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Retinoblastome

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Pädiatrische Hämatologie und Onkologie

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Zusammenfassung

Das Retinoblastom ist der häufigste maligne intraokulare Tumor des Kindesalters. Die Erkrankung betrifft ein Auge oder beide Augen. Sie kann sporadisch oder familiär gehäuft vorkommen. Die Inaktivierung beider Allele des Tumorsuppressorgens RB1 (Chromosom 13) ist Ursache für ein Retinoblastom. Individuen mit konstitutioneller Heterozygotie für eine Rb1-Mutation haben zusätzlich ein erhöhtes Risiko für die Entstehung unabhängiger Zweittumoren. Durch eine Kombination verschiedenster Therapiemethoden liegt die Heilungsrate bei rein intraokularer Erkrankung bei nahezu 100%, während bei Patienten mit disseminierter metastasierter Erkrankung erst in den letzten Jahren eine kurative Behandlung möglich wurde.

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Author information

Authors and Affiliations

  1. Zentrum für Kinderheilkunde Abt. für Pädiatrische Hämatologie, Onkologie und Endokrinologie, Universitäts-Kinderklinik Essen, Hufelandstr. 55, 45122, Essen

    Dr. Regina Wieland

  2. Abt. für Pädiatrische Hämatologie, Endokrinologie und Onkologie, Universitäts-Kinderklinik Essen, Hufelandstr. 55, 45122, Essen

    Prof. Dr. Werner Havers

Authors
  1. Dr. Regina Wieland
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  2. Prof. Dr. Werner Havers
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Editor information

Editors and Affiliations

  1. Forschungsinstitut für krebskranke Kinder, St. Anna Kinderspital, Kinderspitalgasse 6, 1090, Wien, Österreich

    Helmut Gadner

  2. Klinik für Allgemeine Pädiatrie und Knochenmarktransplantation, Charité Campus Virchow-Klinikum Otto-Heubner-Centrum für Kinder- und Jugendmedizin, Augustenburger Platz 1, 13353, Berlin

    Gerhard Gaedicke

  3. Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Freiburg, Mathildenstr. 1, 79106, Freiburg

    Charlotte Niemeyer

  4. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129, Münster

    Jörg Ritter

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© 2006 Springer Medizin Verlag Heidelberg

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Wieland, R., Havers, W. (2006). Retinoblastome. In: Gadner, H., Gaedicke, G., Niemeyer, C., Ritter, J. (eds) Pädiatrische Hämatologie und Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29036-2_67

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  • DOI: https://doi.org/10.1007/3-540-29036-2_67

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-03702-6

  • Online ISBN: 978-3-540-29036-0

  • eBook Packages: Medicine (German Language)

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