Skip to main content
SpringerLink
Log in

Indications for Neoadjuvant Long-Term Radiotherapy

  • Conference paper
Rectal Cancer Treatment

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 165))

Abstract

If radiotherapy is considered in the management of a rectal cancer, there is very strong evidence supporting preoperative settings. To avoid treatment to cases where surgery alone is enough, exact preoperative staging with MRI is crucial.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Påhlman L, Glimelius B (1984) Local recurrences after surgical treatment for rectal carcinoma. Acta Chir Scand 150:331–335

    PubMed  Google Scholar 

  2. Glimelius B, Isacsson U, Jung B, Påhlman L (1997) Radiotherapy in addition to radical surgery in rectal cancer—evidence for a dose-response effect favouring preoperative treatment. Int J Radiat Oncol Biol Phys 37:281–287

    Article  PubMed  Google Scholar 

  3. Withers HR, Taylor JMC, Maciejewski B (1988) The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27:131–146

    PubMed  Google Scholar 

  4. Camma C, Giunta M, Fiorica F, Pagliaro L, Craxi A, Cottone M (2000) Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA 284:1008–1015

    Article  PubMed  Google Scholar 

  5. Glimelius B, Grönberg H, Järhult J, Wallgren A, Cavallin-Ståhl E (2003)Asystematic overview of radiation therapy in rectal cancer. Acta Oncologica 42; 476–492

    Article  PubMed  Google Scholar 

  6. Colorectal Cancer Collaborative Group (2001) Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet 358:1291–1304

    Google Scholar 

  7. Påhlman L, Glimelius B (1990) Pre-or postoperative radiotherapy in rectal and rectosigmoid carcinoma—report from a randomized multicentre trial. Ann Surg 211:187–195

    PubMed  Google Scholar 

  8. Krook JE, Moertel CG, Gunderson LL et al (1991) Effective surgical adjuvant therapy for high-risk rectal cancer. New Engl J Med 324:709–915

    PubMed  Google Scholar 

  9. Gastrointestinal Tumor Study Group (1985) Prolongation of the disease-free interval in surgically treated rectal carcinoma. New Engl J Med 312:1464–1472

    Google Scholar 

  10. Tveit KM, Guldvog I, Hagen S et al (1997) Randomised controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Br J Surg 84:1130–1135

    Article  PubMed  Google Scholar 

  11. Anonymous (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. New Eng J Med 336:980–987

    Google Scholar 

  12. Heald RJ, Karanjia ND. (1992) Results of radical surgery for rectal cancer. World J Surg 16:848–857

    Article  PubMed  Google Scholar 

  13. Enker WE (1992) Potency, cure, and local control in the operative treatment of rectal cancer. Arch Surg 127:1396–1401

    PubMed  Google Scholar 

  14. Moriya Y, Hojo K, Sawada T, Koyama Y (1989) Significance of lateral node dissection for advanced rectal carcinoma at or below the peritoneal reflection. Dis Colon Rectum 32:307–315

    PubMed  Google Scholar 

  15. Wibe A, Rendedal PR, Svensson E, Norstein J, Eide TJ, Myrvold HE, Soreide O(2002) Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg 89:327–334

    Article  PubMed  Google Scholar 

  16. Dahlberg M, Glimelius B, Påhlman L (1999) Changing strategy for rectal cancer is associated with improved outcome. Br J Surg 86:379–384

    Article  PubMed  Google Scholar 

  17. Martling AL, Holm T et al (2000) Effect of a surgical training programme on the outcome of rectal cancer in the County of Stockholm. Lancet 356:93–96

    Article  PubMed  Google Scholar 

  18. Kapiteijn E, Marijnen CAM, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJT, Leer JWH, van Krieken JHJM, Påhlman L, Glimelius B, van de Velde CJH (2001) for the Dutch Colo Rectal Cancer Group and other cooperative investigators. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638–646

    Google Scholar 

  19. Swedish Rectal Cancer Register. http://www.SOS.se/mars/kva.ik.htm (Swe)

    Google Scholar 

  20. Påhlman L, Glimelius B (2002) Radiotherapy for rectal cancer: the European approach. In: Bleiberg H, Kemeny N, Rougier P, Wilke H-J (eds) Colorectal cancer: a clinical guide to therapy. Dunitz, London, pp 229–238

    Google Scholar 

  21. Dahlberg M, Glimelius B, Graf W, Påhlman L (1998) Preoperative irradiation for rectal cancer affects the functional results after colorectal anastomosis—results from the Swedish Rectal Cancer Trial. Dis Colon Rectum 41:543–551

    PubMed  Google Scholar 

  22. Kollmorgen CF, Meagher AP, Pemberton JH et al (1994) The long-term effect of adjuvant postoperative chemoradiotherapy for rectal cancer on bowel function. Ann Surg 220:676–682

    PubMed  Google Scholar 

  23. Akbari RP, Wong WD (2003) Endorectal ultrasound and the preoperative staging in rectal cancer. Scand J Surg 92:25–33

    PubMed  Google Scholar 

  24. Brown G, Richards CJ, Newcombe RG et al (1999) Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology 211:215–222

    PubMed  Google Scholar 

  25. Beets-Tan RGH, Beets GL, Vliegen RFA et al (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357:497–504

    PubMed  Google Scholar 

  26. Adam IJ, Mohamdee MO, Martin IG et al (1994) Role of circumferential resection margin involvement in the local recurrence of rectal cancer. Lancet 344:707–711

    PubMed  Google Scholar 

  27. Nagtegaal ID, van de Velde CJH, van der Worp E, Kapiteijn E, Phil Quirke J, van Krieken J, Han JM (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Onc 20:1729–1734

    Article  Google Scholar 

  28. Påhlman L, Enblad P, Glimelius B (1985) Clinical characteristics and their relation to surgical curability in adenocarcinoma of the rectum and recto-sigmoid: a population-based study in 279 consecutive patients. Acta Chir Scand 151:685–693

    PubMed  Google Scholar 

  29. Moertel CG, Childs DS, Reitemeier RJ et al (1969) Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal carcinoma. Lancet 2:865–867

    Article  PubMed  Google Scholar 

  30. Overgaard M, Berthelsen K, Dahlmark M, Gadeberg CG, van der Maase H, Overgaard J, Sell A (1989) A randomized trial of radiotherapy alone or combined with 5-FU in the treatment of locally advanced colorectal carcinoma (abstract). ECCO 5 meeting, 0-0626, Vienna

    Google Scholar 

  31. Wassif-Boulis S (1982) The role of preoperative adjuvant therapy in management of borderline operability of rectal cancer. Clin Radiol 33:353–358

    Article  PubMed  Google Scholar 

  32. Frykholm GJ, Pahlman L, Glimelius B (2001) Combined chemo and radiotherapy versus radiotherapy alone in the treatment of primary, non-resectable adenocarcinoma of the rectum. Int J Rad Onc Biol Phys 50:433–440

    Google Scholar 

  33. Janjan NA, Abbruzzese J, Pazdur R, Khoo VS, Cleary K, Dubrow R, Ajani J, Rich TA, Goswitz MS, Evetts PA, Allen PK, Lynch PM, Skibber JM (1999) Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 51:153–160

    Article  PubMed  Google Scholar 

  34. Bouzourene H, Bosman FT, Seelentag W, Matter M, Coucke P (2002) Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 94:1121–1130

    Article  PubMed  Google Scholar 

  35. Glynne-Jones R, Sebag-Montefiore D (2002) Chemoradiation schedules—what radiotherapy? Eur J Cancer 38:258–569

    Article  PubMed  Google Scholar 

  36. Rouanet P, Saint-Aubert B, Lemanski C et. al (2002) Restorative and nonrestorative surgery for low rectal cancer after high-dose radiation. Dis Colon Rectum 45:305–315

    Article  PubMed  Google Scholar 

  37. Mohiuddin M, Regine WF, Marks GJ, Marks JW (1998) High dose preoperative radiation and the challenge of sphincter-preservation surgery for rectal cancer of the distal 2 cm of the rectum. Int J Radiat Oncol Biol Phys 40:569–574

    Article  PubMed  Google Scholar 

  38. Habr-Gama A, de Souza PM, Ribeiro U et al (1998) Low rectal cancer: impact of radiation and chemotherapy on surgical treatment. Dis Colon Rectum 41:1087–1096

    PubMed  Google Scholar 

  39. Moore HG, Riedel E, Minsky BD et al (2003) Adequacy of 1 cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy. Ann Surg Oncol 1:80–85

    Article  Google Scholar 

  40. Karnjia ND, Schache DJ, Nort WR, Heald RJ (1990) 'Close shave’ in anterior resection. Br J Surg 63:673–677

    Google Scholar 

  41. Francois Y, Nemoz CJ, Baulieux J et al (1999) Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J Clin Oncol 17:2396–2402

    PubMed  Google Scholar 

  42. Bujko K, Nowacki MP, Bebenek M et al (2004) Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy versus conventionally fractionated radiochemotherapy. Radiation Oncol 72:15–24

    Article  Google Scholar 

  43. Frigell A, Ottander M, Stenbeck H, Påhlman L (1990) Quality of life of patients treated with abdominoperineal resection or anterior resection for rectal carcinoma. Ann Chir Gynaecol 79:26–30

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Colorectal Unit, University Hospital, 75185, Uppsala, Sweden

    Lars Påhlman

Authors
  1. Lars Påhlman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Allgemeine, Viszerale, Unfallchirurgie und Poliklinik, Chirurgische Universitätsklinik Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Markus W. Büchler  & Jürgen Weitz  & 

  2. Chirurgie, Krankenhaus Gerresheim, Kliniken der Landeshauptstadt, Gräulinger Straße 120, 40625, Düsseldorf, Germany

    Bernward Ulrich

  3. The Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, Hampshire, RG24 9NA, UK

    Richard John Heald (OBE, Surgical Director) (OBE, Surgical Director)

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Påhlman, L. (2005). Indications for Neoadjuvant Long-Term Radiotherapy. In: Büchler, M.W., Weitz, J., Ulrich, B., Heald, R.J. (eds) Rectal Cancer Treatment. Recent Results in Cancer Research, vol 165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27449-9_23

Download citation

  • DOI: https://doi.org/10.1007/3-540-27449-9_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23341-1

  • Online ISBN: 978-3-540-27449-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation