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Hemoglobin Degradation

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Malaria: Drugs, Disease and Post-genomic Biology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 295))

Abstract

Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism’s survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin. Each of the enzymes involved has its own peculiarities to be exploited for development of antimalarial agents that will starve the parasite or result in build-up of toxic intermediates. There are a number of unanswered questions concerning the cell biology, biochemistry and metabolic roles of this crucial pathway.

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Authors and Affiliations

  1. Howard Hughes Medical Institute. Departments of Medicine and Molecular Microbiology, Washington University, 660 S. Euclid Ave., St. Louis, MO, 63110, USA

    D. E. Goldberg

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  1. D. E. Goldberg
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Editors and Affiliations

  1. Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, The Johns Hopkins University, 615 North Wolfe Street, E5628, Baltimore, MD, 21205, USA

    David J. Sullivan M.D.

  2. Department of Cellular and Molecular Medicine, Infectious Diseases Group, St. George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK

    Sanjeev Krishna D. Phil, F.R.C.P., F. MED. Sci.

  3. Atlanta, Georgia

    R. W. Compans

  4. Birmingham, Alabama

    M. D. Cooper

  5. Kyoto

    T. Honjo

  6. Philadelphia, Pennsylvania

    H. Koprowski

  7. Basel

    F. Melchers

  8. La Jolla, California

    M. B. A. Oldstone

  9. Oslo

    S. Olsnes

  10. Bethesda, Maryland

    M. Potter

  11. La Jolla, California

    P. K. Vogt

  12. Munich

    H. Wagner

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Goldberg, D.E. (2005). Hemoglobin Degradation. In: Compans, R.W., et al. Malaria: Drugs, Disease and Post-genomic Biology. Current Topics in Microbiology and Immunology, vol 295. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29088-5_11

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