Thermal Ablation in Bone Tumors

  • Bernhard Gebauer
  • Per-Ulf Tunn
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 167)


Radiofrequency Ablation Thermal Ablation Osteoid Osteoma Skeletal Metastasis Symptomatic Bone Metastasis 
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  1. 1.
    Rhim H, Goldberg SN, Dodd GD 3rd et al. (2001) Essential techniques for successful radio-frequency thermal ablation of malignant hepatic tumors. Radiographics 21:S17–S35; discussion S36–S39PubMedGoogle Scholar
  2. 2.
    Goldberg SN, Gazelle GS, Mueller PR (2000) Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol 174:323–331PubMedGoogle Scholar
  3. 3.
    Ahmed M, Liu Z, Afzal KS et al. (2004) Radio-frequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model. Radiology 230:761–767PubMedGoogle Scholar
  4. 4.
    Vogl TJ, Mack MG, Muller PK et al. (1999) Interventional MR: interstitial therapy. Eur Radiol 9:1479–1487PubMedCrossRefGoogle Scholar
  5. 5.
    Matsumoto R, Selig AM, Colucci VM et al. (1992) Interstitial Nd:YAG laser ablation in normal rabbit liver: trial to maximize the size of laser-induced lesions. Lasers Surg Med 12:650–658PubMedGoogle Scholar
  6. 6.
    Vogl TJ, Mack MG, Roggan A et al. (1998) Internally cooled power laser for MR-guided interstitial laser-induced thermotherapy of liver lesions: initial clinical results. Radiology 209:381–385PubMedGoogle Scholar
  7. 7.
    Organ LW (1976) Electrophysiologic principles of radiofrequency lesion making. Appl Neurophysiol 39:69–76PubMedGoogle Scholar
  8. 8.
    Goldberg SN, Dupuy DE (2001) Image-guided radiofrequency tumor ablation: challenges and opportunities — part I. J Vasc Interv Radiol 12:1021–1032Google Scholar
  9. 9.
    Dupuy DE, Goldberg SN (2001) Image-guided radiofrequency tumor ablation: challenges and opportunities — part II. J Vasc Interv Radiol 12:1135–1148PubMedGoogle Scholar
  10. 10.
    Goldberg SN, Gazelle GS, Dawson SL et al. (1995) Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 2:670–674PubMedGoogle Scholar
  11. 11.
    Livraghi T, Goldberg SN, Monti F et al. (1997) Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 202:205–210PubMedGoogle Scholar
  12. 12.
    Miao Y, Ni Y, Yu J et al. (2001) An ex vivo study on radiofrequency tissue ablation: increased lesion size by using an “expandable-wet” electrode. Eur Radiol 11:1841–1847PubMedCrossRefGoogle Scholar
  13. 13.
    Lencioni R, Goletti O, Armillotta N et al. (1998) Radio-frequency thermal ablation of liver metastases with a cooled-tip electrode needle: results of a pilot clinical trial. Eur Radiol 8:1205–1211PubMedCrossRefGoogle Scholar
  14. 14.
    Anderson RL, Kapp DS (1990) Hyperthermia in cancer therapy: current status. Med J Aust 152:310–315PubMedGoogle Scholar
  15. 15.
    Nath S, Haines DE (1995) Biophysics and pathology of catheter energy delivery systems. Prog Cardiovasc Dis 37:185–204PubMedCrossRefGoogle Scholar
  16. 16.
    Kennedy JE, Ter Haar GR, Cranston D (2003) High intensity focused ultrasound: surgery of the future? Br J Radiol 76:590–599PubMedCrossRefGoogle Scholar
  17. 17.
    Kennedy JE (2005) High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer 5:321–327PubMedCrossRefGoogle Scholar
  18. 18.
    Wu F, Wang ZB, Chen WZ et al. (2004) Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience. Ultrasound Med Biol 30:245–260PubMedCrossRefGoogle Scholar
  19. 19.
    Jaffe HL (1935) Osteoid osteoma: a benign osteoblastic tumor composed of osteoid and atypical bone. Arch Surg 31:709–728Google Scholar
  20. 20.
    Mungo DV, Zhang X, O’Keefe RJ et al. (2002) COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res 20:159–162PubMedCrossRefGoogle Scholar
  21. 21.
    Sim FH, Dahlin CD, Beabout JW (1975) Osteoidosteoma: diagnostic problems. J Bone Joint Surg Am 57:154–159PubMedGoogle Scholar
  22. 22.
    Campanacci M, Ruggieri P, Gasbarrini A et al. (1999) Osteoid osteoma. Direct visual identification and intralesional excision of the nidus with minimal removal of bone. J Bone Joint Surg Br 81:814–820PubMedCrossRefGoogle Scholar
  23. 23.
    Kneisl JS, Simon MA (1992) Medical management compared with operative treatment for osteoid osteoma. J Bone Joint Surg Am 74:179–185PubMedGoogle Scholar
  24. 24.
    Marcove RC, Heelan RT, Huvos AG et al. (1991) Osteoid osteoma. Diagnosis, localization, and treatment. Clin Orthop Relat Res 267:197–201PubMedGoogle Scholar
  25. 25.
    Rosenthal DI, Hornicek FJ, Wolfe MW et al. (1998) Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am 80:815–821PubMedGoogle Scholar
  26. 26.
    Pfeiffer M, Sluga M, Windhager R et al. (2003) Surgical treatment of osteoid osteoma of the extremities. Z Orthop Ihre Grenzgeb 141:345–348PubMedCrossRefGoogle Scholar
  27. 27.
    Sluga M, Windhager R, Pfeiffer M et al. (2002) Peripheral osteoid osteoma. Is there still a place for traditional surgery? J Bone Joint Surg Br 84:249–251PubMedCrossRefGoogle Scholar
  28. 28.
    Rosenthal DI, Alexander A, Rosenberg AE et al. (1992) Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure. Radiology 183:29–33PubMedGoogle Scholar
  29. 29.
    Binkert CA, Nanz D, Bootz F et al. (2002) Laserinduced thermotherapy of the vertebral body: preliminary assessment of safety and real-time magnetic resonance monitoring in an animal model. Invest Radiol 37:557–561PubMedCrossRefGoogle Scholar
  30. 30.
    Cove JA, Taminiau AH, Obermann WR et al. (2000) Osteoid osteoma of the spine treated with percutaneous computed tomography-guided thermocoagulation. Spine 25:1283–1286PubMedCrossRefGoogle Scholar
  31. 31.
    Gangi A, Basille A, Buy X et al. (2005) Radiofrequency and laser ablation of spinal lesions. Semin Ultrasound CT MR 26:89–97PubMedCrossRefGoogle Scholar
  32. 32.
    Samaha EI, Ghanem IB, Moussa RF et al. (2005) Percutaneous radiofrequency coagulation of osteoid osteoma of the “Neural Spinal Ring”. Eur Spine J 14:702–705PubMedCrossRefGoogle Scholar
  33. 33.
    Hadjipavlou AG, Lander PH, Marchesi D et al. (2003) Minimally invasive surgery for ablation of osteoid osteoma of the spine. Spine 28:E472–E477PubMedCrossRefGoogle Scholar
  34. 34.
    Erdtmann B, Duda SH, Pereira P et al. (2001) CT-guided therapy of osteoid osteoma by drill trepanation of the nidus. Clinical follow-up results. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 173:708–713PubMedCrossRefGoogle Scholar
  35. 35.
    Klose KC, Forst R, Vorwerk D et al. (1991) The percutaneous removal of osteoid osteomas via CT-guided drilling. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 155:532–537PubMedGoogle Scholar
  36. 36.
    Kohler R, Rubini J, Postec F et al. (1995) Treatment of osteoid osteoma by CT-controlled percutaneous drill resection. Apropos of 27 cases. Rev Chir Orthop Reparatrice Appar Mot 81:317–325PubMedGoogle Scholar
  37. 37.
    Adam G, Neuerburg J, Vorwerk D et al. (1997) Percutaneous treatment of osteoid osteomas: combonation of drill biopsy and subsequent ethanol injection. Semin Musculoskelet Radiol 1:281–284PubMedGoogle Scholar
  38. 38.
    Sanhaji L, Gharbaoui IS, Hassani RE et al. (1996) A new treatment of osteoid osteoma: percutaneous sclerosis with ethanol under scanner guidance. J Radiol 77:37–40PubMedGoogle Scholar
  39. 39.
    Duda SH, Schnatterbeck P, Harer T et al. (1997) Treatment of osteoid osteoma with CT-guided drilling and ethanol instillation. Dtsch Med Wochenschr 122:507–510PubMedGoogle Scholar
  40. 40.
    Baker RC, Kramer RE (1999) Cytotoxicity of short-chain alcohols. Annu Rev Pharmacol Toxicol 39:127–150PubMedCrossRefGoogle Scholar
  41. 41.
    Jemal A, Thomas A, Murray T et al. (2002) Cancer statistics, 2002. CA Cancer J Clin 52:23–47PubMedGoogle Scholar
  42. 42.
    Jemal A, Murray T, Ward E et al. (2005) Cancer statistics, 2005. CA Cancer J Clin 55:10–30PubMedGoogle Scholar
  43. 43.
    Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1:571–573CrossRefGoogle Scholar
  44. 44.
    Liotta LA, Kohn E (1990) Cancer invasion and metastases. JAMA 263:1123–1126PubMedCrossRefGoogle Scholar
  45. 45.
    Woodhouse EC, Chuaqui RF, Liotta LA (1997) General mechanisms of metastasis. Cancer 80[8 Suppl]:1529–1537PubMedCrossRefGoogle Scholar
  46. 46.
    Nielsen OS (1996) Palliative treatment of bone metastases. Acta Oncol 35[Suppl 5]:58–60PubMedGoogle Scholar
  47. 47.
    Nielsen OS, Munro AJ, Tannock IF (1991) Bone metastases: pathophysiology and management policy. J Clin Oncol 9:509–524PubMedGoogle Scholar
  48. 48.
    Campa JA 3rd, Payne R (1992) The management of intractable bone pain: a clinician’s perspective. Semin Nucl Med 22:3–10PubMedCrossRefGoogle Scholar
  49. 49.
    Serafini AN (2001) Therapy of metastatic bone pain. J Nucl Med 42:895–906PubMedGoogle Scholar
  50. 50.
    Serafini AN, Houston SJ, Resche I et al. (1998) Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trial. J Clin Oncol 16:1574–1581PubMedGoogle Scholar
  51. 51.
    Palmedo H, Manka-Waluch A, Albers P et al. (2003) Repeated bone-targeted therapy for hormone-refractory prostate carcinoma: tandomized phase II trial with the new, high-energy radiopharmaceutical rhenium-188 hydroxyethylidenediphosphonate. J Clin Oncol 21:2869–2875PubMedCrossRefGoogle Scholar
  52. 52.
    Aaronson NK, Ahmedzai S, Bergman B et al. (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376PubMedGoogle Scholar
  53. 53.
    Pereira J, Lawlor P, Vigano A et al. (2001) Equianalgesic dose ratios for opioids. A critical review and proposals for long-term dosing. J Pain Symptom Manage 22:672–687PubMedCrossRefGoogle Scholar
  54. 54.
    Ware JE Jr, Gandek B (1998) Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol 51:903–912PubMedCrossRefGoogle Scholar
  55. 55.
    Daut RL, Cleeland CS, Flanery RC (1983) Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain 17:197–210PubMedCrossRefGoogle Scholar
  56. 56.
    Mirels H (1989) Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res 249:256–264PubMedGoogle Scholar
  57. 57.
    Dupuy DE, Safran H, Mayo-Smith WW et al. (1998) Radiofrequency ablation of painful osseous metastases (abstract). Radiology 202[Suppl]:389Google Scholar
  58. 58.
    Janjan N (2001) Bone metastases: approaches to management. Semin Oncol 28[4 Suppl11]:28–34PubMedCrossRefGoogle Scholar
  59. 59.
    Janjan NA (1997) Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals. Cancer 80[8Suppl]:1628–1645PubMedCrossRefGoogle Scholar
  60. 60.
    Friedl G, Tauss J, Portugaller RH et al. (2004) Die perkutane Radiofrequenzablation (PRFA) bei symptomatischen sekundär-neoplastischen Knochenläsionen. Z Orthop Ihre Grenzgeb 142:727–734PubMedCrossRefGoogle Scholar
  61. 61.
    Schaefer O, Lohrmann C, Herling M et al. (2002) Combined radiofrequency thermal ablation and percutaneous cementoplasty treatment of a pathologic fracture. J Vasc Interv Radiol 13:1047–1050PubMedGoogle Scholar
  62. 62.
    Schaefer O, Lohrmann C, Markmiller M et al. (2003) Technical innovation. Combined treatment of a spinal metastasis with radiofrequency heat ablation and vertebroplasty. AJR Am J Roentgenol 180:1075–1077PubMedGoogle Scholar
  63. 63.
    Cotten A, Demondion X, Boutry N et al. (1999) Therapeutic percutaneous injections in the treatment of malignant acetabular osteolyses. Radiographics 19:647–653PubMedGoogle Scholar
  64. 64.
    Cotten A, Boutry N, Cortet B et al. (1998) Percutaneous vertebroplasty: state of the art. Radiographics 18:311–320; discussion 320–313PubMedGoogle Scholar
  65. 65.
    Gangi A, Dietemann JL, Schultz A et al. (1996) Interventional radiologic procedures with CT guidance in cancer pain management. Radiographics 16:1289–1304; discussion 1304–1306PubMedGoogle Scholar
  66. 66.
    Ahmed M, Liu Z, Lukyanov AN et al. (2005) Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology 235:469–477PubMedGoogle Scholar
  67. 67.
    Goldberg SN, Saldinger PF, Gazelle GS et al. (2001) Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intratumoral doxorubicin injection in a rat breast tumor model. Radiology 220:420–427PubMedGoogle Scholar
  68. 68.
    Gronemeyer DH, Seibel RM (1993) Mikroinvasive CT-gesteuerte Tumortherapie von Weichteil-und Sklettmetastasen. Wien Med Wochenschr 143:312–321PubMedGoogle Scholar
  69. 69.
    Tobinick EL (2003) Targeted etanercept for treatment-refractory pain due to bone metastasis: two case reports. Clin Ther 25:2279–2288PubMedCrossRefGoogle Scholar
  70. 70.
    Kolotas C, Baltas D, Zamboglou N (1999) CT-based interstitial HDR brachytherapy. Strahlenther Onkol 175:419–427PubMedCrossRefGoogle Scholar
  71. 71.
    Rosenthal DI, Hornicek FJ, Torriani M et al. (2003) Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology 229:171–175PubMedGoogle Scholar
  72. 72.
    Rimondi E, Bianchi G, Malaguti MC et al. (2005) Radiofrequency thermoablation of primary nonspinal osteoid osteoma: optimization of the procedure. Eur Radiol 15:1393–1399PubMedCrossRefGoogle Scholar
  73. 73.
    Vanderschueren GM, Taminiau AH, Obermann WR et al. (2002) Osteoid osteoma: clinical results with thermocoagulation. Radiology 224:82–86PubMedGoogle Scholar
  74. 74.
    Lindner NJ, Ozaki T, Roedl R et al. (2001) Percutaneous radiofrequency ablation in osteoid osteoma. J Bone Joint Surg Br 83:391–396PubMedCrossRefGoogle Scholar
  75. 75.
    Woertler K, Vestring T, Boettner F et al. (2001) Osteoid osteoma: CT-guided percutaneous radiofrequency ablation and follow-up in 47 patients. J Vasc Interv Radiol 12:717–722PubMedGoogle Scholar
  76. 76.
    Cioni R, Armillotta N, Bargellini I et al. (2004) CT-guided radiofrequency ablation of osteoid osteoma: long-term results. Eur Radiol 14:1203–1208PubMedCrossRefGoogle Scholar
  77. 77.
    Gangi A, Dietemann JL, Clavert JM et al. (1998) Treatment of osteoid osteoma using laser photocoagulation. Apropos of 28 cases. Rev Chir Orthop Reparatrice Appar Mot 84:676–684PubMedGoogle Scholar
  78. 78.
    Witt JD, Hall-Craggs MA, Ripley P et al. (2000) Interstitial laser photocoagulation for the treatment of osteoid osteoma. J Bone Joint Surg Br 82:1125–1128PubMedCrossRefGoogle Scholar
  79. 79.
    Ghanem I, Collet LM, Kharrat K et al. (2003) Percutaneous radiofrequency coagulation of osteoid osteoma in children and adolescents. J Pediatr Orthop B 12:244–252PubMedCrossRefGoogle Scholar
  80. 80.
    Gebauer B, Tunn PU, Gaffke G et al. (2005) Osteoid osteoma: experience with laser-and radiofrequency-induced ablation. Cardiovasc Intervent Radiol 29:210–215CrossRefGoogle Scholar
  81. 81.
    Gallazzi MB, Arborio G, Garbagna PG et al. (2001) Percutaneous radio-frequency ablation of osteoid osteoma: technique and preliminary results. Radiol Med (Torino) 102:329–334PubMedGoogle Scholar
  82. 82.
    Barei DP, Moreau G, Scarborough MT et al. (2000) Percutaneous radiofrequency ablation of osteoid osteoma. Clin Orthop Relat Res 373:115–124PubMedCrossRefGoogle Scholar
  83. 83.
    Venbrux AC, Montague BJ, Murphy KP et al. (2003) Image-guided percutaneous radiofrequency ablation for osteoid osteomas. J Vasc Interv Radiol 14:375–380PubMedGoogle Scholar
  84. 84.
    Sequeiros RB, Hyvonen P, Sequeiros AB et al. (2003) MR imaging-guided laser ablation of osteoid osteomas with use of optical instrument guidance at 0.23 T. Eur Radiol 13:2309–2314PubMedCrossRefGoogle Scholar
  85. 85.
    Callstrom MR, Charboneau JW, Goetz MP et al. (2002) Painful metastases involving bone: feasibility of percutaneous CT-and US-guided radiofrequency ablation. Radiology 224:87–97PubMedGoogle Scholar
  86. 86.
    Goetz MP, Callstrom MR, Charboneau JW et al. (2004) Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol 22:300–306PubMedCrossRefGoogle Scholar
  87. 87.
    Gronemeyer DH, Schirp S, Gevargez A (2002) Image-guided radiofrequency ablation of spinal tumors: preliminary experience with an expandable array electrode. Cancer J 8:33–39PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Bernhard Gebauer
    • 1
  • Per-Ulf Tunn
  1. 1.Dept. of Radiology Charité — Campus BuchHELIOS-KlinikumBerlinGermany

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