265PubMedGoogle Scholar
  85. Rogerson S (2003) HIV-1, antiretroviral therapy, and malaria. Lancet 362:1008–1009PubMedCrossRefGoogle Scholar
  86. Sandmand M, Bruunsgaard H, Kemp K, Andersen-Ranberg K, Pedersen AN, Skinhoj P, Pedersen BK (2002) Is ageing associated with a shift in the balance between type 1 and type 2 cytokines in humans? Clin Exp Immunol 127:107–114PubMedCrossRefGoogle Scholar
  87. Sankoh OA, Kynast-Wolf G, Kouyaté B, Becher H (2003) Patterns of adult and old-age mortality in rural Burkina Faso. J Public Health Med 25:372–376PubMedGoogle Scholar
  88. Schellenberg D, Menendez C, Kahigwa E, Font F, Galindo C, Acosta C, Armstrong Schellenberg J et al (1999) African children with malaria in an area of intense Plasmodium falciparum transmission: Features on admission to the hospital and risk factors for death. Am J Trop Med Hyg 61:431–438PubMedGoogle Scholar
  89. Schim van der Loeff M, Aaby P (1999) Towards a better understanding of the epidemiology of HIV-2. AIDS 13:S69–S84Google Scholar
  90. Schwartz E, Sadetzki S, Murad H, Raveh D (2001) Age as a risk factor for severe Plasmodium falciparum malaria in non-immune patients. Clin InfectDis 33:1774–1777Google Scholar
  91. Schwarzer E, Kühn H, Valente E, Arese P (2003) Malaria-parasitized erythrocytes and haemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions. Blood 101:722–728PubMedCrossRefGoogle Scholar
  92. Skudowitz RB, Katz J, Lurie A, Levin J, Metz J (1973) Mechanisms of thrombocytopenia in malignant tertian malaria. Br Med J 2(5865):515–518PubMedCrossRefGoogle Scholar
  93. Steele RW (1996) Malaria in children. Adv Pediatr Infect Dis 12:325–349PubMedGoogle Scholar
  94. Stein CM, Gelfand M (1985) The clinical features and laboratory findings in acute Plasmodium falciparum malaria in Harare, Zimbabwe. Centr Afr J Med 31:166–170Google Scholar
  95. Steketee RW, Wirima JJ, Bloland PB, Chilima B, Mermin JH, Chitsulo L, Breman JG (1996) Impairment of a pregnant women’s acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1. Am J Trop Med Hyg 55:42–49PubMedGoogle Scholar
  96. Tanios MA, Kogelman L, McGovern B, Hassoun PM (2001) Acute respiratory distress syndrome complicating Plasmodium vivax malaria. Crit Care Med 29:665–667PubMedGoogle Scholar
  97. Tsuchida H, Yamaguchi K, Yamamoto S, Ebisawa I (1982) Quartan malaria following splenectomy 36 years after infection. Am J Trop Med Hyg 31:163–165PubMedGoogle Scholar
  98. Van den Biggelaar AHJ, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YCM, Souverijn JHM, Missinou MA et al (2004) Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 189:892–900PubMedGoogle Scholar
  99. Van Eijk AM, Ayisi JG, Ter Kuile FO, Misore AO, Otieno JA, Kolczak MS, Kager PA et al (2002) Malaria and human immunodeficiency virus infection as risk factors for anaemia in infants in Kisumu, Western Kenya. Am J Trop Med Hyg 67:44–53PubMedGoogle Scholar
  100. Van Eijk AM, Ayisi JG, Ter Kuile FO, Misore AO, Otieno JA, Rosen DH, Kager, P et al (2003) HIV increases the risk of malaria in women of all gravidities in Kisumu, Kenya. AIDS 17:595–603PubMedGoogle Scholar
  101. Van Velthuysen ML, Florquin S (2000) Glomerulopathy associated with parasitic infections. Clin Microbiol Rev 13:55–66PubMedGoogle Scholar
  102. Verhoeff F, Brabin BJ, Hart AC, Chimsuku L, Kazembe P, Broadhead RL (1999) Increased prevalence of malaria in HIV-infected pregnant women and its implications for malaria control. Trop Med Intern Health 4:5–12CrossRefGoogle Scholar
  103. Vinetz JM, Li J, McCutchan TF, Kaslow DC (1998) Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. N Engl J Med 338:367–371PubMedCrossRefGoogle Scholar
  104. Weber MW, Zimmermann U, van Hensbroek MB, Frenkel J, Palmer A, Ehrich JHH, Greenwood BM (1999) Renal involvement in Gambian children with cerebral or mild malaria. Trop Med Intern Health 4:390–394Google Scholar
  105. White NJ (2003) Malaria. In: Cook GC, Zumla A (eds) Manson’s Tropical Diseases, 21st ed. Elsevier, Edinburgh, pp 1205–1295Google Scholar
  106. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N et al (2000) Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet 356:1051–1056PubMedCrossRefGoogle Scholar
  107. Wilairatana P, Loareesuwan S, Charoenlarp P (1994) Liver profile changes and complications in jaundiced patients with falciparum malaria. Trop Med Parasitol 45:298–302PubMedGoogle Scholar
  108. Wongsrichanalai C, Murray CK, Gray M, Miller RS, McDaniel P, Liao WJ, Pickard AL et al (2003) Co-infection with malaria and leptospirosis. Am J Trop Med Hyg 68:583–585PubMedGoogle Scholar
  109. Yazdanbakhsh M, Kremsner PG, van Ree R (2002) Allergy, parasites, and the hygiene hypothesis. Science 296:490–494PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • M. P. Grobusch
    • 1
  • P. G. Kremsner
    • 2
  1. 1.Infectious Diseases Unit, Faculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa
  2. 2.Department of ParasitologyInstitute of Tropical Medicine, Tübingen UniversityTübingenGermany

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