Liver Metastases

  • Andreas Lubienski
  • Thorsten Leibecke
  • Karin Lubienski
  • Thomas Helmberger
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 167)


Liver Metastasis Radiofrequency Ablation Hepatic Metastasis Colorectal Liver Metastasis Ablation Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lencioni R, Crocetti L, Cioni D, Della Pina C, Bartolozzi C (2004) Percutaneous radiofrequency ablation of hepatic colorectal metastases: technique, indications, results, and new promises. Invest Radiol 39:689–697PubMedCrossRefGoogle Scholar
  2. 2.
    Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics, 1999. CA Cancer J Clin 49:8–31PubMedGoogle Scholar
  3. 3.
    Choti MA, Bulkley GB (1999) Management of hepatic metastases. Liver Transplant Surg 5:65–80CrossRefGoogle Scholar
  4. 4.
    Scheele J, Altendorf-Hofmann A, Grube T, Hohenberger W, Stangl R, Schmidt K (2001) Resection of colorectal liver metastases. What prognostic factors determine patient selection? Chirurg 72:547–560PubMedCrossRefGoogle Scholar
  5. 5.
    Redaelli CA, Dufour JF, Wagner M, Schilling M, Hüsler J, Krähenbühl L, Büchler MW, Reichen J (2002) Preoperative galactose elimination capacity predicts complications and survival after hepatic resection. Ann Surg 235:77–85PubMedCrossRefGoogle Scholar
  6. 6.
    Ott R, Wein A, Hohenberger W (2001) Liver metastases-primary or multimodal therapy? Chirurg 71:887–897CrossRefGoogle Scholar
  7. 7.
    Topham C, Adam R (2002) Oncosurgery: a new reality in metastatic colorectal carcinoma. Semin Oncol 29[Suppl 15]:3–10PubMedCrossRefGoogle Scholar
  8. 8.
    Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335–2342PubMedCrossRefGoogle Scholar
  9. 9.
    Gillams AR, Lees WR (2004) Radio-frequency ablation of colorectal liver metastases in 167 patients. Eur Radiol 14:2261–2267PubMedCrossRefGoogle Scholar
  10. 10.
    Gillams A (2001) Thermal ablation of liver metastases. Abdominal Imaging 26:361–368PubMedCrossRefGoogle Scholar
  11. 11.
    Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF, Goldberg SN (2003) Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 226:441–451PubMedGoogle Scholar
  12. 12.
    Kainuma O, Asano T, Aoyama H, Takayama W, Nakagohri T, Kenmochi T, Hasegawa M, Tokoro Y, Sasagawa S, Ochiai T (1999) Combined therapy with radiofrequency thermal ablation and intra-arterial infusion chemotherapy for hepatic metastases from colorectal cancer. Hepatogastroenterology 46:1071–1077PubMedGoogle Scholar
  13. 13.
    Solbiati L, Ierace T, Goldberg SN, Sironi S, Livraghi T, Fiocca R, Servadio G, Rizzatto G, Mueller PR, Del Maschio A, Gazelle GS (1997) Percutaneous US-guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 202:195–203PubMedGoogle Scholar
  14. 14.
    McGahan JP, Dodd GD III (2001) Radiofrequency ablation of the liver: current status. Am J Roentgenol 176:3–16Google Scholar
  15. 15.
    Chen MH, Yang W, Yan K, Zou MW, Solbiati L, Liu JB, Dai Y (2004) Large liver tumors: protocol for radiofrequency ablation and its clinical application in 110 patients-mathematic model, overlapping mode, and electrode placement process. Radiology 232:260–271PubMedGoogle Scholar
  16. 16.
    Dodd GD 3rd, Frank MS, Aribandi M, Chopra S, Chintapalli KN (2001) Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations. AJR Am J Roentgenol 177:777–782PubMedGoogle Scholar
  17. 17.
    Gillams AR (2005) The use of radiofrequency in cancer. Br J Cancer 92:1825–1829PubMedCrossRefGoogle Scholar
  18. 18.
    Atwell TD, Charboneau JW, Que FG, Rubin J, Lewis BD, Nagorney DM, Callstrom MR, Farrell MA, Pitot HC, Hobday TJ (2005) Treatment of neuroendocrine cancer metastatic to the liver: the role of ablative techniques. Cardiovasc Intervent Radiol 228:409–421CrossRefGoogle Scholar
  19. 19.
    Dromain C, de Baere T, Elias D, Kuoch V, Ducreux M, Boige V, Petrow P, Roche A, Sigal R (2002) Hepatic tumors treated with percutaneous radio-frequency ablation: CT and MR imaging follow-up. Radiology 223:255–262PubMedGoogle Scholar
  20. 20.
    Lim HK, Choi D, Lee WJ, Kim SH, Lee SJ, Jang HJ, Lee JH, Lim JH, Choo IW (2001) Hepatocellular carcinoma treated with percutaneous radiofrequency ablation: evaluation with follow-up multiphase helical CT. Radiology 221:447–454PubMedGoogle Scholar
  21. 21.
    Limanond P, Zimmerman P, Raman SS, Kadell BM, Lu DS (2003) Interpretation of CT and MRI after radiofrequency ablation of hepatic malignancies. Am J Roentgenol 181:1635–1640Google Scholar
  22. 22.
    Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK (2000) Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 88:2452–2463PubMedCrossRefGoogle Scholar
  23. 23.
    Dupuy DE, Goldberg SN (2001) Image-guided radiofrequency tumor ablation: challenges and opportunities-Part II. J Vasc Interv Radiol 12:1135–1148PubMedGoogle Scholar
  24. 24.
    Choi H, Loyer EM, DuBrow RA, Kaur H, David CL, Huang S, Curley S, Charnsangavej C (2001) Radio-frequency ablation of liver tumors: assessment of therapeutic response and complications. RadioGraphics 21: S41–S54PubMedGoogle Scholar
  25. 25.
    Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK (2000) Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 88:2452–2463PubMedCrossRefGoogle Scholar
  26. 26.
    Sironi S, Livraghi T, Meloni F, DeCobelli F, Ferero CG, Del Maschio A (1999) Small hepatocellular carcinoma treated with percutaneous RF ablation: MR imaging follow-up. Am J Roentgenol 173:1225–1229Google Scholar
  27. 27.
    Solbiati L, Ierace T, Tonolini M, Osti V, Cova L (2001) Radiofrequency thermal ablation of hepatic metastases. Eur J Ultrasound 13:149–158PubMedCrossRefGoogle Scholar
  28. 28.
    Lim HK, Han JK (2002) Hepatocellular carcinoma: evaluation of therapeutic response to interventional procedures. Abdom Imaging 27:168–179PubMedCrossRefGoogle Scholar
  29. 29.
    Tacke J (2003) Percutaneous radiofrequency ablation-clinical indications and results. Fortschr Roentgenstr 175:156–168CrossRefGoogle Scholar
  30. 30.
    Pereira PL, Clasen S, Boss A, Schmidt D, Gouttefangeas C, Burkart C, Wiskirchen J, Tepe G, Claussen CD (2004) Radiofrequency ablation of liver metastases. Radiologe 44:347–357PubMedCrossRefGoogle Scholar
  31. 31.
    Veit P, Antoch G, Stergar H, Bockisch A, Forsting M, Kuehl H (2005) Detection of residual tumor after radiofrequency ablation of liver metastasis with dual-modality PET/CT: initial results. Eur Radiol16:80–87Google Scholar
  32. 32.
    Barker DW, Zagoria RJ, Morton KA, Kavanagh PV, Shen P (2005) Evaluation of liver metastases after radiofrequency ablation: utility of 18F-FDG PET and PET/CT. Am J Roentgenol 184:1096–1102Google Scholar
  33. 33.
    Goldberg SN, Grassi CJ, Cardella JF, Charboneau JW, Dodd III GD, Dupuy DE, Gervais D, Gillams AR, Kane RA, Lee FT Jr, Livraghi T, McGahan J, Phillips DA, Rhim H, Silverman SG, For the Society of Interventional Radiology Technology Assessment Committee and the International Working Group on Image-Guided Tumor Ablation (2005) Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology 235:728–739PubMedGoogle Scholar
  34. 34.
    Solbiati L, Goldberg SN, Ierace T, Livraghi T, Meloni F, Dellanoce M, Sironi S, Gazelle GS (1997) Hepatic metastases: percutaneous radiofrequency ablation with cooled-tip electrodes. Radiology 205:367–373PubMedGoogle Scholar
  35. 35.
    Lencioni R, Goletti O, Armillotta N, Paolicchi A, Moretti M, Cioni D, Donati F, Cicorelli A, Ricci S, Carrai M, Conte PF, Cavina E, Bartolozzi C (1998) Radio-frequency thermal ablation of liver metastases with a cooled-tip electrode needle: results of a pilot clinical trial. Eur Radiol 8:1205–1211PubMedCrossRefGoogle Scholar
  36. 36.
    Seidenfeld J, Korn A, Aronson N (2002) Radiofrequency ablation of unresectable liver metastases. J Am Coll Surg 195:378–386PubMedCrossRefGoogle Scholar
  37. 37.
    Solbiati L, Ierace T, Goldberg SN, Sironi S, Livraghi T, Fiocca R, Servadio G, Rizzatto G, Mueller PR, Del Maschio A, Gazelle GS (1997) Percutaneous US-guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 202:195–203PubMedGoogle Scholar
  38. 38.
    Jaeck D, Bachellier PGM, Boudjema K, Vaillant JC, Balladur P, Nordlinger B (1997) Long-term survival following resection of colorectal hepatic metastases. Association Française de Chirurgie. Br J Surg 84:977–980PubMedCrossRefGoogle Scholar
  39. 39.
    Jenkins LT, Millikan KW, Bines SD, Staren ED, Doolas A (1997) Hepatic resection for metastatic colorectal cancer. Am Surg 63:605–610PubMedGoogle Scholar
  40. 40.
    Bowles BJ, Machi J, Limm WM, Severino R, Oishi AJ, Furumoto NL, Wong LL, Oishi RH (2001) Safety and efficacy of radiofrequency thermal ablation in advanced liver tumors. Arch Surg 136:864–869PubMedCrossRefGoogle Scholar
  41. 41.
    Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA (2004) Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 239:818–825; discussion 825–827PubMedCrossRefGoogle Scholar
  42. 42.
    Oshowo A, Gillams A, Harrison E, Lees WR, Taylor I (2003) Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases. Br J Surg 90:1240–1243PubMedCrossRefGoogle Scholar
  43. 43.
    Elias D, De Baere T, Smayra T, Ouellet JF, Roche A, Lasser P (2002) Percutaneous radiofrequency thermoablation as an alternative to surgery for treatment of liver tumour recurrence after hepatectomy. Br J Surg 89:752–756PubMedCrossRefGoogle Scholar
  44. 44.
    Livraghi T, Solbiati L, Meloni F, Ierace T, Goldberg SN, Gazelle GS (2003) Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the “test-of-time approach”. Cancer 97:3027–3035PubMedCrossRefGoogle Scholar
  45. 45.
    Mulier S, Mulier P, Ni Y, Miao Y, Dupas B, Marchal G, De Wever I, Michel L (2002) Complications of radiofrequency coagulation of liver tumours. Br J Surg 89:1206–1222PubMedCrossRefGoogle Scholar
  46. 46.
    De Baere T, Risse O, Kuoch V, Dromain C, Sengel C, Smayra T, El Din MG, Letoublon C, Elias D (2003) Adverse events during radiofrequency treatment of 582 hepatic tumors. AJR 181:695–700PubMedGoogle Scholar
  47. 47.
    Llovet JM, Vilana R, Bru C, Bianchi L, Salmeron JM, Boix L, Ganau S, Sala M, Pages M, Ayuso C, Sole M, Rodes J, Bruix J; Barcelona Clinic Liver Cancer (BCLC) Group (2001) Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma. Hepatology 33:1124–1129PubMedCrossRefGoogle Scholar
  48. 48.
    Livraghi T, Lazzaroni S, Meloni F, Solbiati L (2005) Risk of tumour seeding after percutaneous radiofrequency ablation for hepatocellular carcinoma. Br J Surg 92:856–858PubMedCrossRefGoogle Scholar
  49. 49.
    Jaskolka JD, Asch MR, Kachura JR, Ho CS, Ossip M, Wong F, Sherman M, Grant DR, Greig PD, Gallinger S (2005) Needle tract seeding after radiofrequency ablation of hepatic tumors. J Vasc Interv Radiol 16:485–491PubMedGoogle Scholar
  50. 50.
    Gillams AR, Lees WR (2000) Survival after percutaneous, image-guided, thermal ablation of hepatic metastases from colorectal cancer. Dis Colon Rectum 43:656–661PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Andreas Lubienski
    • 1
  • Thorsten Leibecke
  • Karin Lubienski
  • Thomas Helmberger
  1. 1.Institute of RadiologyUniversity Hospital Schleswig-HolsteinLübeckGermany

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