Zusammenfassung
Die erste Warmbluttransfusion zur Behandlung einer unkontrollierbaren Epistaxis bei einem jungen Mann mit einer Thrombozytopenie von 6/nl verlief erfolgreich, die Zahl der Thrombozyten stieg auf 123 G/l und die Blutung stand. Ein Student protokollierte parallel zur Transfusion die Blutungszeit, eine Methode, die er kurz zuvor entwickelt hatte. Die Verkürzung der Blutungszeit verlief parallel zum Sistieren der Schleimhautblutung. Im Jahre 1910 publizierte der Student namens W.W. Duke seine Beobachtungen in JAMA: »The relation of blood platelets to hemorrhagic disease. Description of a method for determining the bleeding time and the coagulation time and report of three cases of hemorrhagic disease relieved by transfusion.« Er konnte belegen, dass die niedrige Thrombozytenzahl ursächlich war für die Verlängerung der Blutungszeit und die klinischen Blutungszeichen, und dass eine normale Gerinnungszeit nicht gleichzeitig eine normale Blutungszeit bedeutet, wenn eine Thrombozytopenie vorliegt.
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Bergmann, F. (2006). Physiologie des Thrombozyten. In: Gadner, H., Gaedicke, G., Niemeyer, C., Ritter, J. (eds) Pädiatrische Hämatologie und Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29036-2_32
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