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Hepatology Principles and Practice pp 31–71Cite as

Biochemistry and Functions of the Liver

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Keywords

  • Bile Acid
  • Kupffer Cell
  • Cholic Acid
  • Urea Cycle
  • Blood Alcohol Concentration

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References

  1. Atkinson, D.E., Camien, M.N.: The role of urea synthesis in the removal of metabolic bicarbonate and the regulation of blood pH. Curr. Top. Cell. Reg. 1982; 21: 261–302

    CAS  Google Scholar 

  2. Baas, J., Senninger, N., Elser, H.: Das retikuloendotheliale System. Eine Übersicht über Funktion, Pathologie und neuere Meßmethoden. Z. Gastroenterol. 1994; 32: 117–123

    CAS  PubMed  Google Scholar 

  3. Bahar, R.J., Stolz, A.: Bile acid transport. Gastroenterol. Clin. North Amer. 1999; 28: 27–58

    CAS  Google Scholar 

  4. Bell, R.M., Ballas, L.M., Coleman, R.A.: Lipid topogenesis. J. Lipid Res. 1980; 22: 391–403

    Google Scholar 

  5. Berk, P.D., Stremmel, W.: Hepatocellular uptake of organic ions. Progr. Liver Dis. 1986; 8: 125–144

    CAS  PubMed  Google Scholar 

  6. Bikle, D.P., Gree, E., Halloran, B., Haddad, J.G.: Free 1,25-dihydroxyvitamin D in serum from normal subjects, pregnant subjects and subjects with liver disease. J. Clin. Invest. 1984; 74: 1966–1971

    CAS  PubMed  Google Scholar 

  7. Blomhoff, R., Holte, K., Naess, L., Berg, T.: Newly administered (3 H) retinol is transferred from hepatocytes to stellate cells in liver for storage. Exp. Cell. Res. 1984; 150: 186–193

    CAS  PubMed  Google Scholar 

  8. Bors, W., Saran, M.: Radical scavenging by flavonoid antioxidants. Free Radic. Res. Commun. 1987; 2: 289–294

    CAS  PubMed  Google Scholar 

  9. Bosron, W.F., Li, T.K.: Genetic determinations of alcohol and aldehyd dehydrogenases and alcohol metabolism. Semin. Liver Dis. 1981; 1: 179–188

    CAS  PubMed  Google Scholar 

  10. Bouwens, L., De Bleser, P., Vanderkerken, K., Geerts, B., Wisse, E.: Liver cell heterogeneity: functions of non-parenchymal cells. Enzyme 1992; 46: 155–168

    CAS  PubMed  Google Scholar 

  11. Boyer, J.L.: Bile duct epithelium: frontiers in transport physiology. Amer. J. Physiol. 1996; 270: 1–5

    Google Scholar 

  12. Bradford, B.U., Enomoto, N., Ikejima, K., Rose, M.L., Bojes, H.K., Forman, D.T., Thurman, F.G.: Peroxisomes are involved in the swift increase in alcohol metabolism. J. Pharm. Exper. Ther. 1999; 288: 254–259

    CAS  Google Scholar 

  13. Bremner, J.: Involvement of metallothioneins in hepatic metabolism of copper. J. Nutr. 1987; 117: 19–24

    CAS  PubMed  Google Scholar 

  14. Calvert, G.D., Abbey, M.: Plasma lipoproteins apoproteins and proteins concerned with lipid metabolism. Adv. Clin. Chem. 1985; 24: 218–298

    Google Scholar 

  15. Chignard, N., Mergey, M., Veissiére, D., Parc, R., Capeau, J., Poupon, R., Paul, A., Housset, C.: Bile acid transport and regulating functions in the human biliary epithelium. Hepatology 2001; 33: 496–503

    CrossRef  CAS  PubMed  Google Scholar 

  16. Christensen, H.E.: Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 1990; 70: 43–70

    CAS  PubMed  Google Scholar 

  17. Clark, D.W.J.: Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs 1985; 29: 342–375

    CAS  PubMed  Google Scholar 

  18. Comparti, M.: Biology of disease: lipid peroxidation and cellular damage in toxic liver injury. Lab. Invest. 1985; 53: 599–623

    Google Scholar 

  19. Crawford, J.M.: Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Semin. Liver Dis. 1996; 16: 169–189

    CAS  PubMed  Google Scholar 

  20. Cuypers, H.T.M., ter Haar, E.M., Jansen, P.L.M.: Microsomal conjugation and oxidation of bilirubin. Biochim. Biophys. Acta 1983; 758: 135–143

    CAS  PubMed  Google Scholar 

  21. De Silva, D.M., Askwith, C.C., Kaplan, J.: Molecular mechanisms of iron uptake in eukaryotes. Physiol. Rev. 1996; 76: 31–47

    PubMed  Google Scholar 

  22. Eichelbaum, M.: Genetische Polymorphismen des oxidativen Arzneimittelstoffwechsels. Therapeutische und toxikologische Implikationen. Internist 1983; 24: 117–127

    CAS  PubMed  Google Scholar 

  23. Elsing, C., Huebner, C.: Biliary tract physiology. Curr. Opin. Gastroenterol. 1997; 13: 405–409

    Google Scholar 

  24. Elstner, E.F.: Oxygen radicals — biochemical basis for their efficacy. Klin. Wschr. 1991; 69: 949–956

    CrossRef  CAS  PubMed  Google Scholar 

  25. Enrich, C., Pol, A., Calvo, M., Pons, M., Jäckle, St.: Dissection of the multifunctional “receptor-recycling” endocytic compartment of hepatocytes. Hepatology 1999; 30: 1115–1120

    CrossRef  CAS  PubMed  Google Scholar 

  26. Ettinger, M.J., Darwish, H.M., Schmitt, R.C.: Mechanism of copper transport from plasma to hepatocytes. Fed. Proc. 1986; 45: 2800–2804

    CAS  PubMed  Google Scholar 

  27. Falk Foundation e.V.: Freiburg 79108/Germany (available).

    Google Scholar 

  28. Gebhardt, R.: Metabolic zonation of the liver: regulation and implications for liver function. Pharmac. Ther. 1992; 53: 275–354

    CAS  Google Scholar 

  29. Genschel, J., Schmidt, H.H.J.: HDL metabolism. Zschr. Gastroenterol. 2001; 39: 321–327

    CAS  Google Scholar 

  30. Hagenbuch, B., Meier, P.J.: Sinusoidal (basolateral) bile salt uptake systems in hepatocytes. Semin. Liver Dis. 1996; 16: 129–136

    CAS  PubMed  Google Scholar 

  31. Halliday, J.W., Powell, L.W.: Ferritin metabolism and the liver. Semin. Liver Dis. 1984; 4: 207–216

    CAS  PubMed  Google Scholar 

  32. Halliwell, B.: Oxigen radicals: a common sense of look at their nature and medical importance. Med. Biol. 1984; 62: 71–77

    CAS  PubMed  Google Scholar 

  33. Halliwell, B., Gutteridge, J.M.C., Cross, C.E.: Free radicals, antioxidants, and human disease: Where are we now? J. Lab. Clin. Med. 1992; 119: 598–620

    CAS  PubMed  Google Scholar 

  34. Häusinger, D.: Organization of hepatic nitrogen metabolism and its relation to acid-base homeostasis. Klin. Wschr. 1990; 68: 1096–1101

    Google Scholar 

  35. Häussinger, D.: Liver regulation of acid-base balance. Min. Electr. Metab. 1997; 23: 249–252

    Google Scholar 

  36. Hendriks, H.F.J., Verhoofstad, W.A.M.M., Brower, A., de Leeuw, A.M., Knook, D.L.: Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver. Exp. Cell Res. 1985; 160: 138–149

    CrossRef  CAS  PubMed  Google Scholar 

  37. Hofmann, A.F.: Bile acid secretion, bile flow, and biliary lipid secretion in humans. Hepatology 1990; 12(S): 17–25

    Google Scholar 

  38. Horton, A.A., Fairhurst, S.: Lipid peroxidation and mechanisms of toxicity. CRC Crit. Rev. Toxicol. 1989; 18: 27–79

    Google Scholar 

  39. Jäger, H., Wilcox, H.G., Bitterle, T., Berr, F.: Intracellular supply of phospholipids for biliary secretion: evidence for a nonvesicular transport component. Biochem. Biophys. Res. Comm. 2000; 268: 790–797

    Google Scholar 

  40. Jaeschke, H.: Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol. 2000; 15: 718–724

    CrossRef  CAS  PubMed  Google Scholar 

  41. Yoon, Y.B., Hagey, L.R., Hofmann, A.F., Gurantz, D., Michelotti, E.L., Steinbach, J. H.: Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 1986; 90: 837–852

    CAS  PubMed  Google Scholar 

  42. Jungermann, K.: Metabolic zonation of liver parenchyma. Semin. Liver Dis. 1988; 8: 329–341

    CAS  PubMed  Google Scholar 

  43. Jungermann, K., Katz, N.: Functional spezialization of different hepatocyte populations. Physiol. Rev. 1989; 69: 708–764

    CAS  PubMed  Google Scholar 

  44. Jungermann, K., Kietzmann, T.: Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 2000; 31: 255–260

    CrossRef  CAS  PubMed  Google Scholar 

  45. Kamisako, T., Gabazza, E.C., Ishihara, T., Adachi, Y.: Molecular aspects of organic transport across the plasma membrane of hepatocytes. J. Gastroenterol. Hepatol. 1999; 14: 405–412

    CrossRef  CAS  PubMed  Google Scholar 

  46. Kanno, N., LeSage, G., Glaser, S., Alvaro, C., Alpini, G.: Functional heterogeneity of the intrahepatic biliary epithelium. Hepatology 2000; 31: 555–561

    CrossRef  CAS  PubMed  Google Scholar 

  47. Kawabata, T., Ogino, T., Awai, M.: Protective effects of glutathione against lipid peroxidation in chronically iron-loaded mice. Biochim. Biophys. Acta 1989; 1004: 89–94

    CAS  PubMed  Google Scholar 

  48. Knolle, P.A., Gerken, G.: Local control of the immune response in the liver. Immunol. Rev. 2000; 174; 21–34

    CrossRef  CAS  PubMed  Google Scholar 

  49. Kullak-Ublick, G.A.: Regulation of organic anion and drug transporters of the sinusoidal membrane. J. Hepatol. 1999; 31: 563–573

    CrossRef  CAS  PubMed  Google Scholar 

  50. Kullak-Ublick, G.A., Stieger, B., Hagenbuch, B., Meier, P.J.: Hepatic transport of bile salts. Semin. Liver Dis. 2000; 20: 273–292

    CrossRef  CAS  PubMed  Google Scholar 

  51. Kuntz, E.: Die Aufklärung der Harnstoffsynthese in der Leberzelle vor 60 Jahren. Zum Gedenken an H. A. Krebs und K. Henseleit. In: Die hepatische Enzephalopathie. Aspekte der Diagnose und Behandlung. E. Kuntz (Hrsg.) Univ. Verlag Jena, 1992, 5–8

    Google Scholar 

  52. Kuntz, H.-D.: Glukuronidierungskapazität der Leber. Fortschr. Med. 1987; 105: 149–152

    CAS  PubMed  Google Scholar 

  53. Kuntz, H.-D., Femfert, U., May, B.: Leber und Alter. Einfluß des Lebensalters auf Leberfunktion und Arzneimittelmetabolismus. Dtsch. Med. Wschr. 1987; 112: 757–759

    CAS  PubMed  Google Scholar 

  54. Kuntz, H.-D., Femfert, U., May, B.: Pharmakokinetik von 7-Hydroxy-4-Methyl-2-H-benzofuran-2on als Funktionsprüfung für die Glukuronidierungskapazität der Leber. Verh. Dtsch. Ges. Inn. Med. 1983; 89: 630–633

    Google Scholar 

  55. Kuntz, H.-D., Femfert, U., May, B.: Biotransformation und biliäre Exkretion von Methylumbelliferon bei Patienten mit chronischer Stauungsleber. Verh. Dtsch. Ges. Inn. Med. 1984; 90: 1853–1856

    Google Scholar 

  56. LeSage, G., Glaser, S., Alpini, G.: Regulatory mechanisms of ductal bile secretion. Dig. Liver Dis. 2000; 32: 563–566

    CrossRef  CAS  PubMed  Google Scholar 

  57. Lindner, M.C.: Other trace elements and the liver. Semin. Liver Dis. 1984; 4: 264–276

    Google Scholar 

  58. Lomri, N., Fitz, J.G., Scharschmidt, B.F.: Hepatocellular transport: role of ATP-binding cassette protein. Semin. Liver Dis. 1996; 16: 201–210

    CAS  PubMed  Google Scholar 

  59. Love, M.W., Dawson, P.A.: New insights into bile acid transport. Curr. Opin. Lipid. 1998; 9: 225–229

    CAS  Google Scholar 

  60. Lundquist, F.: Acetaldehyde and aldehyde dehydrogenases: central problem in the studies of alcoholism. Eur. J. Clin. Invest. 1983; 13: 183–184

    CAS  PubMed  Google Scholar 

  61. Marver, H., Schmid, R.: Biotransformation in the liver: implications for human disease. Gastroenterology 1968; 55: 282–289

    CAS  PubMed  Google Scholar 

  62. McCord, J.M.: The superoxyde free radical: its biochemistry and pathophysiology. Surgery 1983; 94: 412–414

    CAS  PubMed  Google Scholar 

  63. Medina, D., Morrison, D.: Current ideas on selenium as a chemopreventive agent. Path. Immunopath. Res. 1988; 7: 187–199

    CAS  Google Scholar 

  64. Mehal, W.Z., Azzaroli, F., Crispe, N.: Immunology of the healthy liver: old questions and new insights. Gastroenterology 2001; 120: 250–260

    CAS  PubMed  Google Scholar 

  65. Mertz, W.: Chromium, an ultra trace element. Chem. Scripta 1983; 21: 71–83

    Google Scholar 

  66. Milman, N., Laursen, I., Podenphant, I., Asnaes, S.: Trace elements in normal and cirrhotic human liver tissue. I. Iron, copper, zinc, selenium, manganese, titanium and lead measured by X-ray fluorescence spectrometry. Liver 1986; 6: 111–117

    CAS  PubMed  Google Scholar 

  67. Morgan, E.H., Baker, E.: Iron uptake and metabolism by hepatocytes. Fed. Proc. 1986; 45: 2810–2816

    CAS  PubMed  Google Scholar 

  68. Müller, M., Jansen, P.L.M.: The secretory function of the liver: new aspects of hepatobiliary transport. J. Hepatol. 1998; 28: 344–354

    PubMed  Google Scholar 

  69. Nagashima, I.: Experimental study on endotoxinemia and reticuloendothelial system in hepatectomized cirrhotic rats. J. Japan. Surg. Soc. 1991; 92: 551–561

    CAS  Google Scholar 

  70. Nathanson, M.H., Boyer, J.L.: Mechanisms and regulation of bile secretion. Hepatology 1991; 14: 551–565

    CrossRef  CAS  PubMed  Google Scholar 

  71. Nebert, D.W., Russell, D.W.: Clinical importance of the cytochromes P 450 (review). Lancet 2002; 360: 1155–1162

    CrossRef  CAS  PubMed  Google Scholar 

  72. Ockner, R.K., Weisiger, R.A., Gollan, J.L.: Hepatic uptake of albumin bound substances: albumin receptor concept. Amer. J. Physiol. 1983; 245: 413–418

    Google Scholar 

  73. Okada, S., Ohto, M., Kuniyasu, Y., Higashi, S., Arimizu, N., Uematsu, S.: Estimation of the reticuloendothelial function by positron emission computed tomography (PET) study in chronic liver disease. (jap.) Japan. J. Gastroenterol. 1990; 87: 90–99

    CAS  Google Scholar 

  74. Olkonen, V.M., Ikonen, E.: Genetic defects of intrazellular-membrane transport. New Engl. J. Med. 2000; 343; 1095–1104

    Google Scholar 

  75. Oneta, C.M., Simanowski, U.A., Martinez, M., Allali-Hassani, A. Parés, X., Homann, N., Conradt, C., Waldherr, R., Fiehn, W., Coutelle, C., Seitz, H.K.: First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying. Gut 1998; 43: 612–619

    CAS  PubMed  Google Scholar 

  76. Pattison, S.E., Cousins, R.J.: Zinc uptake and metabolism by hepatocytes. Fed. Proc. 1986; 45: 2805–2809

    CAS  PubMed  Google Scholar 

  77. Pilkis, S.J., Granner, D.K.: Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Ann. Rev. Physiol. 1992; 54: 885–909

    CAS  Google Scholar 

  78. Pocker, Y.: Bioinorganic and bioorganic studies of liver alcohol dehydrogenase. Chem. Biol. Interact. 2001; 130: 383–393

    PubMed  Google Scholar 

  79. Poli, G., Albano, E., Dianzani, M.U.: The role of lipid peroxidation in liver damage. Chem. Phys. Lipids 1987; 45: 117–142

    CAS  PubMed  Google Scholar 

  80. Pond, S.M., Tozer, T.N.: First-pass elimination. Basic concepts and clinical consequences. Clin. Pharmacokinetics 1984; 9: 1–25

    CAS  Google Scholar 

  81. Prall, R.T., LaRusso, N.F.: Biliary tract physiology. Curr. Opin. Gastroenterol. 2000; 16: 432–436

    CrossRef  CAS  Google Scholar 

  82. Reynoso-Paz, S., Coppel, R.L., Mackay, I.R., Bass, N.M., Ansari, A.A., Gershwin, M.E.: The immunobiology of bile and biliary epithelium. Hepatology 1999; 30: 351–357

    CrossRef  CAS  PubMed  Google Scholar 

  83. Robak, J., Grygleweski, R.J.: Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 1988; 37: 837–841

    CrossRef  CAS  PubMed  Google Scholar 

  84. Rosenthal, P., Pincus, M., Fink, D.: Sex-and age-related differences in bilirubin concentrations in serum. Clin. Chem. 1984; 30: 1380–1382

    CAS  PubMed  Google Scholar 

  85. Saba, T.M.: Physiology and pathophysiology of the reticuloendothelial system. Arch. Intern. Med. 1970; 126: 1031–1052

    CrossRef  CAS  PubMed  Google Scholar 

  86. Salky, N.K., Di Luzio, N.R., P’Pool, D.B., Sutherland, A.J.: Evaluation of reticuloendothelial function in man. J. Amer. Med. Ass. 1964; 187: 168–172

    Google Scholar 

  87. Seitz, H.K., Korsten, M.A., Lieber, C.S.: Ethanol oxidation by intestinal microsomes: increased activity after chronic ethanol administration. Life Sci. 1979; 25: 1443–1448

    CrossRef  CAS  PubMed  Google Scholar 

  88. Seki, S., Habu, Y., Kawamura, T., Takeda, K., Dobashi, H., Ohkawa, T., Hiraide, H.: The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK 1.1 Ag-T cells in T helper 1 immune response. Immunol. Rev. 2000; 174: 35–46

    CrossRef  CAS  PubMed  Google Scholar 

  89. Sidransky, H., Murty, C.N., Verney, E.: Nutritional control of protein synthesis. Studies related to tryptophan-induced stimulation of nucleocytoplasmatic translocation of mRNA in rat liver. Amer. J. Pathol. 1984; 117: 298–309

    CAS  Google Scholar 

  90. Sies, H.: Strategies of antioxidant defense. Eur. J. Biochem. 1993; 215: 213–219

    CrossRef  CAS  PubMed  Google Scholar 

  91. Smedsrod, B., Pertoft, H., Gustafson, St., Laurent, T.C.: Scavenger functions of the liver endothelial cell. Biochem. J. 1990; 266: 313–327

    CAS  PubMed  Google Scholar 

  92. Solaas, K., Ulvestad, A., Soreide, O., Kase, B.F.: Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. J. Lipid Res. 2000; 41: 1154–1162

    CAS  PubMed  Google Scholar 

  93. Stocker, R., Glaze, A. N., Ames, B. N.: Antioxidant activity of albumin-bound bilirubin. Proc. Nat. Acad. Sci. 1987; 84: 5918–5922

    CAS  PubMed  Google Scholar 

  94. Strazzabosco, M.: Biliary tract physiology. Curr. Opin. Gastroenterol. 1998; 14: 395–401

    CAS  Google Scholar 

  95. Stricker, B.H.C.: Hepatic injury by drugs and environmental agents. Liver Ann. 1986; 5: 419–482

    CAS  Google Scholar 

  96. Suter, P.M., Schutz, Y., Jequier, E.: The effect of ethanol on fat storage in healthy subjects. New Engl. J. Med. 1992; 326: 983–987

    CAS  PubMed  Google Scholar 

  97. Ungemach, F.R.: Pathobiological mechanisms of hepatocellular damage following lipid peroxidation. Chem. Phys. Lipids 1987; 45: 171–205

    CAS  PubMed  Google Scholar 

  98. Vallee, B.L., Galdes, A.: The metallobiochemistry of zinc enzymes. Adv. Enzymol. 1984; 56: 283–430

    CAS  PubMed  Google Scholar 

  99. Vesell, E.S.: Pharmacogenetics: multiple interactions between genes and environment as determinants of drug response. Amer. J. Med. 1979; 66: 183–187

    CAS  PubMed  Google Scholar 

  100. Vlahcevic, Z.R., Pandak, W.M., Stravitz, R.T.: Regulation of bile acid biosynthesis. Gastroenterol. Clin. North Amer. 1999; 28: 1–25

    CAS  Google Scholar 

  101. Voigtmann, R.: Selen. Dtsch. Med. Wschr. 1993; 118: 1094–1095

    CAS  Google Scholar 

  102. Vulpe, C.D., Packman, S.: Cellular copper transport. Ann. Rev. Nutr. 1995; 15: 293–322

    CAS  Google Scholar 

  103. Weber, W.W., Hein, D.W.: N-Acetylation pharmacogenetics. Pharmacol. Rev. 1985; 37: 25–79

    CAS  PubMed  Google Scholar 

  104. Wilson, G.E., Davis, R.E.: Clinical chemistry of vitamin B6. Adv. Clin. Chem. 1983; 23: 1–68

    CAS  PubMed  Google Scholar 

  105. Wolf, C.R., Moll, E., Friedberg, T., Oesch, F., Buchmann, A., Kuhlmann, W.D. Kunz, H.W.: Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P 450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. Carcinogenesis 1984; 5: 993–1001

    CAS  PubMed  Google Scholar 

  106. Wolkoff, A.W.: Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin. Liver Dis. 1996; 16: 121–127

    CAS  PubMed  Google Scholar 

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(2006). Biochemistry and Functions of the Liver. In: Hepatology Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28977-1_3

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