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References
Akabas MH, Kaufmann C, Archdeacon P, Karlin A (1994) Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron 13:919–927
Aleu J, Ivorra I, Lejarreta M, González-Ros JM, Morales A, Ferragut JA (1997) Functional incorporation of P-glycoprotein into Xenopus oocyte plasma membrane fails to elicit a swelling-evoked conductance. Biochem Biophys Res Com 237:407–412
Andreasen TJ, McNamee MG (1980) Inhibition of ion permeability control properties of acetylcholine receptor from Torpedo californica by long-chain fatty acids. Biochemistry 19:4719–4726
Antollini SS, Soto MA, Bonini de Romanelli I, Gutierrez-Merino C, Sotomayor P, Barrantes FJ (1996) Physical state of bulk and protein-associated lipid in nicotinic acetylcholine receptor-rich membrane studied by laurdan generalized polarization and fluorescence energy transfer. Biophys J 70(3):1275–84
Anzai K, Takano C, Tanaka K, Kirino Y (1994) Asymmetrical lipid charge changes the subconducting state of the potassium channel from sarcoplasmic reticulum. Biochem Biophys Res Com 199:1081–1087
Arias HR (1998) Noncompetitive inhibition of nicotinic acetylcholine receptors by endogenous molecules. J Neurosci Res 52:369–379
Arshava B, Taran I, Xie H, Becker JM, Naider F (2002) High resolution NMR analysis of the seven transmembrane domains of a heptahelical receptor in organic-aqueous medium. Biopolymers 64:161–76
Baenziger JE, Chew JP (1997) Desensitization of the nicotinic acetylcholine receptor mainly involves a structural change in solvent-accessible regions of the polypeptide backbone. Biochemistry 36:3617–3624
Baenziger JE, Darsaut TE, Morris ML (1999) Internal dynamics of the nicotinic acetylcholine receptor in reconstituted membranes. Biochemistry 38:4905–11
Baezinger JE, Morris ML, Darsaut TE (2000) Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor. J Biol Chem 275:777–784
Barrantes FJ (1993) The lipid annulus of the nicotinic acetylcholine receptor as a locus of structural-functional interactions. In: Walts A (ed) Protein-lipid interactions. Elsevier, Amsterdam, pp 231–256
Barrantes FJ (2003) Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains. Curr Opin Drug Discov Develop 6:620–632
Barrantes FJ, Antollini SS, Blanton MP, Prieto M (2000) Topography of nicotinic acetylcholine receptor membrane-embedded domains. J Biol Chem 275:37333–37339
Bhushan A, McNamee MG (1993) Correlation of phospholipid structure with functional effects on the nicotinic acetylcholine receptor. A modulatory role for phosphatidic acid. Biophys J 64:716–723
Billah MM, Anthes JC (1990) The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J 269:281–291
Blanton MP, Wang HH (1991) Localization of regions of the Torpedo californica nicotinic acetylcholine receptor labeled with an aryl azide derivative of phosphatidylserine. Biochim Biophys Acta 5:1067:1–8
Blanton MP, Cohen JB (1994) Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications. Biochemistry 33:2859–2872
Blanton MP, McCardy EA, Huggins A, Parikh D (1998) Probing the structure of the nicotinic acetylcholine receptor with the hydrophobic photoreactive probes [125I]TID-BE and [125I]TIDPC/16. Biochemistry 37:14545–4555
Blanton MP, Cohen JB (1992) Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor. Biochemistry 31:3738–3750
Blanton MP, Wang HH (1990) Photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor with an aryl azide derivative of phosphatidylserine Biochemistry 29:1186–1194
Bouzat C, Barrantes FJ (1996) Modulation of muscle nicotinic aceylcholine receptors by the glucocorticoid hydrocortisone: possible allosteric mechanism of channel blockade. J Biol Chem 271:25835–25841
Bouzat C, Roccamo AM, Garbus I, Barrantes FJ (1998) Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics. Molec Pharmacol 54:146–153
Brown DA, London E (1997) Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem Biophys Res Commun 240:1–7
Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Ann Rev Cell Dev Biol 14:111–136
Brown DA, London E (2000) Structure and function of sphingolipid-and cholesterol-rich membrane rafts. J Biol Chem 275:17221–17224
Bruses JL, Chauvet N, Rutishauser U (2001) Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. J Neurosci 21:504–512
Buller AL, White M (1990) Altered patterns of N-linked glycosylation of the Torpedo acetylcholine receptor expressed in Xenopus oocytes. J Membrane Biol 115:179–189
Butler DH, McNamee MG (1993) FTIR analysis of nicotinic acetylcholine receptor secondary structure in reconstituted membranes. Biochim Biophys Acta 1150:17–24
Caldironi HA, ALonso TS (1996) Lipidic characterization of full-grown amphibian oocytes and their plasma membrane-enriched fractions. Lipids 31:651–656
Canti C, Bodas E, Marsal J, Solsona C (1998) Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes. Eur J Pharmacol 363:197–202
Cantor, RS (1997) Lateral pressures in cell membranes: a mechanism for modulation of protein function. J Phys Chem 101:1323–1325
Castresana J, Fernandez-Ballester G, Fernandez AM, Laynez JL, Arrondo JL, Ferragut JA, JM Gonzalez-Ros (1992) Protein structural effects of agonist binding to the nicotinic acetylcholine receptor. FEBS Lett 314:171–175
Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC (1998) Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science 282:2220–2226
Changeux JP (1990) The nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels. Trends Pharmacol Sci 11:485–492
Chiara DC, Dangott LJ, Eckenhoff RG, Cohen JB (2003) Idendtification of nicotinic aceylcholine receptor amino acids photolabeled by the volatile anesthetic halothane. Biochemistry 42:13457–13467
Corbin J, Methot N, Wang HH, Baenziger JE, Blanton MP (1998) Secondary structure analysis of individual transmembrane segments of the nicotinic acetylcholine receptor by circular dichroism and Fourier transform infrared spectroscopy. J Biol Chem 273:771–7
Corbin J, Wang HH, Blanton MP (1998) Identifying the cholesterol binding domain in the nicotinic acetylcholine receptor with [125I]azido-cholesterol. Biochim Biophys Acta 1414:65–74
Cordes FS, Bright JN, Sansom MS (2002) Proline-induced distortions of transmembrane helices. J Mol Biol 323:951–960
Criado, M, Eib H, Barrantes FJ (1984) Functional properties of the acetylcholine receptor incorporated in model lipid membranes Differential effects of chain length and head group of phospholipids on receptor affinity states and receptor-mediated ion translocation. J Biol Chem 259:9188–9198
Cruz-Martin A, Mercado JL, Rojas LV, McNamee MG, Lasalde-Dominicci JA (2001) Tryptophan substitutions at lipid-exposed positions of the gamma M3 transmembrane domain increase the macroscopic ionic current response of the Torpedo californica nicotinic acetylcholine receptor. J Membr Biol 183:61–70
Curtis L, Buisson B, Bertrand S, Bertrand D (2002) Potentiation of human 4 2 neuronal nicotinic acetylcholine receptor by estradiol. Molec Pharmacol 61:127–135
daCosta CJ, Ogrel AA, McCardy EA, Blanton MP, Baenziger JE (2002) Lipid-protein interactions at the nicotinic acetylcholine receptor A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers. J Biol Chem 277:201–208
daCosta CJ, Wagg ID, McKay ME, Baenziger JE (2004) Phosphatidic acid and phosphatidylserine have distinct structural and functional interactions with the nicotinic acetylcholine receptor. J Biol Chem 279:14967–14974
de Kruijff B (1997) Lipid polymorphism and biomembrane function. Curr Opin Chem Biol 1:564–9
de Planque MR, Bonev BB, Demmers JA, Greathouse DV, Koeppe RE 2nd, Separovic F, Watts A, Killian JA (2003) Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions. Biochemistry 42:5341–5348
de Planque MR, Goormaghtigh E, Greathouse DV, Koeppe RE 2nd, Kruijtzer JA, Liskamp RM, de Kruijff B, Killian JA (2001) Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry 40:5000–5010
Denisov G, Wanaski S, Luan P, Glaser M, McLaughlin S (1998) Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4,5-bisphosphate: an electrostatic model and experimental results. Biophys J 74:731–744
Dowhan W (1997) Molecular basis for membrane phospholipid diversity: why are there so many lipids? Annu Rev Biochem 66:199–232
Doyle DA (2004) Structural changes during ion channel gating. Trends Neurosci (6):298–302
Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69–77
Dreger M, Krauss M, Herrmann A, Hucho F (1997) Interactions of the nicotinic acetylcholine receptor transmembrane segments with the lipid bilayer in native receptor-rich membranes. Biochemistry 36:839–847
East JM, Melville D, Lee AG (1985) Exchange rates and numbers of annular lipids for the calcium and magnesium ion dependent adenosinetriphosphatase. Biochemistry 24:2615–2623
Ellena JF, Blazing MA, McNamee MG (1983) Lipid-protein interactions in reconstituted membranes containing acetylcholine receptor. Biochemistry 22:5523–3555
Esmann M, Marsh D (1985) Spin-label studies on the origin of the specificity of lipid-protein interactions in Na+,K+-ATPase membranes from Squalus acanthias. Biochemistry 24:3572–3578
Exton JH (1990) Signalling through phosphatidylcholine breakdown. J Biol Chem 265:1–4
Fernandez AM, Fernandez-Ballester G, Ferragut JA, Gonzalez-Ros JM (1993) Labeling of the nicotinic acetylcholine receptor by a photoactivatable steroid probe: effects of cholesterol and cholinergic ligands. Biochim Biophys Acta 1149:135–144
Fernandez-Ballester G, Castresana J, Fernandez AM, Arrondo JL, Ferragut JA, Gonzalez-Ros JM (1994) A role for cholesterol as a structural effector of the nicotinic acetylcholine receptor. Biochemistry 33:4065–4071
Finer-Moore J, Strooud RM (1984) Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci USA 81:155–9
Fong TM, McNamee MG (1986) Correlation between acetylcholine receptor function and structural properties of membranes. Biochemistry 25:830–40
Fong TM, McNamee MG (1987) Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes. Biochemistry 26:3871–80
Forman SA (1999) A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step. Biochemistry 38:14559–14564
Galzi JL, Edelstein SJ, Changeux JP (1996) The multiple phenotypes of allosteric receptor mutants. Proc Natl Acad Sci USA 93:1853–1858
Garbus I, Bouzat C, Barrantes FJ (2001) Steroids differentially inhibit the nicotinic aceylcholine receptor. Neuro Report 12:227–231
Garidel P, Johann C, Blume A (1997) Nonideal mixing and phase separation in phosphatidylcholine-phosphatidic acid mixtures as a function of acyl chain length and pH. Biophys J 72:2196–2210
Gentry CL, Lukas R (2001) Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther 299:1038–1048
Gonzalez-Ros JM, Llanillo M, Paraschos A, Martinez-Carrion M (1982) Lipid environment of acetylcholine receptor from Torpedo californica. Biochemistry 21:3467–74
Gonzalez-Ros JM, Paraschos A, Martinez-Carrion M (1980) Reconstitution of functional membrane-bound acetylcholine receptor from isolated Torpedo californica receptor protein and electroplax lipids. Proc Natl Acad Sci USA 198077:1796–1800
Guzman GR, Santiago J, Ricardo A, Marti-Arbona R, Rojas LV, Lasalde-Dominicci JA (2003) Tryptophan scanning mutagenesis in the alphaM3 transmembrane domain of the Torpedo californica acetylcholine receptor: functional and structural implications. Biochemistry 42:12243–50
Harder T, Scheiffele P, Verkade P, Simons K (1998) Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol 141:929–942
Harder T, Simons K (1997) Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr Opin Cell Biol 9:534–542
Heginbotham L, Kolmakova-Partensky L, Miller C (1998) Functional reconstitution of a prokaryotic K+ channel. J Gen Physiol 111:741–749
Hogg RC, Raggenbass M, Bertand D (2003) Nicotinic acetylcholine receptors: from structure to brain function. Rev Physiol Biochem Pharmacol 147:1–46
Hol WG, van Duijnen PT, Berendsen HJ (1978) The alpha-helix dipole and the properties of proteins. Nature 273:443–446
Hvidt A, Nielsen SO (1966) Hydrogen exchange in proteins. Adv Protein Chem 21:287–386
Ivorra I, Fernandez A, Gal B, Aleu J, Gonzalez-Ros JM, Ferragut JA, Morales A (2002) Protein orientation affects the efficiency of functional protein transplantation into the Xenopus oocyte membrane. J Membrane Biol 185:117–127
Jones OT, Eubanks JH, Earnest JP, McNamee MG (1988) A minimum number of lipids are required to support the functional properties of the nicotinic acetylcholine receptor. Biochemistry 27:3733–3742
Jones OT, McNamee MG (1988) Annular and nonannular binding sites for cholesterol associated with the nicotinic acetylcholine receptor. Biochemistry 27:2364–2374
Karlin A (2002) Emerging structure of the nicotinic acetylcholine receptor. Nat Rev Neurosci 3:102–114
Karlin A, Cox RN, Dipaola M, Holtzman E, Kao PN, Lobel P, Wang L, Yodh N (1986) Functional domains of the nicotinic acetylcholine receptor. Ann NY Acad Sci 463:53–69
Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL (2003) Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature 421:272–5
Katz B, Miledi R (1975) The effect of procaine on the action of acetylcholine at the neuromuscular junction. J Physiol 249:269–284
Ke L, Lukas RJ (1996) Effects of steroid exposure on ligand binding and functional activities of diverse nicotinic acetylcholine receptor subtypes. J Neurochem 67:1100–1112
Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA (2003) Crystal structure of the potassium channel KirBac11 in the closed state. Science 300:1922–1926
Latorre R, Labarca P, Naranjo D (1992) Surface charge effects on ion conduction in ion channels. Methods Enzymol 207:471–501
Le Cahèrec F, Bron P, Verbavatz JM, Garret A, Morel G, Cavalier A, Bonnec G, Thomas D, Gouranton J, Hubert JF (1996) Incorporation of proteins into (Xenopus) oocytes by proteoliposome microinjection: functional characterization of a novel aquaporin. J Cell Sci 109:1285–1295
Lee AG (1998) How lipids interact with an intrinsic membrane protein: the case of the calcium pump. Biochim Biophys Acta 1376:381–90
Lee AG (2003) Lipid-protein interactions in biological membranes: a structural perspective. Biochim Biophys Acta 1612:1–40
Lee AG (2004) How lipids affect the activities of integral membrane proteins. Biochim Biophys Acta 3:1666:62–87
Liu LP, Deber CM (1997) Anionic phospholipids modulate peptide insertion into membranes. Biochemistry 36(18):5476–5482
Liu Y, Dilger JP, Vidal AM (1994) Effects of alcohols and volatile anaesthetics on the activation of nicotinic acetylcholine receptor channels. Mol Pharmacol 45:1235–1241
Luan P, Yang L, Glaser M (1995) Formation of membrane domains created during the budding of vesicular stomatitis virus. A model for selective lipid and protein sorting in biological membranes. Biochemistry 34:9874–83
Lugovskoy AA, Maslennikov IV, Utkin YN, Tsetlin VI, Cohen JB, Arseniev AS (1998) Spatial structure of the M3 transmembrane segment of the nicotinic acetylcholine receptor alpha subunit. Eur J Biochem 255:455–461
Lundbaek JA, Birn P, Hansen AJ, Søgaard R, Nielsen C, Girshman J, Bruno MJ, Tape SE, Egebjerg J, Greathouse DV, Mattice GL, Koeppe II RE, Andersen OS (2004) Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of micelle-forming amphiphiles and cholesterol. J Gen Physiol 121:599–621
MacKinnon R (2003) Potassium channels. FEBS Lett 555:62–65
Marheineke K, Grunewald S, Christie W, Reilander H (1998) Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection. FEBS Lett 441:49–52
Marsal J, Tigy G, Miledi R (1995) Incorporation of acetylcholine receptors and Cl-channels in Xenopus oocytes injected with Torpedo electroplaque membranes. Proc Natl Acad Sci USA 92:5224–5228
Marsh D, Barrantes FJ (1978) Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata Proc Natl Acad Sci USA 73:4329–4333
Marsh D, Horvath LI (1998) Structure, dynamics and composition of the lipid-protein interface perspectives from spin-labelling. Biochim Biophys Acta 1376:267–296
Marsh D, Pali T (2004) The protein-lipid interface: perspectives from magnetic resonance and crystal structures. Biochim Biophys Acta 1666:118–41
Marsh D, Pellkofer R, Hoffmann-Bleihauer P, Sandhoff K (1982) Incorporation of lipids into cellular membranes — a spin-label assay. Anal Biochem 122:206–12
Marsh D, Watts A, Barrantes FJ (1981) Phospholipid chain immobilization and steroid rotational immobilization in acetylcholine receptor-rich membranes from Torpedo marmorata. Biochim Biophys Acta 645:97–101
Martens JR, Kwak YG, Tamkun MM (1999) Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc Med 8:253–258
Martens JR, Navarro-Polanco R, Coppock EA, Nishiyama A, Parshley L, Grobaski TD, Tamkum MM (2000) Differential targeting of shaker-like potassium channels to lipid rafts. J Biol Chem 275:7443–7446
Martinac B, Hamill OP (2002) Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness. Proc Natl Acad Sci USA 99:4308–4312
Maxfield FR (2002) Plasma membrana microdomains. Curr Opin Cell Biol 14:483–487
Methot N, McCarthy MP, Baenziger JE (1994) Secondary structure of the nicotinic acetylcholine receptor: implications for structural models of a ligand-gated ion channel. Biochemistry 33:7709–7717
Mielke DL, Wallace BA (1988) Secondary structural analyses of the nicotinic acetylcholine receptor as a test of molecular models. J Biol Chem 263(7):3177–3182
Miledi R, Dueñas Z, Martinez-Torres A, Kawas CH, Eusebi F (2004) Microtransplantation of functional receptors and channels from the Alzheimer’s brain to frog oocytes. Proc Natl Acad Sci USA 101:1760–1763
Miledi R, Eusebi F, MartÍnez-Torres A, Palma E, Trettel F (2002) Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes. Proc Natl Acad Sci USA 99:13238–13242
Miledi R, Parker I, Sumikawa K (1989) Transplanting receptors from brains into oocytes. In: Fidia Research Foundation Neuroscience Award Lectures 3, pp 57–90, Raven Press, New York
Miller AJ, Zhou JJ (2000) Xenopus oocytes as an expression system for plant transporters. Biochim Biophys Acta 1465:343–358
Miyazawa A, Fujiyoshi Y, Unwin N (2003) Structure and gating mechanism of the acetylcholine receptor pore. Nature 423:949–955
Moore WM, Holliday LA, Puett D, Brady RN (1974) On the conformation of the acetylcholine receptor protein from Torpedo nobiliana. FEBS Lett 45:145–149
Morales A, Aleu J, Ivorra I, Ferragut JA, González-Ros JM, Miledi R (1995) Incorporation of reconstituted acetylcholine receptors from Torpedo into the Xenopus oocyte membrane. Proc Natl Acad Sci USA 92:8468–8472
Neher E, Steinbach H (1978) Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol 277:153–176
Nurowska E, Ruzzier F (1996) Corticosterone modifies the murine muscle acetylcholine receptor channel kinetics. Neuro Report 8:77–80
Ochoa EL, A Chattopadhyay, MG McNamee (1989) Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators. Cell Mol Neurobiol 9:141–178
Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B (2004) Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science 304:265–270
Olivera S, Ivorra I, Morales A (2005) The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. Br J Pharmacol (in press)
Opekarová M, Tanner W (2003) Specific lipid requirements of membrane proteins — a putative bottleneck in heterologous expression. Biochim Biophys Acta 1610:11–22
Opella SJ, Marassi FM, Gesell JJ, Valente AP, Kim Y, Oblatt-Montal M, Montal M (1999) Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat Struct Biol 4:374–379
Ortiz-Acevedo A, Melendez M, Asseo AM, Biaggi N, Rojas LV, Lasalde-Dominicci JA (2004) Tryptophan scanning mutagenesis of the gammaM4 transmembrane domain of the acetylcholine receptor from Torpedo californica. J Biol Chem 279:42250–42257
Paas Y, Cartaud J, Recouvreur M, Grailhe R, Dufresne V, Pebay-Peyroula E, Landau EM, Changeux JP (2003) Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci USA 100:11309–11314
Palma E, Trettel F, Fucile S, Renzi M, MIledi R, Eusebi F (2003) Microtransplantation of membranes from cultured cells to Xenopus oocytes: A method to study neurotransmitter receptors embedded in native lipids. Proc Natl Acad Sci USA 100:2896–2900
Palsdottir H, Hunte C (2004) Lipids in membrane protein structures. Biochim Biophys Acta 1666:2–18
Paradiso K, Sabey K, Evers AS, Zormski CF, Covey DF, Steinbach JH (2000) Steroid inhibition of rat neuronal nicotinic 4 2 receptors experessed in HEK 293 cells. Mol Pharmacol 58:341–351
Paradiso K, Zhang J, Steinbach JH (2001) The C terminus of the human nicotinic 4 2 receptor forms a binding site required for potentiation by an estrogenic steroid. J Neurosci 21:6561–6568
Pashkov VS, Maslennikov IV, Tchikin LD, Efremov RG, Ivanov VT, Arseniev AS (1999) Spatial structure of the M2 transmembrane segment of the nicotinic acetylcholine receptor alpha-subunit. FEBS Lett 45:117–121
Pebay-Peyroula E, Rosenbusch JP (2001) High-resolution structures and dynamics of membrane protein-lipid complexes: a critique. Curr Opin Struct Biol 11:427–432
Perozo E, Cortes DM, Somporspisut P, Kloda A, Martinac B (2002) Open channel structure of MscL and gating mechanism of mechanosensitive channels. Nature 418:942–948
Pershina L, Hvidt A (1974) A study by the hydrogen-exchange method of the complex formed between the basic pancreatic trypsin inhibitor and trypsin. Eur J Biochem 48:339–344
Polozova A, Litman BJ (2000) Cholesterol dependent recruitment of di22:6-PC by a G proteincoupled receptor into lateral domains. Biophys J 79:2632–4263
Poveda JA, Encinar JA, Fernandez AM, Mateo CR, Ferragut JA, Gonzalez-Ros JM (2002) Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. Biochemistry 41:12253–12262
Powl AM, East JM, Lee AG (2005) Heterogeneity in the binding of lipid molecules to the surface of a membrane protein: hot spots for anionic lipids on the mechanosensitive channel of large conductance MscL and effects on conformation. Biochemistry 44:5873–5883
Revah F, Bertrand D, Galzi JL, Devillers-Thiery A, Mulle C, Hussy N, Bertrands S, Ballivet M, Changeux JP (1991) Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 353:846–849
Revah F, Galzi JL, Giraudat J, Haumont PY, Lederer F, Changeux JP (1990) The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel. Proc Natl Acad Sci USA 87:4675–4679
Sackmann E (1984) Physical basis for trigger processes and membrane structures. In: Chapman D (ed) Biological membranes, Vol. 5, Academic Press, London, pp 105–143
Sali D, Bycroft M, Fersht AR (1988) Stabilization of protein structure by interaction of alphahelix dipole with a charged side chain. Nature 335:740–743
Sanna E, Motzo C, Usala M, Pau D, Cagetti E, Biggio G (1998) Functional changes in rat nigral GABAA receptors induced by degeneration of the striatonigral GABAergic pathway: an electrophysiological study of receptors incorporated into Xenopus oocytes. J Neurochem 70:2539–2544
Sansom MS, Shrivastava IH, Bright JN, Tate J, Capener CE, Biggin PC (2002) Potassium channels: structures, models, simulations. Biochim Biophys Acta 1565(2):294–307
Santiago J, Guzmán GR, Rojas LV, Marti R, Asmar-Rovira GA, Santana LF, McNamee M, Lasalde-Dominicci JA (2001) Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation C418W in Xenopus oocytes. J Biol Chem 276:46523–46532
Santiago J, Guzman GR, Torruellas K, Rojas LV, Lasalde-Dominicci JA (2004) Tryptophan scanning mutagenesis in the TM3 domain of the Torpedo californica acetylcholine receptor beta subunit reveals an alpha-helical structure. Biochemistry 43:10064–70
Schlegel A, Volonte D, Engelman JA, Galbiati F, Mehta P, Zhang XL, Scherer PE, Lisanti MP (1998) Crowded little caves: structure and function of caveolae. Cell Signal 10:457–463
Shogomori H, Brown DA (2003) Use of detergents to study membrane rafts: the good, the bad, and the ugly. J Biol Chem 384:1259–1263
Simmonds AC, East JM, Jones OT, Rooney EK, McWhirter J, Lee AG (1982) Annular and non-annular binding sites on the (Ca2++Mg2+)-ATPase. Biochim Biophys Acta 693 398–406
Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569–572
Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31–39
Singer S, Nicolson GL (1972) The fluid mosaic model of cell membranes. Science 172:720–730
Sivilotti LG, Mcneil DK, Lewis TM, Nassar MA, Schoepfer R, Colquhoun D (1997) Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J Physiol 500:123–138
Soreq H, Seidman S (1992) Xenopus oocyte microinjection: from gene to protein. Meth Enzymol 207:225–265
Starace DM, Bezanilla F (2004) A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427:548–553
Stith BJ, Hall J, Ayres P, Waggoner L, Moore JD, Shaw WA (2000) Quantification of major classes of Xenopus phospholipids by high performance liquid chromatography with evaporative light scattering detection. J Lipid Res 41:1448–1454
Sukharev S, Betanzos M, Chiang CS, Guy HR (2001) The gating mechanism of the large mechanosensitive channel MscL. Nature 409:720–724
Sunshine C, McNamee MG (1992) Lipid modulation of nicotinic acetylcholine receptor function: the role of neutral and negatively charged lipids. Biochim Biophys Acta 1108:240–246
Sunshine C, McNamee MG (1994) Lipid modulation of nicotinic acetylcholine receptor function: the role of membrane lipid composition and fluidity. Biochim Biophys Acta 1191:59–64
Tamamizu S, Guzman GR, Santiago J, Rojas LV, McNamee MG, Lasalde-Dominicci JA (2000) Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry 39:4666–73
Tillman TS, Cascio M (2003) Effects of membrane lipids on ion channel structure and function. Cell Biochem Biophys 38:161–190
Toyoshima C, Unwin N (1998) Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes. Nature 336:247–250
Turnheim K, Gruber J, Cristoph W, Ruiz Gutierrez V (1999) Membrane phospholipids composition affects function of potassium channels from rabit colon epithelium. Am Phys Soc 277:83–90
Unwin N (1993) Nicotinic acetylcholine receptor at 9 Å resolution. J Mol Biol 229:1101–1124
Unwin N (1995) Acetylcholine receptor channel imaged in the open state. Nature 373:37–43
Unwin N (2003) Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett 555:91–95
Valera S, Ballivet M, Bertrand D (1992) Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 89:9949–9953
Valiyaveetil FI, Zhou Y, Mackinnon R (2002) Lipids in the structure, folding and function of the KcsA K+ channel. Biochemistry 41:10771–10777
van den Brink-van der Laan E, Killian JA, de Kruijff B (2004) Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile. Biochim Biophys Acta 1666:275–288
Villar MT, Artigues A, Ferragut JA, Gonzalez-Ros JM (1988) Phospholipase A2 hydrolysis of membrane phospholipids causes structural alteration of the nicotinic acetylcholine receptor. Biochim Biophys Acta 938:35–43
Wenz JJ, Barrantes FJ (2005) Nicotinic acetylcholine receptor induces lateral segregation of phosphatidic acid and phosphatidylcholine in reconstituted membranes. Biochemistry 44(1):398–410
White BH, Cohen JB (1992) Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic non-competitive antagonist. J Biol Chem 267:15770–15783
Williamson IM, Alvis SM, East JM, Lee AG (2002) Interactions of phospholipids with the potassium channel KcsA. Biophys J 83:2026–2038
Williamson PT, Meier BH, Watts A (2004) Structural and functional studies of the nicotinic acetylcholine receptor by solid-state NMR. Eur Biophys J 33(3):247–54
Wu L, Bauer CS, Zhen XG, Xie C, Yang J (2002) Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2. Nature 419:947–952
Yager P, Chang EL, Williams RW, Dalziel AW (1984) The secondary structure of acetylcholine receptor reconstituted in a single lipid component as determined by Raman spectroscopy. Biophys J 45:26–28
Zhang H, Karlin A (1997) Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit. Biochemistry 36:15856–15864
Zhou Y, Morals-Cabral JH, Kaufman A, Mackinnon R (2001) Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution. Nature 414:43–48
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Fernández, A.M., Poveda, J.A., Encinar, J.A., Morales, A., González-Ros, J.M. (2006). Structural and Functional Modulation of Ion Channels by Specific Lipids: from Model Systems to Cell Membranes. In: Mateo, C.R., Gómez, J., Villalaín, J., González-Ros, J.M. (eds) Protein-Lipid Interactions. Springer Series in Biophysics, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28435-4_8
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