Neurodegenerative Diseases with Associated White Matter Pathology

  • Mario Mascalchi
Part of the Medical Radiology Diagnostic Imaging book series (MEDRAD)


Conventional MR imaging can show macroscopic white matter signal changes in degenerative diseases of the CNS which are a useful diagnostic tool for FTD, OPCA, SA, and PLS/ALS.

Non-conventional MR, including DTI, MT and 1H-MRS, demonstrates abnormalities of the white matter in almost every degenerative disease of the CNS. These white matter changes are variably correlated to the severity of the clinical deficit and are currently evaluated as markers of disease progression and possible surrogate markers in pharmacological trials.


White Matter Amyotrophic Lateral Sclerosis Fractional Anisotropy Alzheimer Disease Motor Neuron Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Mario Mascalchi
    • 1
  1. 1.Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia ClinicaUniversità di FirenzeFirenzeItaly

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